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Healthy Tips

Sex, Chemicals and Longevity

A substance released during intercourse can extend the lifespan of an organism:

Intimate bedroom moments have given researchers new clues about combating ageing. A team of European researchers, led by a biologist in Austria, has found that a substance released in copious amounts during sexual intercourse can actually extend the lifespan of a range of organisms — from flies to worms and even mammals.

Spermidine, an important constituent of seminal fluid which helps neutralise the acidic pH of the vagina — the first step in the sperm’s journey towards fertilising an egg — is known to be necessary for cell growth and maturation. Scientists have previously found that when ageing sets in, its concentration dips in living cells. However, it was unclear if its decrease was the cause or consequence of ageing.

But in an interesting study reported online in the journal Nature Cell Biology, scientists led by Frank Madeo of the Institute of Molecular Biosciences, University of Graz, Austria, have shown that the levels of spermidine can be propped up in cells through the oral route. Experimenting with laboratory mice, the scientists found that an additional dose of spermidine rejuvenated the cells, as a result of which the animals lived longer.

“Our studies have shown that spermidine-treated fruit flies and worms can live up to 30 per cent longer than their average lifespan,” Madeo told KnowHow.

Madeo thinks the study is important for a variety of reasons. First, spermidine is an intrinsically natural compound abundantly found in every type of cell or eukaryotic organism and hence part of normal human nutrition. It is found in abundant quantities in soybeans as well as grapefruit, a subtropical citrus fruit known for its bitter taste.

“Intriguingly, spermidine is (released)… in huge concentrations during sexual intercourse. This means that it is already approved by nature,” says Madeo. The second fascinating thing, according to him, is the way it does cellular “clean up”. Spermidine is capable of inducing a process called “autophagy” by which a cell itself destroys its own degraded components. Scientists have known for long that autophagy plays a critical role in halting the progression of cancers and certain neurodegenerative disorders.

A similar study about three months ago by a team of French scientists found that melatonin, a naturally occurring hormone, when supplied externally, could delay the onset of ageing.

“It is too early to speculate if and to which extent these two substances (melatonin and spermidine) might interfere with ageing through similar mechanisms. It is worthwhile, however, to note that both the studies addressed the effect of a single compound that is naturally produced in the human body,” says Madeo.

Altering the concentrations of these compounds through external supply seems to be efficient in retarding the signs of ageing, he adds.

The advantage, particularly in the case of spermidine, says Madeo, is that its application is easy. Madeo and his team received positive results when they used spermidine simply as a nutritional supplement to food or drinking water in their experiments.

The scientists are also hopeful that spermidine will help them formulate therapies for several neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease which are normally associated with longevity.

In fact, Madeo along with his associate Tobias Eisenberg is currently engaged in a series of experiments on mice to see whether spermidine could be effective against such neurodegenerative diseases.

Milind Gajnan Watve, professor of biology at the Indian Institute of Science Education and Research, Pune, feels the work is interesting. It indicates that the biology of ageing is very similar in a range of organisms, from simple single-cell creatures to humans. “The study is promising, but has a long way to go,” he adds.

Source:The Telegraph (Kolkata, India)

 
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Featured

Being Gay is Natural

Homosexuality is widespread in several species, ranging from worms to insects, birds to dolphins, sheep to reptiles. What is more, it serves a purpose:-
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Biologist Nathan Bailey’s recent scientific conclusions may be a shocker for the religious leaders or self-professed moral guardians who are indignant at the recent Delhi High Court ruling decriminalising sexual intimacy between same sex individuals in India.

While some argue that homosexual behaviour is “deviant” or “unnatural”, Bailey, a professor of evolutionary biology at the University of California, Riverside, has amassed scientific evidence that it might be as ubiquitous as life itself.

Bailey and colleague Marlene Zuk, who co-authored the study, collected several past research studies that reveal same sex behaviour — males having sex with males, females with females — in diverse species, from worms to insects, birds to dolphins, sheep to reptiles. While some of them are mere flings, others lead to lifelong relationships. Their study shows that it serves a purpose.

The study, which recently appeared in the journal Trends in Ecology and Evolution, has listed as many as 14 animal species that exhibit homosexual tendencies. “It is by no means an exhaustive list, but it provides a starting point for those interested in obtaining further information and examples,” they say.

