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News on Health & Science

Agents that regulates appetite identified

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Scientists in Japan have identified a molecule responsible for making mammals feel full, a discovery that could lead to new ways to treat obesity in humans.

Scientists believe appetite is controlled in a region of the brain called the hypothalamus, and the group of researchers claims to be the first to pinpoint an agent that triggers an increase or decrease in appetite.

In an article published on Sunday in the online version of the journal Nature, the scientists identified the molecule as nesfatin-1, which is produced naturally in the brain.

After injecting the molecule into the brains of rats, the scientists observed that the rodents began to eat less and lose weight.

The researchers also were able to induce the rats to eat more, by blocking nesfatin-1

After we injected anti-nesfatin-1 antibody, these rats showed increased appetite and finally showed a progressive increase in body weight,” Masatomo Mori of the medicine and molecular science department at Gunma University Graduate School of Medicine told Reuters in a telephone interview.

Mori said the finding could pave the way for treating obesity, which has become a major health problem in the developing world as well as in economically advanced countries.

There are at least a billion overweight adults across the world, 300 million of them considered obese, according to the World Health Organization.

Obesity has been linked to chronic diseases, such as type 2 diabetes, cardiovascular disease, hypertension and stroke, and some forms of cancer.

In a separate study, it has been found that the hormone leptin could help keep the body from producing too much insulin, according to a study in mice with type 2 diabetes.

People with type 2 diabetes often become resistant to the effects of insulin, causing to much of it to build up in the body.

Reporting in the September issue of the journal Peptides, researchers from the University of Florida injected a gene into the brains of diabetic mice, hoping to increase the production of the appetite-controlling hormone leptin in the hypothalamus.

Insulin levels in mice that received gene therapy returned to normal — even when they were fed a high-fat diet, the
researchers found. High-fat diets typically help trigger or worsen type 2 diabetes.

Mice that ate a high-fat diet but did not receive gene therapy, however, continued to overproduce insulin and have high blood-sugar levels.

“This was totally unexpected. Until now, there way no evidence that leptin action in the hypothalamus had control on insulin secretion.

With leptin gene therapy, we can re-impose that control,” senior author Satya Kalra, a University of Florida, Gainesville, professor of neuroscience, said.

(As published in the Times Of India)

Categories
Ailmemts & Remedies

Diabetes

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Diabetes is a disease in which the body does not produce or properly use insulin. Insulin is a hormone that is needed to convert sugar, starches and other food into energy needed for daily life. The cause of diabetes continues to be a mystery, although both genetics and environmental factors such as obesity and lack of exercise appear to play roles.

In order to determine whether or not a patient has pre-diabetes or diabetes, health care providers conduct a Fasting Plasma Glucose Test (FPG) or an Oral Glucose Tolerance Test (OGTT). Either test can be used to diagnose pre-diabetes or diabetes.
With the FPG test, a fasting blood glucose level between 100 and 125 mg/dl signals pre-diabetes. A person with a fasting blood glucose level of 126 mg/dl or higher has diabetes....click & see

In the OGTT test, a person’s blood glucose level is measured after a fast and two hours after drinking a glucose-rich beverage. If the two-hour blood glucose level is between 140 and 199 mg/dl, the person tested has pre-diabetes. If the two-hour blood glucose level is at 200 mg/dl or higher, the person tested has diabetes.

Major Types of Diabetes


Type 1 diabetes

Results from the body’s failure to produce insulin, the hormone that “unlocks” the cells of the body, allowing glucose to enter and fuel them. It is estimated that 5-10% of Americans who are diagnosed with diabetes have type 1 diabetes.
Symptoms of type 1 diabetes are often dramatic and come on very suddenly.
* Type 1 diabetes is usually recognized in childhood or early adolescence, often in association with an illness (such as a virus) or injury.
* The extra stress can cause diabetic ketoacidosis.
* Symptoms of ketoacidosis include nausea and vomiting. Dehydration and often-serious disturbances in blood levels of potassium follow.
* Without treatment, ketoacidosis can lead to coma and death.

Symptoms of type 2 diabetes are often subtle and may be attributed to aging or obesity.
* A person may have type 2 diabetes for many years without knowing it.
# Type 2 diabetes can be precipitated by steroids and stress.
# If not properly treated, type 2 diabetes can lead to complications like blindness, kidney failure, heart disease, and nerve damage

Type 2 diabetes
Results from insulin resistance (a condition in which the body fails to properly use insulin), combined with relative insulin deficiency. Most Americans who are diagnosed with diabetes have type 2 diabetes.

Gestational diabetes
Gestational diabetes affects about 4% of all pregnant women – about 135,000 cases in the United States each year.

