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Campbell de Morgan spots

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Alternative Names :    Cherry hemangioma, Senile angiomas

Definition:
Campbell de Morgan spots are made up of clusters of tiny capillaries at the surface of the skin, forming a small round dome (“papule“), which may be flat topped. They range in colour from bright red to purple. When they first develop, they may be only a tenth of a millimeter in diameter and almost flat, appearing as small red dots. However, they then usually grow to about one or two millimeters across, and sometimes to a centimeter or more in diameter. As they grow larger, they tend to expand in thickness, and may take on the raised and rounded shape of a dome. Multiple adjoining angiomas are said to form a polypoid angioma. Because the blood vessels comprising an angioma are so close to the skin’s surface, cherry angiomas may bleed profusely if they are injured.

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These small red or violet spots most often appear on the chest or trunk and are nothing to worry about. They’re small, benign (non-cancerous) overgrowths of blood vessels in the skin. Medically, they’re called haemangioma or just angioma. Why they develop in the first place isn’t known. They’re usually less than 6mm in diameter and if pressed do not blanch.

They are the most common kind of angioma.They are called cherry angioma because of their colour, or senile angioma because they appear as a person gets older – usually first appearing after the age of 40 and increasing with age.
They are called Campbell de Morgan spots, after the nineteenth-century British surgeon Campbell De Morgan who first noted and described them.

Cherry angiomas occur in all races, ethnic backgrounds, and both sexes.
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Experts agree they’re best left alone since they’re harmless. However, some people do find them cosmetically unacceptable and wish to have them removed.

Symptoms:
Skin lesion or growth:
•Bright cherry-red
•Small — pinhead size to about 1/4 inch in diameter
•Smooth
Cause:
Campbell de Morgan spots  appear spontaneously in many people in middle age but can also, although less common, occur in young people. They can also occur in an aggressive eruptive manner in any age. The underlying cause for the development of cherry angiomas is not understood, much because of a lack of interest in the subject. This is probably because they rarely are caused by an internal malignancy.

The first study trying to bring light to the molecular and genetic mechanisms behind cherry/senile hemangioma was recently published.  The study found that the level of MicroRNA 424 is significantly reduced in senile hemangiomas compared to normal skin resulting in increased protein expression of MEK1 and Cyclin E1. By inhibiting mir-424 in normal endothelial cells they could observe the same increased protein expression of MEK1 and Cyclin E1 which, important for the development of senile hemangioma; induced cell proliferation of the endothelial cells. They also found that targeting MEK1 and Cyclin E1 with small interfering RNA decreased the number of endothelial cells.

Chemicals and compounds that have been seen to cause Campbell de Morgan spots are mustard gas, 2-butoxyethanol,   bromides   and cyclosporine.  A correlation has been seen between cherry hemangiomas and activity of the enzyme carbonic anhydrase   as well as a significant increase in the density of mast cells in cherry hemangiomas compared with normal skin.

A recent study   suggests that Prichard’s structures are the cardiac equivalent of cutaneous senile angioma. The study describes Prichard’s structures in the heart as “adult, fully differentiated, postmitotic-type endothelial cells with virtually no turnover.” and that these cells are senescent cells that “arrest growth and cannot be stimulated to re-enter the cell cycle by physiological mitogens; they become resistant to apoptotic cell death; and they acquire altered functions.”. The study concludes that Prichard’s structures are formed by “infolding of the endothelial lining of the endocardium of the fossa ovalis as an irritational response to altered blood flow, eddies or turbulence.”
Diagnosis:
Doctors  probably diagnose a cherry angioma based on the appearance of the growth. No further tests are usually necessary, though a skin biopsy may be used to confirm the diagnosis.

Treatment:
On  occasions that they require removal, traditionally cryosurgery or electrosurgery have been used. More recently pulsed dye laser or Intense Pulsed Light (IPL) treatment has also been used.

Future treatment based on a locally acting inhibitor of MEK1 and Cyclin E1 could possibly be an option. A natural MEK1 inhibitor is Myricetin.

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Prognosis:
In most patients, the number and size of cherry angiomas increases with advancing age. They are harmless, except in very rare cases that involve a sudden appearance of many angiomas, which can be a sign of a developing internal malignancy.

Disclaimer: This information is not meant to be a substitute for professional medical advise or help. It is always best to consult with a Physician about serious health concerns. This information is in no way intended to diagnose or prescribe remedies.This is purely for educational purpose.

Resources:
http://www.bbc.co.uk/health/physical_health/conditions/campbellmorganspots.shtml
http://en.wikipedia.org/wiki/Cherry_hemangioma
http://www.nlm.nih.gov/medlineplus/ency/article/001441.htm
http://medsapiens.com/2009/03/07/cherry-hemangioma/

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Cutting Carbohydrates From the Diet May Increase Longivity

You may be able to extend your life and stay fit throughout your old age with a simple change of diet that switches on your “youth” gene.