The variety and ubiquity of same sex sexual behaviour in animals is impressive. They found thousands of instances of same sex courtship, pair bonding and copulation in a wide range of species.

Domestic sheep exhibit it. Birds like the laysan albatross and zebra finch indulge in it. So do bonobo monkeys, chinstrap penguins, bottlenose dolphins and garter snakes. Behavioural biologists have recorded male-male pairing among insects like the flour beetle and African bat bug too.

In the past, researchers, investigating whether gay sex is genetically encoded, found that tweaking certain genes can turn fruit flies and roundworms into homosexuals.

The attempts to find a genetic link to homosexuality have a strong Indian connection. The first-ever such gene manipulation study was conducted by an Indian scientist Kulbir Singh Gill who was a visiting researcher at Yale University in the 1960s. Gill, while studying the genetic causes of female sterility, almost serendipitously found in 1963 that male flies lacking a gene — later named fruitless gene — court other males. Gill’s pioneering work opened the floodgates and many other scientists subsequently discovered several other genes whose manipulation yields varying types and degrees of male-male courtship in fruit flies.

“Same sex sexual behaviour has long been viewed as a fascinating puzzle from the evolutionary perspective. The most obvious mystery is why animals would engage in sexual behaviour that does not directly result in reproduction,” says Bailey who, along with Zuk, seeks to understand the significance of such acts in the evolution of species.

Interestingly, a closer examination by them led to several significant conclusions. Some species use same sex pairings as a social glue for bonding (bottlenose dolphins), while for others (the bonobos, dung flies) it is a tool to resolve intra-sexual conflicts. In certain other species like fruit flies, immature individuals use them as an opportunity for practice, but for flour beetles it is a ploy for indirect insemination. More often than not, male members among the beetles use same sex copulation to deposit sperm in other males, which then transfer it to females during subsequent opposite sex mating.

“The secret of the peaceful bonobo society appears to rest with their sexual behaviour; in their society sex is used to solve conflicts,” writes Morten Kringelbach, psychiatrist at the University of Oxford, in his recent book The Pleasure Center.

The authors of the new study think that there may be many more animal species indulging in homosexual behaviour. It is difficult to know their sexual orientation, as there are no means of knowing what their ‘desire’ is. “We can only observe what they do,” they say.

Qazi Rahman of Queen Mary, University of London, who has been studying homosexuality in humans, says genes responsible for such behaviour have a significant role in evolution. One reason nature keeps these genes intact — although they have no role in reproduction — is that they confer certain other traits. A certain dosage of gay genes is found to be beneficial even in heterosexual people because they might express traits that are more attractive to the opposite sex — like kindness, parental skills and co-operative traits. But a higher dosage of these genes leads to homosexuality, he adds.

“Evolution keeps genes for homosexuality intact because they benefit heterosexual carriers of those same genes,” Rahman, a scientist of Pakistani descent, told KnowHow. For instance, a study by Rahman and others, which appeared in the Journal of Sexual Archives last year, showed that gay men may tend to come from larger families with more fertile females. In other words, the females in gay men’s families “outreproduce” those in heterosexual men’s families.

Kringelbach says homosexual behaviour is a natural phenomenon in all human societies. Quoting American sex researcher Alfred C Kinsey, who studied in the 1940s and 1950s sexual habits, he says 37 per cent of all men have homosexual experiences, 10 per cent have homosexual relationships lasting longer than three years, and 4 per cent are exclusively homosexual throughout life. “The exact numbers have been disputed but it remains a fact that all serious sex studies have found that homosexuality is naturally occurring among both men and women,” Kringelbach told KnowHow.

Bailey hopes that scientific contributions from animal studies will shed more light than heat on the topic of same sex sexual behaviour.

Source: The Telegraph (Kolkata, India)

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Health Quaries

Some Health Quaries & Answers

 

Hole in my ear:
Q: I developed a hole in my eardrum and I think it is due to prolonged use of the mobile phone. I cannot manage without my phone.

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A:
The hole (perforation) in the ear drum is unlikely to have been caused by the use of a mobile phone. Usually it develops as a result of an ear infection (otitis media), an injury with a sharp object or a sudden loud sound near the ear. It needs to be evaluated. You should consult an ear, nose and throat (ENT) surgeon.

