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This Fat Can Actually Protect Against Hearing Loss

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Increased intakes of omega-3 fats may reduce the risk of age-related hearing loss, says a new study.

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High omega-3 intake was associated with a significant reduction in the risk of age-related hearing loss (presbycusis) in people over the age of fifty.Hearing loss is the most common sensory disorder in the U.S.

NutraIngredients reports:
“Other micronutrients have been linked to reducing the risk of age-related hearing loss. In 2007 scientists from Wageningen University reported that folic acid supplements delayed age-related hearing loss in the low frequency region …

Another study … indicated a role for beta carotene and vitamins C and E, and the mineral magnesium in preventing prevent both temporary and permanent hearing loss in guinea pigs and mice.”

Source: NutraIngredients June 11, 2010

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Herbs & Plants

Ramie

Botanical Name :Boehmeria nivea
Family : Urticaceae
Genus : Boehmeria
Kingdom: Plantae
Division: Magnoliophyta
Class: Magnoliopsida
Order: Urticales
Species: B. nivea

Synonyms : Boehmeria tenacissima – Gaud.
Common names: Chinese grass, false nettle

Habitat: E. Asia – China to the Himalayas of Bhutan, Sikkim and Nepal. Rocky places to 1200 metres. A very common plant in China, growing in thickets, roadsides, edges of forests in mountains at elevations of 200 – 1700 metres.Woodland Garden; Sunny Edge; Dappled Shade; Cultivated Beds;

Description:
It is a herbaceous perennial growing to 1–2.5 m tall; the leaves are heart-shaped, 7–15 cm long and 6–12 cm broad, and white on the underside with dense small hairs—this gives it a silvery appearance; unlike nettles, the hairs do not sting. The true ramie or China Grass also called Chinese plant or white ramie is the Chinese cultivated plant. A second type, is known as green ramie or rhea and is believed to have originated in the Malay Peninsula. This type has smaller leaves which are green on the underside, and it appears to be better suited to tropical conditions

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It is hardy to zone 7 and is frost tender. It is in flower from September to October. The flowers are monoecious (individual flowers are either male or female, but both sexes can be found on the same plant)
The plant prefers light (sandy) soils and requires well-drained soil. The plant prefers acid, neutral and basic (alkaline) soils and can grow in very acid soil. It can grow in semi-shade (light woodland) or no shade. It requires dry or moist soil.

History
Ramie has been around for so long that it was even used in mummy cloths in Egypt during the period 5000–3300 BC and has been grown in China for many centuries. In the study of the “Lazarus” mummy, three types of textiles were found. The outermost cloth was heavy and coarsely woven; the innermost was the lightest and most tightly woven. The outer cloth appeared to be ramie (which Wiseman notes “contains non-fibrous material that is toxic to bacteria and fungi”—in other words, an ideal textile for mummymaking). Farmers in ancient China are also known to have used the fiber to weave clothing.

Ramie was used to produce an open weave fabric called mechera, used for shirts and dressing gowns suitable for warm climates. The French painter Raoul Dufy designed in the early 20th century patterns for prints on mechera used by the French shirtmaker Charvet.

Brazil began production in the late 1930s with production peaking in 1971. Since then, production has steadily declined as a result of competition with alternative crops, such as soybeans and the important synthetic fibres.

Properties
Ramie is one of the strongest natural fibres. It exhibits even greater strength when wet. Ramie fibre is known especially for its ability to hold shape, reduce wrinkling, and introduce a silky lustre to the fabric appearance. It is not as durable as other fibres, and so is usually used as a blend with other fibres such as cotton or wool. It is similar to flax in absorbency, density and microscopic appearance. However it will not dye as well as cotton. Because of its high molecular crystallinity, ramie is stiff and brittle and will break if folded repeatedly in the same place; it lacks resiliency and is low in elasticity and elongation potential.

