Tag: British Heart Foundation

Health Spreads Really do Lower Heart Risk

Post author By Mukul
Post date October 23, 2009
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The makers of two leading brands of spreads have been cleared to carry on claiming their products can reduce cholesterol.
Benecol and Flora pro.activ contain plant ingredients which EU health watchdogs now agree can help lower the risk of coronary heart disease….click & see

It is Britain’s biggest killer, with 110,000 victims a year.

Some two in three adults in Britain have raised cholesterol, which leads to clogged arteries and is a factor in heart disease.
The vital ingredients work with the body by partially blocking the entry of cholesterol into the bloodstream. It is claimed they lower bad cholesterol, known as LDL, by up to 15 per cent when used every day as part of a healthy diet and lifestyle.
Currently, millions of people rely on statin pills, prescribed by GPs, to reduce cholesterol. However, these can have side-effects, such as muscle pain.
Dietician and nutrition expert Helen Bond said: ‘People concerned about cholesterol need to have access to reliable, evidence based claims that will help them make wise food choices.

‘Dietary and lifestyle advice is always recommended as the first step for reducing cholesterol. Obesity, diabetes, raised cholesterol and a lack of physical activity are major risk factors for coronary heart disease.

‘This decision by the European Food Safety Authority will help people find the foods that will make a real difference.’
The manufacturers hailed the move to allow their so-called disease risk reduction claims as an important breakthrough.
Benecol products using the cholesterol reducing ingredients, called plant stanol esters, include drinks, yoghurts, spreads and cream cheese.
Benecol spokesman Esther van Onselen said: ‘Approval of the disease risk reduction claim is a really exciting step in helping consumers make an informed choice about which foods are proven to have a positive impact on their health.

‘There are more than 50 independent clinical studies which prove the cholesterol-lowering benefits of plant stanol esters.’
Flora pro.activ is made by Unilever, whose spokesman, Caroline Banquet, said: ‘We are delighted that the EU has now formally granted approval of our disease risk reduction claim.

‘Consumers can continue to be reassured that they can confidently trust our cholesterol-lowering health claims, in the knowledge that the science underpinning them has gone through rigorous and independent expert scrutiny.’
Unilever has carried out research into the cholesterol-lowering properties of plant ingredients since the 1980s. It first introduced Flora pro.activ spread in 2001, followed by yoghurt mini-drinks and milk drinks

Source:Mail Online, 23rd. Nov.’09

Tags Benecol, BMJ, British Heart Foundation, Cardiovascular disease, Cardiovascular Disorders, Conditions and Diseases, Coronary disease, England, European Food Safety Authority, Genetically modified crops, Health, Heart Disease, Medical director, Mortality rate, Physical exercise, United Kingdom

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The Little Blood-Sucker Ticks Can Save Lives

Post author By Mukul
Post date September 10, 2009
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Thousands of people who have had, or are at risk of, a heart attack could be saved by a new drug made from a chemical produced by blood-sucking ticks.

………………………….click & see
The drug, called Variegin, contains a man-made version of an anti-clotting chemical found in ticks from Africa and Central America.
Once the tiny insects have latched on to their human or animal prey, they release the chemical to stop blood from clotting and allow them to feed for longer.

Now a team of scientists from Britain, Singapore and Slovakia have discovered it might also slash the risk of heart attacks by stopping blood clots from forming.
They have developed a drug containing a synthetic form of the blood-thinning chemical that is up to 70 times more powerful than the ‘natural’ form produced by the ticks.
Initial tests show it is not only highly effective as an anticlotting agent, but potentially longer-lasting and safer than some existing drugs.

Every year, around 270,000 people in Britain suffer a heart attack, and coronary disease remains Britain’s biggest killer. About a third of heart attack patients die before reaching hospital, often because they have delayed seeking help.
Heart attacks occur when a clot forms and shuts off the supply of blood to cardiac muscle. Clotting is the body’s natural reaction to injury, designed to stem blood loss. But clots that form when there has been no injury can wreak havoc throughout the body, not just on the heart.
If they reach the brain, they can cause a stroke, or if they restrict blood flow to the lungs, they can cause an often fatal condition called a pulmonary embolism.

