Tag Archives: BioMed Central

Fish Oil Promises Shorter Hospital Stay

A new research has shown that patients in the ICU who received intravenous fish oil had shorter hospital stays compared to those given standard Intravenous fish oil promises shorter hospital stays
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Decreased inflammation and improved gas exchange in the lungs from the omega 3 fatty acids in fish oil allowed the patients to get better faster and go home sooner.

Philip Calder, from the University of Southampton, UK, and colleagues investigated the effects of including fish oil in the normal nutrient solution for patients with sepsis, finding a significant series of benefits.

They conducted the study in 23 patients with systemic inflammatory response syndrome or sepsis in the Hospital Padre Américo, Portugal.

The results showed that patients with sepsis given fish oil were discharged from the hospital earlier compared to those receiving traditional nutrition.

“Recently there has been increased interest in the fat and oil component of vein-delivered nutrition, with the realization that it not only supplies energy and essential building blocks, but may also provide bioactive fatty acids,” Calder said.

“Traditional solutions use soybean oil, which does not contain the omega-3 fatty acids contained in fish oil that act to reduce inflammatory responses. In fact, soybean oil is rich in omega-6 acids that may actually promote inflammation in an excessive or unbalanced supply,” he added.

Calder and his colleagues found that the 13 patients in the fish oil group had lower levels of inflammatory agents in their blood, were able to achieve better lung function and left hospital earlier than the 10 patients who received traditional nutrition.

“This is the first study of this particular fish oil solution in septic patients in the ICU. The positive results are important since they indicate that the use of such an emulsion in this group of patients will improve clinical outcomes, in comparison with the standard mix,” he said.

Source: The study appears in BioMed Central’s open access journal Critical Care .

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Fatty Fish-oil May Help Reduce Tumour

An omega 3 fatty acid found in fish oils reduced the size of tumours in mice and made a chemotherapy drug more potent while limiting its  harmful effects, Egyptian researchers reported.

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The findings, published in publisher BioMed Central‘s peer-reviewed Cell Division journal, add to evidence showing a range of health benefits from eating the fatty acids found in foods such as salmon. A.M. El-Mowafy and colleagues from Mansoura University in Egypt looked at how an omega 3 fatty acid called docosahexanoic acid, or DHA, affected solid tumours growing in mice and how well it interacted with the chemotherapy drug cisplatin.

“Our results suggest a new, fruitful drug regimen in the management of solid tumours based on combining cisplatin and possibly other chemotherapeutics with DHA,” El-Mowafy said in a statement. “DHA elicited prominent chemo-preventative effects on its own, and appreciably augmented those of cisplatin as well.” In March, U.S. researchers showed that a diet high in omega 3 fatty acids– the kind found in fish such as salmon, mackerel, herring and sardines- protected against advanced prostate cancer even in men more at risk of the disease.

The fatty acids, also found in foods such as walnuts and leafy greens, have been shown to provide an anti-inflammatory effect and have been linked to a lower risk of heart disease. In their study, El-Mowafy’s team found that, at the molecular level, DHA reduces the accumulation of white blood cells, systemic inflammation, and a harmful condition marked by decreased antioxidant levels- all of which have been linked to tumour growth. Their experiment also showed that the fatty acid reduced toxicity and injury to kidney tissue caused by the chemotherapy drug, the researchers said.

Sources:The Times Of India

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Good Germs Fight Bad Germs

Good germs may work as well as antiseptics in protecting hospital patients from dangerous infections, Swedish researchers reported 

Patients swabbed with probiotic bacteria called Lactobacillus plantarum 299 escaped infection as well as those cleaned up using the antiseptic chlorhexidine, they reported.

Both approaches worked equally well in preventing pneumonia among 50 critically ill patients using ventilators, Bengt Klarin of University Hospital in Lund, Sweden, and colleagues found.

Ventilator-associated pneumonia is common as patients aspirate germs from the equipment — often bacteria that have formed drug-resistant mats called biofilms.

Klarin’s team tested the idea that probiotic bacteria could out-compete pathogenic bacteria. Half the patients were swabbed with chlorhexidine as usual, and half were given a final wipe with L. plantarum 299 instead.

“We hypothesized that swabbing the mouth with probiotics would be an effective (and microbiologically attractive) method of reducing pathogenic oral microorganisms in intubated, mechanically ventilated, critically ill patients,” Klarin said in a statement.

Writing in the BioMed Central journal Critical Care, they noted that L. plantarum is normally found in saliva and in pickled food such as sauerkraut.

“Based on the results of this pilot study, we conclude that the probiotic bacterium Lp299 constitutes a feasible and safe agent for oral care,” they wrote in the study.

Sources: The Times Of India

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Positive Thinkers ‘Avoid Cancer’

Optimists see the world as a benevolent place.Image via Wikipedia

Women who have a positive outlook may decrease their chances of developing breast cancer, say Israeli researchers.

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The role of mental outlook in cancer is controversial
The small study, published in the BioMed Central journal, also found that getting divorced, or being bereaved could increase the risk.

But the researchers admitted that women were questioned after their diagnosis, which might significantly change their outlook on life.

UK experts said it was hard to compare different women’s emotional stresses.

The role of mental outlook on cancer remains controversial, with some studies suggesting that it might play a role.

Meanwhile, others have found no significant effect, either on the likelihood of developing the illness in the first place, or on your chances of surviving it.

The latest study looked at 255 women with breast cancer and compared their answers in a questionnaire on mental outlook and life events with 367 healthy control subjects.

They found that a generally positive outlook appeared to reduce the chance of breast cancer by a quarter.

In addition, exposure to one or more of the traumatic “life events” such as loss of a parent or a spouse increased the risk by more than 60%.

Lead researcher Dr Ronit Peled, from Ben-Gurion University, said that women who had been exposed to a number of negative events should be considered an “at-risk” group for breast cancer.

“We can carefully say that experiencing more than one severe and/or moderate life event is a risk factor for breast cancer among young women.

“On the other hand, a general feeling of happiness and optimism can play a protective role.”

“Emotional stress is highly subjective and is difficult to measure accurately” says Dr Sarah Cant, Breakthrough Breast Cancer

‘Complex disease’

But Dr Sarah Cant, from Breakthrough Breast Cancer, maintained that there was no clear evidence that positive or negative experiences could affect breast cancer risk.

“Emotional stress is highly subjective and is difficult to measure accurately.

“Women in this study were interviewed after breast cancer was diagnosed when they may be more likely to recall feeling depression and anxiety.

“The researchers also didn’t account for other factors known to affect breast cancer risk such as family history or weight.

“Breast cancer is a complex disease and there is unlikely to be one single cause.”

Sources: BBC NEWS:22nd.Aug.’08

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