Tag: Cell growth

Olive Oil Protection Against Breast Cancer

Post author By Mukul
Post date July 1, 2010
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Researchers have decoded a complete cascade of signals within breast tumor cells activated by virgin olive oil, and concluded that benefits include decrease in the activity of the oncogene p21Ras, changes in protein signaling pathways, stimulation of tumor cell death and prevention of DNA damage. The study was carried out in an experimental model and researchers have already begun a new study with human cell lines.

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Breast cancer is the most common type of cancer in Western countries. Research carried out with animal models demonstrate that a diet rich in fats is directly related to the incidence of cancer. Some types of fats however can play a protective role against the development of these tumors. Such is the case of virgin olive oil, rich in oleic acid, a mono-unsaturated fatty acid, and containing several bioactive compounds such as antioxidants. A moderate and regular intake of virgin olive oil, characteristic of the Mediterranean diet, is associated with low incidences of specific types of cancer, including breast cancer, as well as with having a protective role against coronary diseases and other health problems.

The study decoded the mechanisms operating within the tumor cell and induced by the intake of olive oil, in comparison to those activated by corn oil, rich in n-6 polyunsaturated fatty acids, which increase the aggressiveness of tumors.

Scientists demonstrated that virgin olive oil is associated with higher incidences of benign breast tumors and at the same time with a decrease in the activity of the p21Ras oncogene, which spurs uncontrolled cell proliferation and stimulates the growth of tumors. In addition, olive oil suppresses the activity of some proteins, such as the AKT, essential for the survival of cells since they prevent apoptosis, the cell’s “suicide” program. Between proliferation and apoptosis in tumor cells, these effects tip the balance towards cell death, thereby slowing the growth of tumors.

Another result obtained by researchers is the protection of DNA in the cell nucleus. Cells from animals fed a diet rich in virgin olive oil contained less DNA lesions than those fed a control diet.

Scientists of the UAB Breast Cancer Study Multidisciplinary Group (GMECM) have spent over twenty years working to determine the effects fats have on breast cancer, and in particular the effects of virgin olive oil. Previous studies of the group revealed the beneficial effects of this component of the human diet on the clinical conduct of mammary tumors and on their histological grade (malignancy). Scientists also described several molecular mechanisms producing these effects and in 2004 the same group was the one to identify the four genes involved in the effects dietary fats have on experimental breast cancer.

Source: Elements4Health

A key mechanism links virgin olive oil to protection against breast cancer (eurekalert.org)
A key mechanism links virgin olive oil to protection against breast cancer (physorg.com)
Virgin olive oil and a Mediterranean diet fight heart disease by changing how our genes function (eurekalert.org)
Health Benefits of Olive Oil (food-facts.suite101.com)
Melanoma-initiating cell identified by Stanford scientists (eurekalert.org)
Celgene to Acquire Abraxis BioScience Inc. (eon.businesswire.com)
A Breast Cancer Story – How To Cure Breast Cancer (slideshare.net)
Olive-oil enriched diet helps breast cancer survivors lose more weight (eurekalert.org)

Tags Apoptosis, Breast cancer, Cell growth, Olive oil, Tumor

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Red Wine Nutrient Helps Fight Aging and Abnormal Cell Growth

Post author By Mukul
Post date December 25, 2009
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Recent scientific studies have discovered a simple compound that can help enhance, improve and even lengthen your life—without any negative side effects. Imagine living five… 10… or 15 years longer than the average-age man or woman.

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Specialists from the Mayo Clinic and Harvard University state that a miracle nutrient called resveratrol found in red wine could be the elixir to extend your life. Resveratrol can also be found in grapes, peanuts, seeds, various Chinese and Japanese herbs, raspberries, blueberries, and cranberries.

When it comes to protecting your cells from abnormal growth that can lead to cancer, clinical studies show resveratrol can boost the health and lifespan of your cells. Researchers at the University of Illinois in Chicago found that resveratrol interfered with the three major stages of cancer production. Resveratrol was found to neutralize free radical damage in the initiation of the disease, reduce inflammation during the promotion of the disease and inhibit further abnormal cell growth during the progression of the disease. According to the results published in Science, the data suggest that resveratrol is a highly effective nutrient that may present itself as a potential cancer chemopreventive agent in humans, as well.