Cultivation
Requires a rich warm sandy soil that is very well drained. Intolerant of wet soils. This is a very greedy plant and can soon impoverish a soil. All plant remains, after the fibre has been removed, should be returned to the soil. Does best in areas with high temperatures and high humidity plus a rainfall of 1100cm evenly distributed throughout the year. Tolerates a pH in the range 4.3 to 7.3. This species is fairly hardy in Britain when dormant, though it may require some protection in winter (a good mulch to protect the roots should be sufficient). The young growth in spring, even on mature plants, is frost-tender and so it is best to grow the plants in a position sheltered from the early morning sun[K]. The plant has been growing for many years in a sunny well-drained bed at Cambridge Botanical Gardens (which has low humidity and low rainfall), it has made a clump over 2 metres wide though it only reaches about 1.5 metres in height. Boehmeria nivea, an extremely variable species, is widespread over large areas of subtropical and tropical Asia. Its complex species includes several infraspecific taxa, four varieties of which are found in China. The sub-species B. nivea tenacissima. (Gaud.)Miquel., which produces the fibre ‘Rhea’ is a native of Malaysia and is not hardy in Britain. Rami is much cultivated in China for its fibre, with a history of cultivation going back at least 3000 years. It is also occasionally cultivated for its fibre or as an ornamental plant in Europe. A very greedy plant, it requires a lot of feeding if it is to perform well.

Propagation
Seed – sow spring in a warm greenhouse and only just cover the seed. When they are large enough to handle, prick the seedlings out into individual pots and grow them on in the greenhouse for at least their first winter. Plant them out into their permanent positions in late spring or early summer, after the last expected frosts. Division in spring. Very easy, larger divisions can be planted straight into their permanent positions whilst smaller clumps are best potted up and kept in a cold frame until they are growing away well. Layering. Basal cuttings in late spring. Harvest the shoots when they are about 10 – 15cm long with plenty of underground stem. Pot them up into individual pots and keep them in light shade in a cold frame or greenhouse until they are rooting well. Grow them on for their first winter in the cold frame and then plant them out in the summer.

General Uses:
A fibre is obtained from the inner bark of the stem – of excellent quality, it is used for textiles, linen etc and is said to be moth-proof. Yields are from 375 to 900 kilos of fibre (per acre?). Two to four harvests per year are possible depending upon the climate, it is harvested as the stems turn brown. Best harvested as the female flowers open according to another report. The outer bark is removed and then the fibrous inner bark is taken off and boiled before being woven into thread. The fibres are the longest known in the plant realm. The tensile strength is 7 times that of silk and 8 times that of cotton, this is improved on wetting the fibre. The fibre is also used for making paper. The leaves are removed from the stems, the stems are steamed and the fibres stripped off. The fibres are cooked for 2 hours with lye, fresh material might require longer cooking, and they are then beaten in a Hollander beater before being made into paper.

Despite its strength, ramie has had limited acceptance for textile use. The fibre’s extraction and cleaning are expensive, chiefly because of the several steps—involving scraping, pounding, heating, washing, or exposure to chemicals. Some or all are needed to separate the raw fibre from the adhesive gums or resins in which it is ensheathed. Spinning the fibre is made difficult by its brittle quality and low elasticity; and weaving is complicated by the hairy surface of the yarn, resulting from lack of cohesion between the fibres. The greater utilization of ramie depends upon the development of improved processing methods.

Ramie is used to make such products as industrial sewing thread, packing materials, fishing nets, and filter cloths. It is also made into fabrics for household furnishings (upholstery, canvas) and clothing, frequently in blends with other textile fibres (for instance when used in admixture with wool, shrinkage is reported to be greatly reduced when compared with pure wool.) Shorter fibres and waste are used in paper manufacture.

For the 2010 Prius, Toyota will begin using a new range of plant-derived ecological bioplastics made from the cellulose in wood or grass instead of petroleum. One of the two principal crops used is ramie.

Ramie is also used as an ornamental plant in eastern Asia.

Producers
China leads in the production of ramie and exports mainly to Japan and Europe. Other producers include Japan, Taiwan, the Philippines, and Brazil.[7] Only a small percentage of the ramie produced is available on the international market. Japan, Germany, France and the UK are the main importers, the remaining supply is used domestically.

Edible Uses
Edible Parts: Leaves; Root.

Root – peeled and boiled. A pleasant, sweet taste. We can detect very little flavour, but the root has a very strange mucilaginous texture that does not appeal to most people who have tried it. Once in the mouth, it takes a lot of chewing before it is ready to be swallowed. The leaves are used for making cakes. This report could refer to the plants use as a poultice.

