A study may have discovered why breastfeeding might help protect children against allergies such as asthma, scientists say.The French research, published in Nature Medicine, shows female mice exposed to allergens can pass them directly to their offspring in milk.
This allows the newborns to become “tolerant” of the substance.
However, in humans, the link between breastfeeding and reduced asthma risk remains unproven, say experts.
There is some research evidence that being breastfed lowers the risk of becoming asthmatic but other studies have failed to find this.
More than 300 million people worldwide have allergic asthma and some scientists believe exposure to allergens, or a lack of exposure, at a very young age may be important in its development.
Asthma happens when the body’s own immune system recognises as “foreign” a common and harmless substance found in the environment, such as dust mite faeces.
When this substance is inhaled, the immune reaction can cause inflammation in the airways, narrowing them and making it harder to breathe.
For many sufferers, this can mean a lifetime of drugs, both to damp down the immune reaction and to re-open their constricted airways during an attack.
The researchers, from the INSERM institute in France, used an allergen called ovalbumin – a protein found in egg whites.
They allowed the mothers of newborn mice to breathe in the protein but not their offspring.
Tests confirmed the allergen was then transferred to the baby mice via breast milk and that the baby mice developed an immune system tolerance to it.
This effect happened independently of the mother’s own immune system.
“This study may pave the way for the design of new strategies to prevent the development of allergic diseases “ Study researchers
Current advice
The researchers wrote: “This study may pave the way for the design of new strategies to prevent the development of allergic diseases.”
Sally Rose, an asthma nurse specialist at Asthma UK, said: ‘While some research does suggest that breastfeeding may help reduce the chance of babies developing allergic conditions such as asthma, there are other studies that contradict this.
“Because breastfeeding provides many proven benefits for babies, current advice from the Department of Health, which Asthma UK supports, is that, where possible, babies should be exclusively breastfed for the first six months of life.”
Dr Charles McSharry, an immunologist from Glasgow University, said the research did offer a theory as to why breastfeeding might be beneficial in humans.
However, he said comparing the immune reactions of mice and humans was difficult.
“It is far more difficult to induce the kind of immune tolerance they have achieved in mice in humans, which is a key difference,” he said.
Physical Psychological short-term effects. The effects of LSD are unpredictable. They depend on the amount taken; the user‘s personality, mood, and expectations; and the surroundings in which the drug is used. Usually, the user feels the first effects of the drug 30 to 90 minutes after taking it. The physical effects include dilated pupils, higher body temperature, increased heart rate and blood pressure, sweating, loss of appetite, sleeplessness, dry mouth, and tremors.
Sensations and feelings change much more dramatically than the physical signs. The user may feel several different emotions at once or swing rapidly from one emotion to another. If taken in a large enough dose, the drug produces delusions and visual hallucinations. The user’s sense of time and self changes. Sensations may seem to “cross over,” giving the user the feeling of hearing colors and seeing sounds. These changes can be frightening and can cause panic.
LSD trips are long – typically they begin to clear after about 12 hours. Some users experience severe, terrifying thoughts and feelings, fear of losing control, fear of insanity and death, and despair while using LSD. In some cases, fatal accidents have occurred during states of LSD intoxication.
Flashbacks. Many LSD users experience flashbacks, recurrence of certain aspects of a person’s experience, without the user having taken the drug again. A flashback occurs suddenly, often without warning, and may occur within a few days or more than a year after LSD use. Flashbacks usually occur in people who use hallucinogens chronically or have an underlying personality problem; however, otherwise healthy people who use LSD occasionally may also have flashbacks. Bad trips and flashbacks are only part of the risks of LSD use. LSD users may manifest relatively long-lasting psychoses, such as schizophrenia or severe depression. It is difficult to determine the extent and mechanism of the LSD involvement in these illnesses.
