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Probiotic

Definition:
Probiotics are “live microorganisms, which, when administered in adequate amounts, confer a health benefit on the host.” (Microorganisms are tiny living organisms—such as bacteria, viruses, and yeasts—that can be seen only under a microscope.)

Probiotics are not the same thing as prebiotics—nondigestible food ingredients that selectively stimulate the growth and/or activity of beneficial microorganisms already in people’s colons. When probiotics and prebiotics are mixed together, they form a synbiotic.

Probiotics are available in foods and dietary supplements (for example, capsules, tablets, and powders) and in some other forms as well. Examples of foods containing probiotics are yogurt, fermented and unfermented milk, miso, tempeh, and some juices and soy beverages. In probiotic foods and supplements, the bacteria may have been present originally or added during preparation.

Most probiotics are bacteria similar to those naturally found in people’s guts, especially in those of breastfed infants (who have natural protection against many diseases). Most often, the bacteria come from two groups, Lactobacillus or Bifidobacterium. Within each group, there are different species (for example, Lactobacillus acidophilus and Bifidobacterium bifidus), and within each species, different strains (or varieties). A few common probiotics, such as Saccharomyces boulardii, are yeasts, which are different from bacteria.

Probiotic bacterial cultures are intended to assist the body’s naturally occurring gut flora, an ecology of microbes, to re-establish themselves. They are sometimes recommended by doctors, and, more frequently, by nutritionists, after a course of antibiotics, or as part of the treatment for gut related candidiasis. Claims are made that probiotics strengthen the immune system to combat allergies, excessive alcohol intake, stress, exposure to toxic substances, and other diseases. In these cases, the bacteria that work well with our bodies may decrease in number, an event which allows harmful competitors to thrive, to the detriment of our health.

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Maintenance of a healthy gut flora is, however, dependent on many factors, especially the quality of food intake. Including a significant proportion of prebiotic foods in the diet has been demonstrated to support a healthy gut flora and may be another means of achieving the desirable health benefits promised by probiotics.

Adverse Effects:-
There is no published evidence that probiotic supplements are able to completely replace the body’s natural flora when these have been killed off; indeed bacterial levels in faeces disappear within days when supplementation ceases. While the oral use of probiotics is considered safe and even recommended by World Health Organization under specific guidelines , in some specific situations (such as critically ill patients) they could be potentially harmful. In one therapeutic clinical trial, a probiotic cocktail have been shown to increase the death rates of patients with acute pancreatitis , but was given through tube feeding directly in the intestine instead of the usual oral way since oral re-feeding following acute pancreatitis increases morbidity and mortality. Some other therapeutic use of probiotics have been shown to be beneficial for other types of patients.

Potential benefits:-
Experiments into the benefits of probiotic therapies suggest a range of potentially beneficial medicinal uses for probiotics. For many of the potential benefits, research is limited and only preliminary results are available. It should be noted that the effects described are not general effects of probiotics. All effects can only be attributed to the strain(s) tested, not to the species, nor to the whole group of LAB (or other probiotics).

Managing Lactose Intolerance
As lactic acid bacteria actively convert lactose into lactic acid, ingestion of certain active strains may help lactose intolerant individuals tolerate more lactose than what they would have otherwise. In practice probiotics are not specifically targeted for this purpose, as most are relatively low in lactase activity as compared to the normal yogurt bacteria.

Prevention of Colon Cancer
In laboratory investigations, some strains of LAB have demonstrated anti-mutagenic effects thought to be due to their ability to bind with heterocyclic amines, which are carcinogenic substances formed in cooked meat. Animal studies have demonstrated that some LAB can protect against colon cancer in rodents, though human data is limited and conflicting. Most human trials have found that the strains tested may exert anti-carcinogenic effects by decreasing the activity of an enzyme called ?-glucuronidase (which can generate carcinogens in the digestive system). Lower rates of colon cancer among higher consumers of fermented dairy products have been observed in some population studies.

