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“Gout is the most common type of inflammatory arthritis in men… The identification of risk factors for gout… is an important first step in the prevention and management of this common and excruciatingly painful condition,” wrote the study’s authors.
Hyon K Choi, then of University of British Columbia, Vancouver, and now of Boston University School of Medicine, and colleagues examined the relationship between vitamin C intake and gout in 46,994 men between 1986 and 2006.
Every four years, the men completed a dietary questionnaire, and their vitamin C intake through food and supplements was computed. Every two years, participants reported whether they had been diagnosed with or developed symptoms of gout.
During 20-year follow-up, 1,317 men developed gout. Compared with men who had a vitamin C intake of less than 250mg per day, the relative risk of gout was 17% lower for those with a daily intake of 500 to 999 mg, 34% lower for those with an intake of 1,000 to 1,499mg per day and 45% lower for those with an intake of 1,500mg per day or higher.
Vitamin C may affect re-absorption of uric acid by the kidneys, increase the speed at which the kidneys work or protect against inflammation, all of which may reduce gout risk, a Boston University statement quoted the authors as saying.
Sources:These findings were published in the Archives of Internal Medicine.