Find Me A Cure

In a discovery which could have far reaching consequences in not-distant-future, researchers have been able to wipe out a single specific memory from brains of rats using a drug, leaving all other recollections intact.

The study adds to the understanding of how memories are made and altered in the brain, and could help to relieve sufferers of Post-traumatic Stress Disorder of the fearful memories that disrupt their lives. The results are published in Nature Neuroscience.

The brain, the study says, secures memories by transferring them from short-term to long-term storage, through a process called reconsolidation. It has been shown before that this process can be interrupted with drugs.

But Joseph LeDoux of the Centre for Neural Science at New York University and his colleagues wanted to know how specific this interference was — could the transfer of one specific memory be meddled with without affecting others?

The researchers trained rats to fear two different musical tones, by playing them at the same time as giving them an electric shock. Then, they gave half the rats a drug known to cause limited amnesia (which is not approved for people).

When they tested the rats with both tones a day later, untreated animals were still fearful of both sounds, as if they expected a shock. But those treated with the drug were no longer afraid of the tone. The process of re-arousing the rats’ memory of being shocked with the one tone while they were drugged had wiped out that memory completely.

The researchers said the fearful memory is actually deleted, rather than simply breaking the link between the memory and a fearful response.

Source:The Times Of India

YOUR CELLS HELPS YOU BACK TO HEALTH
Idaho man healed with Stem Cells

Mike Brown was told he had just one year to live in April, 2006.

Now, instead of making final arrangements, the Homedale resident is devising plans to take his wife, Betty, on a cruise.

“Every time you look at your wife, your kids or your grandkids, you want to be around a little longer,” said Mike Brown, the father of two and a grandfather to five.

And for his new outlook on life, the 64-year-old retired Morrison- Knudsen employee can thank a medical procedure that isn’t even available in the United States.

In early February, Brown began a process with the trademarked name VesCell and carried out by a company called TheraVitae that entailed his own stem cells being injected into his heart to fight off his advanced heart disease.

The adult stem cell therapy still is in its infancy — in fact, he says he was only the 68th person to receive the treatment — and it wasn’t covered by Brown’s insurance.

“But what was it going to do? Kill me?” asked Brown, who says he suffers from “end stage” heart disease. “I’m dying already.”

Brown has had six bypass surgeries and several stents and other procedures to battle his heart disease. He also has suffered heart attacks — including one 11 months ago that prompted doctors to tell him that the end was near unless he had a heart transplant.

“We went to Salt Lake City and Spokane looking at transplants, but for several reasons I didn’t want to consider it,” Brown said.

“Years ago, I had read about stem cells and heart disease, but
my doctor (Murali N. Bathina of Idaho Cardiology Associates in Caldwell) said no clinical studies were being done in the United States.”

While researching the stem cell option, Brown came across a man from his old stamping grounds in Eastern Oregon who had had the VesCell procedure.

“We knew some of the same people,” Brown said of the gentleman from Athena, Ore. “He had real good results and raved about it.”

After assuring himself that the expensive proposition — it cost about $40,000 — wasn’t a scam, Brown decided to go through with the process.

“Initially, I had some reservations, but (TheraVitae representatives) give you a lot of references and furnished me with information for my doctor,” Brown said.

He said the company even offered to fly his cardiologist to the Far East so he could observe the procedure.

Because the VesCell process isn’t approved for the U.S., Brown and his wife, who have been married 38 years, flew to Bangkok, Thailand, for the procedure.

Traveling was nothing new for the Browns. They have traveled all through Central America both for pleasure and as part of Mike’s former job.

Once Mike Brown was in Thailand, doctors drew about a quarter of a liter of blood. The sample was flown to Israel, where Brown said the originator of the process oversaw “culturing “ of the blood, or the extraction of stem cells. After the weeklong culturing, the stem cells were flown back to Thailand, and on Feb. 7 — the Browns’ 38th wedding anniversary — doctors used a procedure similar to a balloon angioplasty to inject the stem cells into Brown’s heart using a catheter via his femoral artery.

According to company literature, the stem cells injected into the patients encourage growth of new blood vessels, creating natural bypasses for weaker parts of the heart and vascular system.

“I noticed a difference. Maybe it was psychological, but I felt better right away,” Brown said. “My memory was better. Betty said I got some color back.”

Memory loss is one symptom of heart failure because of the lack of oxygen getting to the brain. But Brown also noticed a boost in his energy level.

“I’m staying up longer at night,” he said. “I’m not dead tired the way I was before. I have a more positive outlook.”

Brown said doctors told him that particular procedure has an 81 percent success rate, but neither Mike nor Betty seem to be paying attention to the numbers for signs of success.

“I just have a real good feeling that it’s going to work, and that’s half the battle,” Betty said. “In his day-to-day life, I can already see a difference.”

Although doctors said results wouldn’t be evident for between three weeks and six months, Betty said Mike’s daily routine is much fuller than it had been. “He’d get up in the morning and eat breakfast, and he’d be dead tired,” she said. “Going to Boise was a major thing.”

While Mike said TheraVitae plans to bring the adult stem cell therapy procedure to clinics in Canada and the Bahamas in the coming years, he’s pessimistic that the discipline will find its way to America’s shores anytime soon.
“Stem cell procedures are being done, but not with folks with advanced heart disease,” he said.

Mike added that adult stem cells (actually his own stem cells) are used in these procedures, not embryonic stem cells, which have created such controversy in the U.S.

While he still has a couple weeks before he first electrocardiogram since the stem cell transplant, which will be the first hard evidence of how well the procedure has worked, Brown has faith in the process.

“I feel optimistic about this,” he said, adding anyone interested in more information on his experience and the procedure can e-mail him at brown.mike@frontiernet.net

Source:Vescell <pr@theravitae.com>