Categories
Suppliments our body needs

Policosanol

[amazon_link asins=’B0013OXGBC,B00068JKMA’ template=’ProductCarousel’ store=’finmeacur-20′ marketplace=’US’ link_id=’9ff988a4-0994-11e7-8392-136262e566f7′]

Other names: Octacosanol, 1-Octacosanol, N-Octacosanol, Octacosyl Alcohol

Definition:
Policosanol (or polycosanol) is the generic term for a natural extract of plant waxes. It is used as a nutritional supplement to lower (bad) LDL cholesterol and increase (good) HDL cholesterol and to help prevent atherosclerosis. Independent clinical trials have failed to prove its efficacy.

Physical properties
Policosanol is a mixture of a few fatty alcohols derived from the waxes of such plants as sugar cane and yams, as well as beeswax. The most prevalent alcohol in policosanol is octacosanol, followed by triacontanol.(Formula CH3-(CH2)n-CH2OH n=24-34 )

There is a much lower concentration of several other fatty alcohols: behenyl alcohol, lignoceryl alcohol, ceryl alcohol, 1-heptacosanol, 1-nonacosanol, 1-dotriacontanol, and geddyl alcohol.

Policosanol is marketed by Cuba as a natural way to treat high cholesterol levels.

Modulation of HMG-CoA reductase and bile acid absorption inhibition have been proposed as mechanisms.

Policosanol, a dietary supplement, is a mixture of alcohols isolated from Cuban sugarcane wax. It contains about 60% octacosanol.

Because patent issue and the US trade embargo against Cuba, sugarcane policosanol is not widely available in the United States. Instead, policosanol products sold in the US are generally derived from beeswax and wheat germ.

Studies
Published studies have come to conflicting conclusions regarding the efficacy of policosanol in lowering LDL (i.e., “bad cholesterol”) or raising HDL (i.e., “good cholesterol”). Despite a number of studies funded by the Cuban government (which also produces and markets the drug), no independent clinical trials have found any evidence of the efficacy of Policosanol.

Evidence for Policosanol
Policosanol has been touted as a dietary supplement that can lower cholesterol as well as statin drugs, without the side effects. Studies indicate that it works by inhibiting cholesterol formation in the liver.

However, almost all of the 80+ double-blind studies on sugarcane policosanol were conducted by a single research group in Cuba that owns the policosanol patent.

An independent study published in the Journal of the American Medical Association in 2006 did not find any benefit of policosanol, even at high doses, on cholesterol profile. This finding has casted some doubt on the reliability of the Cuban research on policosanol.

Dosage Information
A typical dosage of policosanol used in studies has been 5 to 10 mg two times a day. Studies generally found that it can take up to two months to notice benefits.

Side Effects of Policosanol
Although the reliability of the Cuban studies has been questioned, side effects of policosanol reported in the trials have generally been mild and short-term. They have included indigestion, skin rash, headache, insomnia, and weight loss.

Possible Drug Interactions
Policosanol may increase the effect of medications that interfere with blood clotting or anti-platelet drugs, such as aspirin, warfarin (Coumadin), heparin, clopidogrel (Plavix), ticlopidine (Ticlid), or pentoxifylline (Trental), or supplements such as garlic, ginkgo, or high-dose vitamin E.

Policosanol may increase the effects and side effects of levodopa, a medication used for Parkinson’s disease.

Production
Policosanol (PPG) is produced, promoted and studied extensively in Cuba, where pharmaceutical research and sugar cane farms both exist in abundance. The supplement is used as a panacea by some Cubans.

Resources:
http://en.wikipedia.org/wiki/Policosanol
http://altmedicine.about.com/od/policosanol/a/policosanol.htm

Reblog this post [with Zemanta]
Categories
News on Health & Science

A Shot for the Heart

Scientists are looking at the possibility of a vaccine for cardiovascular disease.

