Antidepressant drugs, including the best-selling Prozac, simply do not work as advertised, according to a comprehensive review by U.S. and Canadian researchers.
After examining all data available for the drugs — including clinical trials that manufacturers did not publish at the time — it was found that patients taking the drugs improved just as much as those taking placebo pills. The only exception was among severely depressed patients, who improved slightly more on the drugs than the placebos.
This study is unique in that it is the first time a study has been done using a full set of data for the antidepressants Prozac, Seroxat, Effexor, and Serzone.
“Using complete data sets (including unpublished data) and a substantially larger data set of this type than has been previously reported, we find the overall effect of new-generation antidepressant medication is below recommended criteria for clinical significance,” the authors wrote.