Definition:A barium swallow, or upper GI series, is an x-ray test used to examine the upper digestive tract (the esophagus, stomach, and small intestine). Because these organs are normally not visible on x-rays, you need to swallow barium, a liquid that does show up on x-rays. The barium temporarily coats the lining of the esophagus, stomach, and intestine, making the outline of these organs visible on the xray pictures. This test is useful for diagnosing cancers, ulcers, problems that cause narrowing of the esophagus, some causes of inflammation in the intestine, and some swallowing problems.
An upper gastrointestinal (UGI) series looks at the upper and middle sections of the gastrointestinal tract. The test uses barium contrast material, fluoroscopy, and X-ray. Before the test, you drink a mix of barium (barium contrast material) and water. The barium is often combined with gas-making crystals. Your doctor watches the movement of the barium through your esophagus, stomach, and the first part of the small intestine (duodenum) on a video screen. Several X-ray pictures are taken at different times and from different views.
A small bowel follow-through may be done immediately after a UGI to look at the rest of the small intestine. If just the throat and esophagus are looked at, it is called an esophagram (or barium swallow).
Upper endoscopy is done instead of a UGI in certain cases. Endoscopy uses a thin, flexible tube (endoscope) to look at the lining of the esophagus, stomach, and upper small intestine (duodenum).
Why It Is Done:- An upper gastrointestinal (UGI) series is done to:
1.Find the cause of gastrointestinal symptoms, such as difficulty swallowing, vomiting, burping up food, belly pain (including a burning or gnawing pain in the center of the stomach), or indigestion. These may be caused by conditions such as hiatal hernia.
*Find narrow spots (strictures) in the upper intestinal tract, ulcers, tumors, polyps, or pyloric stenosis.
*Find inflamed areas of the intestine, malabsorption syndrome, or problems with the squeezing motion that moves food through the intestines (motility disorders).
*Find swallowed objects.
Generally, a UGI series is not used if you do not have symptoms of a gastrointestinal problem. A UGI series is done most often for people who have:
1.A hard time swallowing.
2.A history of Crohn’s disease.
3.A possible blocked intestine (obstruction).
4.Belly pain that is relieved or gets worse while eating.
5.Severe heartburn or heartburn that occurs often.
How To Prepare for the Test:- Tell your doctor and the x-ray technicians if you :
1.Are taking any medicine.
2.Are allergic to any medicines, barium, or any other X-ray contrast material.
3.Are or might be pregnant. This test is not done during pregnancy because of the risk of radiation to the developing baby (fetus).
4.You may be asked to eat a low-fiber diet for 2 or 3 days before the test. You may also be asked to stop eating for 12 hours before the test. Your doctor will tell you if you need to stop taking certain medicines before the test.
The evening before the test, you may be asked to take a laxative to help clean out your intestines. If your stomach cannot empty well on its own, you may have a special tube put through your nose and down into your stomach just before the test begins. A gentle suction on the tube will drain the stomach contents.
If you are having the small bowel follow-through after the UGI series, you will need to wait between X-rays. The entire small bowel follow-through exam takes up to 6 hours, so bring along a book to read or some other quiet activity.
You may be asked to sign a consent form. Talk to your doctor about any concerns you have regarding the need for the test, its risks, how it will be done, or what the results will mean. To help you understand the importance of this test, fill out the medical test information form (What is a PDF document?) . How It Is Done
A UGI series is usually done in your doctor’s office, clinic, or X-ray department of a hospital. You do not need to stay overnight in the hospital. The test is done by a radiologist and a radiology technologist.
You will need to take off your clothes and put on a hospital gown. You will need to take out any dentures and take off any jewelry. You may not smoke or chew gum during the test, since the stomach will respond by making more gastric juices and this will slow the movement of the barium through the intestines.
You might also be asked to swallow some tablets that “fizz,” causing air-bubbles to be released in your stomach. This might make you feel like burping, but try not to. You will get better pictures if you can keep yourself from burping.
The x-ray technician may ask you to stand or lie in different positions over the next few minutes, to help spread around the liquid you have swallowed. Most often, the x-ray pictures are taken while you lie on your back on a table. The x-ray machine or the table is moved a few times so it can take pictures of all of the internal structures. You are asked to hold your breath for each picture so that your breathing movement does not blur the image.
