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The cochlea and vestibule, viewed from above.Image via Wikipedia

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Scientists have used gene therapy on mouse embryos to grow hair cells with the potential to reduce hearing loss in adult animals, according to a study.

The proof-of-concept experiments are a crucial step toward therapies that could one day treat deafness and inner-ear disease in humans, said the study, published in the British journal Nature on Wednesday.

Sensory hair cells inside the cochlea, the auditory portion of the inner ear, convert sound waves into electrical impulses that are delivered to the brain.

The loss of these cells and the neurons they contain is the most common cause of hearing impairment and so-called nerve deafness. At birth, humans have about about 30,000 hair cells, which can be damaged by factors like infections, aging, genetic diseases, loud noise or treatment with certain drugs.

In most cases, damaged hair cells do not regrow in mature humans. But recent research has kindled hope that nerve deafness may one day be curable.

A team of scientists led by John Brigande at the Oregon Health and Science University, in Portland showed that implanting a gene known as Atoh1 into the inner ear of a mouse embryo coaxed non-sensory cells to become hair cells.

Earlier research had pointed to similar results, but this is the first study to show that the cells generated by the gene therapy are functional.

The production of extra, working hair cells in a mouse embryo could be an important step toward using similar therapies in human patients, the study by the researchers in US said.

Sources:The Times Of India

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Hematuria (Blood in the Urine)

Definition:
Hematuria is the presence of red blood cells (RBCs) in the urine. In microscopic hematuria, the urine appears normal to the naked eye, but examination with a microscope shows a high number of RBCs. Gross hematuria can be seen with the naked eye ,  the urine is red or the color of cola.

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Seeing blood in your urine can cause more than a little anxiety. Yet blood in urine ” known medically as hematuria ” isn’t always a matter for concern. Strenuous exercise can cause blood in urine, for instance. So can a number of common drugs, including aspirin. But urinary bleeding can also indicate a serious disorder.

There are two types of blood in urine. Blood that you can see is called gross hematuria. Urinary blood that’s visible only under a microscope is known as microscopic hematuria and is found when your doctor tests your urine for another condition. Either way, it’s important to determine the reason for the bleeding.

Treatment depends on the underlying cause. Blood in urine caused by exercise usually goes away on its own in a day or two, but other problems often require medical care.

Symptoms:
The only visible sign of hematuria is pink, red or cola-colored urine — the result of the presence of red blood cells. It takes very little blood to produce red urine, and the bleeding usually isn’t painful. Bloody urine often occurs without other signs or symptoms.

In many cases, you can have blood in your urine that’s only visible under a microscope (microscopic hematuria).

Causes:
Several conditions can cause hematuria, most of them not serious. For example, exercise may cause hematuria that goes away in 24 hours. Many people have hematuria without any other related problems. Often no specific cause can be found. But because hematuria may be the result of a tumor or other serious problem, a doctor should be consulted.

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The urinary tract is made up of your bladder, your two kidneys and ureters, and the urethra. The kidneys remove waste and excess fluid from your blood and convert it to urine. The urine then flows through two hollow tubes (ureters)    one from each kidney    to your bladder, where urine is stored until it passes out of your body through the urethra.

In hematuria, your kidneys  or other parts of your urinary tract    allow blood cells to leak into urine.

Mail & femail urinary system->click to see the pictures.

A number of problems can cause this leakage, including:

