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Cholesterol Levels in Women

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What are HDL and LDL?
HDL and LDL are two different kinds of cholesterol that are measured as an index of a patient’s risk for cardiovascular disease. HDL stands for high-density lipoprotein and LDL stands for low-density lipoprotein. Total cholesterol measures the combination of HDL and LDL, along with several other factors. The levels of “fats” in the blood-total cholesterol, HDL (a subset called “good cholesterol”) and LDL (“bad cholesterol”) and triglycerides have been used for years to predict the risk of heart disease in men. Higher cholesterol, LDL, triglycerides, and/or low HDL all are associated with increased risk of heart diseases in men.

What do the numbers mean?
Many studies found that women with higher total cholesterol levels also had higher rates of a form of heart disease called coronary artery disease. That is where the arteries to the heart become clogged. This leads to heart attacks. For cholesterol, levels of about 200 or less are generally not associated with much increased heart disease. Women with total cholesterol levels of 265 or more have been found to have this disease two or three times as often as women with levels of about 200. Even mildly elevated levels, of about 235, had about 70% higher rates, than normal.

Men in the same situation are put on a diet and drugs to lower their cholesterol. The goal was to increase HDL, and lower LDL and total cholesterol. Little was done to lower elevated triglyceride levels. The men’s rates of disease dropped. A closer look at the problem in women found something different. Low HDL (“good cholesterol”) levels were the strongest predictor of heart disease in women. These are generally levels less than 50 (mg/dL). Low HDL and high cholesterol go hand in hand for many, which led to the confusion about what was important. Women with total cholesterol levels as low as 200 who also had low HDL levels still had high risks of heart disease. In fact, the best predictor for women, according to one study, was the ratio of cholesterol to HDL. If a woman’s total cholesterol is about 4 times or so of her HDL level, her risk of heart disease skyrockets to up to five times that of her normal counterpart. If her triglycerides are high, her risk goes up, too. Again, that happens even if she has a low total cholesterol level.

Unlike men, a high LDL (“bad cholesterol”) level is not as strong a predictor of future trouble, although there is still considerable debate on this. Some experts believe LDL is not to be worried about for most women, except for particular sub-groups of women who are affected. As one might expect, until we clarify the importance of LDL for women and factor in the additional significance HDL has for women, the HDL/LDL ratio’s significance is muddied.

The Bottom Line

Total cholesterol in and of itself does not matter so much. Look at the other factors and ratios: especially HDL, triglycerides, and the cholesterol to HDL ratio. The significance of LDL and ratios with it are uncertain. Most of all, keep checking for new research. This area is rapidly changing for women.

Source:www.estronaut.com

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Gene test for lung cancer

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A new gene test developed by Taipei researchers can predict a lung cancer patient’s  outcome after surgery and the survival time……... Sanjit Bagchi reports.

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85% OF LUNG CANCER DEATHS ARE ATTRIBUTABLE TO SMOKING.

Lung cancer is the most common cancer affecting people, especially in big cities. It is treatable, depending on the type, stage and severity, but researchers have always been on the lookout for a measure to predict or tailor the treatment of the disease.

Recently, researchers in Taiwan came up with a simple but effective gene test, which can work wonders in the treatment of lung cancer. The study has been published in the New England Journal of Medicine.

Based on the biology, therapy and prognosis, lung cancer is broadly divided into two classes  non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC), explains Dr A.K. Pathak and associates at the All India Institute of Medical Sciences (AIIMS), New Delhi. Three types of lung cancer    squamous cell carcinoma, adenocarcinoma and large cell carcinoma    are classified as NSCLC and account for 75-80 per cent of all lung cancer cases.

The clinical profile of lung cancer in India differs from that in the West. Generally, in India, the disease sets in in the fifth or sixth decade of a person’s life, almost 15-20 years earlier than in the West, the AIIMS researchers write in Indian Journal of Chest Diseases and Allied Sciences. Squamous cell carcinoma continues to be the commonest type in India whereas adenocarcinoma is gradually becoming the predominant subtype in the Western world,   they add. Dr Pathak and co-workers also note that  of all lung cancer deaths, 85 per cent are attributable to smoking tobacco, which contains harmful carcinogens.

Hsuan-Yu Chen of the National Taiwan University College of Public Health, Taipei, and his team studied more than 600 genes, which seem to influence survival in NSCLC patients. Of these, they singled out five genes   together called the  5-gene signature   which could significantly predict the patient’s outcome after surgery.

The new 5-gene test indicates if there is a need for chemotherapy. Patients belonging to the high-risk  group have a shorter overall survival (20 months) rate than those in the low-risk group (40 months).   This signature could be useful in stratifying patients according to risk in trials of treatment of the disease,   the researchers write, adding it   may reveal targets for the development of therapy for lung cancer.