When it comes to cardiovascular disease, India is either one of the world’s greatest laboratories or killing fields, depending on how you see it. The prevalence rate of this ailment has shot up in the last five decades from 4 per cent to 11 per cent of the population. The World Health Organisation (WHO) predicts that by 2010, 60 per cent of all cardiac patients in the world will be Indians. South Asians are genetically prone to the disease, and should thus greet any new prevention option with enthusiasm. Now there is potential for a new approach at controlling the disease: vaccination.

It is not as if everyone can get vaccinated during childhood and secure lifelong protection from heart disease, although it is not something that can be completely ruled out in the long run. Many scientists the world over are actively pursuing vaccination as a strategy to reduce the risk of heart disease significantly. If all goes well, in four or five years we could see the first vaccine entering the market, and that can decrease certain kinds of cardiovascular risk. “We could start clinical trials for a cardiovascular vaccine in two years,” says Johan Frostegard, a scientist at the Karolinska Institutet in Sweden.

Frostegard and his collaborators at Lund University in Sweden recently discovered a new risk factor for cardiovascular disease: low levels of an antibody against a molecule called phosphorylcholine (PC). These antibodies, called anti-PC, decrease the risk for cardiovascular disease. Some people have large amounts of this antibody, while others do not. Since the discovery is new, people from around the world have not been tested for it. Frostegard knows that Swedes have low levels of the antibody compared to inhabitants of New Guinea who live a traditional life. Cardiovascular disease is rare in such people in New Guinea. Frostegard’s method is to increase anti-PC levels in the blood through vaccination. “A vaccine gives you antibodies you should have had in the first place,” he says.

There have been a few other recent attempts at using vaccination to protect against heart disease. One of them, at the US firm AVANT Immunotherapeutics, uses methods to increase high-density lipoproteins (HDL) in the body. The other strategy, again from Lund University, targets low-density lipoproteins (LDL). Both of these methods are early in their development and have not been tested in clinical trials, and it is not certain if the institutions will try to test them. But both have shown the scientific validity of the vaccination approach at preventing or treating cardiovascular disease.

Cardiovascular disease is complex and has many causes and risk factors. It is not clear if we have discovered all the risk factors, or even the majority of them. Some major risk factors have been known for a long time. These include high blood pressure and diabetes. Two other risk factors were discovered a few decades ago: high levels of LDL and low levels of HDL. Both are cholesterols, and increasing HDL and reducing LDL — through diet or drugs — are now part of all strategies to control cardiovascular disease.

There are other risk factors like high levels of triglycerides whose precise role is not well known. Of late, medical scientists have discovered other risk factors, an important one being a molecule called C-reactive protein.

Although we know the risk factors, cardiologists and researchers are yet to agree on a strategy to fight them effectively. Diet and exercise are the first part of any strategy, and it is well known that they work in some cases, particularly in controlling diabetes and high blood pressure.

However, controlling cholesterol is not so easy with diet and exercise because 80 per cent of the cholesterol is manufactured in the body itself. HDL clearly goes up with exercise, but it may not be enough for people who have very low levels to start with.

This is why a class of drugs called statins has become very popular among cardiologists and patients. Statins reduce LDL and boost HDL, but are toxic for some patients. In this context, a vaccine that can reduce the risk factors would be a safe alternative. For example, Una Ryan and Charles Ritterhaus of AVANT showed two years ago that a vaccine could help to increase HDL. These scientists had targeted choleteryl ester transfer protein (CETP), an intermediary molecule that plays an important role in the balance of HDL and LDL. The vaccine they developed induces antibodies against CETP and ultimately increases HDL. But after the acquisition of AVANT by another company called Celldex, it is not clear if the scientists will proceed with the vaccine.

The Karolinska scientists, however, plan to go ahead with developing a vaccine against PC. They expect to be ready with it in two years, and clinical trials would take another two or three years, by which time there would be many other cardiovascular vaccines under development. Vaccines help to address a large number of people with the lowest possible risk. Within a decade, they could become the most important strategy against a large number of diseases, let alone cardiovascular disease.

