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Lost Sleep Can Never Be Made Up

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Staying in bed on the weekends won’t make up for a weeks’ worth of sleep deprivation. A new study finds that going long periods without sleep can lead to a sort of “sleep debt” that cannot simply be undone with extra sleep later

Such chronic sleep loss may eventually interfere with a person’s performance on tasks that require focus, becoming particularly noticeable at nighttime. This could be due to the effects of your natural sleep-wake cycle, or circadian rhythm.

Your natural tendency to want to be awake during the day may mask signs of sleep debt when it’s light out. But this protective effect may go away as darkness arrives.

Further, just 10 percent of adolescents are getting the optimal hours of sleep each night.

Here’s how parents can help teens get the most possible sleep, despite the demands of school and work:

•Teenagers should stick to a consistent bedtime, preferably before 10 PM

•Keep sleep and wake times as consistent as possible from day to day; maintaining a more regular sleep schedule makes it easier to fall asleep

•Don’t sleep in — strive to wake up no more than two to three hours later on weekends to keep biological clocks on cycle

Resources:
Live Science January 13, 2010
U.S. News & World Report January 15, 2010

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Agents that regulates appetite identified

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Scientists in Japan have identified a molecule responsible for making mammals feel full, a discovery that could lead to new ways to treat obesity in humans.

Scientists believe appetite is controlled in a region of the brain called the hypothalamus, and the group of researchers claims to be the first to pinpoint an agent that triggers an increase or decrease in appetite.

In an article published on Sunday in the online version of the journal Nature, the scientists identified the molecule as nesfatin-1, which is produced naturally in the brain.

After injecting the molecule into the brains of rats, the scientists observed that the rodents began to eat less and lose weight.

The researchers also were able to induce the rats to eat more, by blocking nesfatin-1

After we injected anti-nesfatin-1 antibody, these rats showed increased appetite and finally showed a progressive increase in body weight,” Masatomo Mori of the medicine and molecular science department at Gunma University Graduate School of Medicine told Reuters in a telephone interview.

Mori said the finding could pave the way for treating obesity, which has become a major health problem in the developing world as well as in economically advanced countries.

There are at least a billion overweight adults across the world, 300 million of them considered obese, according to the World Health Organization.

Obesity has been linked to chronic diseases, such as type 2 diabetes, cardiovascular disease, hypertension and stroke, and some forms of cancer.

In a separate study, it has been found that the hormone leptin could help keep the body from producing too much insulin, according to a study in mice with type 2 diabetes.

People with type 2 diabetes often become resistant to the effects of insulin, causing to much of it to build up in the body.

Reporting in the September issue of the journal Peptides, researchers from the University of Florida injected a gene into the brains of diabetic mice, hoping to increase the production of the appetite-controlling hormone leptin in the hypothalamus.

Insulin levels in mice that received gene therapy returned to normal — even when they were fed a high-fat diet, the
researchers found. High-fat diets typically help trigger or worsen type 2 diabetes.

Mice that ate a high-fat diet but did not receive gene therapy, however, continued to overproduce insulin and have high blood-sugar levels.

“This was totally unexpected. Until now, there way no evidence that leptin action in the hypothalamus had control on insulin secretion.

With leptin gene therapy, we can re-impose that control,” senior author Satya Kalra, a University of Florida, Gainesville, professor of neuroscience, said.

(As published in the Times Of India)