You will lie on your back on an X-ray table. The table is tilted to bring you to an upright position with the X-ray machine in front of you. Straps may be used to keep you safely on the table. The technologist will make sure you are comfortable during changes in table position.
You will have one X-ray taken before you drink the barium mix. Then you will take small swallows repeatedly during the series of X-rays that follow. The radiologist will tell you when and how much to drink. By the end of the test, you may have swallowed 1cup to 2.5cups of the barium mixture. See a picture of a barium swallow test.
The radiologist watches the barium pass through your gastrointestinal tract using fluoroscopy and X-ray pictures. The table is tilted at different positions and you may change positions to help spread the barium. Some gentle pressure is put on your belly with a belt or by the technologist’s gloved hand. You may be asked to cough so that the radiologist can see how that changes the barium flow. See an image of a barium swallow.
If you are having an air-contrast study, you will sip the barium liquid through a straw with a hole in it or take pills that make gas in your stomach. The air or gas that you take in helps show the lining of the stomach and intestines in greater detail.
If you are also having a small bowel study, the radiologist watches as the barium passes through your small intestine into your large intestine. X-ray pictures are taken every 30 minutes.
The UGI series 30 to 40 minutes. The UGI series with a small bowel study takes 2 to 6 hours. In some cases, you may be asked to return after 24 hours to have more X-ray pictures taken.
When the UGI series is done, you may eat and drink whatever you like, unless your doctor tells you not to.
You may be given a laxative or enema to flush the barium out of your intestines after the test to prevent constipation. Drink a lot of fluids for a few days to flush out the barium.
How It Feels
The barium liquid is thick and chalky, and some people find it hard to swallow. A sweet flavor, like chocolate or strawberry, is used to make it easier to drink. Some people do not like it when the X-ray table tilts. You may find that pressure on your belly is uncomfortable. After the test, many people feel bloated and a little nauseated.
For 1 to 3 days after the test, your stool (feces) will look white from the barium. Call your doctor if you are not able to have a bowel movement in 2 to 3 days after the test. If the barium stays in your intestine, it can harden and cause a blockage. If you become constipated, you may need to use a laxative to pass a stool.
Risk Factors:
There are no significant risks.
Barium does not move into the blood, so allergic reactions are very rare.
Some people gag while drinking the barium fluid. In rare cases, a person may choke and inhale (aspirate) some of the liquid into the lungs.
There is a small chance that the barium will block the intestine or leak into the belly through a perforated ulcer. A special type of contrast material (Gastrografin) can be used if you have a blockage or an ulcer.
There is always a small chance of damage to cells or tissue from being exposed to any radiation, even the low level of radioactive tracer used for this test.
How long is it before the result of the test is known?
It takes the x-ray department 30 minutes to an hour to develop the pictures from your barium swallow, and it will take additional time for a doctor to examine the x-rays and to decide how they look. Typically you can get the results within a day or two.
Must you do anything special after the test is over
After the test, you can eat normally and do your normal activities. You should drink more water than usual to help clear out the barium and to prevent constipation, which might be a side effect of the test. Your stool may appear light in color for a couple of days.
Results:-
An upper gastrointestinal (UGI) series looks at the upper and middle sections of the gastrointestinal tract. Results are usually ready in 1 to 3 days.
Upper gastrointestinal (UGI) series Normal: The esophagus, stomach, and small intestine all look normal.
Abnormal: A narrowing (stricture), inflammation, a mass, a hiatal hernia, or enlarged veins (varices) may be seen. Spasms of the esophagus or a backward flow (reflux) of barium from the stomach may occur.
The UGI series may show a stomach (gastric) or intestinal (duodenal) ulcer, a tumor, or something pushing on the intestines from outside the gastrointestinal tract. Narrowing of the opening between the stomach and the small intestine (pyloric stenosis) may be seen.
The small bowel follow-through may show inflammation or changes in the lining that may explain poor absorption of food. This may be caused by Crohn’s disease or celiac disease.
What Affects the Test
Reasons you may not be able to have the test or why the results may not be helpful include:
*Eating before or during the test.
*Too much air in the small intestine.
ABOUT THE TEST:
*A gastrointestinal (GI) motility study may be done if the squeezing motions of the small intestine are not normal during the UGI series and small bowel follow-through. The movement of the barium through the lower intestinal tract is recorded every few hours for up to 24 hours. A barium enema or colonoscopy may be needed to confirm the diagnosis.
