Replacement body parts that never wear out could become a reality within a few years as the scientists say.
Dodgy knees and hips will be repaired using tissue engineering, while donor heart valves from animals are being specially treated to last indefinitely.
Longer-lasting artificial joints are already being tested in a bid to ensure people will be able to enjoy another 50 active years.
Unlike studies involving stem cells and growing ‘spare parts’ in a lab, the programme uses the body’s own regenerative systems. The Leeds scientists have developed a chemical wash that strips cells away from donated cartilage, heart valves, blood vessels and other tissue before they are put into a human body.
Research shows they become repopulated with cells within about six months. Some 40 patients have already been treated with modified heart valves in a study in Brazil.
Professor John Fisher, director of the institute and one of the world’s leading researchers into artificial joints, said research so far had shown the valves did not deteriorate and were not rejected by the body, because ‘foreign’ donor cells had all been stripped away.
The unique method of removing living cells from human and animal tissue creates a biological ‘scaffold’ that can be regenerated within the body, at the site which needs repairing.
Worn-out ligaments and cartilage in knees can be replaced with a scaffold that will eventually attract cells to make the joint last longer.
Other areas targeted for treatment are the spine – where discs can be replaced – elbow and shoulder tissues and parts of the knee. Vascular patches are being devised that seal the holes made in arteries when surgeons clear a blockage.
The technique is not suitjointsable for whole organs, however. Professor Fisher has also designed a ceramic-on-metal hip joint that reduces ten-fold the wear and tear on artificial joints.
As a result people should be able to get spare parts at an earlier age, when they are less disabled, and they could last up to 50 years, he said.
The professor added: ‘Hip have been used for nearly 50 years but nowadays people want to cycle, play tennis, even go skiing, so they have to last longer.’
He said a scaffolding transplant would cost only around £1,000 a time. It was much more expensive to grow cells outside the body, and there was a higher infection risk.
Professor Eileen Ingham, deputy director of the Institute, said stem cells were not the answer to structural replacement of wornout bits of the body such as heart valves.
She said: ‘We are working with the NHS National Blood & Transplant Tissue Services to apply it to human donor valves. Once a patient has one, it should last a lifetime.’
Professor Christina Doyle, chief executive of Xeno Medical, predicted that in 20-30 years there would be techniques capable of regenerating human tissue off-the-shelf for use in operations.
She said: ‘It will be a case of the surgeon dialling up for spare parts to be delivered in a sterilised plastic bag.’
Definition:The chest x-ray is the most commonly performed diagnostic x-ray examination. A chest x-ray makes images of the heart, lungs, airways, blood vessels and the bones of the spine and chest.
An x-ray (radiograph) is a noninvasive medical test that helps physicians diagnose and treat medical conditions. Imaging with x-rays involves exposing a part of the body to a small dose of ionizing radiation to produce pictures of the inside of the body. X-rays are the oldest and most frequently used form of medical imaging.
Doctors have used x-rays for over a century to see inside the body in order to diagnose a variety of problems, including cancer, fractures, and pneumonia. During this test, you usually stand in front of a photographic plate while a machine sends x-rays, a type of radiation, through your body. Originally, a photograph of internal structures was produced on film; nowadays, the image created by the x-rays goes directly into a computer. Dense structures, such as bone, appear white on the x-ray films because they absorb many of the x-ray beams and block them from reaching the plate (see Figure 16). Hollow body parts, such as lungs, appear dark because x-rays pass through them. (In some other countries, like the United Kingdom, the colors are reversed, and dense structures are black.)
Back x-rays and chest x-rays are among the most common conventional x-ray tests. You should not have an x-ray if you’re pregnant, because radiation can be harmful to a developing fetus.
A chest x-ray provides black-and-white images of your lungs, ribs, heart, and diaphragm.
Some common uses:
The chest x-ray is performed to evaluate the lungs, heart and chest wall.
A chest x-ray is typically the first imaging test used to help diagnose symptoms such as:
*shortness of breath
*a bad or persistent cough
*chest pain or injury
*fever. Physicians use the examination to help diagnose or monitor treatment for conditions such as:
*heart failure and other heart problems
*other medical conditions.
How should you prepare for the test?
A chest x-ray requires no special preparation.
You may be asked to remove some or all of your clothes and to wear a gown during the exam. You may also be asked to remove jewelry, eye glasses and any metal objects or clothing that might interfere with the x-ray images.
Women should always inform their physician or x-ray technologist if there is any possibility that they are pregnant. Many imaging tests are not performed during pregnancy so as not to expose the fetus to radiation. If an x-ray is necessary, precautions will be taken to minimize radiation exposure to the baby. See the Safety page for more information about pregnancy and x-rays.
You are usually asked to remove all clothing, undergarments, and jewelry above your waist, and to wear a hospital gown.
What does the equipment look like?
The equipment typically used for chest x-rays consists of a wall-mounted, box-like apparatus containing the x-ray film or a special plate that records the image digitally and an x-ray producing tube, that is usually positioned about six feet away. CLICK & SEE
The equipment may also be arranged with the x-ray tube suspended over a table on which the patient lies. A drawer under the table holds the x-ray film or digital recording plate.
A portable x-ray machine is a compact apparatus that can be taken to the patient in a hospital bed or the emergency room. The x-ray tube is connected to a flexible arm that is extended over the patient while an x-ray film holder or image recording plate is placed beneath the patient.
What happens when the test is performed?
Chest x-rays usually are taken while you are standing. A technician positions you against the photographic plate (which looks like a large board) to obtain the clearest pictures. He or she takes pictures from the front and from one side while asking you to take in a deep breath just before each picture. The technician leaves the room or stands behind a screen while the x-rays are taken.
How does the procedure work?
