Month: January 2009

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Diagnonistic Test

Fluorescein Angiography (Test for Diabetic Retinopathy)

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Alternative Names: Retinal photography; Eye angiography

Definition:
Fluorescein angiography is an eye test that uses an special dye and camera to look at blood flow in the retina and choroid……...CLICK & SEE

By looking into the back of your eye (the retina), eye doctors can see changes in the blood vessels there that show whether you are at risk for losing vision from diabetes or other causes. The earliest changes can be seen only with a special test called fluorescein angiography. For this test, a chemical that temporarily makes the blood vessels fluorescent and shows very tiny leaks in them is injected into one of your arm or hand veins while you are having your eyes examined.

This test is used to determine if there is proper circulation in the blood vessels of the retina. It can also be used to diagnose problems in the eye or to determine how well treatment is working.

Preparation  for the test:
You should arrange to have someone else drive you home from the eye doctor, because your eyes will be dilated; this can make your eyes sensitive to the sun and your vision blurry for a while.

You may be told to discontinue drugs that could affect the test. results. Tell your health care provide about any allergies, particularly reactions to iodine.

You must sign an informed consent form. You must remove contact lenses before the test.

Tell the health care provider if you may be pregnant.


How the Test Is Performed
Eye drops that make the pupil dilate will be given. You will be asked to place your chin on a chin rest, and your forehead against a support bar to keep your head still during the test.

Fluorescein angiography->…..CLICK & SEE

The health care provider will take pictures of the inside of your eye. After the first group of pictures are taken, a special dye called fluorescein is injected into your vein, usually at the bend of the elbow. A special camera takes pictures of the dye as it moves through the blood vessels in the back of the eye.

More photographs are taken up to 20 minutes after the injection.

What happens when the test is performed?
You have drops put into your eye to make the pupil dilate (open), and you have to wait for about half an hour while the drops take effect. Before giving you any other medicine, your doctor might first examine your eyes for signs of bleeding or debris outside of your retina arteries; these are signs of more advanced eye disease from diabetes. Then a nurse inserts a small needle into one of the veins in your arm or hand so that you can have a dose of medicine injected. Your doctor uses a special eye camera to take pictures of your retina. You look into one side of the camera while your doctor looks through the other side. The camera shines a dim blue light into your eye, which causes the dye flowing through the retina arteries to show up as fluorescent green. The doctor takes a collection of pictures of your eyes to review more closely later.

This color retinal photograph demonstrates nonproliferative diabetic retinopathy. The image is centered on the macula (the part of the retina responsible for central fine vision) with part of the optic nerve seen on the left of the photo (left eye). There are hemorrhages within the retinal tissue on the right side of the photograph.

How the Test Will Feel
When the needle is inserted , some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.

When the dye is injected, you may have mild nausea and a warm sensation. These symptoms are usually very brief.

Normal Results:
A normal result means the vessels appear a normal size and there are no blockages or leakages.
Back to TopWhat Abnormal Results Mean
If blockage or leakage is present, the pictures will map the location for possible treatment.

An abnormal value on a fluorescein angiography may be due to:

*Blood flow (circulatory) problems
*Cancer
*Diabetic or other retinopathy
*Inflammation or edema
*Macular degeneration
*Microaneurysms — enlargement of capillaries in the retina
*Tumors
*Swelling of the optic disc

Additional conditions under which the test may be performed:

Retinal detachment
Retinal vessel occlusion
Retinitis pigmentosa

Risk Factors:
There are no special risks from this test, although your vision may be blurry for an hour or more after the test because your pupils are dilated. The dye fluorescein is excreted from your body in your urine, which might give your urine a bright or discolored appearance for a day.

There is a slight chance of infection any time the skin is broken. Rarely, a person is hypersensitive to the dye and may experience:

*Dizziness or faintness
*Dry mouth or increased salivation
*Hives
*Increased heart rate
*Metallic taste in mouth
*Nausea and vomiting
*Sneezing
*Serious allergic reactions are rare.

Your urine will be darker, and possibly orange in color, for a day or two after the test.

Must you do  after the test is over?
You will need to wear sunglasses for a few hours until your pupils are no longer dilated.

Considerations:
People with cataracts will have less accurate test results.

How long is it before the result of the test is known?
Your doctor can often discuss the results of the test with you at the end of your visit. He or she might recommend treatment (such as eye laser treatments) if your test reveals retina disease.

Click to see:->How does diabetes affect the retina?

Resources:
https://www.health.harvard.edu/diagnostic-tests/fluorescein-angiography.htm
http://health.nytimes.com/health/guides/test/fluorescein-angiography/overview.html

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Featured

Berry Compound Reduces Aging Effects

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In a new study, elderly laboratory animals that ate a diet rich in the berry and grape compound pterostilbene showed a reversal of some of the negative effects of aging on brain function and behavioral performance.

The researchers wanted to determine if pterostilbene would be effective in reversing the effects of aging on mature rats. They fed older rats either a control diet, or a diet adjusted to include either low or high concentrations of pterostilbene.

The results indicated that in aging rats, pterostilbene was effective in reversing cognitive decline, and that improved working memory was linked to pterostilbene levels in the hippocampus region of the brain.

Sources:
Science Daily December 28, 2008
Journal of Agricultural and Food Chemistry 2008, 56 (22), pp 10544–10551

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News on Health & Science

Longer Ring Finger Predicts Financial Success

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The length of a man’s ring finger may predict his success as a financial trader. Researchers at the University of Cambridge in England  report that men with longer ring fingers, compared to their index fingers, tended to be more successful in the frantic high-frequency trading in the London financial district.
.CLICK & SEE THE PICTURES
Indeed, the impact of biology on success was about equal to years of experience at the job, the team led by physiologist John Coates reports in Monday’s edition of Proceedings of the National Academy of Sciences.
The same ring-to-index finger ratio has previously been associated with success in competitive sports such as soccer and basketball, the researchers noted.

