Single-nucleotide polymorphism

Muskmelon

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Botanical Name: Cucumis dudaim
Family: Cucurbitaceae
Genus: Cucumis
Species: C. melo
Kingdom: Plantae
Order: Cucurbitales

Common Names: Muskmelon (Cucumis melo), Pickling Melon

Habitat:Probably Cucumis dudaim is native of Asia, though it has been in cultivation for so long its native habitat is obscure. Derived through cultivation, it is not known in a truly wild location.

Description:
Cucumis melo conomon is an annual creeping plant, growing to 1.5 m (5ft). It is frost tender. It is in flower from Jul to September, and the seeds ripen from Aug to October. The flowers are monoecious (individual flowers are either male or female, but both sexes can be found on the same plant) and are pollinated by Insects.The plant is self-fertile…….CLICK & SEE THE PICTURES

Cultivation:
Requires a rich, well-drained moisture retentive soil and a warm, very sunny position. A frost-tender annual plant, the pickling melon is occasionally cultivated in gardens and commercially, especially in warmer climates than Britain, for its edible fruit. This form is also of value in breeding programmes for disease resistance. Some varieties may succeed outdoors in Britain in hot summers but in general it is best to grow melons under protection in this country. This form of the melon probably has a better chance of succeeding outdoors than the other forms – see the list of cultivars for suggested forms to grow. Grows well with corn and sunflowers but dislikes potatoes. The weeds fat hen and sow thistle improve the growth and cropping of melons.

Propagation:
Seed – sow early to mid spring in a greenhouse in a rich soil. Germination should take place within 2 weeks. Sow 2 or 3 seeds per pot and thin out to the best plant. Grow them on fast and plant out after the last expected frosts, giving them cloche or frame protection for at least their first few weeks if you are trying them outdoors.

Edible Uses :
Edible Parts: Fruit; Oil; Seed.
Edible Uses:….> Oil.

Fruit – raw or cooked. The fruit is more often cooked, often as a savoury dish. They can be chopped finely and used as a seasoning in salads and soups. Both mature and immature fruits are made into sweet or sour pickles. Seed – raw. Rich in oil with a nutty flavour but very fiddly to use because the seed is small and covered with a fibrous coat. The seed contains between 12.5 – 39.1% oil. An edible oil is obtained from the seed…..CLICK & SEE..>…....FRUITS.……....SEEDS
Medicinal Uses:
The fruits can be used as a cooling light cleanser or moisturiser for the skin. They are also used as a first aid treatment for burns and abrasions. The flowers are expectorant and emetic. The fruit is stomachic. The seed is antitussive, digestive, febrifuge and vermifuge. When used as a vermifuge, the whole seed complete with the seed coat is ground into a fine flour, then made into an emulsion with water and eaten. It is then necessary to take a purge in order to expel the tapeworms or other parasites from the body. The root is diuretic and emetic.

Disclaimer : The information presented herein is intended for educational purposes only. Individual results may vary, and before using any supplement, it is always advisable to consult with your own health care provider.
Resources:
https://en.wikipedia.org/wiki/Muskmelon
http://www.pfaf.org/user/Plant.aspx?LatinName=Cucumis+melo+conomon

The Long and Short of it

Scientists have discovered genes that influence height but are yet to explain the gap between the tallest and shortest of people:

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A meeting between two ordinary men in a remote locale in Mongolia hit the headlines all over the world in July last year. But neither Bao Xishun, 56, nor He Pingping, 19, holds a position of eminence. Nor are they film or sports celebrities. The encounter grabbed world attention because of the two men’s contrasting statures. While Xishun, at 2.36m, is the world’s tallest living man, the 74-cm Pingping claims he is the shortest.

Modern science may not be able to explain the yawning gap between the heights of these two men — both hailing from Inner Mongolia — but it has gained some genetic insight into the varying stature of billions of others who fall between Xishun and Pingping in terms of height.

For nearly a century, scientists have believed that genes handed down from parents are responsible for 90 per cent of the normal variation in human height in a population. And it is not just one gene but probably a few hundred that contribute towards making a person tall or short. But until last year, scientists were clueless about their location on the human genome, which consists of more than 3 billion DNA base pairs.

In September 2007, researchers from both sides of the Atlantic, while foraging through DNA from 35,000 people, stumbled upon a difference in a gene called HMGA2, which plays a decisive role in making people taller or shorter, albeit marginally. They found that if a person had two copies of a longer variant of HMGA2, he or she would be 1cm taller than one who has two shorter versions of it.

The HMGA2 gene thus became the first reliable genetic link to human height. Later, scientists zeroed in on yet another gene, GDF5, which makes for an average height difference of 0.4cm.

What made the discovery of such genes possible is what scientists call genome-wide association studies. This is a relatively new way of identifying genes involved in human diseases. Made possible by advances in genetics and sophistication in scientific tools, this method searches the genome for small variations, called single nucleotide polymorphisms (SNPs). The tools are so advanced that researchers can search for hundreds or thousands of SNPs simultaneously. Such studies pinpoint genes that may contribute to a person’s risk of developing a certain disease or those associated with a trait such as height or eye colour.

If 2007 saw a beginning in understanding the role played by genes in deciding how tall a person will be, 2008 has so far proved to be a watershed. The same consortium of scientists who discovered the HMGA2 and GDF5 genes, now split into two groups, recently discovered 40 more genetic locations. Combined, they may be able to explain a height difference of up to 6cm, or 5 per cent of the population variation in height.

The number and variety of genetic regions discovered so far show that height is determined not just by a few genes operating in the long bones, notes Thomas Frayling of Peninsula Medical School in the UK. Frayling is the lead author of the one of the two studies that appeared in Nature Genetics last month.

Joel Hirschhorn, a paediatric endocrinologist at Broad Institute in the US, who led the other study, says that the new findings account for only a small fraction of the variation in height among people and that there is a lot more to discover. “This is much more than we had even last year. But we are not close to predicting adult height,” Hirschhorn told Knowhow.

The study of genes involved in determining adult height stems from more than sheer curiosity. By identifying which genes affect normal growth, it is easy to understand the processes that lead to abnormal growth, the scientists say. “There appears to be a definite correlation between height and some diseases,” says Michael Weedon, a colleague of Frayling. Weedon was not only part of the original team that discovered the HMGA2 gene but was also instrumental in the latest discovery of 20 new genetic locations linked to height. For instance, there is a strong association between shortness and a slightly increased risk of conditions such as heart disease. Similarly, tall people are more prone to certain cancers and, possibly, osteoporosis.

A predominant factor that determines one’s height may be heredity, but diet too has a role to play. In fact, improved nutrition means that each generation gets successively taller, as has been shown by a recent study on Indians.

That said, Indians still have some catching up to do: an average Indian man (165.3cm) is two centimetres shorter than an average Czech woman who stands 167.3cm tall.

Sources: The Telegraph (Kolkata, India)

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