Categories
Ailmemts & Remedies

Lumps and Bumps

PapillomaMost lumps are benign, but it is very important to be sure exactly what they are and find out if they need any  treatment.

Benign vs malignant :……....click & see
Lumps are normally referred to as tumours, and they may be benign or malignant. In a tumour, one particular type of cell (such as a glandular, fat or muscle cell) has escaped the normal controls on growth and started to multiply.

The most important characteristic is whether these tumour cells can invade other adjacent cell types, and spread around the body (i.e. they are malignant tumours) or not (in which case they are benign).

Benign tumours:-
Benign tumours include :

•Cysts: lumps filled with fluid. Common types include sebaceous cysts on the skin, filled with greasy sebum, and ovarian cysts….
Nodules: formed in inflammatory conditions such as arthritis, sarcoid and polyarteritis…….
•Lipomas: lumps of fat cells….
Fibromas and fibroademonas: lumps of fibrous or fibrous and glandular tissue…..
Haematoma: lump formed by blood escaping into the tissues – simply a large bruise…..
Haemangioma: lump formed by extra growth of blood vessels……
•Papilloma: formed from skin or internal membrane cells, for example warts….

Benign tumours do not invade or spread. They can grow quite large without causing problems, although that doesn’t mean they’re totally harmless because their growth may start to damage the other tissues or organs around them.

This is a particular problem with a type of brain tumour called a meningioma, which grows from cells in the membranes that surround the brain (the meninges). Although benign, the pressure within the skull from the growing meningioma can cause severe headaches and may be life threatening if the tumour is not removed.

Benign tumours can cause others problems, from simply looking unsightly to releasing excess hormones.

Malignant tumours:-
Malignant tumours are also known as cancers. They invade the tissues around them and spread to other parts of the body by sending out cancer cells into the lymphatic system or through the blood stream.

These cells are deposited in other areas of the body, particularly the lungs, liver, brain and bones, to start ‘secondary’ tumours (also called metastases) at the new sites. Most malignant tumours are life threatening.

Breast tumours:-
•Benign: mostly happens at younger age. Usually a round smooth lump with a border that feels separate to the rest of the breast. Changes may occur in the lump with the menstrual cycle, being more obvious just before a period. The lump may be tender.
Malignant: mostly happens at older age. Usually a craggy or irregular lump, which may be seen to tether the skin There may be other symptoms such as discharge from the nipple. There may be a family history of breast cancer especially if at a young age.
Women are advised to be on the look out for lumps in their breasts. However, among younger women at least, lumps are far more likely to be benign – in women under 40, more than nine out of ten breast lumps are benign. But these lumps still cause a lot of anxiety until they are sorted out.

The most common benign breast conditions are fibrocystic change, benign breast tumours and breast inflammation. These are common problems, in fact fibrocystic change used to be known as fibrocystic disease but, as it affects more than 50 per cent of women at some point, it was thought it could no longer be considered a disease.

Fibroadenomas (sometimes called breast mice because they can be moved around) are particularly common in women in their 20s or 30s. They are benign and not cancerous.

In most cases these lumps are quite harmless, although now and then they may cause troublesome symptoms such as tenderness (especially as many are influenced by hormone levels and tend to get more swollen and painful along with other menstrual symptoms).

Malignant breast tumours mostly occur in older women, and tend to be accompanied by other symptoms such as discharge from the nipple. The lump may feel craggy or irregular.

Women who have a family history of breast cancer, especially breast cancer at a young age, have an increased risk of malignant tumours.

Is it cancerous?
Sometimes it’s fairly clear that a lump is either benign or malignant, but further tests may be required, including x-rays, ultrasound or biopsy. Often the best way to get an answer is to remove the whole lump and send it to the laboratory for analysis.

Benign lumps may not need to be removed but this is usually the most effective way to reassure someone because, whatever the problem, it’s gone

If you find a lump
•Get a doctor’s opinion – no one minds checking hundreds of harmless lumps if it means that one malignant or cancerous lump is caught early.
•Don’t hide a lump or fret silently about it – if it does prove to be malignant the sooner it’s dealt with the greater the chance of cure.
•Bear in mind that most lumps, especially in younger people, are benign or relatively harmless.