*Urinary tract infections. Urinary tract infections are particularly common in women, though men also get them. They occur when bacteria enter your body through the urethra and begin to multiply in your bladder. The infections sometimes, though not always, develop after sexual activity. Symptoms can include a persistent urge to urinate, pain and burning with urination, and extremely strong-smelling urine. For some people, especially older adults, the only sign of illness may be microscopic blood. About 30 percent of people with a urinary tract infection have visible bleeding. click & see
*Other urinary tract infections. Kidney infections (pyelonephritis) can occur when bacteria enter your kidneys from your bloodstream or move from up from your ureters to your kidney(s). Signs and symptoms are often similar to bladder infections, though kidney infections are more likely to cause fever and flank pain.
*A bladder or kidney stone. The minerals in concentrated urine sometimes precipitate out, forming crystals on the walls of your kidneys or bladder. Over time, the crystals can turn into small, hard stones. The stones are generally painless, and you probably won’t know you have them unless they cause a blockage or are being passed. Then, there’s no mistaking the symptoms — kidney stones can cause excruciating pain. They can also cause both gross and microscopic bleeding.click & see
*Enlarged prostate. This is one of the leading causes of visible urinary blood in men older than 50. The prostate gland   located just below the bladder and surrounding the top part of the urethra — often begins growing as men approach middle age. When the gland enlarges, it compresses the urethra, partially blocking urine flow. Symptoms of an enlarged prostate (benign prostatic hypertrophy or BPH) include difficulty urinating, an urgent or persistent need to urinate, and either gross or microscopic bleeding. Infection of the prostate (prostatitis) can cause the same signs and symptoms..click & see
*Kidney disease. Microscopic urinary bleeding is a common symptom of glomerulonephritis, which causes inflammation of the kidneys’ filtering system. Glomerulonephritis may be part of a systemic disease such as diabetes, or it can occur on its own. It can be triggered by viral or strep infections, blood vessel diseases (vasculitis), and immune problems such as IgA nephropathy, which affects the small capillaries that filter blood in the kidneys (glomeruli).click  & see
*Cancer. Visible urinary bleeding is often the first sign of advanced kidney, bladder or prostate cancer. Unfortunately, you may not have signs or symptoms in the early stages, when these cancers are more treatable.
*Inherited disorders. Sickle cell anemia — a chronic shortage of red blood cells — can be the cause of blood in urine, both gross and microscopic hematuria. So can Alport syndrome, which affects the filtering membranes in the glomeruli of the kidneys.
Kidney injury. A blow or other injury to your kidneys from an accident or contact sports can cause blood in your urine that you can see.
*Medications. Common drugs that can cause visible urinary blood include aspirin, penicillin, the blood thinners warfarin and heparin, and the anti-cancer drug cyclophosphamide (Cytoxan).
*Strenuous exercise. It’s not quite clear why exercise causes gross hematuria. It may be trauma to the bladder, dehydration or the breakdown of red blood cells that occurs with sustained aerobic exercise. Runners are most often affected, although almost any athlete can develop visible urinary bleeding after an intense workout.

Diagnosis:
To find the cause of hematuria, or to rule out certain causes, the doctor may order a series of tests, including urinalysis, blood tests, kidney imaging studies, and cystoscopic examination.

A medical history and physical exam play a key role in finding the cause of urinary bleeding. So do urine tests. Even if your bleeding was first discovered through urinalysis, you’re likely to have another test to see if your urine still contains red blood cells. Hematuria that occurs just once usually doesn’t need further evaluation. Urinalysis can also help determine if you have a urinary tract infection or are excreting minerals that cause kidney stones.
Sometimes your doctor may recommend additional tests, including:

*Urinalysis is the examination of urine for various cells and chemicals. In addition to finding RBCs, the doctor may find white blood cells that signal a urinary tract infection or casts, which are groups of cells molded together in the shape of the kidneys’ tiny filtering tubes, that signal kidney disease. Excessive protein in the urine also signals kidney disease.

*Blood tests may reveal kidney disease if the blood contains high levels of wastes that the kidneys are supposed to remove.

*Kidney imaging studies include ultrasound, computerized tomography (CT) scan, or intravenous pyelogram (IVP). An IVP is an x ray of the urinary tract. Imaging studies may reveal a tumor, a kidney or bladder stone, an enlarged prostate, or other blockage to the normal flow of urine.

*A cystoscope can be used to take pictures of the inside of the bladder. It has a tiny camera at the end of a thin tube, which is inserted through the urethra. A cystoscope may provide a better view of a tumor or bladder stone than can be seen in an IVP.