*Upper endoscopy is done instead of a UGI test in certain cases. Endoscopy uses a thin, flexible tube (endoscope) to look at the lining of the esophagus, stomach, and upper small intestine (duodenum). For more information, see the medical test Upper Gastrointestinal Endoscopy.
*The UGI series test:
*Cannot show irritation of the stomach lining (gastritis) or esophagus (esophagitis) or ulcers that are smaller than about 0.25in. in diameter.
*Cannot show an infection with the bacteria Helicobacter pylori, which may be a cause of stomach ulcers.
*A biopsy cannot be done during the UGI if a problem is found.
Q: My uncle has started to suspect that everyone is against him. It started with his job where he felt he was being victimised. He then decided that the rest of his family (wife and children) is poisoning him. He has also become involved with a woman in his office, who encourages his beliefs and wants to cut all of us out of his life.
A: It sounds like your uncle is slowly becoming paranoid, suffering from delusions and maybe becoming schizophrenic as well. This is very difficult to treat as he will suspect that the medication is poison as well.
The “other woman” may be mildly schizophrenic herself. People with these illnesses tend to gravitate together. She may have an ulterior motive for encouraging your uncle’s beliefs. You could try to speak to him and try to encourage him to see a psychiatrist.
Preventing pimples Q: I have pimples on the back below the neck. It looks ugly when I wear low-necked outfits. I have tried prickly heat powder to no avail. ………………… A: Pimples or acne on the back of the neck can be itchy and leave disfiguring dark scars. It is aggravated by dandruff. Anti dandruff shampoos will help. Also, do not use powder. Talc blocks the pores and makes the pimples worse. Try to use soap with the correct TFC (total fat content) and TCC (tricholorohexidine) like Neko. If applied using a loofah, it kills the skin bacteria that aggravate acne.
Relief from arthritis Q: I have arthritis and I have been prescribed capsules containing chondroitin sulphate. Will it help?
………………….
A:Chondroitin sulphate is a natural ingredient found in joint cartilage. The question of whether it actually reaches damaged cartilage and repairs it is not proven. Many people who take it feel that it does reduce the symptoms of arthritis. It has to be taken for 3-6 months before its effects are seen. It needs to be taken 2-3 times a day or as recommended. It is relatively expensive. It is often combined with NSAIDs (non-steroidal anti-inflammatory drugs) and physiotherapy. It is difficult to say exactly which of these three ingredients plays the maximum role in reducing the arthritis.
Pop a pill daily Q: I have mild hypertension and have been prescribed 2.5 mg of amlodipin once a day. I check my BP myself with an electronic machine. Whenever I find it is normal I stop the tablet. I take it again only if I have a headache or the reading is high. Is this all right?
… 2.5 mg of amlodipin>.…..
A: Once hypertension has been diagnosed and the treatment started, you have to take the medication every day at the same time, as this particular drug acts for 24 hours. Once you start the treatment the blood pressure will get controlled. Even if you stop the tablets the BP (blood pressure) will remain under control for 2-3 days before it starts to rise again. Therefore, you can’t start and stop medication based on headaches and BP readings. Unlike diabetes where the sugars are controlled on a day-to-day basis, in BP the control is usually monthly. Take the tablets regularly as prescribed to prevent unnoticed elevations in the BP.
Try surgery : Q: I have an umbilical hernia and the doctor told me that as it is small I can leave it alone. I am 47 years old.
………………..
A:Umbilical hernia is a generic term and can be used for a defect exactly at the umbilicus, or above (paraumbilical). Intestines or other contents from the abdomen can pass through the defect. As long as the contents pass freely there is no problem. However the contents can get stuck as they pass outwards. This compromises the blood supply to that area and it can even be fatal.You are young and healthy. It is probably better to have surgery while there are no risk factors.
Brittle-boned babe : Q: My daughter who is 18 years old has weak bones and cannot do any work or lift weights. What can I do?
……………………
A: An 18 year old should not have weak bones unless there is an underlying kidney, intestinal, blood or bone disease. You need to get the diagnosis sorted out first. Remove the cause and the disease will be cured.
Sanitation in India has not kept up with the rest of our advances in the 21st century. We lack hygienic toilet facilities and 40 per cent of our population is forced to use open areas. This propagates a self-perpetuating cycle of diarrhoeal infections.
Most of the time, the diarrhoea settles in a day or two, with or without treatment. Sometimes, blood and mucous appear in the stool. This means that the diarrhoea has progressed to dysentery.