Sources: The Telegraph (Kolkata, India)

Zemanta Pixie
Categories
Featured

Lowering Cholesterol in Kids Starts with Diet, Exercise

[amazon_link asins=’B06W9M74JK,B01EV1OQY4,B072VRT1JV,B01GQU9EZE,B008G3VP66,B014RJOXJ8,B07211SXS5,B01MDQSALL,B0118PHL5C’ template=’ProductCarousel’ store=’finmeacur-20′ marketplace=’US’ link_id=’610d54aa-6c26-11e7-83ad-09c4d1853224′]

 

According to guidelines recently released by the American Academy of Pediatrics, statins may be needed to prevent harmful plaque buildup.

At first blush, the new guidelines on cholesterol control in children were shocking. Statins, one of the most frequently prescribed drugs for adults worldwide, could be prescribed for some children as young as 8, according to recommendations released last week by the American Academy of Pediatrics.

But the vast majority of children will never in their pre-pubescence or teens pop a pill to lower cholesterol. Nor will their parents want them to. “I hear it every time I see parents,” says Dr. Alan Lewis, a pediatric cardiologist and director of the lipid clinic at Childrens Hospital Los Angeles. ” ‘I don’t want my kid taking a pill.’ ”


You may click to see:-

>For youths at risk for high cholesterol, statins are the best remedy

>There are statin alternatives — but check with a doctor first

 

For most children, the new guidelines will simply serve to alert parents that their kids could be accumulating plaque in their arteries that will set them on a road to early heart attacks or strokes. “My own practice and the new guidelines emphasize the importance of lifestyle as the approach to lowering the risk of cardiovascular disease,” Lewis says.

Whether you’re a kid or a grown-up, here’s how to adopt that lifestyle.

Diet and exercise

Children ages 2 to 10 who test in the acceptable range (total cholesterol less than 170 milligrams per deciliter of blood) should simply keep up the good work. Those who test in the borderline range (total cholesterol 170 to 199) need to make some changes in what they eat and how much they exercise. (For adults, total cholesterol of less than 200 is desirable; 200 to 239 is borderline high; above 240 is high, carrying with it twice the risk of heart disease as a level below 200.)

It’s children who test at elevated levels, above 200, who bump into the controversial recommendation of taking a statin as part of their preventive therapy. Even then, “you should always start with lifestyle modifications,” says Dr. Stephen R. Daniels, chairman of the department of pediatrics at the University of Colorado School of Medicine in Denver and lead author of the guidelines.

For starters, dietary fat intake should be lowered to less than 30% of calories, with saturated fat, found in meat and whole-milk dairy products, less than 10% of calories and no more than 200 milligrams of cholesterol a day.

If that doesn’t do the trick, Lewis says, cut saturated fat to 7% of calories, keeping total fat below 27%. Trans-fatty acids should be all but eliminated, with the recommendation at less than 1% of calories. (The American Heart Assn. recommends that all adults keep dietary fat below 30% of daily calories, with no more than 7% of daily calories from saturated fat, and less than 1% from trans fats.) Kids as young as one year, according to the new guidelines, can cut out whole milk and start drinking reduced fat milk. The biggest influence on blood cholesterol is the mix of fats in the diet. Saturated fat, found mostly in animal products but also in coconut and palm oils, increases blood cholesterol levels the most.

Fiber, in the form of whole grains, fruits and vegetables, can lower cholesterol. It binds bile and blood cholesterol to form waste, which the body eliminates. If a fiber supplement is used, the guidelines suggest a dose of the child’s age plus 5 grams a day, up to a dose of 20 grams a day at age 15. Long-standing government recommendations suggest that young kids 2 to 3 should get three ounces of grains a day, building up to seven ounces by age 14 to 18. A slice of whole-grain bread, one-half cup of cooked brown rice and one-half cup of cooked oatmeal add up to about three ounces. Fruits and vegetables also contain fiber, and young children should get a cup of each, building up to two cups of fruit and three cups of vegetables for kids 14 and older.