Medicinal Actions & Uses
Antiphlogistic; Astringent; Demulcent; Diuretic; Febrifuge; Haemostatic; Poultice; Resolvent; Vulnerary; Women’s complaints.

Antiphlogistic, demulcent, diuretic, febrifuge, haemostatic and vulnerary. Used to prevent miscarriages and promote the drainage of pus. The leaves are astringent and resolvent. They are used in the treatment of fluxes and wounds..The leaves are used in the treatment of fluxes and wounds. The root is used to prevent miscarriages and promote the drainage of pus. The root contains the flavonoid rutin. It is antiabortifacient, antibacterial, cooling, demulcent, diuretic, resolvent and uterosedative. It is used in the treatment of threatened abortions, colic of pregnancy, haemorrhoids, leukorrhoea, impetigo etc. The fresh root is pounded into a mush and used as a poultice.

Known Hazards : Although members of the nettle family, plants in this genus do not have stinging hairs.

Disclaimer:The information presented herein is intended for educational purposes only. Individual results may vary, and before using any supplements, it is always advisable to consult with your own health care provider.

Resources:
http://www.pfaf.org/database/plants.php?Boehmeria+nivea
http://www.calflora.org/cgi-bin/species_query.cgi?where-calrecnum=1103
http://en.wikipedia.org/wiki/Ramie
http://commons.wikimedia.org/wiki/Category:Boehmeria_nivea

http://www.herbnet.com/Herb%20Uses_RST.htm

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Herbs & Plants

Benincasa hispida

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Botanical Namne : Benincasa hispida
Family : Cucurbitaceae
Subfamily: Cucurbitoideae
Genus : Benincasa
Synonyms: Benincasa cerifera – Savi.’ Cucurbita hispida – Thunb.
Kingdom: Plantae
Division: Magnoliophyta
Class: Magnoliopsida
Order: Cucurbitales
Tribe: Benincaseae
Subtribe: Benincasinae
Vernacular Names
:    * Assamese: komora
* Bengali:  chal kumra (lit. “thatch pumpkin”)
* Burmese: kyauk pha-yon thee
* Chinese: d?nggu? (lit. “winter melon”)
* English: ash gourd, (Chinese) winter melon, fuzzy melon, green pumpkin, wax gourd, white gourd
* French: courge cireuse, courgette velue (lit. “hairy zucchini”)
* German: Wachskürbis, Wintermelone (Benincasa hispida)
* Hindi: peth?, pethakaddu
* Ilocano: tabungaw
* Indonesian: beligo, kundur
* Japanese:  t?gan ( lit. “winter melon”)
* Kannada: boodagumbala
* Kapampangan: Kundul
* Malay: kundur
* Malayalam:  kumbalanga
* Marathi:  kohja
* Portuguese: abóbora d’água (lit. “water pumpkin”), comalenge
* Sinhala: Puhul
* Taiwanese: dangguev ( lit. “winter melon”)
* Tamil: neer poosanikai
* Tagalog: kundol
* Telugu: boodida gummadikaaya
* Thai:  fak
* Tulu:karkumbuda
* Urdu:  peth?
* Vietnamese: bí ?ao
Sanskrit Name :KUSMANDA (The Sanskrit word kusmanda literally means that, fruit, which does not contain heat at all. It has various synonyms in ancient Ayurvedic scriptures,

Habitat:
Range Tropical Asia.  Cultivated Beds;

Descriptin:

It is a perennial, large trailing gourd climbing with tendrils. The leaves are large, 10-15 cm in diameter, heart-shaped, covered with rather rough bristly hair beneath. The flowers are pale yellow in color, unisexual, male peduncle 7-10 cm long and female peduncle shorter. The fruits are large, broadly cylindrical, 0.33-0.5 meter long, covered with whitish hair throughout. The plant flowers in November and later on fruiting occurs. Each plant yields nearly 50-60 fruits.

click to see the pictures.

It is hardy to zone 10 and is frost tender. It is in leaf from June to October, in flower from July to September, and the seeds ripen from August to November. The flowers are monoecious (individual flowers are either male or female, but both sexes can be found on the same plant) and are pollinated by Bees. The plant is self-fertile.
The plant prefers light (sandy), medium (loamy) and heavy (clay) soils and requires well-drained soil. The plant prefers acid, neutral and basic (alkaline) soils. It cannot grow in the shade. It requires moist soil and can tolerate drought.