Often patients equate dysentery with amoebic infestation and the words ‘diarrhoea’ and ‘amoebic dysentery’ are interchanged. Most of the time they are right and the dysentery is due to the single celled amoebaEntamoeba histolytica. Around four per cent of the Indian population has antibodies to amoebae.
Amoebae have been around a lot longer than humans. They have perfected the art of survival. If exposed to extremes of temperature and medication, they can round themselves off into thick walled hibernating resistant cysts.
Once the cyst is swallowed, amoebic dysentery sets in with an explosive onset of loose bloody stools, cramping abdominal pain and low grade fever. Many people recognise these symptoms, complain of “amoebic dysentery” and self medicate. They use single inadequate suppressant doses of medication. They may eventually become chronic carriers. In some, the amoebae burrow into the intestinal wall, causing perforations, and produce life threatening abscesses in the liver and the brain.
Treatment for amoebic infection is the “azoles” — metronidazole or secnidazole — followed by a second drug like diloxanide furoate. The duration of the treatment is around two weeks.
All dysentery is not caused by amoebae. Infections by other organisms can also produce blood and mucous in the stool. Some bacteria and viruses cause dysentery.
Symptoms of dysentery may occur without any infection at all. In people with diabetes, hypertension or abnormal disordered elevated lipids, the blood vessels supplying the intestine may be partially blocked. The intestine may get damaged in those areas, causing bloody and painful diarrhoea. The person may be diagnosed to have “repeated attacks of dysentery” and given inappropriate antibiotic treatment.
In older people the colon (or the large intestine) can get weakened in certain areas, causing finger-shaped small pouches called diverticula. Food can become trapped and remain in these areas. Inflammation and infection will produce symptoms similar to amoebiasis.
Cells can grow and bulge into the intestine, forming grape-like protrusions called polyps. These can cause recurrent attacks of bleeding from the rectum with or without diarrhoea. Cancers of the intestines can cause intermittent diarrhoea and dysentery.
A number of illnesses, loosely classified as inflammatory bowel diseases (IBD), are characterised by inflammation of various parts of the intestine. One of the common forms is ulcerative colitis that affects the large intestine. It causes intermit attacks of loose stool, with blood and mucous, accompanied by abdominal pain. Although there may be weight loss, many patients remain well between the attacks, giving an initial false impression of repeated attacks of amoebic dysentery. The exact cause of IBD isn’t known. Genes, heredity, environmental factors, stress and autoimmune diseases (where the body attacks its own cells) are all put forward as possible factors.
Milk allergy can cause diarrhoea. If the person is unaware of the condition and overloads the system, severe diarrhoea can result.
Sometimes the cause of the dysentery is obvious. It may follow treatment for cancer with radiation or medication. It can occur after prolonged courses of antibiotics. It may also be due to cancer of the intestines.
A single attack of dysentery may be “amoebiasis”, which can be cured by a complete course of medication. If the symptoms of the dysentery are recurrent, a correct diagnosis is essential. More so if a person over 30 years presents a sudden change in bowel habits or has alternating constipation and diarrhoea. The other danger signals for cancer are blood and mucous in the stool, poor appetite and weight loss.
Diarrhoea needs to be investigated if it lasts longer than two weeks, is recurrent, with blood and mucous in the stool, and there is weight loss.
To prevent infective diarrhoea • Do not drink water that has not been boiled or purified
• Remember ice cubes in juice may be made from contaminated water
• Do not eat cut raw fruits or vegetables
• Eat food which is piping hot
• Always wash your hands before eating
Definition Colon polyps are fleshy growths that occur on the inside (the lining) of the large intestine, also known as the colon. Polyps in the colon are extremely common, and their incidence increases as individuals get older. As many as 30 percent of middle-aged and older adults have one or more colon polyps — a small clump of cells that forms on the colon lining. Although the great majority of colon polyps are harmless, some may become cancerous over time. Anyone can develop colon polyps, but you’re at higher risk if you are 50 or older, are overweight or a smoker, eat a high-fat, low-fiber diet, or have a personal or family history of colon polyps or colon cancer.
Sometimes colon polyps can cause signs and symptoms such as rectal bleeding, a change in bowel habits and abdominal pain. But most small colon polyps don’t cause problems, which is why experts generally recommend regular screening. Colon polyps that are found in the early stages usually can be removed safely and completely.