In spite of testing, the cause of urinary bleeding may never be found. In that case, your doctor is likely to recommend regular follow-up tests, especially if you have risk factors for bladder cancer such as smoking, exposure to environmental toxins and a history of radiation therapy.

 Treatment:

Hematuria has no specific treatment. Treatment for hematuria depends on the cause. If no serious condition is causing the hematuria, no treatment is necessary. Instead, your doctor will focus on the underlying condition:

  • Urinary tract infection. Antibiotics are the standard treatment for urinary tract infections. Symptoms usually subside a few days after you start taking medication, but recurring infections may need multiple or longer therapies.
  • Kidney stones. You may be able to pass a kidney stone by drinking large amounts of water and staying active. Talk to your doctor about an appropriate amount of fluids for you. If this doesn’t work, your doctor is likely to try more invasive measures. These include a procedure that uses shock waves to break the stone into small pieces (extracorporeal shock wave lithotripsy) and, in some cases, surgery to remove the stone.
  • Enlarged prostate. Treatments for an enlarged prostate seek to reduce symptoms and restore normal functioning of the urinary tract. All are effective to varying degrees, and all have some drawbacks. Medications are usually tried first, and they provide long-term relief for many men. When medications don’t help, minimally invasive treatments using heat, lasers or sound waves to destroy excess prostate tissue may be tried.
  • Kidney disease. Most kidney problems often require treatment. No matter what the underlying cause, the goal is to relieve inflammation and limit further damage to your kidneys.
  • Cancer. Though there are a number of treatment options for kidney and bladder cancer, surgery to remove cancerous tissue is often the first choice because the cells are relatively resistant to radiation and most types of chemotherapy. The primary treatment for bladder cancer is surgical resection or complete removal of the bladder. In some cases, surgery may be combined with chemotherapy. In others, the immune system in the bladder is boosted with medications.
  • Inherited disorders. Treatments for inherited disorders that affect the kidneys vary greatly. Benign familial hematuria usually doesn’t require treatment, for instance, whereas people with severe Alport syndrome may eventually need dialysis — an artificial means of removing waste products from the blood when the kidneys are no longer able to do so. Sickle cell anemia is treated with medications, blood transfusions or, in the best-case scenario, a bone marrow transplant.

Click to see:->

Herbal Remedies for Hematuria..………………………….(1)(2).....(3).…...(4)

Hematuria (Blood in Urine) – Natural Cures, Home Remedies

Risk factors:

Almost anyone — including children and teens — can have red blood cells in their urine. Factors that make this more likely include:

  • Age. Many men older than 50 have occasional urinary blood due to an enlarged prostate gland.
  • Your sex. More than half of all women will have a urinary tract infection at least once in their lives, often with some urinary bleeding. Men are more likely to have kidney stones or Alport syndrome, a form of hereditary nephritis that can cause blood in the urine.
  • A recent infection. Kidney inflammation after a viral or bacterial infection (postinfectious glomerulonephritis) is one of the leading causes of visible urinary blood in children.
  • Family history. You may be more prone to urinary bleeding if you have a family history of kidney disease or kidney stones.
  • Certain medications. Aspirin and other nonsteroidal anti-inflammatory pain relievers and antibiotics such as penicillin are known to increase the risk of urinary bleeding.
  • Strenuous exercise. Long-distance runners are especially prone to exercise-induced urinary bleeding. In fact, the condition is sometimes called jogger’s hematuria. But anyone who works out strenuously can develop symptoms.

Prevention:

It’s generally not possible to prevent hematuria, though there are steps you can take to reduce your risk of some of the diseases that cause it. For instance, drinking plenty of water, urinating when you feel the urge and as soon as possible after intercourse, and avoiding irritating feminine hygiene products may reduce your risk of urinary tract infections. Other prevention strategies include:

  • Kidney stones. To help lower the likelihood of kidney stones, drink lots of water and limit salt, protein, and oxalate-containing foods such as spinach and rhubarb.
  • Bladder cancer. Stopping smoking, avoiding exposure to chemicals, drinking plenty of water, and eating more cabbage and broccoli can cut your risk of bladder cancer.
  • Kidney cancer. To help prevent kidney cancer stop smoking, maintain a healthy weight, up your intake of fruits and vegetables, stay active, and avoid exposure to toxic chemicals.

