The editorial linked below appeared in the American Journal of Clinical Nutrition. It traces the rise in fructose consumption, and the rise in chronic diseases that have come in its wake.Fructose is a simple sugar found in honey, fruit, table sugar, and high-fructose corn syrup (HFCS). Because of the increase in the consumption of these sweeteners, fructose intake worldwide has quadrupled since the early 1900s.
Over the past three decades, there has been an even greater acceleration in consumption, in part because of the introduction of HFCS. The increase in fructose consumption parallels the rise in obesity, diabetes, hypertension, and kidney disease.
Studies in animals have shown that fructose can induce insulin resistance, elevated triglycerides, abdominal obesity, elevated blood pressure, inflammation, oxidative stress, endothelial dysfunction, microvascular disease, hyperuricemia, glomerular hypertension and renal injury, and fatty liver. The consumption of large amounts of dietary fructose also can rapidly induce insulin resistance.