Categories
Diagnonistic Test

Pelvic Ultrasound and Transvaginal Ultrasound

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Alternative  Names:Endovaginal ultrasound; Ultrasound – transvaginal; Sonohysterography; Hysterosonography; Saline infusion sonography; SIS
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Definition:
Ultrasound uses sound waves instead of radiation to generate snapshots or moving pictures of structures inside the body. This imaging technique works in a manner similar to radar and sonar, developed in World War II to detect airplanes, missiles, and submarines that were otherwise invisible. After coating your skin with a lubricant to reduce friction, a radiologist or ultrasound technician places an ultrasound transducer, which looks like a microphone, on your skin and may rub it back and forth to get the right view. The transducer sends sound waves into your body and picks up the echoes of the sound waves as they bounce off internal organs and tissue. A computer transforms these echoes into an image that is displayed on a monitor.

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Pelvic organ ultrasound is used to monitor pregnancy, find cysts on your ovaries, examine the lining of your uterus, look for causes of infertility, and find cancers or benign tumors in the pelvic region. Depending on the view needed, the ultrasound sensor is placed either on your abdomen (pelvic ultrasound) or in your vagina (transvaginal ultrasound).

Pelvic ultrasound, primarily performed on females is most frequently used for evaluation of pelvic pain, abnormal vaginal bleeding, inflammatory disease, or detection of a mass. Pelvic ultrasound may help explain findings from a manual examination and provide additional information. Pelvic ultrasound examination will generally result in good depiction of the bladder, uterus, and ovaries.

In some patients, transvaginal ultrasound, which involves the insertion of a small transducer (probe) into the vagina, may be necessary to provide a complete analysis of the ovaries and uterine endometrial lining. Early pregnancy or body habitus (obesity) can obscure adequate evaluation of some structures. The decision to use transvaginal ultrasound is determined by the radiologist following pelvic ultrasound.

Pelvic ultrasound generally requires a full bladder and is performed with the patient lying flat on a padded table. Transvaginal ultrasound testing requires the patient to empty their bladder in the restroom and return to the scanning room for a transvaginal examination. Patients are asked disrobe from the waist down with hips elevated by folded towels or a foam pad. Patients usually insert the probe themselves, but can be assisted.

How to prepare for the test.
You will be asked to undress, usually from the waist down.
Your doctor might ask you to drink a few glasses of water before the test because a full bladder lifts your intestines out of the way and provides a clearer view of your pelvic organs. If you’re having a transvaginal ultrasound and have a tampon in place, you’ll need to remove it before the test.

A full bladder is essential for adequate visualization of the pelvic region.

* Finish drinking 4 glasses (32 ounces total) of water one hour prior to your appointment. It is important to drink water only. Do not substitute other beverages.

* Do not empty your bladder prior to the exam.

* Eat as you normally would before and after the examination and return to your usual or recommended activities after the exam.

To avoid delay or rescheduling of your pelvic / transvaginal ultrasound examination, follow preparation instructions carefully.

* Arrive 15 minutes prior to your scheduled appointment time to register for your test.

* The length of time needed to complete this examination will vary depending on the information needed. Plan for up to 45 minutes to complete your exam.

How the Test is Performed
You will lie down on a table with your knees bent and feet in holders called stirrups. The health care provider will place a probe, called a transducer, into the vagina. The probe is covered with a condom and a gel. The probe sends out sound waves, which reflect off body structures. A computer receives these waves and uses them to create a picture. The doctor can immediately see the picture on a nearby TV monitor.

The health care provider will move the probe within the area to see the pelvic organs. This test can be used during pregnancy.

In some cases, a special transvaginal ultrasound method called saline infusion sonography (SIS), also called sonohysterography or hysterosonography, may be needed to more clearly view the uterus.

This test requires saline (sterile salt water) to be placed into the uterus before the ultrasound. The saline helps outline any abnormal masses, so the doctor can get a better idea of their size.