Patients who have suffered a heart attack or stroke – or are at high risk of them – are often given anti-clotting drugs to prevent more clots forming.
These work by changing the chemical composition of blood in a way that switches off the clotting process. The best known is Warfarin, a drug that has been around for more than 50 years and was once commonly used as a rat killer.
But patients on Warfarin have to be monitored extremely closely to ensure it does not thin their blood so much that they run the risk of bleeding to death from even the slightest cut. Newer drugs, known as direct thrombin inhibitors, have come on to the market in recent years. Although they have a better safety record than Warfarin, they can also increase the danger of a life-threatening bleed.
Around one in 100 people given a direct thrombin inhibitor suffers bleeding severe enough to kill them – unless they have urgent medical attention such as a transfusion.
If a patient is bleeding heavily or needs surgery, it’s vital that doctors can quickly restore normal clotting. But a drawback of modern anticlotting drugs is that their effects are irreversible.
The researchers behind the tick-saliva medicine have found a way of switching the clotting process back on, by injecting a chemical called protamine sulphate.
Professor Patricia Nuttall, who spearheaded the British arm of the tick project-at the Centre for Ecology and Hydrology in Wallingford, Oxfordshire, says: ‘The problem with direct thrombin inhibitors is once you have used them, you cannot switch them off.
‘Then you might get a patient who suffers excessive bleeding that you cannot control. But in our tests we used protamine sulphate, which stops the drug from binding to thrombin, the enzyme in the blood that makes it clot.’
Researchers hope to begin human clinical trials using the tick-saliva drug in the near future.
Professor Jeremy Pearson, associate medical director at the British Heart Foundation, says: ‘Scientists often take lessons from nature in the development of new medicines.
‘Our own researchers have worked with snake venom in the past to reveal clues about blood clotting. We look forward to seeing the results of clinical tests with Variegin.’

Source: Mail Online.Sept.8,2009

Tags Aspirin, Bayer, Blood, British Heart Foundation, Canada, Canadian Cardiovascular Society, Central America, Clinical trial, Conditions and Diseases, Food and Drug Administration, Health, Health Canada, Medicine, Myocardial infarction, Thrombus, University of Ottawa Heart Institute

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New Way to Repair Heart Attack Damage

Post author By Mukul
Post date January 10, 2009
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British scientists have developed a stem cell treatment that could dramatically boost the body’s ability to repair itself. The treatment, which makes the bone marrow release a flood of stem cells into the bloodstream, could heal serious tissue damage caused by heart attacks and even repair broken bones.

Scientists already use stem cell therapy to treat leukemia patients, getting the marrow to release a type of stem cell that can only make fresh blood cells. British researchers said, “They have found a way to get the bone marrow to release two other types of stem cell that can repair bone, blood vessels and cartilage.”

“The bone marrow of treated mice released 100 times as many stem cells, which help to regenerate tissue”, said Sara Rankin who led the research team at Imperial College. “We hope that by releasing extra stem cells, as we were able to do in mice in our study, we could potentially call up extra numbers of whichever stem cells the body needs, in order to boost its ability to mend itself and accelerate the repair process,” she said.

The group hopes to begin trials later this year to investigate how effective it is at repairing tissue damage in rodents. “All the evidence suggests these cells will make a significant difference to the natural repair process,” Rankin said.

Peter Weissberg, medical director at the British Heart Foundation, which co-funded the research along with the Welcome Trust, said: “It now seems increasingly likely that the bone marrow also contains cells that have the capacity to repair damaged internal organs, such as the heart and blood vessels, but that too few of them are released to be effective.”

He further added, “This research has identified some important molecular pathways involved in mobilizing these cells. It may be possible to develop a drug that interacts with these pathways to encourage the right number and type of stem cells to enter the circulation and repair damage to the heart.”

Sources: The Times Of India

Tags Blood vessel, Bone marrow, British Heart Foundation, Imperial College London, Sara Rankin, Stem cell, Stem cell Treatment, Times Of India

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Veg ‘Prevents Artery Hardening’

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Post date October 24, 2008
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Eating vegetables may prevent hardening of the arteries, research suggests.

.CLICK & SEE
Different coloured veg contain different minerals

.US researchers found 38% less build up of fatty deposits in the arteries of mice who were fed a mixture of vegetables, including carrots and peas.

Evidence on the effects of diet on atherosclerosis in humans is not clear but eating fruit and vegetables is known to protect against heart disease.

The study in the Journal of Nutrition said the average person only eats three portions of fruit and veg a day.

The researchers from the Wake Forest University School of Medicine assessed the effect of diet on heart disease by studying mice that had been specially bred to rapidly develop atherosclerosis – the formation of fatty plaques in the arteries which can eventually block blood flow leading to heart attacks and strokes.

“While everyone knows that eating more vegetables is supposed to be good for you, no-one had shown before that it can actually inhibit the development of atherosclerosis” Says Dr Michael Adams, lead researcher

Half the mice were fed a vegetable-free diet and half the mice were fed a diet which included broccoli, green beans, corn, peas and carrots.

After 16 weeks, researchers measured cholesterol content in the blood vessels and estimated that plaques in the arteries of the mice were 38% smaller.

