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Brain Pacemaker for Parkinson’s Patients

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Parkinsonson’s sufferers who had electrodes implanted in their brains improved substantially more than those who took only medicine, according to the biggest test yet of deep brain stimulation.

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The study offers the most hopeful news to date for Parkinson’s sufferers. The technique reduced tremors, rigidity and flailing of the limbs and allowed people to move freely for nearly five extra hours a day.

But the research also revealed higher-than-expected risks. About 40% of the patients who received these “brain pacemakers” suffered serious side effects, including a surprising number of falls with injuries.

“We had one patient who felt so good he went up to repair his roof, fell down and broke both his legs,” said lead author Fran Weaver of Hines Veterans Affairs Hospital, outside Chicago. “Patients are feeling so much better; they forget they still have Parkinson’s.”

With deep brain stimulation, which was approved by the Food and Drug Administration in 2002 for advanced Parkinson’s, a surgeon implants electrodes in the brain, which are then connected to a pacemaker-like device that can be adjusted and turned off and on. That device, implanted under the collarbone or in the abdomen, sends tiny electrical pulses to the brain, disabling overactive nerve cells.

The researchers studied 255 people with advanced Parkinson’s at 13 hospitals. After six months, it was found that in the surgery group, 86 out of 121 (71%) saw improvements in movement, as scored by the neurologists. In the medication group, 43 out of 134 patients (32%) showed improvements. The latest findings were published in the Journal of the American Medical Association.

Sources: The Times Of India

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News on Health & Science

Asthma Medicines Don’t Work and Can Be Dangerous

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An overview of recent studies finds that there are no clear benefits to using long-acting beta2-agonists (LABAs) for the treatment of asthma in children. Researchers report that there is currently insufficient evidence to suggest that the drugs offer any additional benefit when used in conjunction with conventional preventative medications.

asthma,asthma medicine,vitamin DAn overview of recent studies finds that there are no clear benefits to using long-acting beta2-agonists (LABAs) for the treatment of asthma in children. Researchers report that there is currently insufficient evidence to suggest that the drugs offer any additional benefit when used in conjunction with conventional preventative medications.

LABAs, such as salmeterol and formoterol, can reduce the symptoms of asthma for periods of up to 12 hours. They are commonly given to relax the airways overnight or after exercise, and are recommended as add-on therapies to inhaled corticosteroids. But since LABAs have previously been shown to increase the risk of life-threatening adverse effects in adults when used as the only drug, they are not recommended as the main treatment agent in asthma in any age groups.

Now researchers say that their use does not generally provide any further benefit over regular ICS therapy for children. The overview included four previous reviews of trials in children above the age of four. They showed that LABAs did not reduce severity of asthma symptoms as measured by hospital admissions, or the need for steroid medication.

If you want something that really works for asthma, you might want to look into vitamin D. One study has shown that poor diets and the lack of vitamin D among mothers were the two strongest determining factors in whether their children suffered from asthma — more so even than whether or not the mothers smoked.

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Featured WHY CORNER

Why Painkillers Relieve Men Faster

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Does popping a painkiller provide faster relief to you than your wife?
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Thank the middle section of your brain.

Scientists at Georgia State Universitys Neuroscience Institute and Center for Behavioral Neuroscience have for the first time identified the most likely reason why analgesic drug treatment is usually less potent in females than males.

“Opioid-based narcotics such as morphine are the most widely prescribed therapeutic agents for the alleviation of persistent pain. However, it is becoming increasingly clear that morphine is significantly less potent in women compared with men. Until now, the mechanism driving the phenomenon was unknown,” said Anne Murphy, who conducted the research with Dayna Loyd.

Scientists through animal studies have shown that the previously reported differences in morphine’s ability to block pain in male versus female rats are most likely due to sex differences in mu-opioid receptor expression in a region of the brain called the periaqueductal gray area (PAG).

Located in the midbrain area, the PAG plays a major role in the modulation of pain by housing a large population of mu-opioid receptor expressing neurons. Morphine and similar drugs bind to these mu-opioid receptors and ultimately tell the brain to stop responding to pain signals to the nerve cells resulting in the reduced sensation of pain.

The findings have been reported in the December issue of `The Journal of Neuroscience‘.

Scientists say the discovery is a major step toward finding more effective treatments for females suffering from persistent pain.

Reacting to the study, Dr Madhuri Bihari, head of department of neurology at AIIMS said: “There is a difference in reaction of analgesic drugs on male and female bodies even though it is slight. Pain reduces slightly more in men than women after popping a painkiller.”

“It was believed that it’s because of the faster metabolic rate among women. This study is, therefore, significant. How much it will help clinically is yet to be understood,” Dr Bihari said.

Using a series of anatomical and behavioural tests, Murphy and Loyd were able to determine that male rats have a significantly higher level of mu-opioid receptors in the PAG region of the brain compared with females.

This higher level of receptors is what makes morphine more potent in males because less drug is required to activate enough receptors to reduce the experience of pain.

Interestingly, when they used a plant-derived toxin to remove the mu-opioid receptor from the PAG, morphine no longer worked, suggesting that this brain region is required for opiate-mediated pain relief.

