Pueraria mirifica

Botanical Name : Pueraria mirifica
Family: Fabaceae
Subfamily: Faboideae
Genus: Pueraria
Species: P. mirifica
Kingdom: Plantae
Order: Fabales

Common Name :Kwao Krua, Khao Krua Kao, or Kwao Kreu Kao (white root) and Kwao Krua Dang (red root Butea Superba),

Habitat :Pueraria mirifica  is a native herb abundant in the jungles of the north Thailand and Burma.

Description:
The Pueraria mirifica plant is found only in Thailand. Even though there have been reports of findings of plants in the same family of “Pueraria” in Asian countries, these plant are of different species and possess different qualities from Pueraria mirifica. From the study, there are nine species [as many as thirteen have now been reported] of Pueraria in Thailand. This article discussing the efficacy and safety study of Pueraria mirifica refers only to Pueraria candollei var. mirifica from central part of the country. Pueraria mirifica is a climbing plant, usually grows in a mountainous area by tiding with trees. There are three small leaves on each branch and purple blooms on the top. The tubers on its root are round, and stay underground. When cut, white liquid like skim milk would come out. The Shape and size of Pueraria mirifica are diverse up to the environment in which it exists. Active ingredients are found at the roots from which extracts are made.
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History:
Arimuttama was the old capital of the Pookham City of Myanmar. They had a sacred Buddhist precinct and one-day the sacred Buddhist precinct was broken down. The Buddhist monks found this ingredient that was inscribed on the palm leaf and placed it in the sacred Buddhist precinct.

To take the tuberous root of Pueraria with big leaves, pound and blend with cow’s milk. The benefits of this medicine is to support memory, talk big, and be able to remember three books of the astrology, make the skin smooth like six year old kid, live more than 1,000 years and parasite diseases are not able to be of trouble

There are 4 varieties of kwao krua that are considered beneficial and can be used for medicinal, food supplementary and cosmetic purposes. They are White Kwao Krua (Pueraria mirifica), Red Kwao Krua (Butea superba), Black Kwao Krua and Dull Grey Kwao Krua. Local communities in Thailand have used Pueraria mirifica for well over one hundred years, specifically for its supposed rejuvenating qualities

Uses:
Pueraria mirifica, also known as ‘white kwao krua’, is a natural tuberous herbal root and contains high levels of natural phytoestrogens including miroestrol, deoxymiroestrol, daidzein, genistin, genistein, B-Sitosterol, stigmasterol, coumestrol, pueraria, campesterol, mirificoumestan, kwakhurin, and mirificine.

Some cosmetic products and herbal supplements claim various health benefits of the extracts of Pueraria mirifica including increasing appetite, enlarging breasts, improving hair growth, and other rejuvenating effects; however, there is no scientific evidence to support any these claims.   The U.S. Federal Trade Commission has taken action against manufacturers who make such fraudulent claims

Medicinal Uses:
Preliminary data from a clinical trial conducted in Thailand to study the beneficial effect of Pueraria mirifica supplement have recently been obtained. Eight female subjects who were having menopausal symptoms received Pueraria mirifica in the form of capsule once daily at the dose of 200 mg for 4 months followed by the dose of 100 mg, for 8 months. Improvement of menopausal symptoms was observed in 5 out of 8 subjects throughout the study period. Physical examinations and biochemical studies revealed that all subjects were healthy. The dietary supplement dose of Pueraria mirifica recommended by the physician for its estrogenic effect in this case is 100 mg per day.

A series of studies involving breast cell lines and the activity of Pueraria mirifica in vitro have been performed by the Emory University School of Medicine in Atlanta, Georgia, USA, and the Department of Obstetrics and Gynecology, Phramongkutklao College of Medicine, Bangkok, Thailand. These studies have shown that Pueraria mirifica root extract (Smith Naturals Co Ltd., Bangkok) has potent anti-estrogenic properties against aggressive cell cancer lines in vitro, especially the proliferative estrogen receptor-positive (ER+) breast cancer lines (T47-D, MCF-7, and ZR-75-1) obtained from the MD Anderson Cancer Institute (Texas) and the National Cancer Institute (NCI) at the U.S. National Institutes of Health (NIH).

Tectorigenin, an isoflavone present in kudzu, demonstrated antiproliferative activity against human cancer (HL-60) cells. The proposed mechanisms are induction of differentiation in the cells and a reduction in the expression of Bcl-2, an antiapoptotic protein. In addition, isoflavones in Pueraria mirifica are thought to be involved in alleviating symptoms such as hot flashes and night sweats in perimenopausal women and affect cognitive function in postmenopausal women. The isoflavones present in kudzu root extract are also thought to suppress alcohol intake and alcohol withdrawal symptoms in mice although the mechanism is unclear. The anti-inflammatory property of kudzu is attributed to its ability to decrease Prostaglandin E2 and tumor necrosis factor (TNF)-alpha release, both of which are involved in inflammatory process. The flowers of Pueraria thunbergiana exhibit protective effects against ethanol-induced apoptosis in human neuroblastoma cells by inhibiting the expression of a protease, caspase-3 that is responsible for proteolytic cleavage of many proteins.

Herbal Breast Enlargement by Pueraria mirifica. In 90% of women, the phytoestrogen from Pueraria herbal will induce the increasing of the cell turgidity but not cell multiplication or proliferation.

Disclaimer:
The information presented herein is intended for educational purposes only. Individual results may vary, and before using any supplements, it is always advisable to consult with your own health care provider.

Resources:
http://siamnatural.wordpress.com/2011/02/26/siam-natural-kwao-krua-kao-pueraria-mirifica/
http://en.wikipedia.org/wiki/Pueraria_mirifica
http://www.paradisemoon.com/herbal/kwao_krua.htm
http://www.herbnet.com/Herb%20Uses_IJK.htm

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