By supplementing with resveratrol, not only can you fight abnormal cell growth, you can help shut down sick cells and prevent them from multiplying… repair cells faster and keep healthy cells living longer and stronger… increase your lifespan by decades… and virtually wipe out old-age health concerns including blood sugar imbalances, memory loss and cholesterol problems.

Source: Better Health Research. Dec 14. 2009

Tags Cancer, Cell growth, Clinical trial, Harvard University, Health, Mayo Clinic, Specific Substances, Wine

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New Cure for Prostate Cancer

Post author By Mukul
Post date February 11, 2009
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Scientists have developed a potential new treatment for prostate cancer, offering hope to thousands of patients.

It is a monoclonal antibody to a unique tumor marker for prostate cancer, said Pei Xiang Xing, associate professor who heads Burnet Institute‘s Cancer Immunotherapy Lab, Melbourne and led the research team.

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The monoclonal antibody is directed at cancer-producing cells carrying the specific molecule known as PIM-1, which is responsible for cell survival, proliferation and differentiation.

Over-expression of PIM-1 plays a critical role in the development, progression and metastasis of prostate cancer and other cancers such as leukemia. The monoclonal antibody significantly inhibited cancer cell growth when used in laboratory models of prostate cancer.

Xing’s group demonstrated that the monoclonal antibody binds to PIM-1 present in cancer cells and creates a chain of events leading to the death of the cells. In particular, the therapeutic effect was improved by combination of the antibody with other drugs currently used to treat prostate cancer.

Prostate cancer is one of the most frequently diagnosed invasive cancers and the third leading cause of death in men worldwide, which claims more than 3,000 lives every year, equal to the number of women who die from breast cancer.

A new strategy to treat prostate cancer is urgently needed as there is no efficient method to treat advanced prostate cancer, said a Burnet release.

Burnet Institute’s director Brendan Crabb described it as “an exciting step in the development of new treatments for patients with prostate cancer with very promising laboratory-test results”.

Sources: The Times Of India

Tags Breast cancer, Burnet Institute, Cancer, Cell growth, Conditions and Diseases, Diffusion MRI, Health, Hormone therapy, Huntsman Cancer Institute, Magnetic resonance imaging, Monoclonal antibodies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Prostate, Prostate cancer, Prostate specific antigen, Times Of India

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Scientists Show How Certain Vegetables Combat Cancer

Post author By Mukul
Post date January 21, 2009
1 Comment on Scientists Show How Certain Vegetables Combat Cancer

While it has been known for some time that eating cruciferous vegetables, such as broccoli, cauliflower, and cabbage, can help prevent breast cancer, the mechanism by which the active substances in these vegetables inhibit cell proliferation was unknown — until now.

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Scientists in the UC Santa Barbara laboratories of Leslie Wilson, professor of biochemistry and pharmacology, and Mary Ann Jordan, adjunct professor in the Department of Molecular, Cellular, and Developmental Biology, have shown how the healing power of these vegetables works at the cellular level. Their research is published in this month’s journal Carcinogenesis.

“Breast cancer, the second leading cause of cancer deaths in women, can be protected against by eating cruciferous vegetables such as cabbage and near relatives of cabbage such as broccoli and cauliflower,” said first author Olga Azarenko, who is a graduate student at UCSB. “These vegetables contain compounds called isothiocyanates which we believe to be responsible for the cancer-preventive and anti-carcinogenic activities in these vegetables. Broccoli and broccoli sprouts have the highest amount of the isothiocyanates.

“Our paper focuses on the anti-cancer activity of one of these compounds, called sulforaphane, or SFN,” Azarenko added. “It has already been shown to reduce the incidence and rate of chemically induced mammary tumors in animals. It inhibits the growth of cultured human breast cancer cells, leading to cell death.”

Sources:
Science Blog December 23, 2008
Carcinogenesis December 2008; 29(12):2360-8