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Better Sleep From A to Zzzzz

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Stop counting sheep! Check out these tips for getting a good night’s sleep.

Adenosine
Cats nap soundly and often, possibly thanks to this natural substance. Harvard Medical School researchers found in 1997 that levels of adenosine rise before sleep and drop during it, indicating that adenosine may help us slip into slumber. Now the rush is on to determine whether a new sleeping pill could be made of synthetic adenosine. In the meantime we’re left with the current crop of prescription pills .

Babies
New moms often sleep poorly, regardless of whether their offspring sleep well. But even among nonparents, the mere threat of being awakened can disrupt sleep. It triggers what experts have dubbed on-call syndrome, named after the fitful sleep that afflicts emergency workers, medical students, and doctors. These people lose about 1½ hours of sleep when on call, even if their services are never needed, reports Thomas Roth, Ph.D., director of the sleep disorders and research center at Henry Ford Hospital, in Detroit. If you’re in an on-call situation, make up for a little lost sleep by napping for 30 minutes the next day.

Chronotherapy
Sleep problems often arise when the body’s internal clock gets out of kilter. As a result of travel across time zones or a series of late nights in their own hometown, people who once dozed off at 11 p.m. suddenly find that they can’t fall asleep until 3 a.m. and don’t want to awaken before noon. When this occurs, doctors recommend chronotherapy to gradually reset the body’s clock. In this process, sleep is delayed in three-hour increments. For example, someone who’s having trouble falling asleep at 11 p.m. might be told to stay up until 2 a.m. The next night, she stays up until 5 a.m., the next until 8 a.m. and so on, until she has circled the clock and readjusted her natural bedtime to 11 p.m.

Depression
Depression is just one of the health problems reported by people with chronic insomnia. The list also includes cardiovascular, gastrointestinal, and musculoskeletal ills. Insomniacs are four times as likely as the general population to be depressed, and daytime sleepiness can be a warning sign of a blue mood. Researchers aren’t sure which comes first — the depression or the sleep problem. Caution: The typical treatment for depression, antidepressant drugs, can often have a sedative effect as well.

Estrogen
Hormonal changes take a toll on sleep. “It’s not uncommon for women to feel fatigued and need more sleep than usual in the few days before menstruation,” says Margaret Moline, Ph.D., director of the sleep-wake disorders center at New York Hospital-Cornell Medical Center, in White Plains, N.Y.

Another hormone-linked sleep shortage begins just before menopause, at around age 49. “Women with hot flashes are aroused out of restful sleep every eight minutes, while those without hot flashes find their sleep disrupted an average of every 18 minutes,” says Suzanne Woodward, Ph.D., an assistant professor of psychiatry at Wayne State University, in Detroit.

Postmenopausal hormone replacement therapy can help relieve hot flashes, as can lowering the thermostat in your bedroom (for details, see “Temperature,” below).

Exxon Valdez
In perhaps the most famous of a long list of sleep-related disasters, this grounded oil tanker dumped 11 million gallons of crude oil into Alaska’s Prince William Sound. The third mate, who was at the helm, was sleep deprived. Need more incentive to get your nightly eight hours? Lack of sleep also contributed to the space shuttle Challenger explosion and the Chernobyl disaster, according to Stanley Coren, Ph.D., a professor of psychology at the University of British Columbia, in Vancouver, and the author of Sleep Thieves.

Falling Asleep
If you lie awake for an hour or more before dozing off, you have insomnia. About 20% of people have it occasionally; for 10% the condition is chronic. Most insomniacs turn to over-the-counter products such as sedating antihistamines for help. Only 4% take prescription sleeping pills, most often benzodiazepines, which should not be used for more than a month because they can cause dependence and rebound insomnia.

The latest research suggests that the best sleep inducer in people with chronic insomnia is behavioral therapy. A study done in 1998 at the Mayo Clinic, in Rochester, Minn., found that changes in habits can help eliminate persistent insomnia, and that the benefits last longer than those of sleeping pills. Techniques used included having patients attempt to deduce the causes of their insomnia and experiment with lifestyle changes, such as avoiding napping or evening exercise, to see what worked best for them.

