Depression Linked to Alzheimer’s

People who have had depression may be more prone to Alzheimer’s disease, two studies suggest.

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Depression has been linked to loss of brain cells

Dutch researchers found Alzheimer’s was 2.5 times more likely in people with a history of depression.

It was four times more likely in people with depression before aged 60. Dutch and US research appeared in Neurology and Archives of General Psychiatry.

The Dutch study was small – 486 people over an average of six years, with just 33 people developing Alzheimer’s

The researchers, from the Erasmus University Medical Center in Rotterdam, said more work was needed to fully understand the link between Alzheimer’s and depression.

Lead researcher Dr Monique Breteler said: “We don’t know yet whether depression contributes to the development of Alzheimer’s disease, or whether another unknown factor causes both depression and dementia.”

One theory is that depression leads to the loss of cells in two areas of the brain, the hippocampus and the amygdala, which then contributes to Alzheimer’s disease.

However, the latest study found no difference in the size of these two brain areas in people with depression and people who had never developed the condition.

Second study :

The findings were echoed in a second study by Rush University in the US published in Archives of General Psychiatry.

The researchers followed more than 900 members of the Catholic clergy for up to 13 years during which time 190 developed Alzheimer’s.

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They found that those with more signs of depression at the start of the study were more likely to develop Alzheimer’s.

But there was little evidence of an increase in depressive symptoms during the early stages of disease.

Even after the diagnosis of Alzheimer’s was made there was no general increase in depression, but rather an increase that was confined to individuals with certain personality traits.

The researchers said their findings suggested that depression was a risk factor for Alzheimer’s disease – rather than a subtle early sign of its underlying pathology.

Researcher Dr Robert Wilson said: “Depressive symptoms may be associated with distinctive changes in the brain that somehow reduce neural reserve, which is the brain’s ability to tolerate the pathology associated with Alzheimer’s disease.”

Rebecca Wood, of the Alzheimer’s Research Trust, said the research was interesting, and potentially useful.

She said: “Identifying people at higher risk could lead to ways to reduce the number of people who develop dementia, help researchers to understand more about dementia and create new avenues of research.”

Dr Susanne Sorensen, head of research at the Alzheimer’s Society, said: “More research is needed to clarify the relationship between dementia and depression and determine whether depression causes changes in the brain that make dementia more likely.”

“We don’t know yet whether depression contributes to the development of Alzheimer’s disease, or whether another unknown factor causes both depression and dementia”says
Dr Monique Breteler of Erasmus University Medical Center

Sources: BBC NEWS:8Th.April.’08

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