Edible Uses….…..CLICK & SEE

Edible Parts: Flowers; Fruit; Leaves; Seed……..CLICK & SEE

Fruit – raw or cooked. Used as a vegetable, and in pickles, curries and preserves. The fruit can be eaten when it is young or old, it can be picked as early as one week after fertilization. A juicy texture with a mild flavour, the flavour is somewhat stronger in younger fruits. Because of its waxy coating, it will store for several months, sometimes as long as a year. Mature fruits can vary in weight from 2 – 50 kg. A nutritional analysis is available. Young leaves and flower buds are steamed and eaten as a vegetable, or are added as a flavouring to soups. Seed – cooked. Rich in oil and protein.

Composition
Figures in grams (g) or miligrams (mg) per 100g of food.

Fruit (Fresh weight)
13 Calories per 100g
Water: 96.1%
Protein: 0.4g; Fat: 0.2g; Carbohydrate: 3g; Fibre: 0.5g; Ash: 0.3g;
Minerals – Calcium: 19mg; Phosphorus: 19mg; Iron: 0.4mg; Magnesium: 0mg; Sodium: 6mg; Potassium: 111mg; Zinc: 0mg;
Vitamins – A: 0mg; Thiamine (B1): 4mg; Riboflavin (B2): 0.11mg; Niacin: 0.4mg; B6: 0mg; C: 13mg;

Medicinal   Actions &  Uses

Anthelmintic; Antiperiodic; Aphrodisiac; Cancer; Demulcent; Diuretic; Expectorant; Febrifuge; Laxative; Salve; Tonic; VD.

The wax gourd has been used as a food and medicine for thousands of years in the Orient. All parts of the fruit are used medicinally. The rind of the fruit is diuretic. It is taken internally in the treatment of urinary dysfunction, summer fevers etc. The ashes of the rind are applied to painful wounds. The seed is anthelmintic, anti-inflammatory, demulcent, diuretic, expectorant, febrifuge, laxative and tonic. A decoction is used internally in the treatment of vaginal discharges and coughs. In combination with Rheum palmatum it is used to treat intestinal abscesses. In Ayurvedic medicine the seed is used in the treatment of coughs, fevers, excessive thirst and to expel tapeworms. The oil from the seed is also used as an anthelmintic. The fruit is antiperiodic, aphrodisiac, diuretic, laxative and tonic. It is used in Ayurvedic medicine in the treatment of epilepsy, lung diseases, asthma, coughs etc. The fruit juice is used in the treatment of insanity, epilepsy and other nervous diseases. Recent research has shown that the fruits contain anti-cancer terpenes. An infusion of the root is used in the treatment of gonorrhoea. Demulcent, salve. Facilitates pus drainage.

Ayurvedic Properties & Uses

Kusmanda is sweet in taste, sweet in the post digestive effect and has cold potency. It has a special potency as a nervine tonic. It alleviates vata and pitta doshas, but aggravates the kapha dosha. The properties of its fruit changes according to stages of ripening. The tender fruits alleviate pitta dosa. Medium – riped fruits alleviate kapha dosha whereas, fully ripened fruits alleviate all the three doshas. There is an ancient Sanskrit saying- Vrntakam bahubijanam kusmandam komalam visam meaning, over mature fruit of brinjal and very tender fruit of kusmanda is like a toxin to the body . Kusmanda is a refuvenative, diuretic and aphrodisiac in properties and is used in urinary disorders, urinary calculi, general debility etc.

The fruits and seeds are used for medicinal purpose. Externally, the pulp of fruit is applied on wounds and burns to alleviate the burning sensation. The seeds mashed with water, serve the same purpose. In headache the seed oil is massaged for relief.