Additional tests also found females reacted differently to morphine depending on the stage of their estrous cycle.

Analgesic drug market in India has swelled over the years. Painkiller drug Voveran had emerged as the top brand in the domestic pharmaceutical market with the largest sales for the first seven months of 2007

Sources: The Times Of India

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Diagnonistic Test

ERCP (Endoscopic Retrograde Cholangiopancreatography)

Fluoroscopic image of :en:common bile duct sto...
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Endoscopic retrograde cholangiopancreatography (en-doh-SKAH-pik REH-troh-grayd koh-LAN-jee-oh-PANG-kree-uh-TAH-gruh-fee) (ERCP) enables the physician to diagnose problems in the liver, gallbladder, bile ducts, and pancreas. The liver is a large organ that, among other things, makes a liquid called bile that helps with digestion. The gallbladder is a small, pear-shaped organ that stores bile until it is needed for digestion. The bile ducts are tubes that carry bile from the liver to the gallbladder and small intestine. These ducts are sometimes called the biliary tree. The pancreas is a large gland that produces chemicals that help with digestion and hormones such as insulin.
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ERCP is used primarily to diagnose and treat conditions of the bile ducts, including gallstones, inflammatory strictures (scars), leaks (from trauma and surgery), and cancer. ERCP combines the use of x rays and an endoscope, which is a long, flexible, lighted tube. Through the endoscope, the physician can see the inside of the stomach and duodenum, and inject dyes into the ducts in the biliary tree and pancreas so they can be seen on x rays.

For the procedure, you will lie on your left side on an examining table in an x-ray room. You will be given medication to help numb the back of your throat and a sedative to help you relax during the exam. You will swallow the endoscope, and the physician will then guide the scope through your esophagus, stomach, and duodenum until it reaches the spot where the ducts of the biliary tree and pancreas open into the duodenum. At this time, you will be turned to lie flat on your stomach, and the physician will pass a small plastic tube through the scope. Through the tube, the physician will inject a dye into the ducts to make them show up clearly on x rays. X rays are taken as soon as the dye is injected.

If the exam shows a gallstone or narrowing of the ducts, the physician can insert instruments into the scope to remove or relieve the obstruction. Also, tissue samples (biopsy) can be taken for further testing.

Possible complications of ERCP include pancreatitis (inflammation of the pancreas), infection, bleeding, and perforation of the duodenum. Except for pancreatitis, such problems are uncommon. You may have tenderness or a lump where the sedative was injected, but that should go away in a few days.

ERCP takes 30 minutes to 2 hours. You may have some discomfort when the physician blows air into the duodenum and injects the dye into the ducts. However, the pain medicine and sedative should keep you from feeling too much discomfort. After the procedure, you will need to stay at the hospital for 1 to 2 hours until the sedative wears off. The physician will make sure you do not have signs of complications before you leave. If any kind of treatment is done during ERCP, such as removing a gallstone, you may need to stay in the hospital overnight.

Preparation:-
Your stomach and duodenum must be empty for the procedure to be accurate and safe. You will not be able to eat or drink anything after midnight the night before the procedure, or for 6 to 8 hours beforehand, depending on the time of your procedure. Also, the physician will need to know whether you have any allergies, especially to iodine, which is in the dye. You must also arrange for someone to take you home—you will not be allowed to drive because of the sedatives. The physician may give you other special instructions.

For More Information:-
American Gastroenterological Association (AGA)
National Office
4930 Del Ray Avenue
Bethesda, MD 20814
Phone: 301–654–2055
Fax: 301–654–5920
Email: info@gastro.org
Internet: www.gastro.org

National Digestive Diseases Information Clearinghouse
2 Information Way
Bethesda, MD 20892–3570
Phone: 1–800–891–5389
TTY: 1–866–569–1162
Fax: 703–738–4929
Email: nddic@info.niddk.nih.gov
Internet: www.digestive.niddk.nih.gov

Sources:http://digestive.niddk.nih.gov/ddiseases/pubs/ercp/index.htm

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Herbs & Plants

Goat’s Rue

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Botanical Name:Tephrosia virginiana
Family: Fabaceae
Subfamily: Faboideae
Kingdom: Plantae
Division: Magnoliophyta
Class: Magnoliopsida
Order: Fabales
Tribe: Loteae
Genus: Galega
Species: G. officinalis
Parts used: The aboveground parts (talks, leaves and flowers) are collected and dried during the flowering period.

Other Names: American Garden Rue, Catgut, Devil’s Shoestring, Rabbit-pea, Horey turkey peas, Virginia Pea, Virginia Tephrosia, Cheese renet, herba ruta caprariae
Common Names:Galega officinalis, French lilac, Italian fitch or professor-weed.
Habitat:Goat’s rue originates from Europe and Middle East. Goat’s rue is native to Europe and eastern Asia. It was introduced to the western U.S. in the late 1800s as a possible forage crop.Goat’s rue is planted as fodder for animals. Goat’s rue is said to increase the milk production of goats, hence its name. Juice from Goat’s rue was used to clot milk for cheese production. There are also reports of cattle which died after eating goat’s rue.