The new guidelines recommend exercise in general, though without a recommended amount. Exercise in adults has been shown primarily to increase levels of HDL, the protective cholesterol, though it has little effect on lowering LDL. But exercise can also lead to weight loss, and weight loss has been proven to lower total cholesterol in adults.

Children with less than ideal cholesterol levels could need up to six months of lifestyle changes before results are seen.

One study of children 8 to 11, published in the May 10, 1995, Journal of the American Medical Assn., found that those who kept their total fat calories to 28% and saturated fat to 8% of calories dropped levels of LDL cholesterol by an average of 15 points over three years, compared to those in a control group who ate their normal diet.

For children whose cholesterol is mildly or moderately high, the reduction could get them into the normal range. The National Institutes of Health-sponsored study, the Dietary Intervention in Children Study, also found that after three years, children who were in the group that received aggressive nutrition education consumed 67% of their calories from heart-healthy foods, compared to 57% in the group that received no counseling.

Studies of adults have shown that bad cholesterol can be lowered by 5% to as much as 20% by lifestyle changes, including quitting smoking.

Losing excess weight, which requires lowering calories and fat consumption and increasing exercise, is the most successful strategy for lowering cholesterol. “Before starting a statin, try losing 20 pounds,” says Dr. David Becker, cardiologist at the University of Pennsylvania Health System.

“In most kids, you’d want to work on this for three to six months before you go to a more aggressive treatment,” Daniels says. If during that time physicians see evidence of improvement in lower cholesterol numbers and lost weight, the lifestyle treatment could continue without adding a drug.

Leading by example:

For adults and children alike, it’s clear that increasing physical activity while changing eating habits to include more fruits, vegetables, fiber, whole grains and fish and less saturated fat and sugar is easier said than done. But children have an advantage. Their bad habits are relatively new, not ingrained for decades, and might be easier to overcome.

“If children can be introduced to these more healthful lifestyle features — healthy diet, exercise, weight control — then we have a chance that this becomes natural for them,” Lewis says. Making the changes is labor intensive, often involving a nutritionist, an exercise physiologist and a physician advising the entire family. “The children and the family share the same food at the table, the same gene pool,” Lewis says. “It’s really important to get the whole family involved.”

And often, lifestyle changes work. “Adoption of a nutritional approach can usually reduce the serum cholesterol,” Lewis says.

“And if it’s mild to moderately elevated can often lower it to within the normal range. For the majority of children, the nutritional approach is really all that they need.”

Sources: Los Angles Times

Zemanta Pixie
Categories
Featured News on Health & Science

The Omega Balance

Without question, each of us needs omega-6 and omega-3 fatty acids in our diet. But the balance between the two has recently become the center of a hot debate.

click & see

These two key polyunsaturated fats are called “essential fatty acids” because our bodies can’t manufacture them; they must come from the foods we eat. Each has its own actions in the body, often opposing each other: omega-6s, for example, are converted in the body to substances that assist in responding to inflammation and bleeding; omega-3s, by contrast, convert to substances that slow blood clotting and decrease inflammatory responses. Together, they work as a check-and-balance system of sorts, and some researchers argue that our modern Western diets have thrown that balance out of whack.

Throughout most of human history, since our Paleolithic ancestors first hunted game, speared fish and gathered wild greens, humans have eaten a diet that kept the omega-6 to omega-3 balance fairly equal—”close to a 2 to 1 ratio,” notes Artemis Simopoulos, co-author of The Omega Diet. This pattern continues in the traditional diet of Crete, where heart disease and cancer rates are among the lowest in the world.

