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News on Health & Science

‘Good Cholesterol’ Might Not be Good

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Is ‘good cholesterol’ really good for you; not so, suggests a new study.

University of Chicago (U-C) researchers challenged popular notion that simply having high levels of good cholesterol (HDL) and low levels of bad cholesterol (LDL) is necessary for good heath.

Instead, they show that the good cholesterol has varying degrees of quality and that poor quality HDL is actually bad for you.

Cholesterol is a waxy, fat-like substance used by the body to maintain the proper function of cell membranes and is encapsulated within two types of proteins as it travels in the body – low density lipoproteins (LDL) and high-density lipoproteins (HDL).

High levels of LDL or total cholesterol are an indicator of increased risk for heart disease. High blood cholesterol elicits no physical symptoms, making medical screenings necessary for detection.

“For many years, HDL has been viewed as good cholesterol and has generated a false perception that the more HDL in the blood, the better,” said Angelo Scanu, pioneer in blood lipid chemistry from U-C and co-author of the study.

“It is now apparent that subjects with high HDL are not necessarily protected from heart problems and should ask their doctor to find out whether their HDL is good or bad,” he added.

The researchers came to this conclusion after reviewing published research on this subject. They found that the HDL from people with chronic diseases like rheumatoid arthritis, kidney disease, and diabetes is different from the HDL in healthy individuals, even when blood levels of HDL are comparable.

They observed that normal, ‘good’ HDL reduces inflammation, while the dysfunctional, ‘bad’ HDL does not, according to an U-C release.

“This is yet one more line of research that explains why some people can have perfect cholesterol levels, but still develop cardiovascular disease,” said Gerald Weissmann, editor-in-chief of The FASEB Journal, which published the study in its December edition.

“Just as the discovery of good and bad cholesterol rewrote the book on cholesterol management, the realisation that some of the ‘good cholesterol’ is actually bad will do the same,” he added.

US Centres for Disease Control and Prevention said approximately 17% of all American adults have high total cholesterol, putting them at risk for heart disease.

Sources:-The Times Of India

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Ailmemts & Remedies

Muscle Pain

Alternative Name:Muscle pain; Myalgia; Pain – muscles

Definition:
Muscle aches and pains are common and can involve more than one muscle. Muscle pain also can involve ligaments, tendons, and fascia, the soft tissues that connect muscles, bones, and organs.

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Muscle pain is a symptom of many diseases and disorders. The most common causes are overuse or over-stretching of a muscle or group of muscles. Myalgia without a traumatic history is often due to viral infections. Longer-term myalgias may be indicative of a metabolic myopathy, some nutritional deficiencies or chronic fatigue syndrome.

Muscle cramps
Joint pain

Considerations:
Muscle pain is most frequently related to tension, overuse, or muscle injury from exercise or physically-demanding work. In these situations, the pain tends to involve specific muscles and starts during or just after the activity. It is usually obvious which activity is causing the pain.

Muscle pain also can be a sign of conditions affecting your whole body, like some infections (including the flu) and disorders that affect connective tissues throughout the body (such as lupus).

One common cause of muscle aches and pain is fibromyalgia, a condition that includes tenderness in your muscles and surrounding soft tissue, sleep difficulties, fatigue, and headaches.

Causes:
The most common causes of myalgia are overuse, injury or stress. However, myalgia can also be caused by diseases, disorders, medications, as a response to vaccination and withdrawal syndromes. It is also a sign of acute rejection after heart transplant surgery.

The most common causes are:
*Injury or trauma including sprains and strains

*Overuse: using a muscle too much, too soon, too often

*Tension or stress

*Muscle pain may also be due to:

Certain drugs, including:
*ACE inhibitors for lowering blood pressure

*Cocaine

*Statins for lowering cholesterol

*Dermatomyositis

*Electrolyte imbalances like too little potassium or calcium

*Fibromyalgia

*Infections, including:

*Influenza (the flu)

*Lyme disease

*Malaria

*Muscle abscess

*Polio

*Rocky Mountain spotted fever

*Trichinosis (roundworm)

*Lupus

*Polymyalgia rheumatica

*Polymyositis

*Rhabdomyolysis

Overuse
Overuse of a muscle is using it too much, too soon and/or too often. Examples are:Repetitive strain injury.