Disclaimer: This information is not meant to be a substitute for professional medical advise or help. It is always best to consult with a Physician about serious health concerns. This information is in no way intended to diagnose or prescribe remedies.This is purely for educational purpose

Source:BBC Health

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Categories
Herbs & Plants

Snake needle grass

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Botanical Name :Hedyotis diffusa
Family: Rubiaceae
Genus: Hedyotis
Species: H. diffusa
Kingdom: Plantae
Order: Gentianales

Other Scientific Names: Hedyotis diffusa,Oldenladia diffusa
Common Names:Daniri (Bis.),Ulasiman-kalat (Tag.), Snake needle grass (Engl.)

Habitat : Wild Hedyotis diffusa can be found in China, Japan, Nepal.A common weed in towns, gardens, and open lands throughout the Philippines.

Description:
Slender, spreading or ascending, more or less branched, annual herb, reaching a length or 50 cm or less.
* Leaves: linear and 1 to 3 cm long.
* Flowers: white, 3 mm long and occurring singly in the axil of the leaf. Pedicele about as long as the calyx, corolla lobes entire. Ovary 2-celled.
* Fruits: capsules, loculicidal, ovoid, about 4 mm long and do not protrude beyond the calyx segments.

Click to see the picture

Properties:
*Sweet tasting, cooling in effect.
*Considered alterative, antibacterial, antidote, analgesic, antiinflammatory, antitumor, diuretic, febrifuge and sedative.
*Study yielded a four anthraquinones.
Medicinal Uses:
Parts Used:
* Entire plant.
* Harvest the entire plant from April to September.
* Wash and sun-dry.


Constituents :

*Study of chemical constituents yielded anthraquinones, terpenoids, flavonoids, steroid alchols, alkanes, organic acids, polysaccharides, coumarin and alkaloids.

Folkloric
* For any kind of inflammation, e.g., tonsillitis, laryngitis, and appendicitis: use dried preparation 30 to 60 gms (or fresh material 120 to 240 gms) boil to decoction and drink.
* Used for jaundice and hepatitis, malignant tumors.
* Poultice of plant material used for external bruises or blood congestions, boils, and abscesses.
* Plant decoction used for biliousness, fever and gonorrhea.
* Used for fevers, cough, asthma.
* In Chinese folk medicine, used in hepatitis and malignant tumors of the liver, lung and stomach. Also used for carbuncles, skin sores and ulcerations, painful swollen throats, gynecologic infections, and snake bites. source

Studies:
Neuroprotective: Study yielded five flavonol glycosides and four O-acylated iridoid glycosides. All nine compounds exhibited neuroprotective activity in cultures of damaged rat cortical cells.
• Antitumor: Although used in folk medicine for malignant tumors of the liver, lung and stomach, study showed no antiproliferative or antiangiogenic effects to support its folkloric antitumor use.
Immunocompetent Activity: Study showed H diffusa improved the leukopenia and splenic cellular decrease caused by irradiation and increased the immunocompetence of splenic cells after mitogenic stimulation. Study suggests H diffusa may be effective in preventing hematopoietic damage in combination use with radiotherapy.
• Antioxidant: In a study of H diffusa, H corymbosa and M pentaphylla, all three showed varying levels of antioxidant and radical scavenging activities.
• Phytochemicals: Study isolated five flavonoids from H diffusa: kaempferol, kaempferl 3-O-beta-D-glucopyranoside, kaempferol 3-O-(6″-O–L-rhamnosyl)-beta-D glucopyranoside, quercetin 3-O-(2″-O-beta-D-glucopyranosyl)-beta-D-glygopyranoside.
• Anticancer: Study of OD extract against eight cancer cell lines showed strong antiproliferative activity against all cancer cell lines and induced significant increase of apoptosis. Also, there was significant inhibition of lung metastases in the animal model without noticeable side effects. Results suggest a potential for an anticancer agent.
• Methylanthraquinone / Anticancer: Study yielded methylanthraquinone from Hedyotis diffusa which exhibited potent anticancer activity. In a study in human breast cancer cells, results suggested that methylantrhaquinone induced MCF-7 cells apoptosis via Ca2+/calpain/caspase-4-pathway.
• Antitumor / Phytotoxic: Study of leaf methanol extract of Oldenlandia diffusa showed tumor inhibition on potato disc and significant phytotoxicity. Results suggest Oldenlandia diffusa might be a potential source of antitumor agent for use in the treatment of tumors in human.
Oleanolic Acid / Fibroblast Inhibition / Chemopreventive / Chemotherapeutic: Study showed oleanolic acid inhibited the growth of ras oncogene-transformed R6 cells at doses not toxic to normal fibroblasts. Resutls demonstrate oleanolic acid possess both cancer therapeutic and chemopreventive activities and presenting a great potential as a novel anti-cancer drug.