Types of polyps become cancerous:
The polyps that become cancerous are called adenomatous polyps or adenomas. Adenomas account for approximately 75% of all colon polyps. There are several subtypes of adenoma that differ primarily in the way the cells of the polyp are assembled when they are examined under the microscope. Thus, there are tubular, villous, or tubulo-villous adenomas. Villous adenomas are the most likely to become cancerous, and tubular adenomas are the least likely.
Other Factors that may determine a polyp’s chance of becoming cancerous
Another factor that contributes to a polyp’s likelihood of becoming cancerous is its size. The larger a polyp grows, the more likely it is to become cancerous. Once a polyp reaches two centimeters or approximately one inch in size, the risk of cancer is in excess of 20 percent. Therefore, it is advisable to remove polyps of any size, preferably when they are of a small size, to prevent their growth and progression to cancer.
Although adenomas are by far the most common type of colon polyps, there are several other types of polyps. Among the other types of polyps that have no malignant potential are the hyperplastic, inflammatory, and hamartomatous polyps
Symptoms
Colon polyps range from smaller than a pea to golf ball sized. Small polyps, especially, aren’t likely to cause problems, and you may not know you have one until your doctor finds it during an examination of your bowel. Sometimes, however, you may have signs and symptoms such as:
Rectal bleeding. You might notice bright red blood on toilet paper after you’ve had a bowel movement. Although this may be a sign of colon polyps or colon cancer, rectal bleeding can indicate other conditions, such as hemorrhoids or minor tears (fissures) in your anus. Hemorrhoids don’t usually bleed consistently over a period of weeks, however, so if your bleeding is prolonged, be sure to tell your doctor.
Blood in your stool. Blood can show up as red streaks in your stool or make bowel movements appear black. Still, a change in color doesn’t always indicate a problem — iron supplements and some anti-diarrhea medications can make stools black, whereas beets and red licorice can turn stools red.
Constipation or diarrhea. Although a change in bowel habits that lasts longer than a week may indicate the presence of a large colon polyp, it can also result from a number of other conditions.
Pain or obstruction. Sometimes a large colon polyp may partially obstruct your bowel, leading to crampy abdominal pain, nausea, vomiting and severe constipation.
Causes:
Your digestive tract stretches from your mouth to your anus. As food travels along this 30-foot passageway, nutrients are broken down and absorbed by your body to build cells and produce energy.
The last part of your digestive tract is a long muscular tube called the large intestine. The colon is the upper 4 to 6 feet of the large intestine; the rectum makes up the lower 8 to 10 inches. The colon’s main function is to absorb water, salt and other minerals from colon contents. Your rectum stores waste until it’s eliminated from your body.
Why polyps form
The majority of polyps aren’t cancerous (malignant), yet like most cancers, they result from abnormal cell growth. Healthy cells grow and divide in an orderly way — a process that’s controlled by two broad groups of genes. Mutations in any of these genes can cause cells to continue dividing even when new cells aren’t needed. In the colon and rectum, this unregulated growth can cause polyps to form, and over a long period of time, some of these polyps may become malignant.
Polyps can develop anywhere in your large intestine. They can be small or large and flat (sessile) or mushroom shaped and attached to a stalk (pedunculated). Small and mushroom-shaped polyps are much less likely to become malignant than flat or large ones are. In general, the larger a polyp, the greater the likelihood of cancer.
There are three main types of colon polyps:
Adenomatous. Once adenomatous polyps grow beyond the size of a pencil eraser — about 5 millimeters (mm), or 1/4 inch — there’s a small but increasing chance that they’ll become cancerous. This is especially true when their diameter exceeds 10 mm. For that reason, doctors normally take a tissue sample (biopsy) from polyps during a sigmoidoscopy and either biopsy or remove large polyps during a colonoscopy. Hyperplastic. These polyps occur most often in your left (descending) colon and rectum. Usually less than 5 mm in size, they’re rarely malignant. Inflammatory. These polyps may follow a bout of ulcerative colitis or Crohn’s disease of the colon. Although the polyps themselves are not a significant threat, having ulcerative colitis or Crohn’s disease of the colon increases your overall risk of colon cancer.
Anyone can get polyps, but certain people are more likely than others. You may have a greater chance of getting polyps if you
*Are over age 50
*Have had polyps before
*Have a family member with polyps
*Have a family history of colon cancer
*Most colon polyps do not cause symptoms. If you have symptoms, they may include blood on your underwear or on toilet paper after a bowel movement, blood in your stool, or constipation or diarrhea lasting more than a week.
