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‘Hot’ Substance in Chilli Peppers Key to Reduce Pain

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Studying chilli peppers is helping scientists create a new type of painkiller which could stop pain at its source.
…………..click & see

Capsaicin causes the burning sensation in chilli peppers

A team at the University of Texas says a substance similar to capsaicin, which makes chilli peppers hot, is found in the human body at sites of pain.

And blocking the production of this substance can stop chronic pain, the team found.

They report their findings in the Journal of Clinical Investigation.

Capsaicin is the primary ingredient in hot chilli peppers which causes a burning sensation.

It does this by binding to receptors present on the cells inside the body.

Similarly, when the body is injured, it releases capsaicin-like substances – fatty acids called oxidized linoleic acid metabolites or OLAMs – and these, via receptors, cause pain, the researchers have found.

Blocking pain
Dr Kenneth Hargreaves, senior researcher at the Dental School at the University of Texas, and his team next set out to see if they could block these newly discovered pain pathways.

Lab work on mice showed that by knocking out a gene for the receptors, there was no sensitivity to capsaicin.

Armed with this knowledge they set about making drugs to do the same.

Dr Hargreaves said: “This is a major breakthrough in understanding the mechanisms of pain and how to more effectively treat it.

“We have discovered a family of endogenous capsaicin-like molecules that are naturally released during injury, and now we understand how to block these mechanisms with a new class of non-addictive therapies.”

Ultimately, he hopes the drugs will be able to treat different types of chronic pain, including that associated with cancer and inflammatory diseases such as arthritis and fibromyalgia.

Source:BBC NEWS:April 27. 2010

You may also click to see:->
‘Immune jab’ blocks chronic pain
Cup of mint tea ‘can kill pain’
Pain ‘linked with low vitamin D’
Back to nature for pain relief

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Herbs & Plants

Rhododendron molle

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Botanical Name : Rhododendron molle
Family : Ericaceae
Genus :
Rhododendron
Synonyms: Azalea mollis – Blume.,Azalea sinensis – Lodd.,Rhododendron sinense – (Lodd.)Sw.
Common Name: Chinese Azalea ,

Habitat :   Rhododendron molle     is  native to  E. Asia – China.  Grows amongst coarse grasses and shrubs, also in thin pine woods.Woodland Garden; Dappled Shade; Shady Edge;

It grows in pinus forests, thickets on mountain slopes, exposed grassy hillsides, ridges; near sea level to 2500 m. Anhui, Fujian, Guangdong, Guangxi, Guizhou, Henan, Hubei, Hunan, Jiangsu, Jiangxi, Sichuan, Yunnan, Zhejiang.

Description:

Rhododendron molle  is a  decidious  Shrubs, 0.5–2 m tall; branches densely gray-white-pubescent, also sparsely setose when young. Petiole 2–6 mm, puberulent and ± setose; leaf blade papery, oblong to oblong-lanceolate, 5–11 × 1.5–3.5 cm; base cuneate; margin ciliate; apex obtuse and mucronate; abaxial surface densely gray-white-pubescent, yellow-brown setose along midrib; adaxial surface sparsely to densely puberulent when young. Inflorescence terminal, racemose-umbellate: flowers opening before or with the leaves; many-flowered. Pedicel 1–2.5 cm, pubescent and sparsely setose; calyx lobes small, rounded, pubescent and setose-ciliate; corolla broadly funnelform, yellow or golden yellow, with dark red flecks on lobes, ca. 4.5 × 5–6 cm; tube cylindric, tapering towards base, ca. 26 mm wide, outer surface puberulent; lobes 5, elliptic or ovate-oblong, ca. 2.8 cm, puberulent on outer surface; stamens 5, unequal; filaments flat, puberulent below; ovary conical, ca. 4 mm, densely gray-white-pubescent, also sparsely setose; style to 6 cm, glabrous. Capsule conical-cylindric, 5-ribbed, 25–35 mm, puberulent and sparsely setose. Fl. Mar–May, fr. Jul–Aug.

CLICK TO SEE THE PICTURES..>………..(01)..……..(1)....(2).(3)…(4)..…...(5)...(6)..…..(7).

It is hardy to zone 7. It is in flower in May. The flowers are hermaphrodite (have both male and female organs) and are pollinated by Insects.