Internally, kusmanda is used in vast range of diseases. In thirst due to vitiated pitta, it is used with great benefit. In flatulence, it is beneficial because of its mild laxative property. The pulp of the fruit along with laxative is an effective remedy for tapeworm infestation. The seed oil facilitates the stools smoothly as well as renders styptic action, hence beneficial in bleeding piles. The fruit juice, mixed with sugar ameliorates hyperacidity. In tuberculosis with cavitation and haemoptysis, kusmanda is highly recommended, as it bestows rejuvenative, styptic and tonic properties. The root powder is given with water to alleviate the bronchospasm in asthma. The fruit juice, mixed with yastimadhu, is the best panacea for epilepsy. In hysteria, it works well with the powder of kustha, along with honey. The combination of its fruit juice, asafetida and yavaksara is extremely valuable in the treatment of urinary calculi and dysuria. Kusmanda is rewarding in cardiac debility as an adjunct. The seeds mashed with milk or the various preparations from the pulp of fruit in the form of sweetmeats, like Kusmanda paka and petha are commonly used as a general tonic, aphrodisiac, rejuvenative and also a brain tonic. Kusmanda inhibits mental instability, agitation and induces sound sleep. It nourishes the tarpaka kapha, which in turn, augments the memory and intelligence.


Other Uses

Rootstock.

A wax that coats the fruit is used to make candles. The roots have considerable resistance to soil-borne diseases and they are sometimes used as a rootstock for melons and other cucurbits.

Disclaimer:The information presented herein is intended for educational purposes only. Individual results may vary, and before using any supplements, it is always advisable to consult with your own health care provider


Resources:

http://www.pfaf.org/database/plants.php?Benincasa+hispida
http://www.herbalcureindia.com/herbs/benincasa-hispida.htm
http://commons.wikimedia.org/wiki/Category:Benincasa_hispida

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Herbs & Plants

Leptospermum Scoparium

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Botanical Name : Leptospermum scoparium
Family: Myrtaceae
Genus: Leptospermum
Kingdom: Plantae
Division: Magnoliophyta
Class: Magnoliopsida
Order: Myrtales
Species: L. scoparium
Common Name :  “Tea Tree” is also shared with the related Melaleuca tree of Australia suggesting that both were used to make tea by Captain Cook.
Other Names: Manuka or Tea tree or just Leptospermum
Habitat : Native to New Zealand and southeast Australia. It is found throughout New Zealand but is particularly common on the drier east coasts of the North Island and the South Island, and in Australia in Tasmania, Victoria and New South Wales. Manuka (from Maori ‘manuka’) is the name used in New Zealand, and ‘tea tree’ is a common name in Australia and to a lesser extent also in New Zealand. This name arose because Captain Cook used the leaves to make a ‘tea’ drink.

Description :It is a prolific scrub-type tree and is often one of the first species to regenerate on cleared land. It is typically a shrub growing to 2–5 m tall, but can grow into a moderately sized tree, up to 15 m or so in height. It is evergreen, with dense branching and small leaves 7–20 mm long and 2–6 mm broad, with a short spine tip. The flowers are white, occasionally pink, 8–15 mm (rarely up to 25 mm) diameter, with five petals.

CLICK & SEE TE PICTURES

This species is often confused with the closely related species Kanuka – the easiest way to tell the difference between the two species in the field is to feel their foliage – Manuka leaves are prickly while Kanuka leaves are soft. The wood is tough and hard, and was often used for tool handles. Manuka sawdust imparts a delicious flavour when used for smoking meats and fish.

It is hardy to zone 8 and is frost tender. It is in leaf all year, in flower from May to June. The flowers are hermaphrodite (have both male and female organs) and are pollinated by Insects.

The plant prefers light (sandy), medium (loamy) and heavy (clay) soils and requires well-drained soil. The plant prefers acid and neutral soils. It cannot grow in the shade. It requires dry or moist soil. The plant can tolerates strong winds but not maritime exposure.

.Edible Uses
Edible Parts: Manna.

Edible Uses: Tea.

The fresh, pungent leaves are a fragrant and refreshing tea substitute . Of excellent quality, in taste trials this species has often received higher marks than the traditional China tea obtained from Camellia sinensis[K]. It is important to brew the leaves for considerably longer than normal teas to ensure the flavour is released into the water[K]. A sweet manna is sometimes exuded from the stems as a result of insect damage . Another report says that manna is reported to form on the leaves .


Other Uses

Dye; Hedge; Insecticide; Roofing; Wood.

