Tag Archives: Yale University

Eliminate Your Joint Pain Safely And Effectively

 

If you experience nagging pain in your shoulders, elbows, wrists, hands, hips or knees—you know firsthand how it can ruin your life. Throbbing pain takes the joy out of doing things you love… robs you of a good night’s sleep… and ruins your days with constant discomfort.

Nearly 66 million Americans—about one in three adults—suffer from chronic joint pain whether it’s from poor diet, lack of exercise, obesity or just the plain wear and tear of aging. Whatever the reason—muscle soreness and stiff and aching joints can choke the pleasure out of life. And research from Yale University indicates that those suffering from joint pain and arthritis will double by the year 2030.

Solutions from the medical industry usually involve costly prescription drugs—many of which are now infamous for their miserable side effects. And some of those pain relievers have been proven dangerous. Recently, investigators found that the popular joint prescription medication Vioxx® triggered more than 100,000 heart attacks. And two similar pain-relief drugs—Bextra® and Celebrex®—are suspected of causing thousands more.

Supplements containing glucosamine, serrapeptase, bromelain and astaxanthin can help reduce your pain or may make it completely disappear. Imagine how good you would feel if you could reduce muscle stiffness and pain… cool the inflammation of your joints… decrease the nighttime soreness… relieve the creaking and cracking joints… and eliminate the everyday aches and pains.

So stop your suffering now and avoid the dangerous risks associated with prescription and over-the-counter drugs. Get the all-natural relief your joints are aching for with nutrients from Mother Nature’s pharmacy.

You may click to see :

Natural Medicine For Arthritis pain, Joint pain, and Back pain!

Herbal, Natural Home Arthritis Remedies
(& Supplements)

Natural & Home Remedies for Joint Pain

Source: Better Health Research

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Anger Alert for Heart

Episodes of anger may lead to potentially lethal abnormal heart rhythms in patients with heart disease and those who are survivors of heart attacks, a medical study has suggested.

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The study by researchers at the Yale University School of Medicine in the US is the first to show how emotion triggers a distinct pattern of electrical activity that contributes to arrhythmias — abnormal heart rhythms.

The researchers who monitored a group of 62 patients found that those with high levels of anger-induced electrical cardiac activity called T-wave alternans were more likely to experience arrhythmias than patients with low levels of this electrical activity.

Anger appeared to increase the risk of arrythmias by up to 10 times. The findings will appear shortly in the Journal of the American College of Cardiology.

“Our study identified individuals vulnerable to increased electrical instability due to emotion,” said Rachel Lampert, associate professor of medicine at Yale who has been exploring how mental stress can disturb heart rhythms.

The researchers studied patients with heart problems who had implantable cardioverter-defibrillators — small, battery-powered devices in the chest from where they constantly monitor the heart rate and rhythm.

When the device detects abnormal heart rhythms, it delivers an electrical shock to the heart muscle to stop the arrhythmia and return the heart to its normal rhythm.

The study examined incidence of arrhythmias over three years and found that patients with arrhythmias had higher T-wave alternans induced by anger than patients who had not experienced arrhythmias.

Arrhythmias of concern are rare in healthy people. “The implications of our findings are for the increasing number of people who have survived a heart attack or are living with heart failure,” Lampert told The Telegraph.

Cardiologists believe it is important to identify patients who are at risk of developing life-threatening arrhythmias. The results suggest that therapy to help patients deal with anger and other negative emotions may reduce arrhythmias, said Lampert.

Sources:
The Telegraph (Kolkata, India)

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How Mind Can Suppress Hunger Pangs

You might not be keeping a check on the amount of calories you’re consuming during a party, but your brain will, say Yale University researchers, who have identified a molecule that tells brain that the stomach is full – and signals it’s time to say no to a second piece of Delicious food and push back from the dining table.
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In a study on rodents, the researchers have discovered that one type of lipid produced in the gut, called N-acylphosphatidylethanolamines or NAPEs, rises after eating fatty foods.

The NAPEs enter the bloodstream and go straight to the brain, where they concentrate in a brain region that controls food intake and energy expenditure.

Led by Gerald I. Shulman, Yale professor of medicine and cellular & molecular physiology and a Howard Hughes Medical Institute investigator, the researchers suggested that the molecule may help regulate how much animals and people eat.

NAPEs are synthesized and secreted into the blood by the small intestine after fatty foods are eaten. The researchers found that mice and rats injected regularly with NAPEs ate less food and lost weight. In addition, treatment with NAPEs appeared to reduce the activity of “hunger” neurons in the brain while stimulating activity in neurons that are believed to play a role in reducing appetite.

In the last two decades, scientists have made great inroads toward understanding how the body communicates with the brain to control food intake. Till date, hormones such as leptin that act as regulators of this complex system have proved disappointing when tested as potential weight-loss treatments in humans.

The researchers are now planning to investigate how the new findings apply to humans.The team will first study non-human primates to determine if NAPE on centrations increase in a similar fashion after fat ingestion.

Then, Shulman said: “If chronic NAPE treatment is well tolerated and can cause weight loss by a reduction of food intake, we would have strong impetus to move forward with human NAPE trials.” The findings are published in the latest issue of the journal Cell.

Sources: The Times Of India

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How to Live Till a 100

Want to live till 100 years of age? Well, do regular exercises, be married, wash hands and brush your teeth everyday.

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That’s what a new book, ‘The Long Life Equation’, by Dr Trisha Macnair suggests. In the book, the author has listed activities that add years to your life.

Macnair said washing your hands adds two years, and good dental hygiene can add six more years in your life.