Injury
The most common causes of myalgia by injury are: sprains and strain (injury).

Muscle pain due to Diseases/Disorders

Infectious
Acute Endocarditis, African Tick Bite Fever, Bronchitis, Chikungunya, Common cold, Community-acquired pneumonia, Coccidioidomycosis, Dengue fever, Endemic typhus, HIV, Infectious mononucleosis, Influenza, Legionellosis, Leptospirosis, Lyme disease, Malaria, Marburg virus, Meningitis, Monkeypox, Pharyngitis, Pneumonia, Prostatitis, Psittacosis, Q fever, Rabies, Rift Valley fever, Ross River Fever, Severe Acute Respiratory Syndrome (SARS), Toxic shock syndrome, Trichinosis, Typhoid fever, Upper respiratory tract infection, Viral pneumonia, West Nile virus.

Autoimmune
Multiple sclerosis, Myositis, Lupus erythematosus, Familial Mediterranean fever, Polyarteritis nodosa, Devic’s disease, Morphea

Metabolic defect
Carnitine palmitoyltransferase II deficiency, Conn’s syndrome, Adrenal insufficiency

Other
Chronic fatigue syndrome, Hypokalemia, Exercise intolerance, Mastocytosis, Peripheral neuropathy, Eosinophilia myalgia syndrome, Fibromyalgia, Barcoo Fever, Delayed onset muscle soreness

Medications
Aldara, Acrylamide, Darbepoetin, Isotretinoin, Gardasil, Procainamide, Quinupristin/dalfopristin, Spiriva, Sumatriptan, Vardenafil, Statins, Zetia, Zomig, Boniva, Pegetron, Welchol

Withdrawal Syndromes
Sudden cessation of opioids, barbiturates, benzodiazepines, or alcohol can induce myalgia.

Treatment:

Click to see:->
Astounding Treatment for Burns and Muscle Injuries

24 Home Remedies for Muscle Pain

Treatment for Pulled Muscles Ache

Muscle pain treatment

Pain Management: Myofascial Pain Syndrome (Muscle Pain)

Natural Pain Relief– Effective and Safe

Drug Free Pain Relief

Alternative treatment for muscle pain relief

Muscle Sprain Treatment through Acupunture

Use of sympathetic antagonists for treatment of chronic muscle pain

Home Care
For muscle pain from overuse or injury, rest that body part and take acetaminophen or ibuprofen. Apply ice for the first 24 – 72 hours of an injury to reduce pain and inflammation. After that, heat often feels more soothing.

Muscle aches from overuse and fibromyalgia often respond well to massage. Gentle stretching exercises after a long rest period are also helpful.

Regular exercise can help restore proper muscle tone. Walking, cycling, and swimming are good aerobic activities to try. A physical therapist can teach you stretching, toning, and aerobic exercises to feel better and stay pain-free. Begin slowly and increase workouts gradually. Avoid high-impact aerobic activities and weight lifting when injured or while in pain.

Be sure to get plenty of sleep and try to reduce stress. Yoga and meditation are excellent ways to help you sleep and relax.

If home measures aren’t working, call your doctor, who will consider prescription medication, physical therapy referral, or referral to a specialized pain clinic.

If your muscle aches are due to a specific disease, follow the instructions of your doctor to treat the primary illness.