English: TAC_Brain_tumor_glioblastoma-Coronal_plane Italiano: Immagine TAC della zona cerebrale, identificando un tumore di tipo glioblastoma (Photo credit: Wikipedia)
A brain tumor is any intracranial tumor created by abnormal and uncontrolled cell division, normally either in the brain itself (neurons, glial cells (astrocytes, oligodendrocytes, ependymal cells), lymphatic tissue, blood vessels), in the cranial nerves (myelin-producing Schwann cells), in the brain envelopes (meninges), skull, pituitary and pineal gland, or spread from cancers primarily located in other organs (metastatictumors). Primary (true) brain tumors are commonly located in the posterior cranial fossa in children and in the anterior two-thirds of the cerebral hemispheres in adults, although they can affect any part of the brain. In the United States in the year 2005, it was estimated that there were 43,800 new cases of brain tumors (Central Brain Tumor Registry of the United States, Primary Brain Tumors in the United States, Statistical Report, 2005 – 2006), which accounted for 1.4 percent of all cancers, 2.4 percent of all cancer deaths, and 20–25 percent of pediatric cancers. Ultimately, it is estimated that there are 13,000 deaths/year as a result of brain tumors……….click & see
Classification
Primary tumors
Tumors occurring in the brain include: astrocytoma, pilocytic astrocytoma, dysembryoplastic neuroepithelial tumor, oligodendrogliomas, ependymoma, glioblastoma multiforme, mixed gliomas, oligoastrocytomas, medulloblastoma, retinoblastoma, neuroblastoma, germinoma and teratoma.
Most primary brain tumors originate from glia (gliomas) such as astrocytes (astrocytomas), oligodendrocytes (oligodendrogliomas), or ependymal cells (ependymoma). There are also mixed forms, with both an astrocytic and an oligodendroglial cell component. These are called mixed gliomas or oligoastrocytomas. Plus, mixed glio-neuronal tumors (tumors displaying a neuronal, as well as a glial component, e.g. gangliogliomas, disembryoplastic neuroepithelial tumors) and tumors originating from neuronal cells (e.g. gangliocytoma, central gangliocytoma) can also be encountered.
Other varieties of primary brain tumors include: primitive neuroectodermal tumors (PNET, e.g. medulloblastoma, medulloepithelioma, neuroblastoma, retinoblastoma, ependymoblastoma), tumors of the pineal parenchyma (e.g. pineocytoma, pineoblastoma), ependymal cell tumors, choroid plexus tumors, neuroepithelial tumors of uncertain origin (e.g. gliomatosis cerebri, astroblastoma), etc.
From a histological perspective, astrocytomas, oligondedrogliomas, oligoastrocytomas, and teratomas may be benign or malignant. Glioblastoma multiforme represents the most aggressive variety of malignant glioma. At the opposite end of the spectrum, there are so-called pilocytic astrocytomas, a distinct variety of astrocytic tumors. The majority of them are located in the posterior cranial fossa, affect mainly children and young adults, and have a clinically favorable course and prognosis. Teratomas and other germ cell tumors also may have a favorable prognosis, although they have the capacity to grow very large.
Another type of primary intracranial tumor is primary cerebral lymphoma, also known as primary CNS lymphoma, which is a type of non-Hodgkin’s lymphoma that is much more prevalent in those with severe immunosuppression, e.g. AIDS.
In contrast to other types of cancer, primary brain tumors rarely metastasize, and in this rare event, the tumor cells spread within the skull and spinal canal through the cerebrospinal fluid, rather than via bloodstream to other organs.
There are various classification systems currently in use for primary brain tumors, the most common being the World Health Organization (WHO) brain tumor classification, introduced in 1993.
Secondary tumors and non-tumor lesions
Secondary or metastatic brain tumors originate from malignant tumors (cancers) located primarily in other organs. Their incidence is higher than that of primary brain tumors. The most frequent types of metastatic brain tumors originate in the lung, skin (malignant melanoma), kidney (hypernephroma), breast (breast carcinoma), and colon (colon carcinoma). These tumor cells reach the brain via the blood-stream.