Gallup Poll
One-third of American adults are hazardously sleepy, according to a 1997 Gallup Poll sponsored by the National Sleep Foundation (NSF) in Washington. Almost half of Americans — 41% — report getting less sleep than they need, while a third say daytime sleepiness has interfered with routine activities.

Hilton Hotels
Is there such a thing as a caffeine-free hotel room? Actually, there are 35 of them in Hilton hotels across the country. Though these “Sleep Tight” rooms have no coffeepot, they’re outfitted with everything you need for sound sleep, and at no extra charge. The rooms boast features that fitful sleepers might benefit from having in their own bedrooms: blackout drapes; double-paned windows; extra-insulated walls; and an alarm lamp that wakes sleepers with gradually increasing levels of light.

Insomniaphobia
People who miss a night or two of solid sleep often begin to lie awake fretting that they won’t be able to doze off. This fear is self-perpetuating. “We tell people with insomnia to take away their bedside clock,” says Dr. Moline. This tactic works particularly well with insomniaphobes, who tend to be clock watchers.

Jet Lag
It’s a bane of modern living that’s not confined to international travelers: Changing time zones, even within the U.S., can be enough to upset the sleep schedule. In fact, Harvard Medical School researchers reported in 1997 that even the end of daylight savings time in October may be enough to throw off the body’s internal clock and increase the risk of on-the-job accidents. Cautious use of melatonin can help reset the body clock, as can exposure to bright sunlight. Talk to your doctor or a sleep specialist about how to time the use of either therapy for maximum benefit.

Kids

As sleep-deprived as many adults are, kids often fare worse. Mary Carskadon, Ph.D., a professor of psychiatry and human behavior at Brown University, found more depressed moods, lower grades, and more severe behavioral problems among ninth and tenth graders who got fewer than seven hours of sleep a night than among teens who slept more.

Furthermore, as adolescents mature, their body clocks may shift so that their ideal wake-up time is about an hour later than it was in their early teens. The natural bedtime changes from 9:30 in young teens to 10:30 in those over age 14. This means that for a teenager, getting up at 6 a.m. is as difficult as awakening at 3 a.m. would be for an adult. As a result, schools in Minnesota, California, Florida, and Washington have already begun to delay school start times to synchronize them with teens’ ideal sleep schedule. Early reports are that grades and behavioral problems are improving.

Melatonin
Although nonprescription melatonin supplements have become popular as a sleep aid, the hormone isn’t a particularly powerful sleep inducer, according to Josephine Arendt, Ph.D., a professor of endocrinology at the University of Surrey, in England, who has studied melatonin since 1972. Indeed, its only known function in humans is as a “chronobiotic,” a regulator that helps the body adjust to seasonal time changes.

Many people have taken melatonin with no apparent harmful effects. Data showing that it may constrict the coronary arteries as well as create infertility, however, suggest that it is potent and should be used with caution, if at all.

According to the NSF, there are no valid scientific data to support the use of melatonin as a sleep promoter. If you take it as a remedy for jet lag, do so cautiously: At the very least, you could wind up on Japan time when you’re only going to London.

Narcolepsy

One in 1,000 people has this neurological disorder, with its hallmark symptoms: daytime sleepiness; sleep “attacks” in which a person is overwhelmed by the need to sleep; bad dreams; and cataplexy, a sudden loss of muscle control that might cause the knees to buckle.

Narcolepsy typically starts in one’s teens or early 20s, though it may go undiagnosed for years. Unfortunately, effective treatments are limited. Stimulants are prescribed for daytime sleepiness, and tricyclic antidepressants are often given for cataplexy. Two promising drugs, rohypnol and gamma hydroxy butyrate, or GHB, are available only to people in clinical trials and may remain largely inaccessible, because they can be fatal in high doses and have been used in date rapes. The good news is that another medication awaiting FDA approval, Provigil (modafinil), appears to keep patients awake without making them jittery, a side effect of other therapies.

Oversleeping
We all relish an extra hour of rest on an occasional Saturday morning, but researchers say oversleeping on weekends can be a clue to the extent of the sleep debt you’re building up during the workweek. If you sleep more than an hour late on weekends, try to increase the amount of sleep you get during the week.

