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Memory-Improving Nasal Spray

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It’s a dream come true for many college students used to late-night studying. Scientists in Germany have developed a nasal spray containing a molecule from the body’s immune system that can help the brain retain memories during sleep.

Researchers with the University of Lubeck in Germany had 17 healthy young men read either an emotional or neutral short story before bed. Each also had either a fluid containing the immunoregulatory signal interleukin-6 (IL-6) or a placebo sprayed into their nostrils before going to sleep. The next morning subjects wrote down as many words as they could remember from each of the two stories. Those who received the dose of IL-6 could remember more words.

“This is an exciting piece of interdisciplinary science, since IL-6 had previously been considered a by-product of inflammation, not an agent that affects cognition,” said Dr. Gerald Weissmann of The FASEB Journal.

According to TheVitaminandSupplementGuide.com, vitamin B12 is one of the key vitamins for improving memory in healthy people. Nutritional supplements containing carnitine, coenzyme Q10, DMAE, ginkgo, huperzine A and kava all have special uses in treating age-related memory loss.

Source:http://www.betterhealthresearch.com/news/scientists-develop-memory-improving-nasal-spray-19393963/

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Healthy Secret of Red Wine Uncorked

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Resveratrol in red wine is known for controlling inflammation and promoting health. However, how the ingredient works was not known to  scientists – up till now.

In the FASEB Journal, scientists from Scotland and Singapore have unravelled how resveratrol works as an effective therapy for life-threatening inflammation.

The study, not only explains resveratrol’s one-two punch on inflammation, but also shows how it-or a derivative-can be used to treat potentially deadly inflammatory disease, such as appendicitis, peritonitis, and systemic sepsis.

“Strong acute inflammatory diseases such as sepsis are very difficult to treat and many die every day due to lack of treatment,” said Alirio Melendez, senior lecturer on the faculty of medicine at Glasgow Biomedical Research Centre in Scotland and one of the researchers involved in the work.

“Moreover, many survivors of sepsis develop a very low quality of life due to the damage that inflammation causes to several internal organs. The ultimate goal of our study was to identify a potential novel therapy to help in the treatment of strong acute inflammatory diseases,” the expert added.

To reach the conclusion, researchers administered an inflammatory agent to two groups of mice. One group was pretreated with resveratrol and the other group was not. The mice that were not pre-treated with resveratrol experienced a strong inflammatory response, simulating disease in humans, while the group pretreated with resveratrol was protected from the inflammation.

The scientists then examined the tissues of the mice to determine exactly how resveratrol was able to protect the mice from inflammation. They found that resveratrol used a one-two punch to stop inflammation in the mice by preventing the body from creating two different molecules known to trigger inflammation, sphingosine kinase and phospholipase D.

This finding suggests that resveratrol may be harnessed as a treatment for inflammatory diseases and may also lead to entirely new resveratrol-based drugs that are even more effective.

“The therapeutic potential of red wine has been bottled up for thousands of years,” said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, “and now that scientists have uncorked its secrets, they find that studies of how resveratrol works can lead to new treatments for life-threatening inflammation.”

Source: The Times Of India

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What Your Gray Hair Says about You

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Gray hair, according to new findings, is caused by a massive build up of hydrogen peroxide due to wear and tear on hair follicles. The peroxide winds up blocking the normal synthesis of melanin, your hair’s natural pigment.

All hair cells make a tiny bit of hydrogen peroxide, but as you age, the amount increases. Essentially, you bleach our hair pigment from within, and your hair turns gray and then white.

Researchers made this discovery by examining cell cultures of human hair follicles. They found that the build up of hydrogen peroxide was caused by a reduction of an enzyme that breaks up hydrogen peroxide into water and oxygen.

They also discovered that hair follicles could not repair the damage caused by the hydrogen peroxide because of low levels of the enzymes MSR A and B, which normally serve this function. The high levels of hydrogen peroxide and low levels of these enzymes also disrupt the formation of tyrosinase, another enzyme that leads to the production of melanin in hair follicles.

Sources:

Science Daily February 24, 2009

The FASEB journal : official publication of the Federation of American Societies for Experimental Biology

The New York Times March 9, 2009

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Experts Uncover Cause of Greyness

Scientists at Bradford University believe they have uncovered the root cause of why hair turns grey.
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Experts found grey hair was caused by a build-up of hydrogen peroxide

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It is an accepted part of the ageing process, but experts say understanding how grey hair happens could help find a way to prevent it.

Experiments found it is caused by a massive build-up of hydrogen peroxide due to wear and tear of hair follicles, which blocks hair’s natural pigment.

The research has been hailed as a “major breakthrough”.

The scientists worked in collaboration with experts in Mainz and Luebeck in Germany and the discoveries have been published in the FASEB scientific journal, published by the Federation of the American Societies for Experimental Biology.

Lead researcher Karin Schallreuter said experts examined hair as well as cells from human hair follicles to uncover the findings.

He said: “This discovery is a major breakthrough in the understanding of hair greying and opens up some novel ideas to combat this scenario.

“These are being followed up at the current time in our laboratory.”

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Sources:BBC NEWS:3rd.March ’09

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Going gray? Hair ‘Bleaches Itself as People Age’

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Why people turn gray is no longer a gray area, for scientists have finally solved the mystery by discovering that hair bleaches itself as  people age.

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A team in Europe has found that going gray is caused by a massive build up of hydrogen peroxide due to wear and tear of our hair follicles. The peroxide winds up blocking the normal synthesis of melanin, our hair’s natural pigment.

According to Gerald Weissmann, the Editor-in-Chief of the ‘FASEB Journal‘, which published the study, “All of our hair cells make a tiny bit of hydrogen peroxide, but as we get older, this little bit becomes a lot.

“We bleach our hair pigment from within, and our hair turns gray and then white. This research, however, is an important first step to get at the root of the problem, so to speak.”

In fact, the scientists made this discovery by examining cell cultures of human hair follicles. They found the build up of hydrogen peroxide was caused by a reduction of an enzyme that breaks up hydrogen peroxide into water and oxygen (catalase).

They also discovered that hair follicles could not repair the damage caused by the hydrogen peroxide because of low levels of enzymes that normally serve this function (MSR A and B).

Sources: The Times Of India

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