Botanical Name :Inonotus obliquus
Species: I. obliquus
Common Names : Chaga Mushroom , Cinder conk, Birch mushroom
Habitat : Inonotus obliquus grows in birch forests of Russia, Korea, Eastern and Northern Europe, northern areas of the United States, in the North Carolina mountains and in Canada. The chaga mushroom is considered a medicinal mushroom in Russian and Eastern European folk medicine
It is parasitic on birch and other trees. The sterile conk is irregularly formed and has the appearance of burnt charcoal. It is not the fruiting body of the fungus, but a mass of mycelium, mostly black due to the presence of massive amounts of melanin. The fertile fruiting body can be found very rarely as a resupinate (crustose) fungus on or near the clinker, usually appearing after the host tree is dead.
Geographically this fungus is mostly found in very cold habitats. It grows very slowly, suggesting it is not a reliable source of bioactive compounds in the long run. Attempts at cultivating this fungus all resulted in a reduced and markedly different production of bioactive metabolites.Secondary metabolites were either absent or present in very different ratios, and in general showed significantly less potency in cultivated Chaga. Cultivated Chaga furthermore results in a reduced diversity of phytosterols, particularly lanosterol, an intermediate in the synthesis of ergosterol and lanostane-type triterpenes. This effect was partially reversed by the addition of silver ion, an inhibitor of ergosterol biosynthesis.
Additionally, the bioactive triterpene betulinic acid is completely absent in cultivated Chaga. In nature Chaga grows pre-dominantly on birches, and birch bark contains up to 22% of betulin. Betulin is poorly absorbed by humans, even when taken intravenously; its bioavailability is very limited. However, the Chaga mushroom converts betulin into betulinic acid, and many internet sources state Chaga’s betulinic acid is bioavailable, even when taken orally. Unfortunately there is no research that confirms this claims.
Chaga mushrooms, or cinder conks, have been a staple of traditional medicine for centuries among the peoples of the boreal forests in Siberia, Asia and North America. They are used as a tonic and blood purifier. They belong to the Polypores, a group of mushrooms that grow on wood and may be the ancestors of most gilled mushrooms. Chaga and the similar reishi mushroom both have a reputation as tonics for longevity and health which are born out by recent scientific studies. These mushrooms show great promise for their anti-viral activities, immune response stimulation and anti-tumor effects that inhibit the spread of cancer cells.
In China, Japan and South Korea, extracts of chaga and other mushrooms from the family Hymenochaetaceae are being produced, sold and exported as anticancer medicinal supplements. The main bioactive ingredient in these extracts are usually (1>3)(1>6) Beta-D-glucans, a type of water-soluble polysaccharide. The biologic properties of crude preparations of these specific Beta-D-glucans have been subject of research since the 1960s.
Although these macro-molecules exhibit a wide range of biologic functions, including antitumor activity, their ability to prevent a range of infectious diseases (by triggering and supporting the immune function) has been studied in the greatest detail. Recent scientific research in Japan and China has been focused more on the anticancer potential and showed the effects of these specific beta-glucans to be comparable to chemotherapy and radiation, but without the side effects. Further research indicated these polysaccharides have strong anti-inflammatory and immune balancing properties, stimulating the body to produce natural killer (NK) cells to battle infections and tumor growth, instead of showing a direct toxicity against pathogens. This property makes well-prepared medicinal mushroom extracts stand out from standard pharmaceuticals – no side effects will occur or develop; the body is healing itself, triggered into action by the BRM effect of the chaga extract. Herbalist David Winston maintains it is the strongest anticancer medicinal mushroom. Russian literature Nobel Prize laureate Alexandr Solzhenitsyn wrote two pages on the medicinal use and value of chaga in his autobiographical novel, based on his experiences in a hospital in Tashkent, Cancer Ward (1968).
Since the 16th century, chaga mushrooms were recorded as being used in folk medicine and the botanical medicine of the Eastern European countries as a remedy for cancer, gastritis, ulcers, and tuberculosis of the bones. A review from 2010 stated, “As early as in the 16th century, chaga was used as an effective folk medicine in Russia and Northern Europe to treat several human malicious tumors and other diseases in the absence of any unacceptable toxic side effects.”
Chemical analysis shows that I. obliquus produces during its development and growth a range of secondary metabolites, including phenolic compounds such as melanins, and lanostane-type triterpenes, which include a small percentage of betulinic acid. Among these metabolites are biologically active components which have been researched and tested for their potential antioxidant, antitumoral, and antiviral activities. Both betulin and betulinic acid are being studied for use as chemotherapeutic agents and are already used as anti-HIV agents ). In an animal study, researchers found betulin from birch bark lowered cholesterol, obesity and improved insulin resistance.
In 1958, scientific studies in Finland and Russia found chaga provided an epochal effect in breast cancer, liver cancer, uterine cancer, and gastric cancer, as well as in hypertension and diabetes.
A 1998 study in Poland demonstrated chaga’s inhibiting effects on tumor growth. Noda and colleagues found betulin seems to work highly selectively on tumor cells because the interior pH of tumor tissues is generally lower than that of normal tissues, and betulinic acid is only active at those lower levels. Fulda et al. found, in 1997, once inside the cells, betulinic acid induces apoptosis (programmed cell death) in the tumors. In 2005, I. obliquus was evaluated for its potential for protecting against oxidative damage to DNA in a human keratinocyte cell line. The study found the polyphenolic extract protected these cells against hydrogen peroxide-induced oxidative stress. Another study that year found the endopolysaccharide of chaga produced indirect anticancer effects via immunostimulation. The mycelial endopolysaccharide of I. obliquus was identified as a candidate for use as an immune response modifier and indicated the anticancer effect of endopolysaccharide is not directly tumoricidal, but rather is immunostimulation. It also has anti-inflammatory properties. Saitoh Akiko published on the antimutagenic effects of chaga in 1996. Mizuno et al. published on the antitumor and hypoglycemic activities of the polysaccharides from the sclerotia and mycelia of chaga. Due to the serum glucose-lowering activity of polysaccharides, caution should be taken by those with hypoglycemia
Disclaimer : The information presented herein is intended for educational purposes only. Individual results may vary, and before using any supplement, it is always advisable to consult with your own health care provider