Professor Cynthia Kenyon, whom many experts believe should win the Nobel Prize for her research into aging, has discovered that carbohydrates directly affect the genes that govern youthfulness and longevity.

By tweaking the genes of roundworms, she has been able to help them live up to six times longer than normal.
->The carbohydrates we eat directly affect two key genes that govern youthfulness and longevity
The genes that controlled aging in worms also do the same thing in rats and mice, probably monkeys, and there are signs they are active in humans, too. She found that turning down the gene that controls insulin in turn switches on another gene which acts like an elixir of life.

The Daily Mail reports:
“Discovering the … [first] gene has prompted the professor to ­dramatically alter her own diet, cutting right back on carbohydrates. That’s because carbs make your body produce more insulin (to mop up the extra blood sugar carbs ­produce) … so the vital second gene, the ‘elixir’ one, won’t get turned on.”

Source: Daily Mail October 26, 2010

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Cancer is Purely Man-Made Disease’ Say Scientists

A study of ancient bodies has determined that cancer is a man-made disease, one fueled by the excesses. Tumors turn out to be extremely rare until very recent times, when pollution and poor diet became issues.

Scientists found no signs of cancer in their extensive study of mummies apart from one isolated case.

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Researchers analyzed potential references to the disease in classical literature, and also searched for signs in the fossil record and in mummified bodies. But despite examining tissue from hundreds of Egyptian mummies, they confirmed only one case of cancer

According to the Daily Mail:

“Dismissing the argument that the ancient Egyptians didn’t live long enough to develop cancer, the researchers pointed out that other age-related disease such as hardening of the arteries and brittle bones did occur …

Fossil evidence of cancer is also sparse, with scientific literature providing a few dozen, mostly disputed, examples in animal fossil”.


Resources:

Daily Mail October 15, 2010

Nature Reviews Cancer October 2010; 10: 728-733


Cancer September 1977; 40(3): 1358-1362

Posted By Dr. Mercola | December 03 2010

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Washing Hands Affects Judgement


Good health is in your hands, it is often said. And, now a new study has suggested that washing hands is not only an easy way of preventing infection, but it can also affect one’s moral judgement.

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Researchers in Britain have carried out the study and found that people who clean themselves are less judgemental — in fact, they are more likely to be lenient before making such judgements, the ‘Daily Mail‘ reported.

According to them, the findings mean jurors who wash their hands may make their verdict less severe — and what is more interesting is that people who take shower before voting may be more likely to overlook political misdemeanours.

“We like to think we arrive at decisions because we deliberate, but incidental things can influence us. This could have implications when voting and when juries make up their minds,” lead researcher Dr Simone Schnall said.

Dr Schnall and colleagues at Plymouth University came to the conclusion after analysing the impact of washing hands on a group of people.

In the study, 22 people who had washed their hands, and 22 who had not, were made to watch a disgusting scene from the film ‘Trainspotting‘, about heroin addicts. They were then to rate how morally wrong a series of actions were on scale of one to nine with one being acceptable and seven being wrong.

The actions included stealing money from a wallet, lying on a job application, cooking and eating the family dog, killing a dying plane crash survivor to avoid starvation, and abusing a kitten.

All put the actions on the “wrong” side of the scale. But, in results which echo Pontius Pilate washing his hands of Christ’s death, those who had washed their hands were less likely to judge the actions as harshly as those who had not, the researchers found.

Sources: The Times Of India

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Snoring Good for the Elderly

If you think that snoring is bad for your health, think again, for a study has suggested that the nocturnal snorts, whistles and wheezes can give you a long and healthy life, particularly if you are elderly.

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Researchers in Israel have carried out the study and found that people aged over 65 years who suffer from a snoring -related condition, called sleep apnoea, tend to live longer than those who do not snore.

According to the researchers, this is because short bursts of hypoxia — interrupted breathing — actually have a protective effect on the elderly people by conditioning their cardiovascular system to cope with lack of oxygen.

This means that when oxygen supplies are cut off, as in a heart attack or stroke, the body is better able to cope, they said.

But the study has found that the effects of sleep apnoea do not have the same effect in younger people — in fact, middle-aged men in particular are at a higher risk of heart disease, the Daily Mail paper reported.

The researchers at Technion Institute have based their findings on an analysis of more than 600 elderly people over a period of four years — they found fewer heart-related deaths than in a control group of ‘healthy’ volunteers.

The findings of the study have been presented at a meeting of the European Association for Sleep Research in Glasgow.

Sources: The Times Of India