It may heal and close with antibiotics and the use of ear drops. A long-standing non-healing perforation may require an operation called a tympanoplasty.

In any case, why not use the speaker phones option?

Tingling feet :
Q: My 72 years old father, is a diabetic, whose blood sugar is well controlled by oral medications. He has a lot of discomfort in his lower legs and feet. He had consulted a neurologist and after certain tests was found to have neuropathy. Although he was given vitamin combinations he has had no relief.

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A: Diabetic neuropathy is a nerve disorder that can occur as a complication of diabetes usually if there is poor blood sugar control. It can cause problems with the sensation in the feet. The symptoms are numbness, pain, or tingling in the feet or lower legs. There may be difficulty in walking and balance.

The first step is to bring blood sugar levels under control. You could purchase a glucometer and check the sugar level regularly at home. Make sure he always wears well fitting shoes. Walking regularly, taking warm baths, or using elastic stockings may help relieve leg pain. Analgesics, low doses of antidepressants, and some anticonvulsant medication can be prescribed, in addition to vitamins, in severely affected individuals.

Potty tot
Q: I have a son who is three and half years old. He has been suffering from acute constipation for the last one year. He passes hard stool, with pain. Sometimes small amounts are passed 10-12 times a day. He eats well and his diet includes 1,000ml of milk, which I give in a bottle at night.

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A: The quantity of milk that you are giving is far in excess of what he requires. He needs only 400ml of milk a day at the very most. It can be split into two 200ml feeds, in the morning and evening, not at night. At three and a half years he is far beyond the stage of feeding bottles. Encourage bowel movement in the morning by making him sit in the toilet at a fixed time even if he does not feel the urge.

If the constipation persists a further evaluation with a paediatrician can be done to rule out thyroid deficiency or bowel malfunctions.

Worried about AIDs
Q: Does a married couple need to have sex with a condom? I want to prevent HIV infection in myself and my wife. I am worried about AIDS.

A: If either party has had prior sexual encounters, it is better to use a condom until you check for HIV and hepatitis B. It is better to check again after six months when the window period for HIV infection is over. If you go to a Voluntary Counselling and Testing Centre, the tests are free.

Married people need to use condoms as a contraceptive device if they wish to prevent pregnancy, or if one of the parties is HIV or HbAg positive (hepatitis B).

Seeking perfect eyesight :
Q: I want perfect eyesight. What diet should I eat and what can I do?

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A: Green leafy vegetables like spinach, beetroot, carrot and drumsticks help eyesight because of their vitamin and antioxidant content. Overcooking destroys heat sensitive labile beneficial vitamins of the B group. Steaming or microwave cooking vegetables or eating them raw is, therefore, better. Eating two raw tomatoes a day will give you all the vitamins you need.

There are eye exercises in yoga which, done regularly, help to maintain and improve your eyesight.

More children
Q: I am 41 and my wife is 35. We have an eight-year-old daughter. We decided to try for a son. Despite our best attempts over the last one year, we failed. Although my wife’s periods are irregular, no tests have been done. We have received all kinds of tablets from various doctors. Now we read that some of them have potentially dangerous side effects.

A: All medicines have some side effects even if they are aryuvedic, homeopathic or herbal. The tablets used to induce ovulation can be dangerous if given for too many cycles in improper doses.

Before proceeding consider the following:

• You already have a healthy daughter.

• Do you really want another child?

•Test yourself — do a semen analysis

• Do an ultrasound for your wife to see why the periods are irregular.

Sources: The Telegraph (Kolkata, India)

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News on Health & Science

Plant May Produce Anti-HIV Gel

 

A genetically-altered Australian cousin of tobacco plant could become the source of a potent chemical that promises to contain spread of  HIV through sexual intercourse, a new finding announced today suggests.

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The scientists have shown that transgenic versions of a plant Nicotiana benthamiana, also known as ‘Tjuntiwari’ in the native language, may be able to produce large quantities of a protein griffithsin which can be used as an anti-HIV microbicide gel.

The protein has shown capabilities of neutralizing HIV as it binds to the virus molecule in such a way that the virus could not disguise itself from the immune system of humans.

Anti-HIV microbicide gel directly targets entry of the virus and averts infection at the surfaces but at present they are being produced using biologicals like bacteria E.coli, an expensive process which is not cost-effective.