A number of factors may contribute to the formation of colon polyps and colon cancer. They include:
*Age. The great majority of people with colon cancer are 50 or older. Your risk generally starts increasing around age 40.
*Your sex. More men than women develop colon polyps and colon cancer.
Inflammatory intestinal conditions. Long-standing inflammatory diseases of the colon such as ulcerative colitis and Crohn’s disease can increase your risk.
In an autosomal dominant disorder, the mutated gene is dominant, which means you only need one mutated gene to have the disorder. A person with an autosomal dominant disorder — in this case, the father — has a 50 percent chance of having an affected child with one mutated gene (dominant gene) and a 50 percent chance of having an unaffected child with two normal genes (recessive genes). These chances are the same in each pregnancy. .
*Family history. You’re more likely to develop colon polyps or cancer if you have a parent, sibling or child with them. If many family members have them, your risk is even greater. In some cases this connection isn’t hereditary or genetic. For example, cancers within the same family may result from shared exposure to an environmental carcinogen or from similar diet or lifestyle factors.
*Diet. Eating a high-fiber diet — one plentiful in fruits, vegetables and whole grains — can reduce your risk of colon polyps and colon cancer. Fiber seems protective against colon cancer because it provides bulk that moves your stool more quickly through your bowel. This means that cancer-causing substances (carcinogens) in the foods you eat aren’t in contact with your bowel wall as long as they might be if you ate a low-fiber diet. Fruits and vegetables are also rich in antioxidants — substances that protect cells from damage caused by unstable molecules (free radicals) that may lead to cancer.
*Smoking and alcohol. Smoking significantly increases your risk of colon polyps and colon cancer. Smokers are 30 percent to 40 percent more likely to die of colon cancer than are nonsmokers. Drinking alcohol in excess also makes it more likely that you’ll develop colon polyps. If you smoke and drink, your risk increases even more.
*A sedentary lifestyle. If you’re inactive, you’re more likely to develop colon cancer. This may be because when you’re inactive, waste stays in your colon longer.
*Obesity. Being significantly overweight — 30 pounds or more — has been linked to an increased risk of several types of cancer, including colon cancer.
*Race. If you are black, you are at higher risk of developing colon cancer than if you are white.
Inherited gene mutations
Another risk factor for colon polyps is genetic mutations. A small percentage of colon cancers result from gene mutations. These cancers are autosomal dominant, meaning you need to inherit only one defective gene from either of your parents. If one parent has the mutated gene, you have a 50 percent chance of inheriting the mutation. Although inheriting a defective gene greatly increases your risk, not everyone with a mutated gene develops cancer.
One genetic defect that plays a key role in colon cancer occurs in the adenomatous polyposis coli (APC) gene. When the APC gene is normal, it helps control cell growth. But if it’s defective, cell growth accelerates, leading to the formation of multiple adenomatous polyps in your intestinal lining. Conditions related to APC gene defects include:
*Familial adenomatous polyposis (FAP). This is a rare, hereditary disorder that results from an APC gene defect. FAP causes you to develop hundreds, even thousands, of polyps in the lining of your colon beginning in your teenage years. If these go untreated, your risk of developing colon cancer is nearly 100 percent. The encouraging news about FAP is that in some cases, genetic testing can help determine whether you’re at risk of the disease.
*Gardner’s syndrome. This syndrome is a variant of FAP. This condition causes polyps to develop throughout your colon and small intestine. You may also develop noncancerous tumors in other parts of your body, including your skin (sebaceous cysts and lipomas), bone (osteomas) and abdomen (desmoids).
*Hereditary nonpolyposis colorectal cancer (HNPCC). This is the most common form of inherited colon cancer. It, too, results from a defect in the APC gene, but unlike people with FAP or Gardner’s syndrome, people with hereditary nonpolyposis colorectal cancer tend to develop relatively few colon polyps. They do, however, often have tumors in other organs. Hereditary nonpolyposis colorectal cancer includes Lynch I and Lynch II syndromes. People with Lynch I syndrome usually develop a small number of polyps that quickly become malignant. Those with Lynch II syndrome tend to develop tumors in the breast, stomach, small intestine, urinary tract and ovaries as well as in the colon.