Disclaimer: This information is not meant to be a substitute for professional medical advise or help. It is always best to consult with a Physician about serious health concerns. This information is in no way intended to diagnose or prescribe remedies.This is purely for educational purpose.

.Resources:
http://kidney.niddk.nih.gov/kudiseases/pubs/hematuria/index.htm
http://www.mayoclinic.com/health/blood-in-urine/

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Hearing Loss

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Introduction:
The gradual hearing loss that occurs as you age (presbycusis) is a common condition. An estimated one-quarter of Americans between the ages of 65 and 75 and around three-quarters of those older than 75 have some degree of hearing loss.

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Over time, the wear and tear on your ears from noise contributes to hearing loss by damaging your inner ear. Doctors believe that heredity and chronic exposure to loud noises are the main factors that contribute to hearing loss. Other factors, such as earwax blockage, can prevent your ears from conducting sounds as well as they should.

You can’t reverse hearing loss. However, you don’t have to live in a world of quieter, less distinct sounds. You and your doctor or hearing specialist can deal with hearing loss by taking steps to improve what you hear.

Signs and symptoms
Signs and symptoms of hearing loss may include:

*Muffled quality of speech and other sounds
*Difficulty understanding words, especially against background noise or in a crowd of people
*Asking others to speak more slowly, clearly and loudly
*Needing to turn up the volume of the television or radio
*Withdrawal from conversations
*Avoidance of some social settings
How you hear:….click & see
Hearing occurs when sound waves reach the structures inside your ear, where the sound wave vibrations are converted into nerve signals that your brain recognizes as sound.

Your ear consists of three major areas: the outer ear, middle ear and inner ear. Sound waves pass through the outer ear and cause vibrations at the eardrum. The eardrum and three small bones of the middle ear  the hammer, anvil and stirrup   amplify the vibrations as they travel to the inner ear. There, the vibrations pass through fluid in the cochlea, a snail-shaped structure in the inner ear. Attached to nerve cells in the cochlea are thousands of tiny hairs that help translate sound vibrations into electrical signals that are transmitted to your brain. The vibrations of different sounds affect these tiny hairs in different ways, causing the nerve cells to send different signals to your brain. That’s how you distinguish one sound from another.

What causes hearing loss……....click & see
For some people, the cause of hearing loss is the result of a gradual buildup of earwax, which blocks the ear canal and prevents conduction of sound waves. Earwax blockage is a cause of hearing loss among people of all ages.

Most hearing loss results from damage to the cochlea. Tiny hairs in the cochlea may break or become bent, and nerve cells may degenerate. When the nerve cells or the hairs are damaged or missing, electrical signals aren’t transmitted as efficiently, and hearing loss occurs. Higher pitched tones may become muffled to you. It may become difficult for you to pick out words against background noise.

Ear infection and abnormal bone growths or tumors of the outer or middle ear can cause hearing loss. A ruptured eardrum also may result in loss of hearing.

Risk factors:
Factors that may damage or lead to loss of the hairs and nerve cells in your inner ear include:

Aging. The normal wear and tear from sounds over the years can damage the cells of your inner ear.

Loud noises. Occupational noise, such as from farming, construction or factory work, and recreational noise, such as from shooting firearms, snowmobiling, motorcycling, or listening to loud music, can contribute to the damage inside your ear.

Heredity. Your genetic makeup may make you more susceptible to ear damage.

Some medications. Drugs such as the antibiotic gentamicin and certain chemotherapy drugs can damage the inner ear. Temporary effects on your hearing — ringing in the ear (tinnitus) or hearing loss — can occur if you take very high doses of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs), antimalarial drugs or loop diuretics.

Some illnesses. Diseases or illnesses that result in high fever, such as meningitis, may damage the cochlea.