SIS is not done on pregnant women.

What happens when the test is performed.

You lie on your back on a table for the test. For a pelvic ultrasound, after squirting some clear jelly onto your lower abdomen to help the ultrasound sensor slide around easily, a doctor or technician places the sensor against your skin. For a transvaginal ultrasound, the doctor or technician covers a sensor with a condom and some jelly before inserting it into your vagina.When the sensor is in place, a picture will appear on a video screen. The technician or doctor moves the sensor on your abdomen or in your vagina to see the uterus and ovaries from many different views.

How the Test Will Feel
The test is usually painless, although some women may have mild discomfort from the pressure of the probe. Only a small part of the probe is placed into the vagina.

Risk Factors:
There are no known harmful effects of transvaginal ultrasound on humans.

Unlike traditional x-rays, there is no radiation exposure with this test.

How long is it before the result of the test is known.

If a doctor does the test, you might be able to get preliminary results immediately; this will not be possible if a technician performs the test.Whether a doctor or technician performs the test, he or she records it on a videotape so that it can be formally reviewed by a radiologist. Your doctor should receive the radiologist’s report in a day or two.

Results:
Normal Results

The pelvic structures or fetus are normal.

What Abnormal Results Mean

An abnormal result may be due to many conditions. Some problems that may be seen include:

* Cancers of the uterus, ovaries, vagina, and other pelvic structures
* Non-cancerous growths of the uterus and ovaries (such as cysts or fibroids)
* Twisting of the ovaries
* Infection, including pelvic inflammatory disease
* Birth defects

Some problems that may be found specifically in pregnant women include:

* Ectopic pregnancy
* More than one fetus (twins, triplets, etc.)
* Miscarriage
* Placenta previa
* Placental abruption
* Tumors of pregnancy including gestational trophoblastic disease

Resources:
https://www.health.harvard.edu/fhg/diagnostics/pelvic-ultrasound-and-transvaginal-ultrasound.shtml
http://www.tacomarad.com/exams/ultrasound/pelvic.html
http://www.nlm.nih.gov/medlineplus/ency/article/003779.htm

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News on Health & Science

Oxidative Stress Extends Lifespan

Scientists at the University of California, San Diego claim to have identified a mechanism of oxidative stress that prevents cellular  damage.

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“We may drink pomegranate juice to protect our bodies from so-called ‘free radicals‘ or look at restricting calorie intake to extend our lifespan,” said Dr Trey Ideker, chief of the Division of Genetics in the Department of Medicine at UC San Diego’s School of Medicine and professor of bioengineering at the Jacobs School of Engineering.

“But our study suggests why humans may actually be able to prolong the aging process by regularly exposing our bodies to minimal amounts of oxidants,” Ideker added.

Reactive oxygen species (ROS), ions that form as a natural byproduct of the metabolism of oxygen, play important roles in cell signalling. However, due to environmental stress like ultraviolet radiation or heat or chemical exposure the ROS levels can increase dramatically, resulting insignificant damage to cellular damage to DNA, RNA and proteins, cumulating in an effect called oxidative stress.

The scientists claim to have discovered the gene responsible for this effect.

One major contributor to oxidative stress is hydrogen peroxide. While the cell has ways to help minimize the damaging effects of hydrogen peroxide by converting it to oxygen and water, this conversion isn’t 100 percent successful.

During the study, the researchers designed a way to identify genes involved in adaptation to hydrogen peroxide.

To figure out which genes might control this adaptation mechanism, the team ran a series of experiments in which cells were forced to adapt while each gene in the genome was removed, one by one, covering a total of nearly 5,000 genes.

They identified a novel factor called Mga2, which is essential for adaptation.

“This was a surprise, because Mga2 is found at the control point of a completely different pathway than those which respond to acute exposure of oxidative agents,” said Ideker.

“This second pathway is only active at lower doses of oxidation,” Ideker added.