Click to see:->Muscle Pain – Causes – Symptoms – Diagnosis – Treatment – Pain Relief

When to Contact a Medical Professional:-

Call your doctor if:

*Your muscle pain persists beyond 3 days

*You have severe, unexplained pain

*You have any sign of infection, like swelling or redness around the tender muscle

*You have poor circulation in the area where you have muscles aches (for example, in your legs)

*You have a tick bite or a rash

*Your muscle pain has been associated with starting or changing doses of a medicine, such as a statin


Your doctor will perform a physical examination and ask questions about your muscle pain, such as:

*When did it start? How long did it last?
*Where is it exactly? Is it all over or only in a specific area?
*Is it always in the same location?
*What makes it better or worse?
*Do other symptoms occur at the same time, like joint pain, fever, vomiting, weakness, malaise, or difficulty*

*using the affected muscle?
*Is there a pattern to the muscle aches?
*Have you taken any new medications lately?
*Tests that may be done include:

*Complete blood count (CBC)
*Other blood tests to look at muscle enzymes (creatine kinase) and possibly a test for Lyme disease or a *connective tissue disorder
*Physical therapy may be helpful.

Prevention
*Warm up before exercising and cool down afterward.
*Stretch before and after exercising.
*Drink lots of fluids before, during, and after exercise.
*If you work in the same position most of the day (like sitting at a computer), stretch at least every hour.

Disclaimer: This information is not meant to be a substitute for professional medical advise or help. It is always best to consult with a Physician about serious health concerns. This information is in no way intended to diagnose or prescribe remedies.This is purely for educational purpose.


Resources:

http://www.nlm.nih.gov/medlineplus/ency/article/003178.htm
http://en.wikipedia.org/wiki/Myalgia

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Herbal Care News on Health & Science

Olive Leaf Extract Lowers Blood Pressure

Taken by Nick Fraser in 2005. The fruit of an ...
Image via Wikipedia

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The leaves of the olive tree have been used for medicinal purposes since ancient times, and research has suggested that olive leaf extracts have antibacterial, anti-inflammatory and antioxidant properties. Now it also appears that a supplement containing olive leaf extract could help lower blood pressure and cholesterol.

A study looked at 20 sets of identical twins with “borderline” hypertension — blood pressure that is above the optimal level of 120/80, but below the cutoff of 140/90 used to diagnose high blood pressure. One member of each twin pair was given tablets containing olive leaf extract, while the other received no supplements but did get lifestyle advice on lowering blood pressure.

After eight weeks, supplement users taking 1,000 mg of olive leaf extract per day showed a substantial dip in their blood pressure overall, and lowered levels of LDL or “bad” cholesterol. The twins who received no supplements showed no significant change in their blood pressure and a smaller improvement in cholesterol.

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Suppliments our body needs

Policosanol

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Other names: Octacosanol, 1-Octacosanol, N-Octacosanol, Octacosyl Alcohol

Definition:
Policosanol (or polycosanol) is the generic term for a natural extract of plant waxes. It is used as a nutritional supplement to lower (bad) LDL cholesterol and increase (good) HDL cholesterol and to help prevent atherosclerosis. Independent clinical trials have failed to prove its efficacy.

Physical properties
Policosanol is a mixture of a few fatty alcohols derived from the waxes of such plants as sugar cane and yams, as well as beeswax. The most prevalent alcohol in policosanol is octacosanol, followed by triacontanol.(Formula CH3-(CH2)n-CH2OH n=24-34 )

There is a much lower concentration of several other fatty alcohols: behenyl alcohol, lignoceryl alcohol, ceryl alcohol, 1-heptacosanol, 1-nonacosanol, 1-dotriacontanol, and geddyl alcohol.

Policosanol is marketed by Cuba as a natural way to treat high cholesterol levels.

Modulation of HMG-CoA reductase and bile acid absorption inhibition have been proposed as mechanisms.

Policosanol, a dietary supplement, is a mixture of alcohols isolated from Cuban sugarcane wax. It contains about 60% octacosanol.

Because patent issue and the US trade embargo against Cuba, sugarcane policosanol is not widely available in the United States. Instead, policosanol products sold in the US are generally derived from beeswax and wheat germ.

Studies
Published studies have come to conflicting conclusions regarding the efficacy of policosanol in lowering LDL (i.e., “bad cholesterol”) or raising HDL (i.e., “good cholesterol”). Despite a number of studies funded by the Cuban government (which also produces and markets the drug), no independent clinical trials have found any evidence of the efficacy of Policosanol.