This species can be grown as a hedge in the milder areas of Britain  and is reasonably tolerant of maritime exposure. Plants should not be trimmed back into old wood, however, because they do not regenerate from such treatment. A yellow-green dye is obtained from the flowers, branches and leaves. A greenish-black dye is obtained from the flowers. Source of an insecticide (no further details). Wood – red, strong, elastic. Used for inlay work, cabinet making etc. The bark is used for roofing huts.

Scented Plants
Flowers: Crushed
The flowers, when handled, possess an aromatic fragrance.
Leaves: Crushed
The leaves, when handled, possess an aromatic fragrance.
Cultivation details
Succeed in almost any neutral or acid soil of good or reasonable quality[200], preferring a light sandy loam and full sun. Succeeds in dry soils. Prefers a position sheltered from hot or cold drying winds. We have found the plants to be fairly tolerant of maritime exposure[K]. The plant only succeeds outdoors in the milder areas of Britain. Hardy to about -10°c, succeeding outdoors in most of Southern Britain. A polymorphic species, many forms have been developed for their ornamental value. There are some dwarf varieties that grow very well in pots in cold greenhouses and conservatories. Resents root disturbance. Plants do not regenerate from old wood. The bruised leaves and the flowers are pleasantly aromatic. Plants in this genus are notably resistant to honey fungus.

Propagation:-
Seed – sow spring in a greenhouse and only just cover the seed. Prick out the seedlings into individual pots when they are large enough to handle and grow them on in the greenhouse for at least their first winter. Plant out in late spring or early summer, after the last expected frosts, and give some protection from the cold for their first winter or two outdoors. The seed remains viable for many years. Cuttings of half-ripe wood, 5 – 8 cm with a heel, early August in a frame. Over-winter in the greenhouse for its first year. Good percentage. Cuttings of almost mature wood, 4 – 5 cm with a heel, October/November in a frame. Good percentage.

Cultivars

‘Kea’
A dwarf form with small white flowers.
‘Kiwi’
A dwarf form with small red flowers

Medicinal Uses:
Manuka products have high antibacterial potency for a limited spectrum of bacteria and are widely available in New Zealand. Similar properties led the Maori to use parts of the plant as natural medicine.

Kakariki parakeets (Cyanoramphus) use the leaves and bark of Manuka and Kanuka to rid themselves of parasites. Apart from ingesting the material, they also chew it, mix it with preen gland oil and apply it to their feathers.

Manuka honey, produced when honeybees gather the nectar from its flowers, is distinctively flavoured, darker and richer in taste than clover honey and has strong antibacterial and antifungal properties. The finest quality Manuka honey with the most potent antimicrobial properties is produced from hives placed in wild, uncultivated areas with abundant growth of Manuka bushes. However a very limited number of scientific studies have been performed to verify its efficacy.

The University of Waikato in Hamilton, New Zealand has formed the Waikato Honey Research Unit to study the composition of honey and its antimicrobial activity. The Active Manuka Honey Association (AMHA) is the industry association that promotes and standardizes the production of Manuka honey for medical uses. They have created the Unique Manuka Factor (UMF) standard which grades honey based on its anti-bacterial strength. In January 2008 Professor Thomas Henle, University of Dresden (Germany) identified methylglyoxal as the active compound in Manuka honey. This is now shown on products as MGO Manuka honey. E.g. MGO 100 represents 100 mg of methylglyoxal per kilogram.

Disclaimer:The information presented herein is intended for educational purposes only. Individual results may vary, and before using any supplements, it is always advisable to consult with your own health care provider

Resources;

http://www.pfaf.org/database/plants.php?Leptospermum+scoparium

http://en.wikipedia.org/wiki/Leptospermum_scoparium

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Better Prescription

After open source software, it is now the turn of open source drug research. If this unique process can find a new anti-TB drug, it might well become the future of drug research. G.S. Mudur reports
In the temple town of Thanjavur, Aparna Venkatachalam, a final year engineering student, has turned into a foot soldier in a fresh scientific assault on the microbe that causes tuberculosis. After combing through some 200 research papers and spending dozens of hours searching online biological databases, she has assigned functions — biological tasks — to 60 proteins found in the TB microbe. She picked up a reward for her efforts last week — an Acer Netbook.

Venkatachalam is one of a group of 120 students and researchers scattered across India, Dubai, Japan and Germany, who have put together the most detailed map constructed so far to describe the biochemistry of a living organism. The 18-month science project, spearheaded by India’s Council of Scientific and Industrial Research (CSIR), is seeking new drugs against the TB microbe in a manner never attempted before.