Some non-tumoral masses and lesions can mimic tumors of the central nervous system. These include tuberculosis of the brain, cerebral abscess (commonly in toxoplasmosis), and hamartomas (for example, in tuberous sclerosis and von Recklinghausen neurofibromatosis).
Symptoms of brain tumors may depend on two factors: tumor size (volume) and tumor location. The time point of symptom onset in the course of disease correlates in many cases with the nature of the tumor (“benign”, i.e. slow-growing/late symptom onset, or malignant (fast growing/early symptom onset).
Many low-grade (benign) tumors can remain asymptomatic (symptom-free) for years and they may accidentally be discovered by imaging exams for unrelated reasons (such as a minor trauma).
New onset of epilepsy is a frequent reason for seeking medical attention in brain tumor cases.
Large tumors or tumors with extensive perifocal swelling edema inevitably lead to elevated intracranial pressure (intracranial hypertension), which translates clinically into headaches, vomiting (sometimes without nausea), altered state of consciousness (somnolence, coma), dilatation of the pupil on the side of the lesion (anisocoria), papilledema (prominent optic disc at the funduscopic examination). However, even small tumors obstructing the passage of cerebrospinal fluid (CSF) may cause early signs of increased intracranial pressure. Increased intracranial pressure may result in herniation (i.e. displacement) of certain parts of the brain, such as the cerebellar tonsils or the temporal uncus, resulting in lethal brainstem compression. In young children, elevated intracranial pressure may cause an increase in the diameter of the skull and bulging of the fontanelles.
Depending on the tumor location and the damage it may have caused to surrounding brain structures, either through compression or infiltration, any type of focal neurologic symptoms may occur, such as cognitive and behavioral impairment, personality changes, hemiparesis, (hemi) hypesthesia, aphasia, ataxia, visual field impairment, facial paralysis, double vision, tremor etc. These symptoms are not specific for brain tumors – they may be caused by a large variety of neurologic conditions (e.g. stroke, traumatic brain injury). What counts, however, is the location of the lesion and the functional systems (e.g. motor, sensory, visual, etc.) it affects.
A bilateral temporal visual field defect (bitemporal hemianopia—due to compression of the optic chiasm), often associated with endocrine disfunction—either hypopituitarism or hyperproduction of pituitary hormones and hyperprolactinemia is suggestive of a pituitary tumor.
Brain tumors in infants and children
In 2000 approximately 2.76 children per 100,000 will be affected by a CNS tumor in the United States each year. This rate has been increasing and by 2005 was 3.0 children per 100,000. This is approximately 2,500-3,000 pediatric brain tumors occurring each year in the US. The tumor incidence is increasing by about 2.7% per year. The CNS Cancer survival rate in children is approximately 60%. However, this rate varies with the age of onset (younger has higher mortality) and cancer type.
In children under 2, about 70% of brain tumors are medulloblastoma, ependymoma, and low-grade glioma. Less commonly, and seen usually in infants, are teratoma and atypical teratoid rhabdoid tumor
Diagnosis
Although there is no specific clinical symptom or sign for brain tumors, slowly progressive focal neurologic signs and signs of elevated intracranial pressure, as well as epilepsy in a patient with a negative history for epilepsy should raise red flags. However, a sudden onset of symptoms, such as an epileptic seizure in a patient with no prior history of epilepsy, sudden intracranial hypertension (this may be due to bleeding within the tumor, brain swelling or obstruction of cerebrospinal fluid’s passage) is also possible.
Symptoms include phantom odors and tastes. Often, in the case of metastatic tumors, the smell of vulcanized rubber is prevalent.