Although there was also a reduction in total cholesterol and body weight in mice fed the vegetable-rich diet, analysis showed that this could not explain the reduction in atherosclerosis.

Lead researcher Dr Michael Adams said: “While everyone knows that eating more vegetables is supposed to be good for you, no-one had shown before that it can actually inhibit the development of atherosclerosis.”

Inflammation
He added that there was a 37% reduction in serum amyloid – a marker of inflammation in mice – suggesting that vegetable consumption may inhibit inflammatory activity

“Although the pathways involved remain uncertain, the results indicate that a diet rich in green and yellow vegetables inhibits the development of hardening of the arteries and may reduce the risk of heart disease,” he said.

“It is well known that atherosclerosis progression is intimately linked with inflammation in the arteries.”

Dr Adrian Brady, consultant cardiologist at Glasgow Royal Infirmary, said: “It’s an interesting study and it is encouraging. There is a public health message that dietary interventions are helpful.

“And now this animal model shows maybe there is long-term dietary involvement that could lead to less plaques.”

He added more work was needed to look at the development of plaques and confirm the protective effect of eating fruit and veg.

Dr Charmaine Griffiths, spokesperson for the British Heart Foundation, said: “This study supports the recommendation of eating at least five portions of fruit and vegetables a day.

“Different coloured fruit and vegetables contain different vitamins and minerals, so the more types of fruit and vegetables you can include in your diet the better.”

Sources:BBC NEWS:18th.June,’08

Tags Asda, Atherosclerosis, Baked potato, Blood sugar, Blood vessel, Boston Medical Center, Bottled water, British Heart Foundation, Food waste, French language, Fruit, Glasgow Royal Infirmary, Health, Heart Disease, Michael Adams, Soup, Vegetable, Wake Forest University School of Medicine

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Health Moves ‘Halve Early Deaths’

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Post date September 21, 2008
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Women could halve their risk of premature death by adopting a healthier lifestyle, research suggests…..
Smoking accounted for nearly a third of the deaths

By avoiding cigarettes, exercising regularly, eating healthily and keeping weight in check, 55% of early deaths from chronic diseases could be avoided.

Following all four lifestyle tips could cut 44% of cancer deaths and 72% of cardiovascular deaths, the study of nearly 80,000 nurses suggests.

The work is published on the British Medical Journal website.

In the 24-year study, 28% of the 8,882 deaths could be attributed to smoking and 55% to the combination of smoking, being overweight, not doing enough exercise and a poor diet.

Drinking too much alcohol also contributed, but women with “light-to-moderate” alcohol consumption of up to one drink a day were less likely to die from cardiovascular diseases than teetotallers.

Report author Dr Rob van Dam, from the Brigham and Women’s Hospital and Harvard Medical School, said the study’s positive findings on moderate consumption of alcohol should not encourage people to “go overboard”.

“It seems to be that drinking a little alcohol can lower the risk of heart disease, but you have to look at the overall picture too. We also saw in our study that people who drink a lot of alcohol have a higher risk of dying from cancer.”

He said it could be easy for people to adopt the basic lifestyle recommendations.

Simple advice

“In busy, modern life it’s more difficult to adapt to these factors, but people don’t have to spend hours lifting heavy weights.

“It’s simple dietary changes like eating more whole-grains and less red meat, walking to work and to the grocery shop, these really add up. And of course the thing to state is not to smoke.”

According to Dr van Dam, the recommendations in his study could apply to men as well as women.

The 77,782 women aged 34 to 59 who took part in the study completed detailed follow-up questionnaires every two years about their diet, frequency of physical activity, alcohol intake, weight, how much they smoked, and disease history.

Over the follow-up period the authors documented 8,882 deaths including 1,790 from heart disease and 4,527 from cancer.

A spokeswoman from the British Nutrition Foundation said: “This study reaffirms the importance of prevention.

“It is worth making lifestyle changes now, so that our later years are spent free from diseases such as cancer and heart disease.”

“It is worth making lifestyle changes now, so that our later years are spent free from diseases”.…as per British Nutrition Foundation spokeswoman

Risk reduction

Meanwhile, a study by the British Heart Foundation has found women at high risk of diabetes can reduce their body’s insulin resistance – the most important biological risk factor for diabetes – by exercising.

After seven weeks of an exercise programme of three 30 minute exercise sessions in the first week, working up to five 60 minute sessions in weeks six and seven, insulin resistance had reduced by 22% in women whose family history put them at a high risk of type 2 diabetes.

Professor Peter Weissberg, medical director at the BHF, said: “I hope the findings will encourage people to get active for their health.”

Sources: BBC NEWS:Sept. 16. ’08