Comparing loudness of common sounds
What kind of decibel levels are you exposed to during a typical workday? To give you an idea, compare noises around you to these specific sounds and their corresponding decibel levels:

  • drugs can damage the inner ear. Temporary effects on your hearing — ringing in the ear (tinnitus) or hearing loss — can occur if you take very high doses of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs), antimalarial drugs or loop diuretics.
  • Some illnesses. Diseases or illnesses that result in high fever, such as meningitis, may damage the cochlea.

Comparing loudness of common sounds
What kind of decibel levels are you exposed to during a typical workday? To give you an idea, compare noises around you to these specific sounds and their corresponding decibel levels:


Sound levels of common noises
30 Whisper
60 Normal conversation
80 Heavy traffic, garbage disposal
85 to 90 Motorcycle, snowmobile, lawn mower
90 Belt sander, tractor
95 to 105 Hand drill, bulldozer, impact wrench
110 Chain saw, jack hammer
120 Ambulance siren
140 (pain threshold) Jet engine at takeoff
165 Shotgun blast
180 Rocket launch

Maximum sound exposure durations
Below are the maximum noise levels on the job to which you should be exposed without hearing protection — and for how long.

Maximum job-noise exposure allowed by law
90 8 hours
95 4 hours
100 2 hours
105 1 hour
115 15 minutes

When to seek medical advice:
Talk to your doctor if you have difficulty hearing. Your hearing may have deteriorated if you find that it’s harder to understand everything that’s said in conversation, especially when there’s background noise, if sounds seem muffled, or if you find yourself having to turn the volume higher when you listen to music, the radio or television.

Screening and diagnosis:
At first, your doctor may perform a general screening test to get an overall idea of how well you can hear. Your doctor may ask you to cover one ear at a time to see how well you hear words spoken at various volumes and how you respond to other sounds.

To determine your ability to hear and the extent of your hearing loss, your doctor may refer you to a hearing specialist (audiologist) for hearing tests.

During more thorough testing conducted by an audiologist, you wear earphones and hear sounds directed to one ear at a time. The audiologist presents a range of sounds of various tones and asks you to indicate each time you hear the sound. Each tone is repeated at faint levels to find out when you can barely hear. The audiologist will also present various words to determine your hearing ability.

Treatment:
Hearing loss treatment depends on the cause and severity of your hearing loss.

If your hearing loss is due to damage to your inner ear, a hearing aid can be helpful by making sounds stronger and easier for you to hear. If you can’t hear well because of earwax blockage, your doctor can remove the wax and improve your hearing. If you have severe hearing loss, a cochlear implant may be an option for you.

Removing wax blockage……...click & see
Earwax blockage is a common reversible cause of hearing loss. Your doctor may remove earwax by:

*Loosening the wax. Your doctor uses an eyedropper to place a few drops of baby oil, mineral oil or glycerin in your ear to loosen the wax, then squirts warm water into your ear using a bulb syringe. As you tilt your ear, the water drains out. Your doctor may need to repeat the process several times before the wax eventually falls out.

*Scooping out the wax. Your doctor may loosen the wax, and then scoop it out with a small instrument called a curette.

*Suctioning out the wax. Your doctor uses a suction deviceto remove the softened wax.

Hearing Aids:

An audiologist can discuss with you the potential benefits of using a hearing aid, recommend a device and fit you with it.

Hearing aids can’t help everyone with hearing loss, but they can improve hearing for many people. The components of a hearing aid include:

*A microphone to gather in the sounds around you
*An amplifier to make sounds louder
*An earpiece to transmit sounds to your ear
*A battery to power the device
The louder sounds help stimulate nerve cells in the cochlea so that you can hear better. Getting used to a hearing aid takes time. The sound you hear is different because it’s amplified. You may need to try more than one device to find one that works well for you. Most states have laws requiring a trial period before you buy a hearing aid, making it easier for you to decide if the hearing aid helps.

