Tag Archives: Antimalarial medication

Sweet Wormwood(Artemisia annu)

Botanical Name:Artemisia annu

Family: Asteraceae
Genus: Artemisia
Species: A. annua
Kingdom: Plantae
Order: Asterales

Common Names:Sweet Wormwood, Sweet Annie, Sweet Sagewort or Annual Wormwood.   Annual sagebrush ,  Chinese wormwood,   qing hao

Habitat :Sweet Wormwood is a common type of wormwood that is native to temperate Asia, but naturalized throughout the world.

Description:
It has fern-like leaves, bright yellow flowers, and a camphor-like scent. Its height averages about 2 m tall, and the plant has a single stem, alternating branches, and alternating leaves which range 2.5–5 cm in length. It is cross-pollinated by wind or insects. It is a diploid plant with chromosome number, 2n=18.Sweet Wormwood  has leaves that are mildly perfume scented.
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Medicinal uses:
Medicinal properties: bitter   febrifuge   antimalarial   antibiotic
Parts Used: Leaves

Sweet Wormwood was used by Chinese herbalists in ancient times to treat fever, but had fallen out of common use, but was rediscovered in 1970’s when the Chinese Handbook of Prescriptions for Emergency Treatments (340 AD) was found. This pharmacopeia contained recipes for a tea from dried leaves, prescribed for fevers (not specifically malaria).

Extractions:
In 1971, scientists demonstrated that the plant extracts had antimalarial activity in primate models, and in 1972 the active ingredient, artemisinin (formerly referred to as arteannuin), was isolated and its chemical structure described. Artemisinin may be extracted using a low boiling point solvent such as diethylether and is found in the glandular trichomes of the leaves, stems, and inflorescences, and it is concentrated in the upper portions of plant within new growth.

Parasite treatment:
It is commonly used in tropical nations which can afford it, preferentially as part of a combination-cocktail with other antimalarials in order to prevent the development of parasite resistance.

Malaria treatment:
Artemisinin itself is a sesquiterpene lactone with an endoperoxide bridge and has been produced semi-synthetically as an antimalarial drug. The efficacy of tea made from A. annua in the treatment of malaria is contentious. According to some authors, artemesinin is not soluble in water and the concentrations in these infusions are considered insufficient to treatment malaria. Other researchers have claimed that Artemisia annua contains a cocktail of anti-malarial substances, and insist that clinical trials be conducted to demonstrate scientifically that artemisia tea is effective in treating malaria. This simpler use may be a cheaper alternative to commercial pharmaceuticals, and may enable health dispensaries in the tropics to be more self-reliant in their malaria treatment. In 2004, the Ethiopian Ministry of Health changed Ethiopia’s first line anti-malaria drug from Fansidar, a Sulfadoxine agent which has an average 36% treatment failure rate, to Coartem, a drug therapy containing artemesinin which is 100% effective when used correctly, despite a worldwide shortage at the time of the needed derivative from A. annua.

Cancer treatment:
The plant has also been shown to have anti-cancer properties. It is said to have the ability to be selectively toxic to some breast cancer cells [Cancer Research 65:(23).Dec 1, 2005] and some form of prostate cancer, there have been exciting preclinical results against leukemia, and other cancer cells.

Mechanism:
The proposed mechanism of action of artemisinin involves cleavage of endoperoxide bridges by iron producing free radicals (hypervalent iron-oxo species, epoxides, aldehydes, and dicarbonyl compounds) which damage biological macromolecules causing oxidative stress in the cells of the parasite.[citation needed] Malaria is caused by Apicomplexans, primarily Plasmodium falciparum, which largely resides in red blood cells and itself contains iron-rich heme-groups (in the from of hemozoin).

Precaution:During pregnancy this herb should not used.

Other uses:
In modern-day central China, specifically Hubei Province, the stems of this wormwood are used as food in a salad-like form. The final product, literally termed “cold-mixed wormwood”, is a slightly bitter salad with strong acid overtones from the spiced rice vinegar used as a marinade. It is considered a delicacy and is typically more expensive to buy than meat.

