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News on Health & Science

New Way to ‘Stop’ Premature Birth

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A drug used to treat cancer can stop contractions and may prevent premature labour, researchers say.
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The Newcastle University team tested the drug Trichostatin A on tissue taken from 36 women undergoing a caesarean.

The researchers said the therapy worked by increasing the levels of a protein that controls muscle relaxation.

One expert said with rates of premature births rising – there are 50,000 a year in the UK – a new treatment was badly needed.

Preterm labour and birth continue to be the single biggest cause of death in infants in the developed world and around 1,500 babies die in the UK every year.

A number of drugs are used to try to stop early labour, but most have serious side effects.

Trichostatin A (TSA) is known to promote the death of cancer cells.

The researchers got permission to take samples of the muscles of women undergoing caesarean sections at the Royal Victoria Infirmary in Newcastle, the Cellular and Molecular Medicine journal reported.

Contractions
They exposed the muscle to TSA and measured the effects on both spontaneous contractions and those induced by the labour drug, oxytocin.

They found an average 46% reduction in contractions for the spontaneously contracting tissue and an average 54% reduction in the oxytocin induced contractions.

It has been previously shown that a protein kinase A (PKA) is involved in controlling the relaxation of the uterus during pregnancy.

The researchers showed that TSA increased the levels of a protein sub-unit of PKA.

Professor Nick Europe-Finner, who led the research, said: “We will not give this drug to a patient because it can damage as many as 10% of the genes in a cell.

“But it does show us that other more specific agents that act on the same enzymes but only one at a time are worth investigating.”

New treatment
Dr Yolande Harley, deputy director of research at Action Medical Research which funded the study, said: “This project has uncovered some of the molecular pathways that regulate uterine contractions and so could be linked to premature birth.

“It could have a role in preventing premature birth – finding a new treatment for early labour would be a major step forward.”

Professor Jane Norman, a spokeswoman for the Royal College of Obstetrics and Gynaecology (RCOG), said: “At the moment, it’s not possible to treat preterm labour effectively. We only have drugs that delay it by 24 hours or so – not enough to deliver the baby safely.

“One of the interesting things about this research is that they are using a new kind of drug – the drugs we are currently using have been around for a long time.

“And they are targeting pathways we have not known about before.

“When you consider that preterm birth rates are rising in all four countries of the UK a new more effective drug is badly needed.”

Source:BBC News:Oct.22 ’09

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Pediatric

Feeders May Affect Your Baby’s Health

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Giving a bottle of milk to a baby in the cot is an easy way for working mothers to put their child to sleep and complete their official  and household chores.
However, the next time you plan to purchase a feeder for your baby, think twice as it may cause your child an infection.

Dr Daljeet Singh, principal and paediatrician at Dayanand Medical College and Hospital (DMCH), said, “There is no need to give feeders or sippers to infants as they are the main carriers of infections. Breast feeding is important for a child till six months. A child should be fed semi-solid foods after that.”

He advised the use of wider mediums like a saucer, glass and cup etc for feeding as there was less scope for infection to be transmitted.

“Feeders have narrow space and sometimes they are not sterilized properly. This may lead to infections. It is best to use a spoon and saucer to keep infections at bay,” he added.

Dr Ashwani Singal, consultant and neonatologist at Apollo Hospital said, “There is no need to use feeders and I tell my patients to avoid using it. A child must be breast-fed for at least six months.”
He said it had been observed that those children who used feeders had 20 times higher risk of getting diarrohea, pneumonia, ear infections and allergies.

He said, “Working mothers can store their breast milk for up to 24 hours in the refrigerator. This can be given to the child with a spoon and saucer.”

Talking on similar lines, Dr Rajinder Gulati, president of the Indian Academy of Paediatricians, Punjab, said, “Infants must be breast-fed for up to 6 months or one year.”

Discussing the issue, Gauri Sharma, a mother said, “My son was prone to carry infections. He used to suffer from diarrhoea every three months. Things have become better after I stopped feeding him through bottles.”

Source:   The Times Of India

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News on Health & Science

Breastfeeding Cuts Mums’ Heart Attack, Stroke risk

It is known that breastfeeding is important for babies’ health. But now, a new study has shown that nursing is equally vital for  mothers’ health.

University of Pittsburgh researchers said that the longer women breastfed, the lower their risk of heart attacks, strokes and cardiovascular disease.

Heart disease is the leading cause of death for women, so it’s vitally important for us to know what we can do to protect ourselves. We have known for years that breastfeeding is important for babies’ health; we now know that it is important for mothers’ health as well,” said Eleanor Bimla Schwarz, M.D., M.S., assistant professor of medicine, epidemiology, and obstetrics, gynaecology and reproductive sciences at the University of Pittsburgh.

According to the study, postmenopausal women who breastfed for at least one month had lower rates of diabetes, high blood pressure and high cholesterol, all known to cause heart disease.