Preparatory Napping
If you know you’re going to be shortchanging yourself on sleep, store up rest by napping ahead of time. William Anthony, Ph.D., a professor of psychiatric rehabilitation at Boston University and the author of The Art of Napping, coined the term “preparatory napping” and says good “naptitude” includes limiting naps to 15 minutes (a longer snooze may leave you groggy). Studies show napping improves skills and performance for hours afterward, and nappers report no greater sleep difficulties at night than non-nappers.

Restless Legs Syndrome
This annoying neurological condition triggers a pulling or crawling sensation in the legs that can be relieved only by movement. Because RLS disrupts sleep severely, it is often handled by sleep specialists. “It’s one of the toughest things we treat,” says Alex Clerk, M.D., director of the University of California at San Francisco/Stanford sleep disorders clinic.

According to the Restless Legs Syndrome Association in Rochester, Minn. (www.rls.org), the condition affects 3% to 8% of the population, though many people aren’t aware that the annoyance has a name, much less a treatment. Taking iron supplements, avoiding caffeine, and taking hot or cold baths helps many people, but dopaminergic or anticonvulsant drugs may eventually be needed.

Sleep Laboratories
Sleep science has surged in recent years, and there’s now a center specializing in treating sleep disorders within 150 miles of almost anyone in the U.S. Most sleep labs require an overnight stay while doctors, using wires and electrodes connected to a sleeping patient’s body, measure brain waves, eye and leg movement, and muscle tension. A microphone records snoring while airflow sensors track breathing. Technologists read each subject’s 1,000-page record to assess sleep quality and quantity.

If you decide to visit a sleep lab, check with your insurer to make sure you’ll be reimbursed for the test, which runs about $1,200. Because sleep science is a relatively new field, the treatment of sleep disorders is sometimes challenged by insurance companies. Avoid clinics that treat only sleep apnea, a breathing disorder; a good lab will diagnose and treat a variety of conditions.

Sleep Quotient
Generally speaking, adults require about eight hours of sleep a night; Americans average only six or seven hours. Sleep researchers agree, however, that it’s not how close we come to our sleep quotient that’s important, but how well we sleep. A common myth is that our need for sleep declines as we age. In fact, it’s sleep quality that may deteriorate. As both sexes age, says Dr. Moline, they find it harder to fall asleep; sleep may become more fragmented and nighttime awakenings occur more easily. If you’re awakening unrefreshed, talk to your doctor about screening for a possible sleep disorder.

Snoring
Not just a nighttime nuisance, snoring is also a symptom of sleep apnea, a condition in which the muscles in the nose and throat relax during sleep, causing breathing to stop for up to a minute at a time. The resulting strain can damage arteries, leading to high blood pressure.

Apnea’s most common symptoms are loud snoring and daytime sleepiness. The typical patient is an overweight, fortysomething man who snores, but women are at increased risk after menopause. It’s not yet clear whether this higher risk is hormone related or due to weight gain. “If a woman has very little space where the tongue and upper airway meet, is obese or has large tonsils,” she may be at greater risk, says Dr. Moline.

Premenopausal women with apnea may be particularly hard to diagnose, because their symptoms don’t show up on the standard sleep-lab workup. A special test that measures the pressure between lung surfaces inside the chest is often needed, according to Dr. Clerk.

Treatment for apnea has come a long way since the 1970s, when the only therapy was a tracheotomy. In 1981 researchers developed the continuous positive airway pressure (CPAP) device, a breathing apparatus worn during sleep to keep the airway from collapsing. Losing weight, avoiding alcohol and cigarettes, and not sleeping on one’s back can help minimize symptoms. When the CPAP isn’t effective, a procedure that uses radio-frequency waves can reshape tissues in the throat. For information about apnea, call the Sleep Apnea Association, in Washington, at 202-293-3650. To stop non-apnea snoring, try a flatter pillow. Puffy pillows keep the neck in a snore-promoting position.