Disclaimer:The information presented herein is intended for educational purposes only. Individual results may vary, and before using any supplements, it is  always advisable to consult with your own health care provider.

Resources:
http://en.wikipedia.org/wiki/Artemisia_annua
http://www.crescentbloom.com/Plants/Specimen/AO/Artemisia%20annua.htm

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Deltoid Balsamroot(Balsamorhiza deltoidea)

Botanical Name : Balsamorhiza deltoidea
Family : Compositae / Asteraceae
Genus : Balsamorhiza
Common Namedeltoid balsamroot.
Kingdom: Plantae
Order: Asterales
Tribe: Heliantheae
Species: B. deltoidea

Habitat : Western N. AmericaBritish Columbia to California.Open places but not on thin soils.


Description:

This is a taprooted perennial herb growing erect to a maximum height near 90 centimeters. The stems are hairy and glandular. The large leaves are up to 25 centimeters long and 20 wide, and are roughly triangular in shape, hairy and glandular, and often toothed along the edges. The inflorescence bears usually one or sometimes a few large flower heads, each lined with hairy, pointed phyllaries up to 4 centimeters long. The head has a center of yellowish disc florets and a fringe of pointed yellow ray florets each up to 4 or 5 centimeters long. The fruit is an achene 7 to 8 millimeters in length.

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It is hardy to zone 5. It is in flower from May to June. The flowers are hermaphrodite (have both male and female organs) and are pollinated by Insects.

The plant prefers light (sandy) and medium (loamy) soils and requires well-drained soil. The plant prefers acid, neutral and basic (alkaline) soils. It cannot grow in the shade. It requires dry or moist soil.

Cultivation:
Requires a deep fertile well-drained loam in full sun. Plants strongly resent winter wet. Hardy to at least -25°c. Plants are intolerant of root disturbance and should be planted into their permanent positions whilst still small.

Propagation:
Seed – sow early spring in a greenhouse and only just cover the seed. Germination usually takes place within 2 – 6 days at 18°c. Either sow the seed in individual pots or pot up the seedlings as soon as they are large enough to handle and plant them out into their permanent positions in the summer. Division in spring. Very difficult since the plant strongly resents root disturbance. It is probably best to take quite small divisions, or basal cuttings, without disturbing the main clump. Pot these up into individual pots and keep them in light shade in the greenhouse until they are growing away well. Plant them out in the summer if they have grown sufficiently, otherwise over-winter them in the greenhouse and plant out in late spring.

Edible Uses
Edible Parts: Leaves; Root; Seed.

Edible Uses: Coffee.

Root – raw or cooked. A sweet taste when cooked[161]. Young shoots – raw. Seed – raw or cooked. It can be ground into a powder and made into a bread. The ground seeds can be formed into cakes and eaten raw. The roasted root is a coffee substitute.

Medicinal Uses:
Miscellany.
A decoction of the split roots has been used in the treatment of coughs and colds.

Disclaimer:The information presented herein is intended for educational purposes only. Individual results may vary, and before using any supplements, it is always advisable to consult with your own health care provider.

Resources:
http://www.pfaf.org/database/plants.php?Balsamorhiza+deltoidea
http://plants.usda.gov/java/profile?symbol=BADE2
http://en.wikipedia.org/wiki/Balsamorhiza_deltoidea
http://www.ubcbotanicalgarden.org/potd/2007/04/balsamorhiza_deltoidea.php
http://www.pbase.com/rodg/image/78822814

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Ageratum Houstonianum

Botanical Name: Ageratum houstonianumBlue Danube
Family  : Compositae
Genus : Ageratum
Synonyms : Ageratum caeruleum – Hort., Ageratum mexicanumSims.
Common Name: ‘Blue Danube’ ageratum, ‘Blue Danube’ floss flower

Habitat: South-western N. AmericaMexico. An occasional garden escape in Britain.  Pine woods and cultivated ground.