But in the United States, omega-6 fatty acids now dominate the ratio because people are eating more processed foods, such as chips and packaged cookies, which are made with high-omega-6 oils like soybean or cottonseed. Our meats, poultry and dairy products have also become more omega-6 heavy as we feed our animals grains instead of grasses. Today, the omega-6 to omega-3 ratio hovers around 17 to 1, says Simopoulos, explaining that this imbalance is a key contributor to the modern plague of heart disease. “Major dietary studies have shown that when people are fed diets that lower this ratio, their death rates from heart disease fall significantly.”

Not everyone agrees that increased omega-6s threaten our health, however. Frank Hu, of the Harvard Nurses’ Health Study, argues that omega-6s also have beneficial effects on heart-disease risk. “Because omega-6 has very strong LDL-lowering effects, it actually lowers the LDL to HDL ratio, which is the most powerful predictor of heart disease.” Reducing omega-6 levels, then, would take away some of those benefits.

Although he is skeptical, Hu suggests the following for anyone who wants to lower their omega-6 to omega-3 ratio: focus on getting more omega-3s, rather than cutting omega-6s, by eating more fish, freshly ground flaxseeds and walnuts, and by using oils that provide omega-3s, like canola and walnut.

Simopoulos counters, “If you have too many omega-6s, you can’t use omega-3s as efficiently. To get the full benefit of omega-3s, you must lower the omega-6 to omega-3 ratio.” She recommends following a dietary pattern similar to that of the traditional diet of Crete: vegetable-and-fruit laden, low in saturated fats, generous in omega-3s and stingy with omega-6s. “It is the diet on which humans evolved, and which our genetic profile has adapted to.”

Related Omega-3 Recipes:

* Basic Basil Pesto
* Orange-Miso Sauce
* Edamame Lo Mein
* Grilled Rosemary-Salmon Spedini
* Chard with Shallots, Pancetta & Walnuts

Sources:http://bl147w.blu147.mail.live.com/mail/mail.aspx?&n=1809073841

Zemanta Pixie
Categories
News on Health & Science

Natural Trans Fats May be Good for You

[amazon_link asins=’B00CJZ4FD2′ template=’ProductLink’ store=’finmeacur-20′ marketplace=’US’ link_id=’b49a58c8-7fe2-11e7-a4a8-e550404b56e9′][amazon_link asins=’B00FRFRZF6′ template=’ProductLink’ store=’finmeacur-20′ marketplace=’US’ link_id=’a8f2a526-7fe2-11e7-afc3-13eea81724a9′][amazon_link asins=’B00032G1S0′ template=’ProductLink’ store=’finmeacur-20′ marketplace=’US’ link_id=’99fbecd9-7fe2-11e7-9c98-797056bef479′]

[amazon_link asins=’B074CLFV8J’ template=’ProductLink’ store=’finmeacur-20′ marketplace=’US’ link_id=’682f0d89-7fe2-11e7-b0ad-25c6b04e01ca’][amazon_link asins=’B00PLD76Q2′ template=’ProductLink’ store=’finmeacur-20′ marketplace=’US’ link_id=’4e4328bb-7fe2-11e7-acae-cbddc68ce85a’][amazon_link asins=’B00CSRMYDE’ template=’ProductLink’ store=’finmeacur-20′ marketplace=’US’ link_id=’4115becc-7fe2-11e7-8762-97fb826778fc’][amazon_link asins=’B01JHPBDQI’ template=’ProductLink’ store=’finmeacur-20′ marketplace=’US’ link_id=’1802757a-7fe2-11e7-80ea-c7177d412e5c’][amazon_link asins=’B00CHUGFNW’ template=’ProductLink’ store=’finmeacur-20′ marketplace=’US’ link_id=’debff304-7fe1-11e7-83a8-db0f27b79c93′][amazon_link asins=’B01E7N2U1C,B01N9O0L7O,B01NCP38KI,B01NBR1OCX,B01NASE75O,B01NCS21PW,B01NCS8CAL,B016DJ5RC2′ template=’ProductCarousel’ store=’finmeacur-20′ marketplace=’US’ link_id=’b6261e25-7fe1-11e7-8b7c-739a61768d5c’]

Found in milk and yogurt, vaccenic acid — a naturally occurring trans fat — lowered cholesterol in rats, a Canadian study finds.