Imaging plays a central role in the diagnosis of brain tumors. Early imaging methods—invasive and sometimes dangerous—such as pneumoencephalography and cerebral angiography, have been abandoned in recent times in favor of non-invasive, high-resolution modalities, such as computed tomography (CT) and especially magnetic resonance imaging (MRI). Benign brain tumors often show up as hypodense (darker than brain tissue) mass lesions on cranial CT-scans. On MRI, they appear either hypo- (darker than brain tissue) or isointense (same intensity as brain tissue) on T1-weighted scans, or hyperintense (brighter than brain tissue) on T2-weighted MRI. Perifocal edema also appears hyperintense on T2-weighted MRI. Contrast agent uptake, sometimes in characteristic patterns, can be demonstrated on either CT or MRI-scans in most malignant primary and metastatic brain tumors. This is due to the fact that these tumors disrupt the normal functioning of the blood-brain barrier and lead to an increase in its permeability.
Electrophysiological exams, such as electroencephalography (EEG) play a marginal role in the diagnosis of brain tumors.
The definitive diagnosis of brain tumor can only be confirmed by histological examination of tumor tissue samples obtained either by means of brain biopsy or open surgery. The histologic examination is essential for determining the appropriate treatment and the correct prognosis.
Treatment and prognosis
Meningiomas, with the exception of some tumors located at the skull base, can be successfully removed surgically, but the chances are less than 50%. In more difficult cases, stereotactic radiosurgery, such as Gamma Knife radiosurgery, remains a viable option.
Most pituitary adenomas can be removed surgically, often using a minimally invasive approach through the nasal cavity and skull base (trans-nasal, trans-sphenoidal approach). Large pituitary adenomas require a craniotomy (opening of the skull) for their removal. Radiotherapy, including stereotactic approaches, is reserved for the inoperable cases.
Although there is no generally accepted therapeutic management for primary brain tumors, a surgical attempt at tumor removal or at least cytoreduction (that is, removal of as much tumor as possible, in order to reduce the number of tumor cells available for proliferation) is considered in most cases. However, due to the infiltrative nature of these lesions, tumor recurrence, even following an apparently complete surgical removal, is not uncommon. Postoperative radiotherapy and chemotherapy are integral parts of the therapeutic standard for malignant tumors. Radiotherapy may also be administered in cases of “low-grade” gliomas, when a significant tumor burden reduction could not be achieved surgically.
Survival rates in primary brain tumors depend on the type of tumor, age, functional status of the patient, the extent of surgical tumor removal, to mention just a few factors.
Patients with benign gliomas may survive for many years while survival in most cases of glioblastoma multiforme is limited to a few months after diagnosis.
The main treatment option for single metastatic tumors is surgical removal, followed by radiotherapy and/or chemotherapy. Multiple metastatic tumors are generally treated with radiotherapy and chemotherapy. Stereotactic radiosurgery, such as Gamma Knife radiosurgery, remains a viable option. However, the prognosis in such cases is determined by the primary tumor, and it is generally poor.
A shunt operation is used not as a cure but to relieve the symptoms. The hydrocephalus caused by the blocking drainage of the cerebrospinal fluid can be removed with this operation.
Disclaimer: This information is not meant to be a substitute for professional medical advise or help. It is always best to consult with a Physician about serious health concerns. This information is in no way intended to diagnose or prescribe remedies.This is purely for educational purpose.
There is no question that dogs can provide companionship, protection, and other services. But could there be another use for our canine friends? Some anecdotal evidence and a sprinkling of scientific studies suggest that dogs can detect seizures and cancers (like skin melanoma and prostate cancer). Though the research is still in its infancy, preliminary results have already provided insight on developing new medical technologies…………..CLICK & SEE
Detecting Seizures
Though many anecdotal stories suggest dogs can alert their owners before a seizure, there has been little research on how dogs might detect seizures before they happen. Some theorize that the dogs may smell a chemical or other scent that is released just prior to a seizure. Others believe the dog‘s attachment to his or her owner helps in detecting subtle scent and behavioral changes before a seizure. Only a very small percentage of these service dogs are currently able to reliably warn their owners before a seizure. Some researchers have studied whether these skills could be taught………….click & see
Researchers in the UK reported in the January 1999 and January 2001 issues of Seizure on dogs they had trained that could detect seizures 15 to 45 minutes prior to the episodes beginning. In addition, the researchers found that the people using these dogs actually reported fewer seizures. Though these results are promising, in most cases it still seems that this skill is inherent in a dog’s personality, rather than something that can be taught. Future research may reveal what these dogs are detecting and how this information can be applied in the hospital setting.