Scientists across the world were looking for a natural source of the protein, for producing anti-HIV microbicide gel, which can prevent women from getting sexually transmitted diseases.

The researchers from USA and UK altered the genetic nature of the plant using a tobacco mosaic virus which produced the protein griffithsin.

Sources: The Times Of India

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Featured

No Baby Blues

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It’s difficult to believe but true that despite our 1.2 billion  population in India, many of our young adults have difficulty in producing children. They may be called “sterile, infertile or sub fertile”. But before a couple is labelled “infertile”, they should have had at least 12 months of regular contraception-free intercourse.

Worldwide, infertility affects 7-10 per cent of the population. Although women actually produce the babies, if the reasons for the infertility are investigated the woman is at fault in a third of the cases; in a third it is the man and in the remainder either both are responsible or no real cause can be found.

Before embarking on a planned pregnancy, the woman should have had immunisations for measles, mumps rubella (MMR) and hepatitis B (3 doses). She should also start folic acid supplements (5mg/day). Children born with physical or mental defects because these basic facts were forgotten are a human tragedy. Both partners need to keep their body mass index (BMI, or weight in kilograms divided by height in metre squared) at around 23 and be physically active for around 40 minutes a day. They also need to treat any existing underlying disease like diabetes, high blood pressure or thyroid problems.

Studies show that caffeine (found in tea, coffee and cola drinks) affects fertility. Women who drink alcohol can produce babies with “foetal alcohol syndrome”. It also reduces the sperm count in men. Smoking affects the quality of the sperms and inhaled passive smoke is bad for the growing baby. Sperm counts may be reduced by inhaling hazardous chemicals in the work place or by working in high temperatures.

Women ovulate cyclically and the egg is released 14 days before the next period. For a woman to conceive, intercourse must take place around this time and the sperm count must be optimal. Initially, if a menstrual calendar is maintained, the fertile days can be calculated. A semen analysis for sperm count is a non-invasive simple test. Also, after intercourse lie down, don’t douche, and avoid lubricants and cleansing agents.

If these simple methods fail in a couple where the woman menstruates regularly and the man has a normal sperm count, a visit to a reproductive medical unit is warranted. Further investigations to establish the patency of the tubes and quality of the sperm may be needed. Depending on the problem, medication or surgical correction of a specific defect may be needed.

Conservative medical treatments are usually tried for periods varying from 6 months to a year. If they fail, assisted reproductive technology (ART) techniques are started.

In IUI (intrauterine insemination) the woman is scanned during her most fertile period to determine ovulation. Healthy treated sperms from her partner are then inserted into the uterus. The technique is used when the sperm count is low, the motility unsatisfactory or if donor sperm is being used.

In GIFT (gamete intra-fallopian transfer), eggs and sperms are collected, mixed and then placed in the woman’s fallopian tube. Fertilisation takes place naturally in the body.

In IVF (in vitro fertilisation) the eggs are harvested and fertilised with sperm in the laboratory. The resulting embryos are then placed in the uterus. This is used in cases where the fallopian tubes are blocked, the fertility unexplained or when several attempts with the other forms of ART have failed. It can result in multiple pregnancies. Some clinics offer “natural cycle IVF”. This involves collecting and fertilising the one egg released during the normal monthly cycle. It avoids the side effects of fertility drugs and multiple pregnancies are less likely.

In ICSI (intracytoplasmic sperm injection) a single sperm is injected into the centre of an egg. This is used when the male partner has a very low sperm count or if other problems with the sperm have been identified.

Donor eggs from other women can be used if the woman has no eggs of her own, or if she is over 40 and the eggs are of poor quality. Sperm from donors can be used if the husband has a low count (oligospermia) or no sperms (azoospermia). Surrogate mothers can be hired to carry the baby to term.

There is no right time to seek medical help, but if sexual intercourse at least three times a week without contraception for a year has been unsuccessful, it is probably time for proactive action. If, however, the woman has periods at intervals less than 21 days or more than 90 days, the flow is unpredictable (if it starts it does not stop and if it stops it does not start) or if there has been pelvic infection in the past, an evaluation should be done at the earliest. In men, if the testes are not felt in the scrotum, or there is a hydrocoele (swelling) or a past prostate infection, investigation and treatment should be started sooner.

Sources:The Telegraph (Kolkata,India)

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