Now, Native to Eastern N. America from New Hampshire to Florida, west to Texas and Manitoba. Found growing in dry sandy woods, openings, fields, and roadsides.

Description & Cultivation:Goat’s rue is a leguminous perennial herb with a height up to 1 meter. The erect stems bear pinnately compound leaves consisting of several pairs of lance shaped leaflets. The legume flowers are white or pink and produce small cylindrical pods.
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Goat’s Rue is fairly easy to grow, it is a deep rooted plant, requiring a moist, deep, light or medium very well-drained soil in a sunny position. Goat’s Rue has a symbiotic relationship with soil bacteria, these bacteria form nodules on the roots and fix nitrogen. Some of this nitrogen can be used by other plants growing nearby. Goat’s Rue is 1 to 2 ft. tall, covered with silky silver hairs. Root is long and tough, stems erect and branched. Leaves are alternate, compound (pinnately) and divided into 8-14 pairs of narrow oblong leaflets and one leaflet at the tip. Flower clusters are terminal racemes atop the plant. Each of the large flowers is pea like, 1/2 to 3/4 in. long, yellowish at the top, and purplish-pink below. When cultivated there may be 20 to 30 flowers per raceme and up to 200 flowers per plant. The flowers have a faint but definite pleasant aroma and bees visit them often for nectar. Flowers blooms from May through August. The root is a source of the natural insecticide ‘rotenone’, especially effective against flying insects but relatively harmless to animals. Cattle do graze on it but the plant is said to be toxic in large or strong doses. Gather after flowers bloom, dry for later herb use. Plant is not edible.

Distribution:
In 1891, goat’s rue was introduced to Cache County, Utah, for use as a forage crop. It escaped cultivation and is now a weed and agricultural pest, though it is still confined to that county. As a result it has been placed on the Federal Noxious Weed List in the United States. It was collected in Colorado, Connecticut and New York prior to the 1930s, and in Maine and Pennsylvania in the 1960s, but no more collections have been made in these areas since and the populations are presumed to have died out. It has also been found in Argentina, Chile, Ecuador, and New Zealand.

Phytochemicals: Goat’s Rue contains the following phytochemicals: Galegine, Peganine, Vasicinone, Luteolin, Carnavine, Saponins, Flavonoids, Tannins

Medicinal Uses & Properties
Goat’s rue is a diaphoretic, galactagogue and hypoglycaemic. The phytochemical galegin lowers the blood sugar levels and explains why goat?s rue is used to treat diabetes mellitus. Studies have shown that extracts from goat’s rue inhibits the transport of glucose in the cells. It is not recommended to use goat?s rue for self medication of diabetes because diabetes is a serious condition and it?s difficult to standardize the strength of the active components.
Goat’s rue has also diuretic properties. Goat’s rue is also used to treat skin problems such as skin ulcers and to increase the milk production of nursing mothers.

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Goat’s Rue was much used by Native Americans who considered it to be an aphrodisiac and most useful in restoring manhood to those with impotency and as a female herb to restore a woman’s beauty and health. The root is used in alternative medicine as an antirheumatic, anthelmintic, diaphoretic, diuretic, emmenagogue, febrifuge, galactagogue, pectoral, restorative and tonic. A medicinal herb tea is used to treat rheumatism, bladder problems, fever, hard coughs, impotency, to expel intestinal worms, irregular menstruation and to increase the flow of breast milk. Goat’s Rue is used cosmetically in hand and foot bathes. Experimentally, the root has shown both anticancer and cancer-causing activity. research on this herb and its chemical constituents is ongoing and early results are proving to show it may be useful in Diabetes, Alzheimer’s and many other disorders. The root is a source of the insecticide ‘rotenone’ found to be especially effective against flying insects but appears to be relatively harmless to animals.
Folklore:
Used by Indians to poison fish. A medicinal tea made from the roots is said to make children muscular and strong. A cold herb tea was used for male potency. Goat’s Rue earned the names Devil’s Shoestring and Catgut from its tough rootstocks. A decoction of the roots has been used as a hair shampoo to prevent hair loss.

Goat’s Rue has been known since the Middle Ages for relieving the symptoms of diabetes mellitus. Upon analysis, it turned out to contain guanidine, a substance that decreases blood sugar by decreasing insulin resistance.

Chemical derivatives from the biguanide class of medication include metformin (Glucophage, commonly prescribed for diabetics) and the older, withdrawn agent phenformin.

Goat’s Rue is also cited by the SAS Survivial Guide by John “Lofty” Wiseman, as having a sedative effect on fish. The roots and flowers are the most potent, but the most common method is to simply crush the entire plant and throw into a body of water with restricted flow. The fish that then float to the top are safe to consume.

Disclaimer:The information presented herein is intended for educational purposes only. Individual results may vary, and before using any supplements, it is always advisable to consult with your own health care provider.

Resources:
http://en.wikipedia.org/wiki/Galega_officinalis
http://www.phytochemicals.info/plants/goat-rue.php

http://threatsummary.forestthreats.org/threats/threatSummaryViewer.cfm?threatID=258

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