Temperature
Lowering body temperature at bedtime may help insomniacs sleep better, says new research from New York Hospital-Cornell Medical Center. Taking a hot bath about 90 minutes before bedtime prompts a slight drop in body temperature, which may help you doze off. Your bedroom’s temperature is also a factor in how well you sleep: 60ºF to 65ºF is ideal.

Ultradian Rhythms
Adults sleep in these daily cycles, switching between REM (rapid eye movement) and non-REM sleep every 90 minutes in an astonishingly predictable pattern. The body produces much of its growth hormone during deep sleep, and an age-related drop in deep sleep may contribute to the bone density decline that leads to osteoporosis. So have that glass of warm milk before bed: You need the calcium.

Victims of Drowsy Drivers
Sleep-related crashes kill about 1,550 people each year and cause almost 40,000 nonfatal accidents, reports the National Highway Traffic Safety Administration, in Washington. These accidents are likeliest to occur after midnight and before 7 a.m., and are likelier than others to be fatal. Their sinister sign: no skid marks at the accident scene — a clue that the driver wasn’t awake to hit the brakes.

A 1999 NSF survey found that 17% of Americans had nodded off at the wheel. But even if a sleepy driver doesn’t doze, her reaction time can be delayed. Sleep deprivation also heightens the effects of alcohol. An adult who drinks the equivalent of two beers after four hours of rest averages 35 hazardous situations in a driving simulator, while someone who drinks the same amount after eight hours of sleep makes only five errors.

So how can you stay alert behind the wheel? The combination of a short nap and 200 milligrams of caffeine (the equivalent of roughly two cups of coffee) was the most effective emergency measure in a recent British study. Another strong deterrent: Check out the chilling memorial to victims of drowsy drivers at the Parents Against Tired Truckers Website, www.patt.org.

Websites
More information on sleep and sleep disorders can be found at the NSF Website, www.sleepfoundation.org, or by calling 888-41-AWAKE. For a list of sleep centers, check out the American Sleep Disorders Association site at www.asda.org.

Yawning
Despite the fact that we all do it, no one seems to know exactly why we yawn. Some experts hold that, like laughing or crying, yawning is a physical response to an emotional state — namely boredom — or fatigue. Frequent yawning may be a sign that you need to examine your sleep schedule.

Zinc
A deficiency of this mineral, or of iron, calcium or copper may be to blame for insomnia. If you’re losing sleep, try adding a multivitamin to your routine.

If you’re tired of feeling like you’re not at your best or like you’re not getting the sleep you need, then it’s time to take action! Sign-up for the National Sleep Foundation’s Sleep Challenge today!

Source:Reader’s Digest

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Pancreatic cancer stem cells found

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Researchers have discovered a small population of stem cells in pancreatic cancer that appear to drive tumour growth, opening the door for a potential new approach for treating this particularly deadly disease.

Writing in Cancer Research, University of Michigan scientists said finding cancer stem cells in pancreatic tumours could lead to the development of drugs intended to target and kill these cells.

Scientists have toiled with little success to find better ways to treat cancer of the pancreas, which has the lowest survival rate of any major form of cancer.

It kills 97% of people diagnosed with it within five years half within six months of diagnosis. Pancreatic cancer spreads quickly and is rarely is detected at an early stage. In the United States alone, it kills 33,000 people a year.

The pancreas is a gland located behind the stomach that secretes a digestive fluid and the hormone insulin.
“The implications of this work are significant,” Diane Simeone, director of the Gastrointestinal Oncology Program at the University of Michigan Comprehensive Cancer Centre and lead author of the study, said.

“We’ve made baby steps in improving the survival in these patients over the past decade or so. But we really haven’t had a major breakthrough in coming up with something that has the potential to provide a cure,” she said.

Simeone said there is emerging evidence that within cancers, there is a small subset of cells that are responsible for the growth and propagation of tumours.

The idea is that these cells with stem-cell characteristics the ability to self-renew and differentiate into other cell types are the ones fuelling tumour formation.

Source:The Times Of India

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Ailmemts & Remedies

Endometriosis

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Many women suffer from the pain and heavy bleeding of endometriosis. In the past, they often were told their complaints were “just cramps” or “all in your head”. Today, doctors take this condition more seriously, but conventional medicine offers little to ease its symptoms.