The plant prefers light (sandy) and medium (loamy) soils and requires well-drained soil. The plant prefers acid soils and can grow in very acid soil. It can grow in semi-shade (light woodland). It requires moist soil.


Cultivation :

Succeeds in a most humus-rich lime-free soils except those of a dry arid nature or those that are heavy or clayey. Prefers a peaty or well-drained sandy loam[1]. Succeeds in sun or shade, though it prefers a shady position. A pH between 4.5 and 5.5 is ideal[1]. Succeeds in a woodland though, because of its surface-rooting habit, it does not compete well with surface-rooting trees. Plants need to be kept well weeded, they dislike other plants growing over or into their root system, in particular they grow badly with ground cover plants, herbaceous plants and heathers. Plants form a root ball and are very tolerant of being transplanted, even when quite large, so long as the root ball is kept intact. A very ornamental plant, it is the parent of many cultivars. Plants in this genus are notably susceptible to honey fungus.

Propagation:

Seed – best sown in a greenhouse as soon as it is ripe in the autumn and given artificial light. Alternatively sow the seed in a lightly shaded part of the warm greenhouse in late winter or in a cold greenhouse in April. Surface-sow the seed and do not allow the compost to become dry. Pot up the seedlings when they are large enough to handle and grow on in a greenhouse for at least the first winter. Layering in late July. Takes 15 – 24 months. Cuttings of half-ripe wood, August in a frame. Difficult

Medicinal Actions & Uses
Anaesthetic; Analgesic; Sedative.

The flowers are analgesic, anaesthetic and sedative. They are applied externally in the treatment of arthritis, caries, itch, maggots and traumatic injuries.  The root is used in the treatment of arthritis, rheumatism and traumatic injuries.

Other Uses

Insecticide.

The powdered flowers have a mild insecticidal effect.

.

Cultivars
There are some named forms for this species, but these have been developed for their ornamental value and not for their other uses. Unless you particularly require the special characteristics of any of these cultivars, we would generally recommend that you grow the natural species for its useful properties. We have, therefore, not listed the cultivars in this database

Known Hazards: The plant is very toxic. The pollen of many if not all species of rhododendrons is also probably toxic, being said to cause intoxication when eaten in large quantities.

Disclaimer:The information presented herein is intended for educational purposes only. Individual results may vary, and before using any supplements, it is always advisable to consult with your own health care provider.

Resources:
http://www.pfaf.org/database/plants.php?Rhododendron+molle
http://en.wikiversity.org/wiki/BCP/Rhododendron_molle
http://www.efloras.org/florataxon.aspx?flora_id=2&taxon_id=200016492

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Vitamin K May Protect You From Non-Hodgkin Lymphoma

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Individuals who are worried that they may be at risk for developing Non-Hogkin lymphoma may want to consider ingesting more vitamin K supplements, as a new study is suggesting that the medication may lower the risk of developing the disease.

According to researchers from the Mayo Clinic in Minnesota, patients who had a higher daily intake of vitamin K had a dramatically lower risk of developing Non-Hodgkin lymphoma, which affects the immune system and is the most common hematologic malignancy in the U.S.

“These results are provocative, since they are the first work we have done on the connection between vitamin K and Non-Hodgkin lymphoma, and this is a fairly strong protective effect,” said the study’s lead investigator, Dr. James Cerhan.

Individuals can ensure that they are getting a healthy dietary intake of vitamin K by eating leaf lettuce, spinach, vegetable oils and fruits. However, the researchers point out that one of the most common ways to incorporate the vitamin is to take nutritional supplements

You may click to see :->Vitamin K is a fat-soluble vitamin that plays an important role in blood clotting.

Source: Better Health Research. April 22nd. 2010

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Herbs & Plants

Sago Cycad (Cycas revoluta)

Botanical Name : Cycas revoluta
Family: Cycadaceae
Genus: Cycas
Kingdom: Plantae
Division: Cycadophyta
Class: Cycadopsida
Order: Cycadales
Species: C. revoluta

Habitat : E. Asia – China, Japan. Found mainly on the sea shore in S. Japan. Thickets on hillsides on islands, sparse forests on mainland at elevations of 100 – 500 metres in Fujian, China

Description:
Cycas revoluta (sago cycad), is an attractive plant native to southern Japan. Though often known by the common name of king sago palm, or just sago palm, it is not a palm at all, but a cycad.

click & see the pictures.
This very symmetrical plant supports a crown of shiny, dark green leaves on a thick shaggy trunk that is typically about 20 cm (7.9 in) in diameter, sometimes wider. The trunk is very low to subterranean in young plants, but lengthens above ground with age. It can grow into very old specimens with 6–7 m (over 20 feet) of trunk; however, the plant is very slow-growing and requires about 50–100 years to achieve this height. Trunks can branch multiple times, thus producing multiple heads of leaves.