Disclaimer:
The information presented herein is intended for educational purposes only. Individual results may vary, and before using any supplements, it is always advisable to consult with your own health care provider.

Resources:
http://www.stuartxchange.com/UlasimanKalat.html
http://en.wikipedia.org/wiki/Hedyotis_diffusa
http://www.righthealth.com/topic/hedyotis_diffusa

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Categories
Health Alert News on Health & Science

An Increase in Leptin Could Promote Colorectal Cancer

While researchers have known that obesity increases the risk for the development of colon cancer, the underlying molecular mechanisms have remained unclear.
…CLICK & SEE
Now, for the first time, researchers have found that an increase in leptin, a cytokine that is normally increased in obese or overweight individuals, may promote colorectal neoplasms by activating colorectal cancer stem cells.

Cancer stem cells constitute a small subfraction of tumor cells that are characterized by long lifespan and capacity for self-renewal, and are responsible for tumor development, resistance to treatments and cancer recurrence. In colon cancer, leptin is able to increase the growth, survival, and resistance to certain chemotherapy treatments in this key cell population.

Leptin, a fat tissue-derived pluripotent cytokine regulating appetite and energy balance in the brain, also controls many physiological and pathological processes in peripheral organs, including carcinogenesis.

Colon cancer has increased in developed countries, possibly due to sedentary lifestyles and high caloric diets. Prior research has linked obesity to colorectal cancer risk by .4-1.0 fold in men and up to 2.0 fold in premenopausal women.

“Since targeting cancer stem cells may be a translationally relevant strategy to improve clinical outcomes, interfering with leptin signaling by targeting leptin receptors might become a novel attractive option for colorectal cancer treatment, particularly in obese patients,” says senior author of the study, Eva Surmacz.

“It is important to consider that cancer stem cells have been identified in several human malignancies,” says Monica Bartucci, study co-author. “Understanding how cancer stem cells interact with a tumor environment, including hormones like leptin, is likely to have significant implications for treatment management of different cancer types in human patients. We hope, in collaboration with Dr. Surmacz, not only to test the effects of leptin antagonist compounds on colon cancer stem cells but also to study the results of leptin stimulation on cancer stem cells isolated in other cancer tissues.”

Source: Elements4Health

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Categories
Healthy Tips

Olive Oil Protection Against Breast Cancer

Researchers have decoded a complete cascade of signals within breast tumor cells activated by virgin olive oil, and concluded that benefits include decrease in the activity of the oncogene p21Ras, changes in protein signaling pathways, stimulation of tumor cell death and prevention of DNA damage. The study was carried out in an experimental model and researchers have already begun a new study with human cell lines.

…CLICK & SEE

Breast cancer is the most common type of cancer in Western countries. Research carried out with animal models demonstrate that a diet rich in fats is directly related to the incidence of cancer. Some types of fats however can play a protective role against the development of these tumors. Such is the case of virgin olive oil, rich in oleic acid, a mono-unsaturated fatty acid, and containing several bioactive compounds such as antioxidants. A moderate and regular intake of virgin olive oil, characteristic of the Mediterranean diet, is associated with low incidences of specific types of cancer, including breast cancer, as well as with having a protective role against coronary diseases and other health problems.