Pre-diabetes

Pre-diabetes is a condition that occurs when a person’s blood glucose levels are higher than normal but not high enough for a diagnosis of type 2 diabetes. There are 41 million Americans who have pre-diabetes, in addition to the 20.8 million with diabetes.

CAUSES OF DIABETES:
Diabetes mellitus occurs when the pancreas doesn’t make enough or any of the hormone insulin, or when the insulin produced doesn’t work effectively. In diabetes, this causes the level of glucose in the blood to be too high.

In Type 1 diabetes the cells in the pancreas that make insulin are destroyed, causing a severe lack of insulin. This is thought to be the result of the body attacking and destroying its own cells in the pancreas – known as an autoimmune reaction.

* infection with a specific virus or bacteria;
* exposure to food-borne chemical toxins; and
* exposure as a very young infant to cow’s milk, where an as yet unidentified component of this triggers the autoimmune reaction in the body.

However, these are only hypotheses and are by no means proven causes.

Type 2 diabetes: Type 2 diabetes is believed to have a strong genetic link, meaning that it tends to run in families. Several genes are being studied that may be related to the cause of type 2 diabetes.
Type 2 diabetes is believed to develop when:
* the receptors on cells in the body that normally respond to the action of insulin fail to be stimulated by it – this is known as insulin resistance. In response to this more insulin may be produced, and this over-production exhausts the insulin-manufacturing cells in the pancreas;
* there is simply insufficient insulin available; and
* the insulin that is available may be abnormal and therefore doesn’t work properly..

The following risk factors increase the chances of someone developing Type 2 diabetes:
* High blood triglyceride (fat) levels
* Gestational diabetes or giving birth to a baby weighing more than 9 pounds
* High-fat diet
* High alcohol intake
* Sedentary lifestyle
* Obesity or being overweight

* Ethnicity: Certain groups, such as African Americans, Native Americans, Hispanic Americans, and Japanese Americans, have a greater risk of developing type 2 diabetes than non-Hispanic whites.

* Aging: Increasing age is a significant risk factor for type 2 diabetes. Risk begins to rise significantly at about age 45 years, and rises considerably after age 65 years.
Rarer causes of diabetes include:
* Certain medicines;
* pregnancy (gestational diabetes); and
* any illness or disease that damages the pancreas and affects its ability to produce insulin e.g. pancreatitis.

It’s important to also be aware of the different myths that over the years have arisen about the causes of diabetes.
Eating sweets or the wrong kind of food does not cause diabetes. However, it may cause obesity and this is associated with people developing Type 2 diabetes.
Stress does not cause diabetes, although it may be a trigger for the body turning on itself as in the case of Type 1 diabetes. It does, however, make the symptoms worse for those who already have diabetes.
Diabetes is not contagious. Someone with diabetes cannot pass it on to anyone else.

TAKE CARE AND CHARGE OF YOUR HEALTH ONE STEP AT A TIME:
If you have diabetes, you would be wise to make healthful lifestyle choices in diet, exercise, and other health habits. These will help to improve glycemic (blood sugar) control and prevent or minimize complications of diabetes.

Diet: A healthy diet is key to controlling blood sugar levels and preventing diabetes complications.

Managing type 2 diabetes means making some changes to how you live. Your doctor will ask you to eat healthy, be more active, lose weight if you need to, and quit smoking. He or she may prescribe one or more medicines, too.
It may seem like a lot to do. But keeping your blood sugar under control now can help reduce the risk of health problems from diabetes later.
.
Regular Yoga exercise, meditation and proper Ayurvedic treatment can keep a diabetec patient well all his or her life through.

(Help taken from:http://www.emedicinehealth.com/diabetes/article_em.htm and http://www.diabetes.org/about-diabetes.jsp)

Categories
Herbs & Plants Herbs & Plants (Spices)

Magic of Methi or Fenugreek

 

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Fenugric; Botanical name: Trigonella foenum-graecum

Family: Fabaceae/Leguminosae
Genus: Trigonella
Species: T. foenum-graecum
Kingdom: Plantae
Order: Fabales

Fenugreek,commonly known as Methi, seeds provide a tangy flavor and powerful curry scent to the vegetable and lentil dishes. Fenugreek seed are used in wide range of curry powder. Fenugreek can also be used as a fresh herb.

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Fenugreek are always roasted before using. Light roast gives a mellow flavor and dark roast will give a bitter. Sometimes the seeds are soaked overnight, when they becomes easier to combine in curry paste. Soaked seeds can also be used as main ingredient for a vegetable or chutney.

