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Resveratrol Slows The Aging Process

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A natural compound that can help enhance your memory and restore your brain’s cell function is resveratrol. This nutrient is found in grapes, red wine, peanuts, seeds, nuts, various Chinese and Japanese herbs, raspberries, blueberries and cranberries.

The power of resveratrol was first discovered in association with French diets. Longevity and increased heart health were abundant among the Europeans even though they consumed high levels of saturated fats and wine. The key to the French peoples’ life expectancy, razor-sharp mind and low rate of coronary heart disease was linked with the nutrient resveratrol.

In his book, The Longevity Factor: How Resveratrol and Red Wine Activate Genes For A Longer and Healthier Life, Joseph Maroon, M.D., explains the power of resveratrol. During testing on mice at Harvard University, he observed results that show a reduction in the occurrence of Alzheimer’s and other neurodegenerative diseases in those mice that received resveratrol.

Testing conducted at Harvard University by Joseph Baur, Ph.D., and David Sinclair, Ph.D., found that the compound resveratrol can slow down the aging process by repairing and protecting your cell membranes. By increasing the strength of your cells—especially your brain cells—you can virtually extend your life expectancy and sharpen your mind because you won’t have lost those essential cells.

In the book How Can the New Discovery of the Anti-aging Gene and Resveratrol Benefit You?, author Brook Henderson indicates resveratrol attacks genes that are harmful to your body. When this happens, abnormal cell growth decreases… dying and decaying cells are repaired… and the cells’ natural ability to repair themselves is restored.

Source : Better Health Research. July 5. 2010

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Extend Your Life Span with this Antioxidant

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In 2003, research showed that resveratrol, a powerful polyphenol and anti-fungal chemical, was able to increase the lifespan of yeast cells. The results ignited flames of hope for an anti-aging pill. According to the findings, resveratrol could activate a gene called sirtuin1, which is also activated during calorie restriction in various species.
Since then studies in nematode worms, fruit flies, fish, and mice have linked resveratrol to longer lives. Other studies with only resveratrol have reported anti-cancer effects, anti-inflammatory effects, cardiovascular benefits, anti-diabetes potential, energy endurance enhancement, and protection against Alzheimer’s.

Resveratrol is found in grapes and red wine, and has particularly been associated with the so-called ‘French Paradox‘ — the low incidence of heart disease and obesity among the French, despite their relatively high-calorie diet and levels of wine consumption.
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Reources:

NutraIngredients September 14, 2009
NutraIngredients September 10, 2009

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The Secrets of Resveratrol’s Health Benefits

Scientists have unraveled a mystery that has perplexed scientists since resveratrol, a chemical found in red wine and other foods, was first discovered to have health benefits: how does it control inflammation?
…………….RED WINE.
New research explains resveratrol’s effect on inflammation, and also shows how it can be used to treat potentially deadly inflammatory disease, such as appendicitis, peritonitis, and systemic sepsis.

Resveratrol stops inflammation with a one-two punch that prevents your body from creating two different molecules known to trigger inflammation — sphingosine kinase and phospholipase D.

Resources:
Science Daily August 3, 2009
The FASEB Journal August 2009;23:2412-2424

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Red Wine Beneficial for Health

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A polyphenol present in red wine, called resveratrol, has been found to have a large number of health benefits for drinkers, say researchers.
……………………………
Red wine contains a complex mixture of bioactive compounds, including flavonols, monomeric and polymeric flavan-3-ols, highly coloured anthocyanins, as well as phenolic acids and the stilbene polyphenol, resveratrol.

Lindsay Brown, an associate professor in the School of Biomedical Sciences at The University of Queensland and corresponding author for the study, says that some of these compounds, particularly resveratrol, appear to have health benefits.

“The breadth of benefits is remarkable – cancer prevention, protection of the heart and brain from damage, reducing age-related diseases such as inflammation, reversing diabetes and obesity, and many more,” said Brown.

“It has long been a question as to how such a simple compound could have these effects but now the puzzle is becoming clearer with the discovery of the pathways, especially the sirtuins, a family of enzymes that regulate the production of cellular components by the nucleus. ‘Is resveratrol the only compound with these properties?’ This would seem unlikely, with similar effects reported for other components of wine and for other natural products such as curcumin. However, we know much more about resveratrol relative to these other compounds,” he said.

One of the main points of the review included that resveratrol exhibits therapeutic potential for cancer chemoprevention as well as cardioprotection.

“It sounds contradictory that a single compound can benefit the heart by preventing damage to cells, yet prevent cancer by causing cell death. The most likely explanation for this, still to be rigorously proved in many organs, is that low concentrations activate survival mechanisms of cells while high concentrations turn on the in-built death signals in these cells,” said Brown.

The study suggests that resveratrol may aid in the prevention of age-related disorders, such as neurodegenerative diseases, inflammation, diabetes, and cardiovascular disease.

“The simplest explanation is that resveratrol turns on the cell’s own survival pathways, preventing damage to individual cells. Further mechanisms help, including removing very reactive oxidants in the body and improving blood supply to cells,” said Brown.

The researchers also said that low doses of resveratrol could improve cell survival as a mechanism of cardio- and neuro-protection, while high doses increase cell death.

“The key difference is probably the result of activation of the sirtuins in the nucleus. Low activation reverses age-associated changes, while high activation increases the process of apoptosis or programmed cell death to remove cellular debris. Similar changes are seen with low-dose versus high-dose resveratrol: low-dose resveratrol produces cellular protection and reduces damage, while high-dose resveratrol prevents cancers,” said Brown.

She concluded that current scientific research is starting to explain reports from the last 200 years that drinking red wine improves health.

However, the researchers added that low to moderate drinking, especially of red wine, appears to reduce all causes of mortality, while too much drinking causes multiple organ damage.

The findings will be published in the September issue of Alcoholism: Clinical & Experimental Research.

 

Source: The Times Of India

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