Description:

It is hardy to zone 8. It is in flower from June to October, and the seeds ripen from August to October. The flowers are hermaphrodite (have both male and female organs) and are pollinated by Lepidoptera (Moths & Butterflies).

click & see the pictures.
Plant details:-
Height : 6 in. to 12 in.
Spread :  6 in. to 12 in.
Growth Habit :  Clumps
Growth Pace :  Fast Grower
Light :   Full Sun Only
Moisture:    Medium Moisture
Maintenance :    Low
Characteristics:    Attracts Butterflies; Showy Flowers
Bloom Time:    Early Fall; Late Summer; Summer
Flower Color :    Blue Flower
Uses :   Beds and Borders, Container
Style  :  Formal Garden
Seasonal Interest:    Summer Interest, Fall Interest
Type :  Annuals

Cultivation :
Grows well in ordinary garden soil. Requires a sheltered position in full sun[200]. This species is not hardy in the colder areas of the country, it tolerates temperatures down to between -5 and -10°c[200]. A very ornamental plant[1], the flowers are very attractive to butterflies[30]. The removal of dead flowers will extend the flowering season.

Propagation:
Seed – surface sow March in a light position in a greenhouse. The seed usually germinates in 1 – 3 weeks at 20°c. When large enough to handle, prick the seedlings out and plant them out after the last expected frosts.

The plant prefers light (sandy), medium (loamy) and heavy (clay) soils. The plant prefers acid, neutral and basic (alkaline) soils. It cannot grow in the shade. It requires dry or moist soil.

Medicinal Uses
Anodyne.
The juice of the plant is used externally to treat cuts and wounds.

Resources:
http://www.pfaf.org/database/plants.php?Ageratum+houstonianum
http://www.finegardening.com/plantguide/ageratum-houstonianum-blue-danube.aspx
https://www.anniesannuals.com/signs/a/ageratum_houstonium_b.htm
http://www.desert-tropicals.com/Plants/Asteraceae/Ageratum_houstonianum.html

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Bhumiamla / Phyllanthus niruri

Botanical Name:Phyllanthus niruri
Family:Phyllanthaceae
Genus:Phyllanthus
Species:P. niruri
Kingdom:    Plantae
Order:Malpighiales

Common names : Chanca Piedra in Spanish, Bhumyamalaki in Ayurveda, and Quebra-Pedra in Portuguese, Keezha Nelli  in Tamil, Nela Nelli  in Kannada,Keezhar Nelli in Malayalam and Nela Usiri in Telugu. It has many other common names in assorted languages, including dukong anak, dukong-dukong anak, amin buah, rami buah, turi hutan, bhuiaonla, and Meniran (in Indonesia).

Habitat : Common in central and southern India extending to Sri Lanka.
Historical aspects:
Charaka mentions the plant. In ayurveda the expressed juice of the fresh plant is given for a sluggish liver and also for chronic liver diseases. It is commonly and widely used for dysentery and intestinal colic. Phyllanthus niruri, also called “stonebreaker” due to its strong roots, is native to South America. The plant is dried into an extract that acts as a diuretic and an astringent.

Description:  The annual herb is 30-60cm high, quite glabrous, stem often branched at the base, angular. Leaves numerous subsessile distichous often imbricating, elliptic oblong obtuse.Stem is angular with numerous distichous, elliptic-oblong leaves. Stipules present, very acute. Flowers yellowish, very numerous, axillary, the male flowers 1-3, female flowers are solitary pistillate flower borne axillary. Fruits capsule, very small, globose, smooth, seeds 3-gonous, longitudinally ribbed on the back. Seed to seed cycle occurs in two or four weeks. The flowering time in Indian conditions is July to August.

You may click to see the picture......(01).....(1)…..   (2)…..

Pharmacognoy:
It is safe lipotropic drug and its primary action is on the liver. Blumberg showed in inhibition of DNA polymerase of Hepatitis b virus and a viral-agglutinating activity. The characteristics have been well studied.