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Fenugreek are used and grown throughout the South Asia. The Fenugreek plant grows 2 feet tall with light green leaves and white flower. Each Fenugreek pod gives from 10 to 20 seeds. Fenugreeks are rich in protein, vitamins and mineral

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It is a herb with small, aromatic green leaves. It is also used in dried form (kasoori methi) to flavour chicken and fish and cooked as a classic vegetable dish with potatoes (alumethi). Slightly bitter in taste, it is a popular winter green.

Methi seeds, whole, fried or roasted and powdered, are used as ‘tarka’ or garnishing. It is used commonly in pickles across India and is part of a five spice mixture used in Bengal. Like most herbs, Methi has many medicinal properties.

Fenugreek seeds contain a high percentage of mucilage a natural gummy substance present in the coatings of many seeds. Although it does not dissolve in water, mucilage forms a thick, gooey mass when exposed to fluids. Like other mucilage-containing substances, fenugreek seeds swell up and become slick when they are exposed to fluids. The resulting soft mass is not absorbed by the body, but instead passes through the intestines and also triggers intestinal muscle contractions. Both actions promote the emptying of intestinal contents. Therefore, fenugreek is a mild but effective laxative.

In addition, fenugreek seeds contain chemicals that slow down the time that food takes to go through the intestinal tract. As one result, sugars are absorbed from foods more slowly and blood sugar levels may not rise as high or fluctuate as much as usual. Fenugreek may further affect blood sugar levels by decreasing the activity of an enzyme that is involved in releasing stored sugar from the liver into the blood. Also, fenugreek contains an amino acid called 4-hydroxyisoleucine, which appears to increase the body’s production of insulin when blood sugar levels are high. For many individuals, higher insulin production decreases the amounts of sugar that stay in the blood In some studies of animals and humans with both diabetes and high cholesterol levels, fenugreek lowered cholesterol levels as well as blood sugar levels. However, no blood-sugar lowering effect was seen in non-diabetic animals. Similarly, individuals with normal cholesterol levels showed no significant reductions in cholesterol while taking fenugreek.

Some evidence suggests that fenugreek may also have other medical uses. It may reduce the amounts of calcium oxalate in the kidneys. Calcium oxalate often contributes to kidney stones. In animal studies, fenugreek also appeared to lessen the chance of developing colon cancer by blocking the action of certain enzymes. It may have some ability to protect the liver against damage from alcohol and other chemicals, but much further research is needed to prove or disprove all these possible uses of fenugreek.

Methi is supposed to be natural cure for arthritis. According to ayurveda, the cause of arthritis is a noxious gas produced within the human body known as Va and the gas that causes joint arthritis is known as Sandhiva.

During the course of time, intestines fill with undigested food particles which become glued to the intestine lining. These particles create several different layers in the intestine and act as chemicals that release gases with different constituents. The gas, sandhiva, finds refuge in the joints and creates pressure, immobilizing them and making movement painful, due to inflamation. Methi, if consumed twice a day, cleans the intestines and directs the waste out of the body naturally.

According to Ayurveda, Methi is an antipyretic and anthelmintic herb. Translation: It is an appetizer, relieves constipation, and reduces colic. It is also known to cure leprosy, vomiting, bronchitis, and piles.

Traditional healers recommend that people suffering from digestive problems eat Methi leaves. It also helps you lose weight and reduces dullness, dizziness and drowsiness. In general, it is considered as good appetizer. Methi seeds are considered very effective in combative diabetes.

Topically, the gelatinous texture of fenugreek seed may have some benefit for soothing skin that is irritated by eczema or other conditions. It has also been applied as a warm poultice to relieve muscle aches and gout pain

The fresh juice of Methi leaves prevents hair fall. You can massage it in your hair, particularly the roots, to get rid of dandruff and promote new hair growth. It can also be used in a facepack to reduce wrinkles.

Fenugreek seed is widely used as a galactagogue (milk producing agent) by nursing mothers to increase inadequate breast milk supply. Studies have shown that fenugreek is a potent stimulator of breast milk production and its use was associated with increases in milk production. It can be found in capsule form in many health food stores.

Several human intervention trials demonstrated that the antidiabetic effects of fenugreek seeds ameliorate most metabolic symptoms associated with type-1 and type-2 diabetes in both humans and relevant animal models by reducing serum glucose and improving glucose tolerance.  click & see

Disclaimer : The information presented herein is intended for educational purposes only. Individual results may vary, and before using any supplements, it is always advisable to consult with your own health care provider

Extracted from: /www.purpleparka.com and http://www.drugdigest.org/DD/DVH/HerbsWho/0,3923,552024%7CMethi,00.html

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