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Symptoms

*Intense menstrual cramps that begin before your period starts and reach their peak after it ends.
*Abnormally heavy menstrual bleeding, often with large clots.
*Nausea and vomiting just before a menstrual period.
*Sharp pain during sexual intercourse at any time of the month.
*Diarrhea, constipation, or pain during bowel movements.
*Blood in the stool or urine during menstrual period.
*Infertility.

When to Call Your Doctor

If you have any of the above symptoms.
Reminder: If you have a medical condition, talk to your doctor before taking supplements.

What It Is

In endometriosis, bits of the uterine lining (endometrium) migrate out of the uterus and embed themselves in other abdominal tissues, often the ovaries, uterine ligaments, or intestines. Each month, as estrogen and other hormones cause the lining of the uterus to thicken with blood, the wayward cells also expand. The uterine tissues then slough off normally. But the stray cells have nowhere to release the blood they’ve amassed, leading to cysts, scarring, or adhesions (fibrous tissue that binds parts of the body that are normally not attached to each other). Although not all women with endometriosis have symptoms, the condition can cause severe pain. Endometriosis is a leading cause of female infertility.

What Causes It

No one knows why endometriosis develops, but speculation abounds. According to the reflux menstruation theory, menstrual blood travels backward through the fallopian tubes, funneling endometrial cells into other abdominal areas where they seed and grow. Another hypothesis suggests that endometriosis is congenital — meaning that some endometrial cells have been outside the uterus since birth. Still another idea is that endometriosis is caused by a faulty immune system, which neglects to destroy the out-of-place cells.

How Supplements Can Help

All of the supplements listed can be used together and with any medications prescribed by your doctor. Begin by taking the traditional combination of chasteberry and dong quai. These herbs aid in correcting the hormonal imbalances that can intensify the pain of endometriosis. They also relax the uterus, as does wild yam. In addition, take a lipotropic combination, which stimulates the liver to clear excess estrogen from the body. Use these supplements throughout your menstrual cycle for best results. If menstrual cramps are painful, take the high doses of calcium and magnesium listed, but only during your period. These minerals help to lower the body’s production of prostaglandins, substances made by endometrial cells that cause menstrual cramps.

What Else You Can Do

Eat soy products, which contain phytoestrogens (plant estrogens) that may offset the effect of estrogen on symptoms of endometriosis.
Exercise. In several studies, it has been shown to suppress symptoms and may actually prevent endometriosis.

Supplement Recommendations

Chasteberry
Dong Quai
Wild Yam
Lipotropic Combination
Calcium/Magnesium
Vitamin C
Vitamin E
Flaxseed Oil
Evening Primrose Oil

Chasteberry
Dosage: 225 mg standardized extract 3 times a day.
Comments: Also called vitex. Should contain 0.5% agnuside.

Dong Quai
Dosage: 200 mg, or 30 drops tincture, 3 times a day.
Comments: Standardized to contain 0.8%-1.1% ligustilide.

Wild Yam
Dosage: 500 mg twice a day.
Comments: Take with food to minimize stomach upset.

Lipotropic Combination
Dosage: 1 or 2 pills 3 times a day.
Comments: Should contain milk thistle, choline, inositol, methionine, dandelion, and other ingredients.

Calcium/Magnesium
Dosage: 500 mg calcium 4 times a day; 500 mg magnesium twice a day.
Comments: Use this dose only during menstruation.

Vitamin C
Dosage: 1,000 mg 3 times a day.
Comments: Reduce dose if diarrhea develops.

Vitamin E
Dosage: 400 IU twice a day.
Comments: Check with your doctor if taking anticoagulant drugs.

Flaxseed Oil
Dosage: 1 tbsp. (14 grams) a day.
Comments: Can be mixed with food; take in the morning.

Evening Primrose Oil
Dosage: 1,000 mg 3 times a day.
Comments: Can substitute 1,000 mg borage oil once a day.