“It may be that adaptation to oxidative stress is the main factor responsible for the lifespan-expanding effects of caloric restriction,” said Ideker.

“Our next step is to figure out how Mga2 works to create a separate pathway, to discover the upstream mechanism that senses low doses of oxidation and triggers a protective mechanism downstream.”

Click to see : Extend Your Life By Eating Right

Sources: :The study is published in PLoS Genetics.

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Categories
Diagnonistic Test

Enhanced Alpha Fetoprotein Test (“Triple Screen”)

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Definition:This is a  blood test that measures the levels of alpha-fetoprotein (AFP), a protein released by the fetal liver and found in the mother’s blood. AFP is sometimes called MSAFP (maternal serum AFP )  This blood test for pregnant women, also called a “triple screen,” checks the levels of protein and hormones being produced by the fetus. The levels of three different substances together can enable doctors to identify pregnancies that are at a higher risk for birth defects such as Down syndrome or neural tube defects (brain and spinal cord problems). If the blood test suggests problems, your doctor might recommend additional tests, such as amniocentesis or fetal ultrasound, to confirm the findings.
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The alpha-fetoprotein (AFP) test is available to women between their 15th and 20th week of pregnancy to screen for fetal abnormalities. This simple blood test measures the level of a protein called alpha-fetoprotein which is secreted by the liver of the fetus and enters the mother’s blood stream. Elevated levels of AFP may indicate an increased risk of neural tube defects such as spina bifida or anencephaly, while low levels suggest Down Syndrome or other chromosomal defects.

The AFP test does not determine the existence of these genetic disorders; it only predicts their likelihood. And while the AFP test is most often used to screen for these defects, it can also be used to identify abdominal wall defects, some renal and urinary tract abnormalities, Turner syndrome, low birth weight, and placental complications. An incorrectly-calculated gestational age and multiple fetuses can also cause abnormal AFP levels.


How do you prepare for the test?

* Before having this test done, you need to think carefully about what you would do with the results once you have them. The results of this blood test cannot show for sure whether you have either a healthy fetus or one with a problem; it can only suggest which patients might want to go ahead with further testing. Because amniocentesis (the test that is usually recommended after an abnormal triple screen) has a small risk of miscarriage, and because most people with an abnormal triple screen decide to go ahead with amniocentesis, this is an important decision. You should have this test done only if you think the information it offers would help you to make decisions about your pregnancy.

What happens when the test is performed?

* Your blood is drawn for this test sometime between your 15th and 20th weeks of pregnancy. The blood is tested for three protein and hormone levels: maternal serum alpha fetoprotein (MSAFP), unconjugated estriol (uE3), and human chorionic gonadotropin (hCG). Your doctor needs to weigh you on the day you have your blood drawn and ask when your last period began or what your expected due date is. The analysis of the results will take into account your weight and stage of pregnancy to determine whether the levels are normal.

What risks are there from the test?

* There are no risks from this test itself, but there are some risks from tests that might be recommended if the test result comes back abnormal (see-> “Amniocentesis,” ). This test can be stressful for expectant parents. Several things can cause the test to come back as abnormal even when there are no real health problems. Confusing results can happen, for example, in twin pregnancies and when mistakes have been made in estimating the age of the pregnancy.

How long is it before the result of the test is known?
The test results are available to your doctor within two or three days.

For more information You may click to see:->

Health informations for pregnant women:
Pregnancy & Childbirth :
Integrated test during pregnancy:
Common Tests During Pregnancy:
Glossary:  From “abdomen” to “zygote,” here’s your guide to pregnancy terminology.
:
High-Risk Pregnancy :
Healthy & Safe Pregnancy
:

Resources:

https://www.health.harvard.edu/fhg/diagnostics/AFP/AFP.shtml?Submit=Know+More+About+This+Test%3F
http://www.parentingweekly.com/pregnancy/pregnancy_information/afp_test.htm

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