X-rays are a form of radiation like light or radio waves. X-rays pass through most objects, including the body. Once it is carefully aimed at the part of the body being examined, an x-ray machine produces a small burst of radiation that passes through the body, recording an image on photographic film or a special digital image recording plate.
Different parts of the body absorb the x-rays in varying degrees. Dense bone absorbs much of the radiation while soft tissue, such as muscle, fat and organs, allow more of the x-rays to pass through them. As a result, bones appear white on the x-ray, soft tissue shows up in shades of gray and air appears black.
On a chest x-ray, the ribs and spine will absorb much of the radiation and appear white or light gray on the image. Lung tissue absorbs little radiation and will appear dark on the image.
Until recently, x-ray images were maintained as hard film copy (much like a photographic negative). Today, most images are digital files that are stored electronically. These stored images are easily accessible and are sometimes compared to current x-ray images for diagnosis and disease management.
How is the procedure performed?
Typically, two views of the chest are taken, one from the back and the other from the side of the body as the patient stands against the image recording plate. The technologist, an individual specially trained to perform radiology examinations, will position the patient with hands on hips and chest pressed the image plate. For the second view, the patient’s side is against the image plate with arms elevated.
Patients who cannot stand may be positioned lying down on a table for chest x-rays.
You must hold very still and may be asked to keep from breathing for a few seconds while the x-ray picture is taken to reduce the possibility of a blurred image. The technologist will walk behind a wall or into the next room to activate the x-ray machine.
When the examination is complete, you will be asked to wait until the radiologist determines that all the necessary images have been obtained.
The chest x-ray examination is usually completed within 15 minutes.
Additional views may be required within hours, days or months to evaluate any changes in the chest.
What will you experience during and after the procedure?
A chest x-ray examination itself is a painless procedure.
You may experience discomfort from the cool temperature in the examination room and the coldness of the recording plate. Individuals with arthritis or injuries to the chest wall, shoulders or arms may have discomfort trying to stay still during the examination. The technologist will assist you in finding the most comfortable position possible that still ensures diagnostic image quality. Who interprets the results and how do you get them?
A radiologist, a physician specifically trained to supervise and interpret radiology examinations, will analyze the images and send a signed report to your primary care or referring physician, who will discuss the results with you.
In an emergency, the results of a chest x-ray can be available almost immediately for review by your physician. What are the benefits vs. risks? Benefits:
*No radiation remains in a patient’s body after an x-ray examination.
*X-rays usually have no side effects in the diagnostic range.
*X-ray equipment is relatively inexpensive and widely available in emergency rooms, physician offices, ambulatory care *centers, nursing homes and other locations, making it convenient for both patients and physicians.
*Because x-ray imaging is fast and easy, it is particularly useful in emergency diagnosis and treatment.
*There is always a slight chance of cancer from excessive exposure to radiation. However, the benefit of an accurate diagnosis far outweighs the risk.
*The chest x-ray is one of the lowest radiation exposure medical examinations performed today. The effective radiation dose from this procedure is about 0.1 mSv, which is about the same as the average person receives from background radiation in 10 days. See the Safety page for more information about radiation dose.
*Women should always inform their physician or x-ray technologist if there is any possibility that they are pregnant. See the Safety page for more information about pregnancy and x-rays.
How long is it before the result of the test is known?
Although digital images may be available immediately, it will take additional time for a doctor to examine and interpret them. You’ll probably get the results later in the day.
A Word About Minimizing Radiation Exposure:
Special care is taken during x-ray examinations to use the lowest radiation dose possible while producing the best images for evaluation. National and international radiology protection councils continually review and update the technique standards used by radiology professionals.
State-of-the-art x-ray systems have tightly controlled x-ray beams with significant filtration and dose control methods to minimize stray or scatter radiation. This ensures that those parts of a patient’s body not being imaged receive minimal radiation exposure.
What are the limitations of Chest Radiography?
The chest x-ray is a very useful examination, but it has limitations. Because some conditions of the chest cannot be detected on an x-ray image, this examination cannot necessarily rule out all problems in the chest. For example, very small cancers may not show up on a chest x-ray. A blood clot in the lungs, a condition called a pulmonary embolism, cannot be seen on chest x-rays.
Further imaging studies may be necessary to clarify the results of a chest x-ray or to look for abnormalities not visible on the chest x-ray.
: Researchers studying a disease that causes people to suddenly drop off to sleep are trying to turn what they have learnt into a new way to help insomniacs get some shut-eye…...click & see
They found that blocking brain receptors for orexin, a blood peptide, promoted sleep in rats, dogs and people, according to a paper in Sunday’s online issue of the journal Nature Medicine.
Orexin, also known as hypocretin, is important in maintaining wakefulness. It is absent in the brains of people who suffer from narcolepsy, a chronic disorder in which people cannot regulate sleep-wake cycles normally.
The research team, led by Francois Jenck of the Swiss drug company Actelion Pharmaceuticals, reasoned that they might be able to induce sleep if they could block orexin.
They developed a drug that can block the receptors in the brain that respond to orexin-hypocretin. The researchers reported successful testing in rodents, dogs and men.
The first tests were proof of the concept and the drug is now being evaluated to establish the correct dosage, said Roland Haefeli, an Actelion spokesman.
Researchers hope to decide this year whether to conduct a phase-three study, a detailed assessment of the drug that would be the final step before seeking US government approval for its use. Such studies can take a few years.
Narcolepsy victims often also experience cataplexy, a condition in which they lose control of muscle tone for a few seconds to minutes. Jenck said in a telephone interview that the drug tests did not prompt indications of cataplexy.
Thomas Scammell, an assistant professor of neurology at Harvard University, said the work was “promising, with a certain amount of caution”.
“I think it may be the beginning of something quite exciting,” said Scammell, who was not part of the research team.