After surgical resection, adjuvant chemotherapy is often administered  by chemotherapeutic drugs like cisplatin,   says Prof. Kalyan Dasgupta, former head of the department, chest medicine, Calcutta Medical College, Calcutta. However, it’s difficult to determine which patient is an ideal candidate for chemotherapy, as chemotherapy is helpful in only those who are at a high risk of cancer recurrence.  According to Chen and colleagues, The identification of the 5-gene signature has clinical implications. Cisplatin-based adjuvant chemotherapy is effective in some patients with NSCLC. We propose that patients who have tumours with a high-risk gene signature could benefit from this type of therapy, whereas those with a low-risk gene signature could be spared what may be called unnecessary treatment.

Prof. Dasgupta explains, Unnecessary use of chemotherapy may lead to side effects such as bone marrow suppression, fever, nausea and vomiting. Cost is another important factor.  He adds,  The new gene test can solve this problem. Since it can predict the patient’s surgery outcome and survival, it can determine if he/she needs chemotherapy or not. Treatment can thus be tailored accordingly.

The 5-gene test developed by Chen and co-workers is carried out through a technique known as reverse-transcriptase polymerase chain reaction (RT-PCR). This test needs a small number of genes for analysis, a very small amount of specimen (of the tumour) and yields accurate results.

Dr Bikram Saha, assistant professor of medicine, North Bengal Medical College and Hospital, Darjeeling, says, As the test profiles gene expression, it may be relied on. Moreover, it seems to be acceptable in clinical practice since it does not involve complicated procedures. However, further studies are needed before it can be implemented in general clinical practice.

Source:The Telegraph (Kolkata,India)

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One Flu Shot May Offer ‘Whole Herd’ Protection

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FLU SHOTS for KIDS HELP PROTECT the WHOLE FAMILY.

Flu shots for elementary school children can help reduce flu like illness in the whole family, finds new research published in the New England Journal of Medicine this week. Doctors compared families and schools where, in some cases, the elementary school-age kids were offered free flu vaccination. Adults in the families of the vaccinated kids had fewer bouts of flu like illness, and they missed less work due to sickness in either themselves or their children. Elementary-age and high school age children were absent from school less frequently in families where at least one child was vaccinated. Researchers say that vaccinated kids are less likely to catch the flu and bring it home, thus offering “whole herd” protection to people around them.

Source      :ABC News

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Getting a Grip on the Winter Blues (SAD)

It is that time of year again, when despite the ratcheting up of festivities for the holidays, fully one person in five in the United States ratchets down. The cause is a now well-known but still infrequently treated disorder, winter blues or SAD, for seasonal affective disorder.

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There are several remedies to help those affected by SAD escape an affliction that leaves many wanting to climb into bed, put their heads under the covers and not come out until spring. Indeed, some experts refer to SAD as a form of hibernation.

The problem typically starts gradually as the days become shorter in late summer or fall and peaks in midwinter in regions where there may be just 9 or 10 hours of daylight, if that.

For the estimated 14 million severely affected American adults, SAD can send them into a tailspin that makes it difficult if not impossible to fulfill daily responsibilities and derive any joy from life. An additional 33 million people are less severely affected but may experience declines in energy, cheerfulness, creativity or productivity in the dark days of winter.

The most commonly used treatment is exposure for up to several hours a day to high-intensity artificial light, in an effort to simulate the longer days of summer when people with SAD function at top speed.

Jet Lag and Circadian Rhythm
Dr Alfred J. Lewy, a psychiatrist who has been studying the biology behind SAD, describes it as a form of jet lag, a concept he proposed 20 years ago. He recently published experimental evidence that he says attests to the validity of this theory. If true, this would make SAD a disturbance in the circadian rhythm, the 24-hour pattern that normally aligns the sleep-wake cycle with all the other bodily rhythms. Dr. Lewy suggests that with the delayed dawn and shorter days of fall and winter, the rhythms of people afflicted with SAD drift out of phase with the sleep-wake cycle, as if they had traveled across many time zones.

With jet lag, recovery occurs over a matter of days, and the circadian rhythm once again becomes synchronized with day and night. “In people with SAD, this adjustment takes five months,” Dr. Lewy said.

If his theory is substantiated by further research, it may one day be possible to treat SAD with tiny daily doses of time-released melatonin, the substance in the brain that regulates the sleep-wake cycle. Melatonin naturally increases in the evening, causing sleepiness, and falls off as morning approaches. The idea would be to tailor the administration of melatonin in a way that realigns the out-of-sync circadian rhythm in people with SAD, just as tiny doses (much smaller than those typically sold in health-food and drug stores) of melatonin can be used to speed recovery from jet lag.