Hearing aids come in a variety of sizes, shapes and styles. Some hearing aids rest behind your ear with a small tube delivering the amplified sound to the ear canal. Other styles fit in your outer ear or within your ear canal.

Cochlear implants
If your hearing loss is more severe, often due to damage to your inner ear, an electronic device called a cochlear implant may be an option. Unlike a hearing aid that amplifies sound and directs it into your ear canal, a cochlear implant compensates for damaged or nonworking parts of your inner ear. If you’re considering a cochlear implant, your audiologist, along with a medical doctor who specializes in disorders of the ears, nose and throat (ENT), will likely discuss the risks and benefits with you

The components of a hearing aid are held in a small plastic container called the casing. All hearing aids use these common parts to help conduct sound from your environment into your ear. But different styles and different technologies make for many different types of hearing aids from which to choose.

Hearing aid styles vary by size. Though smaller styles may be less noticeable, they’re generally more expensive and have a shorter battery life. An audiologist can show you the various styles of hearing aids to help you decide which is best for you.

A microphone (1) picks up sounds. The sounds travel through a thin cable to a speech processor (2). You can wear the processor on a belt, in a pocket, or behind the ear. The processor converts the signal into an electrical code and sends the code back up the cable to the transmitter (3) fastened to your head. The transmitter sends the code through your skin to a receiver-stimulator (4 and 5) implanted in bone directly beneath the transmitter. The stimulator sends the code down a tiny bundle of wires threaded directly into your cochlea, the snail-shaped primary hearing organ. Nerve fibers are activated by electrode bands on this bundle of wires. Your auditory nerve carries the signal to your brain, which interprets the signal as a form of hearing.

Newer cochlear implants use an externally worn computerized speech processor that you can conceal behind your ear. The speech processor sends signals to a surgically implanted electronic chip that stimulates the hearing nerve of deaf people.

Click & see

causes of hearing loss

Hearing loss prevention consists of steps you can take to help you prevent noise-induced hearing loss and avoid worsening of age-related hearing loss:

  • Protect your ears in the workplace. Specially designed earmuffs that resemble earphones can protect your ears by bringing most loud sounds down to an acceptable level. Foam, pre-formed, or custom-molded earplugs made of plastic or rubber also can effectively protect your ears from damaging noise.
  • Have your hearing tested. Consider regular hearing tests if you work in a noisy environment. Regular testing of your ears can provide early detection of hearing loss. Knowing you’ve lost some hearing means you’re in a position to take steps to prevent further hearing loss.
  • Avoid recreational risks. Activities such as riding a snowmobile, hunting, and listening to extremely loud music for long periods of time can damage your ears. Wearing hearing protectors or taking breaks from the noise during loud recreational activities can protect your ears. Turning down the volume when listening to music can help you avoid damage to your hearing.

Coping skills

Try these tips to communicate more easily despite your hearing loss:

  • Position yourself to hear. Face the person with whom you’re having a conversation.
  • Turn off background noise. For example, noise from a television may interfere with conversation.
  • Ask others to speak clearly. Most people will be helpful if they know you’re having trouble hearing them.
  • Choose quiet settings. In public, such as in a restaurant or at a social gathering, choose a place to talk that’s away from noisy areas.
  • Consider using an assistive listening device. Hearing devices, such as TV-listening systems or telephone-amplifying devices, can help you hear better while decreasing other noises around you.

Click for Information from NIH about Hearing Loss

Hearing Loss Association Of America

Information abour Hearing Loss & Hearing Aids

What is Hearing Loss

Hearing impairment

Chinese herbs for improving hearing loss due to natural aging, ear …

How to Improve Hearing With Ear Candles

Conductive hearing loss can be treated with alternative therapies that are specific to the particular condition.

Hearing Loss: Alternative treatment

Disclaimer: This information is not meant to be a substitute for professional medical advise or help. It is always best to consult with a Physician about serious health concerns. This information is in no way intended to diagnose or prescribe remedies.This is purely for educational purpose

Resources:http://www.mayoclinic.com/health/hearing-loss/DS00172

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