Cholesterol Lowering
Animal studies have demonstrated the efficacy of a range of LAB to be able to lower serum cholesterol levels, presumably by breaking down bile in the gut, thus inhibiting its reabsorption (which enters the blood as cholesterol). Some, but not all human trials have shown that dairy foods fermented with specific LAB can produce modest reductions in total and LDL cholesterol levels in those with normal levels to begin with, however trials in hyperlipidemic subjects are needed.

Lowering Blood Pressure
Several small clinical trials have shown that consumption of milk fermented with various strains of LAB can result in modest reductions in blood pressure. It is thought that this is due to the ACE inhibitor-like peptides produced during fermentation.

Improving Immune Function and Preventing Infections
LAB are thought to have several presumably beneficial effects on immune function. They may protect against pathogens by means of competitive inhibition (i.e., by competing for growth) and there is evidence to suggest that they may improve immune function by increasing the number of IgA-producing plasma cells, increasing or improving phagocytosis as well as increasing the proportion of T lymphocytes and Natural Killer cells. Clinical trials have demonstrated that probiotics may decrease the incidence of respiratory tract infections and dental caries in children. LAB foods and supplements have been shown to be effective in the treatment and prevention of acute diarrhea, and in decreasing the severity and duration of rotavirus infections in children and travelers’ diarrhea in adults.

Helicobacter pylori
LAB are also thought to aid in the treatment of Helicobacter pylori infections (which cause peptic ulcers) in adults when used in combination with standard medical treatments.

Antibiotic-associated diarrhea
A meta-analysis suggested probiotics may reduce antibiotic-associated diarrhea. A subsequent randomized controlled trial also found benefit in elderly patients.

Reducing Inflammation
LAB foods and supplements have been found to modulate inflammatory and hypersensitivity responses, an observation thought to be at least in part due to the regulation of cytokine function. Clinical studies suggest that they can prevent reoccurrences of inflammatory bowel disease in adults, as well as improve milk allergies and decrease the risk of atopic eczema in children.


Improving Mineral Absorption

It is hypothesized that probiotic lactobacilli may help correct malabsorption of trace minerals, found particularly in those with diets high in phytate content from whole grains, nuts, and legumes.[27]


Prevents Harmful Bacterial Growth Under Stress

In a study done to see the effects of stress on intestinal flora, rats that were fed probiotics had little occurrence of harmful bacteria latched onto their intestines compared to rats that were fed sterile water.

Irritable Bowel Syndrome and Colitis
B. infantis 35624, sold as Align, was found to improve some symptoms of irritable bowel syndrome in women in a recent study. Another probiotic bacterium, Lactobacillus plantarum 299V, was also found to be effective in reducing IBS symptoms. Additionally, a probiotic formulation, VSL3, was found to be effective in treating ulcerative colitis. Bifidobacterium animalis DN-173 010 may help.

Synbiotics:
It is also possible to increase and maintain a healthy bacterial gut flora by increasing the amounts of prebiotics in the diet such as inulin, raw oats, and unrefined wheat.

As probiotics are mainly active in the small intestine and prebiotics are only effective in the large intestine, the combination of the two may give a synergistic effect. Appropriate combinations of pre- and probiotics are synbiotics.

Synbiotics have also been defined as metabolites produced by ecoorgan or by synergistic action of prebiotics and probiotics e.g. short chain fatty acids, other fatty acids, amino acids, peptides, polyamines, carbohydrates, vitamins, numerous antioxidants and phytosterols, growth factors, coagulation factors, various signal molecules such as cytokine-like bacteriokines.

Foods that contain probiotic:
Probiotics are available in foods and dietary supplements (for example, capsules, tablets, and powders) and in some other forms as well. Examples of foods containing probiotics are yogurt, fermented and unfermented milk, miso, tempeh, and some juices and soy beverages. In probiotic foods and supplements, the bacteria may have been present originally or added during preparation.It is found plenty in garlic,honey, leeks,onions and whole grains.

The most common form for probiotics are dairy products and probiotic fortified foods. However, tablets, capsules, powders and sachets containing the bacteria in freeze dried form are also available.