“When you want to destroy an enemy, it’s good to identify vulnerabilities,” said Samir Brahmachari, director general of the CSIR. “This map will provide us unprecedented insights into the biochemistry of the TB micro-organism.”

The search for new drugs against TB is the first project of the CSIR’s Open Source Drug Discovery (OSDD) programme, a Rs 150 crore effort to solve complex problems by breaking them into smaller “work packets” open to virtually anyone across the scientific community to solve. The challenges are posed on the OSDD website, and researchers wishing to try and tackle them need only to register and join the effort.

An international consortium of scientists had sequenced the genome of the microbe Mycobacterium TB [MTB] nearly 12 years ago. And over the past decade, scientists have identified 3,998 genes, and assigned biological functions to all but nine of them.

The OSDD effort has now generated a map that places about 3,700 MTB genes and their protein products into a network of biochemical pathways. The network, a web of biochemical reactions, shows how these genes and proteins allow MTB to carry out its myriad life-cycle activities — from invading human cells to evading the human immune system to routine housekeeping.

“It’s a very big and a very complex circuit,” said Hiraoki Kitanu, director of the Systems Biology Institute in Japan, who leads a research team that has contributed significantly to the development of a computer-readable format to display models of biological processes, and who has joined the OSDD effort. “This is a new approach for drug discovery,” Kitanu said.

Scientists believe MTB is an appropriate organism to pit innovative ideas against. This killer microbe claims about 1,000 lives across India each day. The four best anti-TB drugs that make up the first line of therapy were developed in the 1950s and 1960s. Secondary drugs are toxic and expensive. There are now drug-resistant versions of MTB, which pose a new challenge. While clinical trials are under way, a new drug is not expected to be ready for use until 2012.

All previous efforts at finding drugs to fight MTB involved a laborious trial-and-error method in which researchers exposed the organism to compounds and picked the ones that appeared most effective in killing bacteria or suppressing their growth. Researchers believe that the map of biochemical pathways will now allow them to choose specific regions of the pathway as targets for future drugs. “Instead of shooting in the dark, we’ll be searching for targets in a rational way,” said Anshu Bharadwaj, a scientist at the Institute of Genomics and Integrative Biology, New Delhi, who, among other roles, also assigns work packets to OSDD researchers.

Some 800 researchers — most of them students — joined the effort, but only some 120 who succeeded in assigning functions to at least 40 genes — Venkatachalam among them — were picked to receive the reward. One of them was a homemaker from Dubai who had used her skills in bioinformatics to help build the pathways map. All those who won a reward, however, did not attend the meeting in Delhi — a software engineer from Germany told the OSDD that he doesn’t travel as he is wheelchair bound.

Venkatachalam, a bioinformatics student at SASTRA University in Thanjavur, and her colleague Ahalyaa Subramanian scanned published scientific literature to tell the stories of 60 MTB genes. In all, Brahmachari estimates, the consortium of researchers scanned at least 12,000 research papers on TB and compiled the information in a standardised format to build the map.

Some biologists caution people not to expect a new drug too soon. “I’m very optimistic this is going to have an impact,” said Richard Jefferson, a molecular biologist based in Australia and chief executive officer of Cambia, a non-profit institute seeking to promote innovation. “But it’s important we do not expect too much too soon. It’s going to be a long fight,” Jefferson said at the OSDD meeting last week.

In the drug discovery process, scientists will have to look for “vulnerabilities” in MTB pathways that can be exploited to design a new drug. Researchers say that one of the biggest challenges will be to find compounds that act exclusively on MTB. “We’ll need to find a vulnerability exclusive to MTB that leaves the human system alone,” said Bharadwaj.

Brahmachari himself has ventured to suggest that the effort could lead to a new candidate drug ready for clinical trials within two years. If that happens, said Brahmachari, the OSDD will invite five drug companies to invest four per cent of drug development costs, while the CSIR will provide the remainder 80 per cent. Each company would then get an opportunity to produce inexpensive generic versions of the drug.

If the OSDD does indeed deliver a new and effective drug for TB, it might trigger a paradigm change in drug research.

Source: The Telegraph (Kolkata, India)

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