Phytochemistry
:
In the aerial parts, three crystalline lignans including phyllanthine and hypophyllanthine have been found. Five flavonoids have been identified, quercetin, astralgin, quercitrin, and rutin. Four leucodelphinidine alkaloids were separated from the leaves and stems one of then being and enantiomorph of securinine.

Medicinal Uses:
A clinical study with Phyllanthus niruri, indicated that it may reduce the levels of urinary calcium.  A subsequent study of 150 patients over a 6-month period indicated that an extract of this herb reduces the incidence of stone formation, and concluded, “Regular self-administration of P. niruri after extracorporeal shock wave lithotripsy for renal stones results in an increased stone-free rate that appears statistically significant for lower caliceal location. Its efficacy and the absolute lack of side effects make this therapy suitable to improve overall outcomes after extracorporeal shock wave lithotripsy for lower pole stones.”  A more recent rat study found that Phyllanthus niruri has been shown to interfere with many stages of stone formation, reducing crystals aggregation, modifying their structure and composition as well as altering the interaction of the crystals with tubular cells leading to reduced subsequent endocytosis.”

Ayurvedic properties :
Guna: Laghu, Ruksha.
Rasa
: Tikta, kashaya.
Veerya: Sheeta.Vipaka: Katu.
Dosha: Kaphapittaghna
karma: Kasaswasahara, Dahaprashamana, Rochana, Yakrutottejaka, kandughna.

Safety:
With the formulation and dosage used no adverse reactions have been reprted.

Cinical Usage:
The fresh root is used for the treatment of viral hepatitis.the plant is also used as a diuretic in oedema.it is also used to increase appetite and locally to relieve inflammations.

Healing Options:
Phyllanthus has been used in Ayurvedic medicine for over 2,000 years and has a wide number of traditional uses.

This includes employing the whole plant for jaundice, gonorrhea, frequent menstruation, and diabetes and using it topically as a poultice for skin ulcers, sores, swelling, and itchiness

CHANCA PIEDRA (Phyllanthus niruri) is a composite name, “chanca” meaning “to break” in Quechua and “piedra” meaning “stone” in Spanish. It is the popular name given to several small shrub-like plants in the Phyllanthus genus (botanical family Euphorbiaceae), including Phyllanthus niruri, and Phyllanthus stipulatis. These two species have the same medicinal effects and look identical, except for their seeds, by which the botanist can tell them apart. A third species, Phyllanthus amarus, has been considered identical (perhaps not a different species at all) to Phyllanthus niruri. These species of Phyllanthus have been proven in scientific research to have antihepatotoxic, antispasmodic, antiviral, bactericidal, febrifugal, and hypoglycemic activity.*

Liver Disorders/ Jaundice :
The herb stimulates the liver and is useful in liver and spleen disorders. It can be used in jaundice and enlargement of liver. The leaf should be administered with black salt and ginger every morning for 10 days in the treatment of such disorders.

Loss of Appetite:
Its root, leaves, fruits, milky juice is very useful in Loss of appetite . It is a major component of many popular liver tonics which increase Appetite & locally to relieve inflammations.

Oedema:
The plant is also used as a diuretic in oedema. Powdered leaves & roots – pulverized & made into poultice with rice-water useful in oedematous swelling and ulcers.

Formulation and Dosage:
Juice: 10-20 ml b.i.d
Herb powder: 3-6 gms b.i.d

Ayurvedic supplements made from Bhumiamla:
Livgood
Livrol Syrup
Arogyavardhini Bati

Liver Tonic Livogod
Herbal Liver Tonic for cirrhosis,alcholic ilver and jaundice

Disclaimer:The information presented herein is intended for educational purposes only. Individual results may vary, and before using any supplements, it is always advisable to consult with your own health care provider.
Resources:
http://en.wikipedia.org/wiki/Phyllanthus_niruri
allayurveda.com

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