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Disclaimer: This information is not meant to be a substitute for professional medical advise or help. It is always best to consult with a Physician about serious health concerns. This information is in no way intended to diagnose or prescribe remedies.

Source:Your Guide to Vitamins, Minerals, and Herbs(Reader’s Digest)

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Obesity Is Found to Make Ovarian Cancer Deadlier

 

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Ovarian cancer is fairly common. ”About one in 60 American women will develop ovarian cancer,” said Dr. Andrew J. Li, the senior author of the study, a faculty physician at the Cedars-Sinai Medical Center and an assistant professor of obstetrics and gynecology at the University of California, Los Angeles. Each year, about 20,000 new cases are diagnosed and about 15,000 women die of the disease, according to the American Cancer Society.

It is well known that obesity is associated with various malignancies, including kidney, throat, breast and colon cancers. Findings about obesity and ovarian cancer have been somewhat less clear, the researchers say, but evidence from previous studies suggests that obesity predicts a worse outcome for ovarian cancer patients as well.

The scientists wanted to know whether excess fat, apart from any other health problems it might cause, had direct effects on tumor growth. They reviewed the medical records of 216 patients at Cedars-Sinai who had surgery for epithelial ovarian cancer. The data included information on height, weight, age and any other diseases. The cause of death was presumed to be cancer related if the patient had advanced recurrent disease at the time of death.

Half the patients had ideal weight, with a body mass index from 18.5 to 24.9, and 8 percent had a B.M.I. of less than 18.5, considered underweight. Twenty-six percent were overweight, with indexes exceeding 25, and 16 percent were obese, with indexes higher than 30.

The overweight and obese differed little from normal and underweight people in age or in health status, except that they had more hypertension and diabetes.

But among patients with Stage III or Stage IV disease, the most advanced stages, those with B.M.I.’s greater than 25 survived disease free for an average of 17 months, compared with 25 months for people with indexes lower than 25.

For each increase of one unit in the index, the researchers found a 4 percent increase in the risk of recurrence and a 5 percent increase in the risk of death.

This ”dose response” effect strongly suggests that obesity alone is responsible for the decreased survival time, Dr. Li said.

The researchers acknowledge that their study, published yesterday in the journal Cancer, has certain weaknesses.

They found that a slightly lower dose of chemotherapy relative to body surface was given to obese patients, and it is possible that this underdosing may have had a role.

In addition, fluid in the body cavity, a symptom of the disease, may have artificially increased the B.M.I. of some patients. And it is possible that other diseases like hypertension and diabetes, more prevalent among the obese, could have decreased survival among those patients.

The study was also limited by its retrospective method and small sample population.

The researchers said they believed that it was unlikely that those factors could have accounted for the decreased overall survival time of obese women. More likely, they said, is that the presence of fat tissue encourages tumor growth or increases resistance to treatment.

”There may be some factor secreted by adipose tissue that makes tumors less sensitive to chemotherapy,” Dr. Li said, referring to fat tissue. ”We have some ideas, and we’re working on looking at those factors now.”

Dr. Li said obesity did not increase the risk of developing ovarian cancer, but did affect the chance of survival when a person developed it.

”Reducing obesity and maintaining an ideal body weight,” he said, ”is important for many reasons. This is just one more health problem in which obesity plays a role.”

Source:The New York Times

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News on Health & Science

SHOULD YOUNG WOMEN GET MAMMOGRAMS?

Research from The Lancet questions the benefit of women starting annual mammograms at age 40. New data from a large United Kingdom study of more than 160,000 women finds that mammogram screening in younger women may provide little benefit in terms of reducing breast cancer risk, while at the same time exposing women to more radiation and the possibility of false alarms. Overall, women in the 40s who received mammograms saw a small drop in breast cancer deaths, around 17 percent, a figure that was not statistically different from chance. Also, 23 percent of the women had at least one false alarm   higher than the rate of 12 percent seen in women in their 50s. A related editorial says that it’s not clear that women in the 40s get a net benefit from mammogram screening because the potential harms may offset any benefit, and that women should decide individually whether they want the peace of mind from screening or the possibility of unnecessary radiation exposure from additional mammograms.

Source:   ABC News

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