Evidence for Policosanol
Policosanol has been touted as a dietary supplement that can lower cholesterol as well as statin drugs, without the side effects. Studies indicate that it works by inhibiting cholesterol formation in the liver.

However, almost all of the 80+ double-blind studies on sugarcane policosanol were conducted by a single research group in Cuba that owns the policosanol patent.

An independent study published in the Journal of the American Medical Association in 2006 did not find any benefit of policosanol, even at high doses, on cholesterol profile. This finding has casted some doubt on the reliability of the Cuban research on policosanol.

Dosage Information
A typical dosage of policosanol used in studies has been 5 to 10 mg two times a day. Studies generally found that it can take up to two months to notice benefits.

Side Effects of Policosanol
Although the reliability of the Cuban studies has been questioned, side effects of policosanol reported in the trials have generally been mild and short-term. They have included indigestion, skin rash, headache, insomnia, and weight loss.

Possible Drug Interactions
Policosanol may increase the effect of medications that interfere with blood clotting or anti-platelet drugs, such as aspirin, warfarin (Coumadin), heparin, clopidogrel (Plavix), ticlopidine (Ticlid), or pentoxifylline (Trental), or supplements such as garlic, ginkgo, or high-dose vitamin E.

Policosanol may increase the effects and side effects of levodopa, a medication used for Parkinson’s disease.

Production
Policosanol (PPG) is produced, promoted and studied extensively in Cuba, where pharmaceutical research and sugar cane farms both exist in abundance. The supplement is used as a panacea by some Cubans.

Resources:
http://en.wikipedia.org/wiki/Policosanol
http://altmedicine.about.com/od/policosanol/a/policosanol.htm

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News on Health & Science

Linseed Food to Keep Cancer at Bay

Illustration of flaxImage via Wikipedia

Linseed is believed to protect against cancer, but the taste is a real turn-off for most people.

Researchers have now isolated the valuable components of linseed (flax seeds), which when mixed with bread, cakes or dressings, don’t leave an unpleasant aftertaste

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Cakes that can ward off cancer or noodles that lower the cholesterol level could soon be a reality. Scientists at the Fraunhofer Institute for Process Engineering and Packaging IVV in Freising (Germany) have isolated valuable components of linseed and lupin seeds.

They have experimentally incorporated them in various foodstuffs: the linseed in cakes, bread, dressings and sauces, the lupins in bread, rolls and pasta. The result is not only delicious, but healthy as well.

“Flax is not only high in soluble fibre, but also contains lignans. These substances are phytoestrogens, so they have a similar effect to that of the isoflavones that we know from soya beans,” said IVV project manager Katrin Hasenkopf.

“According to literature, they protect the organism against hormone-dependent forms of cancer – that is, breast and prostate cancer,” added Hasenkopf. “The lupins, on the other hand, contain substances that our studies have found to have a positive impact on the cholesterol level.”

But how do the researchers isolate the valuable components? “We make use of the differing solubility of the various constituents: If the pH value is acidic, the unwanted bitter substances are the first to dissolve.

pH value is a way of expressing the acidity or alkalinity of a solution. The neutral point is pH value 7.0, with acids having lower values and alkalis having higher values.

“If the pH value is then set back to neutral, you get the valuable proteins – without the bitter taste. We are also able to separate large components from small ones by a series of filtration steps,” explained Hasenkopf.

“The healthy effects of linseed and lupin seeds are already known from literature, but so far there is a lack of conclusive scientific investigations on the subject. These substances undoubtedly have very high potential,” she said.

In about three years, the new cholesterol-lowering foodstuffs are expected to be available on supermarket shelves – maybe even including cakes, bread rolls and sauces enriched with the valuable substances obtained from flax seeds.

The researchers will be presenting the linseed and lupin foods at the Biotechnica trade fair in Hanover on Oct 7-9.

Sources: The Times Of India

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