TOP KILLERS OF PROBIOTICS:

*Overuse of prescription antibiotics
*Sugar
*GMO foods
*Inflammatory gluten
*Emotional stress
*Medications
*Alcohol (except for red wine)
*Lack of exercise
*Over-sanitation
*Smoking
*Poor sleep habits

Research:
Research about probiotics shows both benefits and harm.

A 2007 study at University College Cork in Ireland showed that a diet including milk fermented with Lactobacillus bacteria prevented Salmonella infection in pigs.

A 2007 clinical study at Imperial College London showed that preventive consumption of a commercially available probiotic drink containing L casei DN-114001, L bulgaricus, and S thermophilus can reduce the incidence of antibiotic-associated diarrhea and C difficile-associated diarrhea.

In a double-blind, placebo-controlled therapeutic study on the effects of a probiotic cocktail on pancreatitis at University Medical Center Utrecht (UMC), 24 out of 296 patients died between 2004 and 2007, with more deaths among those receiving the probiotic cocktail directly in the intestine. According to the spokesman of UMC, it is likely that some of these deaths would not have occurred without the probiotics, although other therapeutic trials conducted on probiotics were more positively conclusive
You may click to see:->Beneficial effects of probiotic strains

Probiotics and Colorectal Cancer

The Probiotics Revolution

Sources:
http://en.wikipedia.org/wiki/Probiotic
http://www.medicinenet.com/probiotics/article.htm

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Bacterial Vaginosis

Bacterial vaginosis (BV) is the most common cause of vaginal infection (vaginitis). For grammatical reasons, some people prefer to call it vaginal bacteriosis. It is NOT generally considered to be a sexually transmitted infection . BV is caused by an imbalance of naturally occurring bacterial flora, and should not be confused with yeast infection (candidiasis), or infection with Trichomonas vaginalis (trichomoniasis) which are not caused by bacteria.

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Symptoms:

The most common symptom of BV is an abnormal vaginal discharge (especially after sex) with an unpleasant fishy smell. There is rarely itching.Nearly half of all women with BV don’t notice any symptoms. By contrast, a ‘normal’ discharge will be odourless and will vary in consistency and amount with your menstrual cycle – a normal discharge is at its clearest about 2 weeks before your period starts.

General Diagnosis:
When you go to your healthcare provider with questions about vaginal discharge, he or she will have several diagnoses in mind to account for it. These may include:

1.The discharge is normal for you
2.Candidiasis (thrush, or a yeast infection)
3.Trichomonas vaginalis (trichomoniasis)
4.Bacterial vaginosis
To find out which of these is the case, a few simple tests are done. The provider will carry out a speculum examination and take some swabs from high in the vagina. These swabs will be tested for:

1.A characteristic smell—this is called the whiff test. A small amount of an alkali is added to a microscope slide that has been swabbed with the discharge—a ‘fishy’ odour is a positive result for bacterial vaginosis.
2.Loss of acidity—the vagina is normally slightly acidic (with a pH of 3.8–4.2), which helps to control bacteria. A swab of the discharge is put onto litmus paper to check the acidity.A positive result for bacterial vaginosis would be a pH of over 4.5.

3.’Clue cells’—so called because they give a clue to the reason behind the discharge. These are epithelial cells (like skin) that are coated with bacteria. They can be seen under microscopic examination of your discharge.
Two positive results in addition to the discharge itself are enough to diagnose BV. If there is no discharge, then all 3 criteria are needed.

What might be done?
Your doctor may be able to diagnose bacterial vaginosis from your symptoms. swabs of any discharge may be taken and tested to confirm the diagnosis.

Causes:
Bacterial vaginosis is caused by excess growth of some of the bacteria that normally live in the vagina, particularly gardnerella vaginalis and mycoplasma hominis. as a result, the natural balance of organisms, in the vagina is altered. the reason for this excess growth is unknown, but the condition is more common in sexually active women and often, but notalways, occurs in association with sexually transmitted diseases. vaginal infections can also be caused by an overgrowth of the candida fungus and the protozoan trichomonas vaginalis. Bacterial vaginosis often causes no symptoms. however, some women have a grayish white vaginal discharge with a fishy or musty odor and vaginal or vulval itching. rarely, the disorder leads to pelvic inflammatory disease, in which some of thereproductive organs become inflamed.