The study decoded the mechanisms operating within the tumor cell and induced by the intake of olive oil, in comparison to those activated by corn oil, rich in n-6 polyunsaturated fatty acids, which increase the aggressiveness of tumors.

Scientists demonstrated that virgin olive oil is associated with higher incidences of benign breast tumors and at the same time with a decrease in the activity of the p21Ras oncogene, which spurs uncontrolled cell proliferation and stimulates the growth of tumors. In addition, olive oil suppresses the activity of some proteins, such as the AKT, essential for the survival of cells since they prevent apoptosis, the cell’s “suicide” program. Between proliferation and apoptosis in tumor cells, these effects tip the balance towards cell death, thereby slowing the growth of tumors.

Another result obtained by researchers is the protection of DNA in the cell nucleus. Cells from animals fed a diet rich in virgin olive oil contained less DNA lesions than those fed a control diet.

Scientists of the UAB Breast Cancer Study Multidisciplinary Group (GMECM) have spent over twenty years working to determine the effects fats have on breast cancer, and in particular the effects of virgin olive oil. Previous studies of the group revealed the beneficial effects of this component of the human diet on the clinical conduct of mammary tumors and on their histological grade (malignancy). Scientists also described several molecular mechanisms producing these effects and in 2004 the same group was the one to identify the four genes involved in the effects dietary fats have on experimental breast cancer.


Source:
Elements4Health

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Categories
Health Problems & Solutions

Some Health Quaries & Answers

 

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————————————-–click & see

A: The manufacturers of Today claim 89 to 91 per cent efficiency, if used correctly. It is a spermicide — that is, it kills any sperm that comes into contact with it. It has to be inserted prior to intercourse and left inside for a minimum of six hours. Independent consumer surveys have placed the efficiency at around 65 per cent. The effectiveness increases to 99 per cent if used with condoms.

Invasive thymoma
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Q: I had a cough. When a chest X-ray was taken, I was found to have “invasive thymoma”. What is that?

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A: The thymus is a gland situated in front of the chest. It usually involutes and disappears after puberty. However, it can persist and grow, forming a “thymoma”. This can present at any age but is commoner after the age of 50. It causes no symptoms in a third of the people (as in your case) and is picked up only during a routine X-ray. As it is situated close to the heart, lungs and large blood vessels in the chest, it can penetrate and invade these structures forming an “invasive thymoma”.Treatment involves surgery radiation and chemotherapy. Take your doctor’s advice and go to a tertiary care hospital that specialises in cancer treatment.

Gay matter
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Q: My cousin is a homosexual. Is there any medication that can be given to him?

click & see

A: The reason for sexual orientation is still tentative and not proven. It is probably the result of a combination of genetic, hormonal and environmental factors. There have been some articles recently in biology journals speculating that sexual orientation depends on whether the person has a preponderance of male or female receptor pheromones. This is genetic. Sexual orientation is established in early childhood. This gives credence to the genetic theory. There is no scientific evidence that abnormal parenting, sexual abuse or other adverse life event influences sexual orientation. Being “gay” is not due to a chemical imbalance in the brain. There is no medication to change it.

Always tearful…click & see
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Q: My mother has tears rolling out of her left eye all the time. Please help.

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A: There is a small opening in the lower eye lid near the bridge of the nose which leads into the lachrymal (tear) duct and also opens into the nose. The opening near the eye lid seems to have become blocked . This is commoner in women after menopause and can occur for a variety of reasons. An ophthalmologist can determine if it is due to an infection or if debris has blocked it. Medical treatment for the infection involves massage, drops and ointments. If these do not work, surgery may be required.

Lump near genitalia
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Q: I have a lump on the right side of my penis. It hurts when I stand up but I cannot feel it when I lie down….click & see

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A: It sounds like you have inguinal hernia. Since it disappears when you lie down, it means the hernia is still reducible and has not become obstructed. You need to see a surgeon to have it corrected. It is not a tumour or cancer.

Source: The Telegraph (Kolkata, India)

 
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