Trans fats: We’ve been told that they’re worse for our hearts than saturated animal fats. Now, as consumers increasingly turn to food that’s trans-fat-free and manufacturers pull them from more and more processed foods, comes a twist. Some trans fats, ones that exist naturally, may be good for you.

In a 4-month study at the University of Alberta presented in March at a scientific meeting, obese rats fed a diet enriched with vaccenic acid — a naturally occurring trans fat found in milk and yogurt — had significant reductions in total cholesterol, LDL (or “bad”) cholesterol and triglycerides.

The researchers reported that a key benefit of vaccenic acid is its ability to reduce the production of chylomicrons — small particles of fat, protein and cholesterol formed in the gut that transport fats to various tissues of the body.

Like humans, obese rats produce too many chylomicrons, which raises lipids in the bloodstream. After 16 weeks of consuming vaccenic acid-enriched chow, however, the levels of chylomicrons dropped by more than half.

It’s not clear what this finding means for humans. First, the study was done in rats — the researchers say they’re planning some human clinical trials with vaccenic acid supplementation. Second, because the study diets were supplemented with vaccenic acid, the amounts the rats ate relative to their body weight was more than we would naturally eat in our usual diet.

The study is in line with other reports that natural trans fats have different effects on the body than the industrially created ones.

Most of the trans fats we eat — by far — come from partially hydrogenated vegetable oils, produced from liquid oils by industrial processing to create a firmer fat. Others occur naturally in milk products, formed in the rumen (or first stomach) of ruminant animals such as cows, goats, sheep and yaks when they’re fed a grass-rich diet.

Several studies of large populations have looked at the link between trans fatty acid intake and risk of developing atherosclerosis, and all have shown that the risk goes up only with the intake of “industrial” trans fatty acids, not the natural ones. Several clinical trials — in which people were fed special diets for weeks or months — have shown that manufactured trans fats raise LDL cholesterol levels to the same degree as saturated fats, and also lead to lower levels of the good, or HDL, cholesterol. It’s been estimated that it takes only about 12 grams of manmade trans fats to see this effect.

Trans-fat-free foods are big business, and today the majority of margarines, cookies, snack cakes and chips are devoid of the stuff. The change was fueled by the fact that, two years ago, it became law that food labels disclose industrial trans fat content.

Even if all the partially hydrogenated vegetable oil disappeared from our foods, we’d still consume about 1% to 5% of our calories from naturally occurring trans fatty acids, mostly vaccenic acid.

At this point, it’s not known how much vaccenic acid we’d need to consume to reap benefits. But in the meantime, anyone wanting to increase their natural-trans-fat intake might want to develop a taste for exotic cheese.

A study published in February in the Journal of Agriculture and Food Chemistry reported that yak cheese, from animals grazing in alpine grassland, contains more than four times the vaccenic acid of conventional cheddar cheese from grain-fed dairy cows. (The study didn’t investigate the levels in cheese from grass-fed cattle.) It also contains three times more beneficial omega-3 fatty acids. The authors conclude that a daily serving of 3 ounces of yak cheese might promote health.

Yak cheese isn’t easy to find — but the bottom line seems to be that the fatty acid composition of milk, cheese and yogurt from grass-fed animals may be more healthful than we knew — and perhaps, when the clinical trials are done, vaccenic acid-rich milkfat may join the ranks of other healthful fats along with those found in fish oil and nuts.

Cheese as a new, heart-positive snack? Just make sure you put it on a whole-grain, trans-fat-free cracker.

Susan Bowerman is a registered dietitian and assistant director of the UCLA Center for Human Nutrition.

Sources: Lon Angeles Times

Zemanta Pixie
css.php