The length ratio between those two fingers is determined during the development of the fetus and the relatively longer ring finger indicates greater exposure to the male hormone androgen, the researchers noted.
Previous studies have found that such exposure can lead to increased confidence, risk preferences, search persistence, heightened vigilance and quickened reaction times.

In the new study, the researchers measured the right hands of 44 male stock traders who were engaged in a type of trade that involved rapid decision-making and quick physical reactions.

Over 20 months those with longer ring fingers compared to their index fingers made 11 times more money than those with the shortest ring fingers. Over the same time the most experienced traders made about 9 times more than the least experienced ones.

Looking only at experienced traders, the long-ring-finger folks earned 5 times more than those with short ring fingers.

While the finger ratio, showing fetal exposure to male hormones, appears to signal likely success in high-actively trading that calls for risk-taking and quick reactions, it may not indicate people who would do well at other sorts of financial activities, the researchers said. Some traders require additional skills on dealing with clients and sales workers.

Sources: The Times Of india

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Featured

Youth May Underestimate Heart Risk

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Young American adults who learn they have a low immediate risk of heart disease may be making a mistake if they sigh with relief and  relax – their lifetime risk could be high

A new analysis of heart disease risk studies shows that about half of people under the age of 50 who appeared to have a low risk of heart disease for the next 10 years already had damage to the arteries that could cause trouble later.

“We found that about half of individuals who are 50 years of age or younger and at low short-term risk for heart disease may not remain at low risk throughout their lives,” said Dr Jarett Berry of the University of Texas Southwestern Medical School, who helped lead the study.

Usually, a doctor assesses a patient’s risk of heart disease using the Framingham Risk Score, which takes into account cholesterol levels, blood pressure and other factors to predict cardiovascular risk for the next 10 years. And, almost automatically, anyone under the age of 50 has a low 10-year risk.

But heart disease usually develops slowly, as “plaque” builds up in arteries, reducing blood flow and causing unstable clumps that can break off and cause strokes or heart attacks. Berry’s team looked at the 10-year and lifetime risk scores for nearly 4,000 people age 50 and younger taking part in two clinical studies. They found that 91% of those 50 and younger had a low immediate risk of heart disease.

The volunteers had undergone unusually thorough examinations because they were in the studies, so Berry and colleagues looked at the ultrasound measurements of their carotid arteries and CAT scans for calcium.

Both types of scans can show early evidence of artery disease. They showed that the people who had a high lifetime risk according to cholesterol, blood pressure and other measures also had the beginnings of physical evidence of heart disease – thicker artery linings and hardened plaques.

“What we found was there were significant differences in the presence and progress of atherosclerosis,” Berry said. Usually, doctors just tell patients about their 10-year risk, but if patients knew their lifetime risks they could act right away to change their lifestyles.

Sources: The Times Of India

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News on Health & Science

Researchers Make Synthetic HDL Cholesterol

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US researchers have developed a synthetic form of good cholesterol known as HDL they hope will be able to keep levels of bad cholesterol  in check. The compound, which has a tiny core of gold, is manufactured using nanotechnology, and its developers think it has the potential to rid the body of excess bad cholesterol.

lipoprotein (HDL) particles like the one depicted here nevertheless incorporate large proteins that are difficult to mimic artificially.This is required  to  treat atherosclerosis.

.
“The idea is you take this and effectively just urinate it out,” said Chad Mirkin of Northwestern University in Chicago. Mirkin, director of Northwestern’s International Institute for Nanotechnology said, “The molecule mirrors the size and structure of high-density lipoprotein, or HDL. It is comprised of a carefully sized gold particle swathed in fat molecules known as lipids and capped off with a protein layer.”

It is designed to attract and trap low-density lipoprotein, or LDL, the bad kind of cholesterol that can build up in arteries and cause heart attacks and strokes. Powerful drugs known as statins can help lower LDL levels, but they do little to raise levels of protective HDL cholesterol.

“The hope is this will be a material that doesn’t have side effects, that allows you to do what the statins don’t do. That is raise the HDL level, which might be able reverse a lot of the damage and plaques that are already there,” Mirkin said.

Current drugs that raise natural levels of HDL, such as niacin, cause unpleasant side effects such as flushing. And while many drug companies are working to develop better HDL-raising drugs, few have succeeded. “HDL is a natural nanoparticle, and we’ve successfully mimicked it,” Mirkin said.

Gold is an ideal scaffolding material because its shape can be easily tailored, and it is non-toxic, making it a good drug candidate. Mirkin said “Gold is already used in therapies for arthritis and as contrast agent in imaging.”

Mirkin is testing the synthetic HDL molecules in animals. “Will they bind to cholesterol and effectively lower cholesterol, and will they reverse the damage of plaques? That would be absolutely spectacular,” he said. Analysts believe the market potential for HDL-raising drugs is well over $10 billion.

Current HDL-raising drugs include Abbott Laboratories Inc’s Niaspan, which also lowers a type of blood fat called triglycerides. In Europe, Merck & Co markets a drug called Tredaptive that combines niacin with an anti-flushing agent. Merck is already well into development of an HDL-raising drug called anacetrapib and plans to start late-stage trials in humans this year. The drug, also called MK-859, has a similar mechanism of action to a failed compound by Pfizer Inc called torcetrapib that was linked with deaths .

Sources: The Times Of India

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