Women who had breastfed their babies for more than a year were 10 percent less likely to have had a heart attack, stroke, or developed heart disease than women who had never breastfed.

Dr Schwarz and colleagues found that the benefits from breastfeeding were long-term and an average of 35 years had passed since women enrolled in the study had last breastfed an infant.

“The longer a mother nurses her baby, the better for both of them. Our study provides another good reason for workplace policies to encourage women to breastfeed their infants,” Schwarz said.

The findings are based on 139,681 postmenopausal women enrolled in the Women’s Health Initiative study of chronic disease, initiated in 1994.

The study is published in the May issue of Obstetrics & Gynaecology.

Sources:The Times Of India

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Healthy Tips

Chat Reduces Post-Natal Depression

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An intimate chat with a peer cuts down the chances of postnatal depression by half among high risk women, a new study has shown.
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Cindy-Lee Dennis, associate professor at the Lawrence S. Bloomberg Faculty of Nursing, examined the effectiveness of phone-based peer support to prevent postnatal depression among high risk women.

After web-based screening of more than 21,000 women from seven health regions in Ontario, 701 high risk mothers were recruited and randomised to receive standard postnatal care or standard care and the support of a peer volunteer (who had experienced postnatal depression themselves).

Mothers who received peer support had half the risk of developing postnatal depression at 12 weeks after birth compared to those in the control group.

Mothers were receptive to receiving telephone-based peer support and more than 80 percent said they were satisfied with their experience and would recommend this support to a friend.

In an accompanying write-up, Dennis said: “Women and family members need to be educated about postnatal depression so they can recognise the symptoms.”

“Treatment needs to be convenient and accessible to new mothers.” Although antidepressants are effective, many women are reluctant to take medication, especially when breast feeding, said a Bloomberg release.

She called for a coordinated multidisciplinary approach to identify postnatal depression involving all health professionals who come into contact with new mothers including midwives, doctors, nurses and health visitors.

Sources: These finding were published in the British Medical Journal Online.

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Diagnonistic Test

Upper Endoscopy

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Upper endoscopy enables the physician to look inside the esophagus, stomach, and duodenum (first part of the small intestine). The procedure might be used to discover the reason for swallowing difficulties, nausea, vomiting, reflux, bleeding, indigestion, abdominal pain, or chest pain. Upper endoscopy is also called EGD, which stands for esophagogastroduodenoscopy (eh-SAH-fuh-goh-GAS-troh-doo-AH-duh-NAH-skuh-pee).

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For the procedure you will swallow a thin, flexible, lighted tube called an endoscope (EN-doh-skope). Right before the procedure the physician will spray your throat with a numbing agent that may help prevent gagging. You may also receive pain medicine and a sedative to help you relax during the exam. The endoscope transmits an image of the inside of the esophagus, stomach, and duodenum, so the physician can carefully examine the lining of these organs. The scope also blows air into the stomach; this expands the folds of tissue and makes it easier for the physician to examine the stomach.

The physician can see abnormalities, like inflammation or bleeding, through the endoscope that don’t show up well on x rays. The physician can also insert instruments into the scope to treat bleeding abnormalities or remove samples of tissue (biopsy) for further tests.

Possible complications of upper endoscopy include bleeding and puncture of the stomach lining. However, such complications are rare. Most people will probably have nothing more than a mild sore throat after the procedure.

The procedure takes 20 to 30 minutes. Because you will be sedated, you will need to rest at the endoscopy facility for 1 to 2 hours until the medication wears off.

Preparation
Your stomach and duodenum must be empty for the procedure to be thorough and safe, so you will not be able to eat or drink anything for at least 6 hours beforehand. Also, you must arrange for someone to take you home—you will not be allowed to drive because of the sedatives. Your physician may give you other special instructions.

For More Information
American Gastroenterological Association (AGA)
National Office
4930 Del Ray Avenue
Bethesda, MD 20814
Phone: 301–654–2055
Fax: 301–654–5920
Email: info@gastro.org
Internet: www.gastro.org

National Digestive Diseases Information Clearinghouse
2 Information Way
Bethesda, MD 20892–3570
Phone: 1–800–891–5389
TTY: 1–866–569–1162
Fax: 703–738–4929
Email: nddic@info.niddk.nih.gov
Internet: www.digestive.niddk.nih.gov

The National Digestive Diseases Information Clearinghouse (NDDIC) is a service of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The NIDDK is part of the National Institutes of Health of the U.S. Department of Health and Human Services. Established in 1980, the Clearinghouse provides information about digestive diseases to people with digestive disorders and to their families, health care professionals, and the public. The NDDIC answers inquiries, develops and distributes publications, and works closely with professional and patient organizations and Government agencies to coordinate resources about digestive diseases.

Sources: http://digestive.niddk.nih.gov/ddiseases/pubs/upperendoscopy/index.htm

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