In his study, conducted with three colleagues at Oregon Health Sciences University, Dr. Lewy identified two types of SAD patients. About two-thirds required morning light or evening melatonin to correct their body clocks. The remainder needed evening light or morning melatonin to put their body rhythms back on track. Currently, there is no commercial source of time-release low-dose melatonin that could be used, with or without light therapy, to help people with SAD.

Current Remedies
Dr. Norman E. Rosenthal, a native of South Africa who discovered his own serious problem with SAD while a resident in psychiatry at the New York State Psychiatric Institute in 1976, has become an expert in diagnosing and treating the problem. His knowledge and experience in helping himself and countless patients afflicted with SAD are summarized in “Winter Blues: Everything You Need to Know to Beat Seasonal Affective Disorder,” whose revised edition the Guilford Press published this year.

Dr. Rosenthal aptly describes SAD as “an energy crisis.” Patients are not depressed in the usual emotional sense, but rather feel as if their batteries have run down.

The symptoms of SAD do mimic those of serious depression. Patients say they have to drag themselves out of bed in the morning, even after 10 hours of sleep, and force themselves to perform necessary chores. They feel leaden and would just as soon not see anybody or do anything. They find it difficult to concentrate and think clearly and quickly.

Sex drive often dwindles markedly but is often replaced by an insatiable appetite for carbohydrates — breads, pasta, potatoes, rice and sweets — that results in weight gain. Many people with SAD have two wardrobes, the one for winter being two sizes larger.

The most common remedy is light therapy. But not just any light. Patients are advised to sit in front of a specially designed light box that emits about 10,000 lux from a fluorescent bulb, most often in the morning for at least 45 minutes. Some patients require hours of light therapy each day to ward off the symptoms of SAD, which may mean having one light box at home and a second at work.

Among commercial sources for these light boxes is the Center for Environmental Therapeutics, which sells them for $200. Its Web site, www.cet.org, is a useful source of information about SAD.

Among other light-enhancing suggestions from Dr. Rosenthal are planning a winter vacation in a sunny climate or relocating to someplace nearer the Equator, where the days are longer in winter. (But, he cautions, first be sure you can tolerate the summer there.)

Helpful Machines and Therapies
For those who remain in northern latitudes, Michael and Jiuan Su Terman of the New York State Psychiatric Institute at Columbia University, who have conducted pioneering studies of SAD remedies, suggest considering a “dawn simulator.” This device gradually turns on a bedroom light every morning while you are still asleep, helping ease SAD symptoms by making the body think that it is experiencing the early sunrises of summer.

This might also help people who do not have SAD but who hate getting up in the morning when it is still dark out.

The Termans have also found another helpful gadget, a negative-ion generator. They showed that sitting in front of a machine that emits negative ions at a high rate for 30 minutes every morning was as effective as sitting in front of a light box for the same time. The generators are available for $165 from the Center for Environmental Therapeutics (Michael Terman is the president of its board). The advantage of this device is that it can be used while sleeping.

A third approach that has proved effective is cognitive behavioral therapy, when used with or without light therapy. Kelly J. Rohan of the Uniformed Services University of the Health Sciences in Bethesda, Md., (and currently of the University of Vermont) found that this therapy, a brief form of psychotherapy that helps people change negative thoughts and behaviors, was as effective as light therapy in a study of 23 patients with SAD.

And unlike light therapy used alone, cognitive behavioral therapy helped prevent a relapse of SAD symptoms the next winter.

Dr. Rosenthal also recommends eating a diet relatively high in protein and low in carbohydrates and performing regular physical exercise, which is especially helpful if it is outdoors in the morning or, if indoors, in front of a light box.

Source:The New York Times

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MEDICINES DON’T HELP BRONCHITIS

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Antibiotics are often prescribed for treatment of bronchitis, but they are mostly useless, since nearly all cases of bronchitis are caused by viruses, not bacteria. A new review published in the New England Journal of Medicine finds that 70 to 80 percent of people with bronchitis are still prescribed antibiotics, which means they may get side effects like abdominal pain, diarrhea and rashes without getting any benefit from the medication. Furthermore, reviewers from Virginia Commonwealth University find that nearly 100 percent of bronchitis patients received a prescription for cough medication, despite the fact that cough medications are also ineffective for bronchitis. Most cases of bronchitis clear up easily in a few days, but people with high fevers, especially those that persist more than a day or two, should consult a doctor.

Source:ABC News

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