But smoking, fast food, no exercise and a stressful life can strip away 20 years.

“There’s no doubt younger people take life and health for granted – more than any generation before, they idle time away watching TV or playing computer games, ignoring the activities that keep them healthy or develop meaning in their lives,” Courier Mail quoted Macnair, as saying.

“As we get older and start to feel the years slipping away, we suddenly realise how precious it is.

“But by then we may have already established habits (smoking, drinking, obesity, lack of exercise, stressful occupations) which take their toll and are difficult to reverse.

“Still, it’s never too late to change. Also, our attitudes to older age are changing so there is more freedom now to do things later in life if we are healthy and able,” she added.

A 2006 study from University of California in Los Angeles showed that men and women live healthier, wealthier, happier and longer lives when they are in a stable partnership

The study confirmed that married couples were more likely to live to an old age than their divorced, widowed or unmarried counterparts.

A stable partnership can actually add on seven years to life.

Regular exercise also adds as much as two or more years to your life.

A Harvard Alumni Study, which took into account more than 71,000 men who had graduated from Harvard University and the University of Pennsylvania between 1916 and 1954, found that those men who regularly burned 8400kJ a week while exercising lived, on average, two years longer than sedentary types.

But cigarette smoking can actually reduce 8 years from your life

Tobacco smoke contains more than 4000 chemicals, many of which are highly toxic.

A divorce can also strip away 3 years from your life, as it takes longer-lasting, emotional and physical toll on former spouses than virtually any other life stress.

Recent studies indicate that divorced adults have higher rates of emotional disturbance, accidental death and death from heart disease.

The divorced also have higher rates of admission to psychiatric facilities and make more visits to doctors than people who are married, single or widowed.

Sources: The Times Of India

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The Long and Short of it

 

Scientists have discovered genes that influence height but are yet to explain the gap between the tallest and shortest of people:

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A meeting between two ordinary men in a remote locale in Mongolia hit the headlines all over the world in July last year. But neither Bao Xishun, 56, nor He Pingping, 19, holds a position of eminence. Nor are they film or sports celebrities. The encounter grabbed world attention because of the two men’s contrasting statures. While Xishun, at 2.36m, is the world’s tallest living man, the 74-cm Pingping claims he is the shortest.

Modern science may not be able to explain the yawning gap between the heights of these two men — both hailing from Inner Mongolia — but it has gained some genetic insight into the varying stature of billions of others who fall between Xishun and Pingping in terms of height.

For nearly a century, scientists have believed that genes handed down from parents are responsible for 90 per cent of the normal variation in human height in a population. And it is not just one gene but probably a few hundred that contribute towards making a person tall or short. But until last year, scientists were clueless about their location on the human genome, which consists of more than 3 billion DNA base pairs.

In September 2007, researchers from both sides of the Atlantic, while foraging through DNA from 35,000 people, stumbled upon a difference in a gene called HMGA2, which plays a decisive role in making people taller or shorter, albeit marginally. They found that if a person had two copies of a longer variant of HMGA2, he or she would be 1cm taller than one who has two shorter versions of it.

The HMGA2 gene thus became the first reliable genetic link to human height. Later, scientists zeroed in on yet another gene, GDF5, which makes for an average height difference of 0.4cm.

What made the discovery of such genes possible is what scientists call genome-wide association studies. This is a relatively new way of identifying genes involved in human diseases. Made possible by advances in genetics and sophistication in scientific tools, this method searches the genome for small variations, called single nucleotide polymorphisms (SNPs). The tools are so advanced that researchers can search for hundreds or thousands of SNPs simultaneously. Such studies pinpoint genes that may contribute to a person’s risk of developing a certain disease or those associated with a trait such as height or eye colour.

If 2007 saw a beginning in understanding the role played by genes in deciding how tall a person will be, 2008 has so far proved to be a watershed. The same consortium of scientists who discovered the HMGA2 and GDF5 genes, now split into two groups, recently discovered 40 more genetic locations. Combined, they may be able to explain a height difference of up to 6cm, or 5 per cent of the population variation in height.

The number and variety of genetic regions discovered so far show that height is determined not just by a few genes operating in the long bones, notes Thomas Frayling of Peninsula Medical School in the UK. Frayling is the lead author of the one of the two studies that appeared in Nature Genetics last month.

Joel Hirschhorn, a paediatric endocrinologist at Broad Institute in the US, who led the other study, says that the new findings account for only a small fraction of the variation in height among people and that there is a lot more to discover. “This is much more than we had even last year. But we are not close to predicting adult height,” Hirschhorn told Knowhow.

The study of genes involved in determining adult height stems from more than sheer curiosity. By identifying which genes affect normal growth, it is easy to understand the processes that lead to abnormal growth, the scientists say. “There appears to be a definite correlation between height and some diseases,” says Michael Weedon, a colleague of Frayling. Weedon was not only part of the original team that discovered the HMGA2 gene but was also instrumental in the latest discovery of 20 new genetic locations linked to height. For instance, there is a strong association between shortness and a slightly increased risk of conditions such as heart disease. Similarly, tall people are more prone to certain cancers and, possibly, osteoporosis.

A predominant factor that determines one’s height may be heredity, but diet too has a role to play. In fact, improved nutrition means that each generation gets successively taller, as has been shown by a recent study on Indians.

That said, Indians still have some catching up to do: an average Indian man (165.3cm) is two centimetres shorter than an average Czech woman who stands 167.3cm tall.

Sources: The Telegraph (Kolkata, India)