There is no doubt that trained seizure alert dogs can alert help, help prevent injury and watch over someone when they are having a seizure. However, the Epilepsy Foundation cautions people against rushing into spending thousands of dollars for a dog said to have skills of prior seizure detection, at least until the research supports a specific training regimen.
Detecting Cancer
There has also been anecdotal evidence of dogs being able to sniff out cancer and warn their owners. A brief report in a 1989 issue of the Lancet describes how one dog discovered a cancerous skin tumor on her owner’s leg. Researchers have been able to teach bomb-sniffing dogs how to detect cancer using similar training techniques. Other research supports the theory that dogs have the ability to smell cancer. But the real promise may be in learning how dogs can do this and possibly developing medical technology to do the same..…click & see
The Future of Dogs as Doctors….click & see
Dogs may never be used in the physician’s office. However, studying how animals can detect disease conditions in humans could lead to future advancements in medicine and medical technology. For instance, by learning about the ways dogs smell a seizure or cancer cells, we can develop technologies to detect those same molecules. Medical sniffing machines have already been developed and are providing insight into the smells of disease for disease detection. RESOURCES:
There is no question that dogs can provide companionship, protection, and other services. But could there be another use for our canine friends? Some anecdotal evidence and a sprinkling of scientific studies suggest that dogs can detect seizures and cancers (like skin melanoma and prostate cancer). Though the research is still in its infancy, preliminary results have already provided insight on developing new medical technologies. CLICK & SEE THE PICTURES DetectingSeizures
Though many anecdotal stories suggest dogs can alert their owners before a seizure, there has been little research on how dogs might detect seizures before they happen. Some theorize that the dogs may smell a chemical or other scent that is released just prior to a seizure. Others believe the dog’s attachment to his or her owner helps in detecting subtle scent and behavioral changes before a seizure. Only a very small percentage of these service dogs are currently able to reliably warn their owners before a seizure. Some researchers have studied whether these skills could be taught.
Researchers in the UK reported in the January 1999 and January 2001 issues of Seizure on dogs they had trained that could detect seizures 1545 minutes prior to the episode’s beginning. In addition, the researchers found that the people using these dogs actually reported fewer seizures. Though these results are promising, in most cases it still seems that this skill is inherent in a dog’s personality, rather than something that can be taught. Future research may reveal what these dogs are detecting and how this information can be applied in the hospital setting.
There is no doubt that trained seizure alert dogs can alert help, help prevent injury and watch over someone when they are having a seizure. However, the Epilepsy Foundation cautions people against rushing into spending thousands of dollars for a dog said to have skills of prior seizure detection, at least until the research supports a specific training regimen.
Detecting Cancer
There has also been anecdotal evidence of dogs being able to sniff out cancer and warn their owners. A brief report in a 1989 issue of the Lancet describes how one dog discovered a cancerous skin tumor on her owner’s leg. Researchers have been able to teach bomb-sniffing dogs how to detect cancer using similar training techniques. Other research supports the theory that dogs have the ability to smell cancer. But the real promise may be in learning how dogs can do this and possibly developing medical technology to do the same.
The Future of Dogs as Doctors
Dogs may never be used in the physicians office. However, studying how animals can detect disease conditions in humans could lead to future advancements in medicine and medical technology. For instance, by learning about the ways dogs “smell†a seizure or cancer cells, we can develop technologies to detect those same molecules. Medical “sniffing machines†have already been developed and are providing insight into the smells of disease for disease detection.
