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Researchers at Northwestern University in Chicago have made a new discovery that could lead to better cochlear implants for deaf people.
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Infrared light can stimulate neurons in the inner ear as precisely as sound waves, a discovery that could lead to better cochlear implants
They have found that infrared light can stimulate neurons in the inner ear as precisely as sound waves, reports New Scientist.

A healthy inner ear uses hair cells that respond to sound to stimulate neurons that send signals to the brain. However, hair cells can be destroyed by disease or injury, or can contain defects at birth, leading to deafness. In such cases, cochlear implants can directly stimulate neurons.

The hearing provided by implants is good enough to enable deaf children to develop speech skills that are remarkably similar to hearing children’s.

However, implant users still find it tough to appreciate music, communicate in a noisy environment and understand tonal languages like Mandarin and that’s because the implants use only 20 or so electrodes, a small number compared to the 3000-odd hair cells in a healthy ear.

More sources of stimulation should make hearing clearer but more electrodes cannot be packed in because tissue conducts electricity, so signals from different electrodes would interfere.

On the contrary, laser light targets nerves more precisely and doesn’t spread, which could allow an implant to transmit more information to the neurons.

In order to explore that idea, a research team led by Claus-Peter Richter at Northwestern University in Chicago shone infrared light directly onto the neurons in the inner ear of deaf guinea pigs.

At the same time, the researchers recorded electrical activity in the inferior colliculus, a relay between the inner ear and the brain cortex, producing a set of frequency “maps”.

These maps are a good indication of the quality of sound information sent to the brain.

Richter said that electrical stimulation of the inner ear by a cochlear implant produces blurred maps, but the light stimulation produced maps that were as sharp as those produced by sound in hearing guinea pigs.

While it’s a mystery how light stimulates the neurons, as they do not contain light-sensitive proteins, Richter hypothesizes the heat that accompanies the light may play a role, and his team is now investigating the long-term effects of heating neurons.

The findings were presented at the Medical Bionics conference in Lorne, in the Australian state of Victoria, earlier this week.

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Light-wave implant hope for deaf

Original Signal-Transmitting Science

Light may bring sound to the deaf

Light opens up a world of sound for the deaf

Sources: The Times Of India

Bromelain

The cochlea and vestibule, viewed from above.

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Scientists have used gene therapy on mouse embryos to grow hair cells with the potential to reduce hearing loss in adult animals, according to a study.

The proof-of-concept experiments are a crucial step toward therapies that could one day treat deafness and inner-ear disease in humans, said the study, published in the British journal Nature on Wednesday.

Sensory hair cells inside the cochlea, the auditory portion of the inner ear, convert sound waves into electrical impulses that are delivered to the brain.

The loss of these cells and the neurons they contain is the most common cause of hearing impairment and so-called nerve deafness. At birth, humans have about about 30,000 hair cells, which can be damaged by factors like infections, aging, genetic diseases, loud noise or treatment with certain drugs.

In most cases, damaged hair cells do not regrow in mature humans. But recent research has kindled hope that nerve deafness may one day be curable.

A team of scientists led by John Brigande at the Oregon Health and Science University, in Portland showed that implanting a gene known as Atoh1 into the inner ear of a mouse embryo coaxed non-sensory cells to become hair cells.

Earlier research had pointed to similar results, but this is the first study to show that the cells generated by the gene therapy are functional.

The production of extra, working hair cells in a mouse embryo could be an important step toward using similar therapies in human patients, the study by the researchers in US said.

Sources:The Times Of India

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