A healthy vagina normally contains many microorganisms, some of the common ones are Lactobacillus crispatus and Lactobacillus jensenii. Lactobacillus, particularly hydrogen peroxide-producing species, appears to help prevent other vaginal microorganisms from multiplying to a level where they cause symptoms. (Note: Lactobacillus acidophilus is not one of the species of Lactobacillus identified as playing a protective role in vaginal flora.) The microorganisms involved in BV are very diverse, but include Gardnerella vaginalis, Mobiluncus, Bacteroides, and Mycoplasma. A change in normal bacterial flora including the reduction of lactobacillus, which may be due to the use of antibiotics or pH imbalance, allows more resistant bacteria to gain a foothold and multiply. In turn these produce toxins which affect the body’s natural defenses and make re-colonization of healthy bacteria more difficult.

Most cases of bacterial vaginosis occur in sexually active women between the ages of 15 and 44, especially after contact with a new partner. Condoms may provide some protection and there is no evidence that spermicide increases BV risk. Although BV appears to be associated with sexual activity, there is no clear evidence of sexual transmission.Rather, BV is a disordering of the chemical and biological balance of the normal flora. Recent research is exploring the link between sexual partner treatment and eradication of recurrent cases of BV. Pregnant women and women with sexually transmitted infections are especially at risk for getting this infection. Bacterial vaginosis does not usually affect women after menopause. A 2005 study by researchers at Ghent University in Belgium showed that subclinical iron deficiency (anemia) was a strong predictor of bacterial vaginosis in pregnant women. A longitudinal study published in February 2006 in the American Journal of Obstetrics and Gynecology showed a link between psychosocial stress and bacterial vaginosis independent of other risk factors.

Complications:
Although previously considered a mere nuisance infection, untreated bacterial vaginosis may cause serious complications, suchas increased succeptibility to sexually transmitted infections including HIV, and may present other complications for pregnant women. It has also been associated with an increase in the development of Pelvic inflammatory disease (PID) following surgical procedures such as a hysterectomy or an abortion.

Modern Treatment:
Bacterial vaginosis can be cured by antibiotics such as metronidazole and clindamycin. However, there is a high rate of recurrence. Currently, there are very few over the counter products that address bacterial vaginosis. A vaginal gel product called

RepHresh claims to regulate the pH level. Boric acid capsules inserted vaginally is considered a home treatment.

Lactobacillus supplements may also be used; Fem-dophilus (Jarrow Formulas) is a lactobacillus product which specifically claims to help maintain healthy vaginal flora.

It should be noted that seeking medical attention is often necessary, because none of the over the counter products can claim to treat an active infection. More importantly, patients often inaccurately diagnose BV as a yeast infection, and delay proper treatment which may lead to complications.

In a randomized controlled trial, researchers found the efficacy of 0.75% metronidazole vaginal gel in treating bacterial vaginosis (cure rate 70.7%) was equivalent to that of standard oral metronidazole treatment (cure rate 71%). Treatment with vaginal metronidazole gel was associated with fewer gastrointestinal complaints.

Natural Remedies of Bacterial Vaginosis

Herbal Remedy for Bacterial Vaginosis

Homeopathic Therapeutics. Aspergillus; Candida; Notatum ..

Bacterial Vaginosis & Homeopathy

Homeopathic Medicines for Bacterial Vaginosis

Disclaimer: This information is not meant to be a substitute for professional medical advise or help. It is always best to consult with a Physician about serious health concerns. This information is in no way intended to diagnose or prescribe remedies.

Resources:
http://www.charak.com/DiseasePage.asp?thx=1&id=226
http://en.wikipedia.org/wiki/Bacterial_vaginosis.

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