The leaves are a deep semiglossy green and about 50–150 cm (20–59 in) long when the plants are of a reproductive age. They grow out into a feather-like rosette to 1 m (3.3 ft) in diameter. The crowded, stiff, narrow leaflets are 8–18 cm (3.1–7.1 in) long and have strongly recurved or revolute edges. The basal leaflets become more like spines. The petiole or stems of the Sago Cycad are 6–10 cm (2.4–3.9 in) long and have small protective barbs that must be avoided.

Cultivation :
Requires a strong loam with sharp sand and good drainage. Succeeds in dry soils. Requires a sunny position. Although it is the hardiest cycad, this species is not fully hardy in Britain but can tolerate occasional lows to about -5°c so long as the crown is protected and so is worthwhile trying outdoors in a sheltered position in the mildest areas of the country. Alternatively, it can be given greenhouse or conservatory protection over the winter and be placed outdoors in the summer. Plants are very slow growing. This plant is often used as a food source in its native range but recent research has shown that it can cause chronic nervous disorders if it is not treated properly. Overall its use is not to be recommended, especially since it is becoming rare in the wild. The plants produce special upward growing roots where nitrogen is produced in symbiosis with algae. Dioecious, male and female plants must be grown if seed is required.

Cycas revoluta is one of the most widely cultivated cycads, grown outdoors in warm temperate and subtropical regions, or under glass in colder areas. It grows best in sandy, well-drained soil, preferably with some organic matter. It needs good drainage or it will rot. It is fairly drought-tolerant and grows well in full sun or outdoor shade, but needs bright light when grown indoors. The leaves can bleach somewhat if moved from indoors to full sun outdoors.

Propagation:
Cycas revoluta is either by seed or by removal of basal offsets. As with other cycads, it is dioecious, with the males bearing cones and the females bearing groups of megasporophylls. Pollination can be done naturally by insects or artificially.

Seed – best sown in a greenhouse as soon as it is ripe, 2cm deep in individual pots which are then sealed in plastic bags to keep them moist until germination takes place. Germinates in 1 – 3 months at 25°c. Pre-soak stored seed for 24 hours in warm water then treat as above. Division of suckers in the spring.

Edible Uses

Edible Parts: Seed; Stem.
Seed – raw or cooked. They can be dried and ground into a powder then mixed with brown rice and fermented into ‘date miso’ or ‘sotetsu miso’. Caution is advised, see the notes above on toxicity. The heart or pith of the trunk is sliced and eaten baked or powdered. A toxic principal must first be removed. A starch can be extracted from this pith and is used for making dumplings. It is very sustaining.

You may click see : How  Sago  starch is extracted from the pith of sago palm stems and make edible.

Medicinal Actions & Uses

Astringent; Cancer; Diuretic; Emmenagogue; Expectorant; Tonic.

The leaves are used in the treatment of cancer and hepatoma. The terminal shoot is astringent and diuretic. The seed is emmenagogue, expectorant and tonic. It is used in the treatment of rheumatism. Substances extracted from the seeds are used to inhibit the growth of malignant tumours.

Other Uses:
Of all the cycads, the Sago Palm is the most popular in horticulture. It is seen in almost all botanical gardens, in both temperate and tropical locations. In many areas of the world, it is heavily promoted commercially as a landscape plant. It is also quite popular as a bonsai plant. First described in the late 1700s, it is native to various areas of southern Japan and is thus tolerant of mild to somewhat cold temperatures, provided the ground is dry. Frond damage can occur at temperatures below -10 °C or 15 degrees F and there are several healthy plants that have been grown with little protection as far north as Nashville Tennessee and Newport News Virginia, both are in zone 7b… The cycad revoluta usually defoliates in this temperate climate, but it usually will flush (or grow) several new leaves by April. It does however require hot summers with mean temperatures of 30 to 35 °C (86 to 95 F) for successful growth, making outdoor growing impossible in colder places such as northern Europe or the Northeast US, even where winter temperatures are not too cold. One disadvantage of its domestic use is that it is poisonous to animals and humans. One skin breaking scrape can lead to a hospital visit.

