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Long bed rest bad during pregnancy

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Long periods of bed rest could be harmful for pregnant women and may cause degeneration of their musculoskeletal and cardiovascular systems, says a new study.

The musculoskeletal system gives human beings and animals the ability to physically move by using the muscles and skeletal system. The cardiovascular system is composed of the heart, blood vessels, or vasculature, and the cells and plasma that make up the blood.

Doctors often advice women to go on bed rest if they suffer (blood) spotting, contractions before 37 weeks’ gestation, high blood pressure or have a history of pre-term labour, as well as if the foetus appears to be growing abnormally. A majority of the women rest at home, while others are hospitalised, the report added.

Studies by Nasa scientists, who used bed rest to simulate weightlessness in space, found that as a result of long periods of bed rest, a person’s entire musculoskeletal and cardiovascular system become de-conditioned. This degeneration begins in less than 48 hours.

The American College of Obstetricians and Gynaecologists no longer advises bed rest to prevent pre-term births because no large-scale studies have proven the method effective. Researchers recommend that women on bed rest see a physical therapist and begin a light exercise programme, if appropriate.

Source:The Times Of India

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Researchers find key to treating insomnia

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: Researchers studying a disease that causes people to suddenly drop off to sleep are trying to turn what they have learnt into a new way to help insomniacs get some shut-eye…...click & see

They found that blocking brain receptors for orexin, a blood peptide, promoted sleep in rats, dogs and people, according to a paper in Sunday’s online issue of the journal Nature Medicine.

Orexin, also known as hypocretin, is important in maintaining wakefulness. It is absent in the brains of people who suffer from narcolepsy, a chronic disorder in which people cannot regulate sleep-wake cycles normally.

It is estimated to affect more than 135,000 people in the United States, according to the National Institutes of Health.

The research team, led by Francois Jenck of the Swiss drug company Actelion Pharmaceuticals, reasoned that they might be able to induce sleep if they could block orexin.

They developed a drug that can block the receptors in the brain that respond to orexin-hypocretin. The researchers reported successful testing in rodents, dogs and men.

The first tests were proof of the concept and the drug is now being evaluated to establish the correct dosage, said Roland Haefeli, an Actelion spokesman.

Researchers hope to decide this year whether to conduct a phase-three study, a detailed assessment of the drug that would be the final step before seeking US government approval for its use. Such studies can take a few years.

Narcolepsy victims often also experience cataplexy, a condition in which they lose control of muscle tone for a few seconds to minutes. Jenck said in a telephone interview that the drug tests did not prompt indications of cataplexy.

Thomas Scammell, an assistant professor of neurology at Harvard University, said the work was “promising, with a certain amount of caution”.

“I think it may be the beginning of something quite exciting,” said Scammell, who was not part of the research team.

Source:The Times Of India

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