Known Hazards :  The plants contain alkaloids of carcinogens and also an amino-acid that causes chronic nervous disorders. Regular consumption of the plant leads to severe health problems and death. This toxic principle can be removed if the food is properly prepared but consumption of the plant still cannot be recommended because its use often means the death of the plant and it is becoming rare in the wild.

Disclaimer:The information presented herein is intended for educational purposes only. Individual results may vary, and before using any supplements, it is always advisable to consult with your own health care provider.

Resources:
http://www.pfaf.org/database/plants.php?Cycas+revoluta
http://en.wikipedia.org/wiki/Cycas_revoluta

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Great Masterwort(Astrantia major )

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Botnical Name : Astrantia major
Family : Umbelliferae/Apiaceae
Genus : Astrantia
Kingdom: Plantae
Order: Apiales
Species: A. major

Synonyms : Astrantia biebersteinii – Trautv.  Astrantia carinthiaca – Hoppe. ex Mart.&Koch.,  Astrantia carniolica – Hort. non Wulfen.,Astrantia trifida – Hoffm.Great_Masterwort

Common Name: Great Masterwort(

Habitat : C. and E. Europe. Naturalized in Britain.  Moist woodlands and the banks of streams. It grows on  Woodland Garden; Dappled Shade; Shady Edge.

Description:
Perennial growing to 0.8m by 0.5m.
It is hardy to zone 6. It is in flower from May to July, and the seeds ripen from August to September. The flowers are hermaphrodite (have both male and female organs) and are pollinated by Beetles, insects. The plant is self-fertile.

click to see the pictures.>…....(01)......(1).……....(2).……..…(3)..……...(4)..

Masterwort produces many small, ivory flowers that are flushed pink and bloom continuously throughout the summer and fall, wafting a sweet scent. Like Queen Anne’s lace, each masterwort blossom is an umbel of tiny flowers, framed by a collar of papery bracts.

The plant prefers light (sandy), medium (loamy) and heavy (clay) soils. The plant prefers acid, neutral and basic (alkaline) soils. It can grow in semi-shade (light woodland) or no shade. It requires moist soil.

Cultivation:
Prefers a fertile moisture-retentive soil. Succeeds in most well-drained soils in full sun or part shade. Succeeds in an open woodland and along the sides of streams so long as the soil is well above the water level. Plants are hardy to at least -17°c. Plants spread by means of underground runners. There are some named varieties, selected for their ornamental value. The flowers are sometimes dried and used for winter decoration.

Propagation:
Seed – best sown in a cold frame as soon as it is ripe. Sow stored seed as early in the year as you can obtain it. When large enough to handle, prick the seedlings out into individual pots and plant them out in the summer. If you have sufficient seed then it can be sown in situ either as soon as it is ripe or in the following spring. Division in spring. Large clumps can be planted out straight into their permanent positions. Smaller clumps are best potted up and kept in a cold frame until they are growing away well and can then be planted out in the summer.

Cultivars
There are some named forms for this species, but these have been developed for their ornamental value and not for their other uses. Unless you particularly require the special characteristics of any of these cultivars, we would generally recommend that you grow the natural species for its useful properties. We have, therefore, not listed the cultivars in this database

Medicinal Actions &  Uses:

Diuretic; Purgative.
The rhizomes and flowering stems have medicinal action.  Their main constituent is an essential oil that acts as a stomachic.  In herbal medicine the dried herb is used in an infusion or as a powder to promote the flow of digestive juices and thus stimulate the appetite.  Great masterwort is also included in diuretic tea mixtures.  A decoction of the root is purgative.

Disclaimer:The information presented herein is intended for educational purposes only. Individual results may vary, and before using any supplements, it is always advisable to consult with your own health care provider.


Resources:

http://www.pfaf.org/database/plants.php?Astrantia+major
http://www.finegardening.com/plantguide/astrantia-major-masterwort.aspx
http://en.wikipedia.org/wiki/Great_Masterwort
http://www.heronswood.com/perennials_perennials-a_astrantia/astrantia-major-sunningdale-variegated/

http://www.herbnet.com/Herb%20Uses_LMN.htm

 

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