Tests and diagnosis:
Nearly all colon cancers develop from polyps, but the polyps grow slowly, usually over a period of years. Screening tests play a key role in detecting polyps before they become cancerous. These tests can also help find colorectal cancer in its early stages, when you have a good chance of recovery. When early-stage cancers are found and removed during routine screening, the five-year survival rate may be as high as 90 percent.
Several screening methods exist — each with its own benefits and risks. Be sure to discuss these with your doctor:
*Digital rectal exam. In this office exam, your doctor uses a gloved finger to check the first few inches of your rectum for polyps. Although safe and relatively painless, the exam is limited to your lower rectum and can’t detect problems with your upper rectum and colon. In addition, it’s difficult for your doctor to feel small polyps. This test should not be used alone as a screening method.
*Fecal occult (hidden) blood test. This noninvasive test checks a sample of your stool for blood. It can be performed in your doctor’s office, but you’re usually given a kit that explains how to take the test at home. Be sure to follow the instructions carefully, because your diet and other factors can affect the results. You then return the test to a lab or your doctor’s office to be checked. The problem is that most polyps don’t bleed, nor do all cancers. This can result in a negative test result, even though you may have a polyp or cancer. On the other hand, if blood shows up in your stool, it may be the result of hemorrhoids or an intestinal condition other than cancer. For these reasons, many doctors recommend other screening methods instead of, or in addition to, fecal occult blood tests.
*Flexible sigmoidoscopy. In this test, your doctor uses a slender, lighted tube to examine your rectum and sigmoid — approximately the last 2 feet of your colon. Nearly half of all colon cancers are found in this area. Yet a sigmoidoscopy only looks at the last third of your colon, and doesn’t detect polyps elsewhere in the large intestine. It’s often combined with a barium enema to better visualize the entire colon, or your doctor may recommend performing a colonoscopy instead. A sigmoidoscopy can be somewhat uncomfortable, and though there’s a slight risk of perforating the colon, the risks are less than they are for colonoscopy.
*Barium enema. This diagnostic test allows your doctor to evaluate your entire large intestine with an X-ray. Barium, a contrast dye, is placed into your bowel in an enema form. The barium fills and coats the lining of the bowel, creating a clear silhouette of your rectum, colon and sometimes a small portion of your small intestine. Air may also be added to provide better contrast on the X-ray. The test typically takes about 20 minutes and can be somewhat uncomfortable because the barium and air distend your bowel. There’s also a slight risk of perforating the colon wall. Because barium enema has a higher miss rate for colon polyps, it’s not nearly as reliable as other screening tests. It also doesn’t allow your doctor to take a biopsy during the procedure to determine whether a polyp is cancerous.
*Colonoscopy. This procedure is the most sensitive test for colorectal polyps and colorectal cancer. It’s better at detecting polyps than is a barium enema X-ray alone. Colonoscopy is similar to flexible sigmoidoscopy, but the instrument used — a colonoscope, which is a long, slender tube attached to a video camera and monitor — allows your doctor to view your entire colon and rectum. If any polyps are found during the exam, your doctor may remove them immediately or take tissue samples (biopsies) for analysis. A colonoscopy takes about a half-hour. You’re likely to receive a mild sedative to make you more comfortable. The risks of diagnostic colonoscopy include hemorrhage and perforation of the colon wall. Complications are more likely to occur when polyps are removed.
*Genetic testing. If you have a family history of colorectal cancer, you may be a candidate for genetic testing. This blood test may help determine if you’re at increased risk of colon or rectal cancer, but it’s not without drawbacks. The results can be ambiguous, and the presence of a defective gene doesn’t necessarily mean you’ll develop cancer. Knowing you have a genetic predisposition can alert you to the need for regular screening.
*Pill camera. Colonoscopy is effective at detecting polyps in the colon, but the colonoscope can’t reach the small intestine. Until recently, a barium X-ray was the only way to screen the small intestine, but the test is often inaccurate. Now doctors have found that a tiny camera fitted inside a capsule that you swallow can identify polyps in the small intestine with a high degree of accuracy. But because small intestine polyps are rare, the test isn’t routinely performed.
*New technologies. New technologies such as virtual colonoscopy (CT colonography) may make colon screening safer, more comfortable and less invasive. In virtual colonoscopy, you have a two-minute computerized tomography scan, a highly sensitive X-ray of your colon. Then, using computer imaging, your doctor rotates this X-ray in order to view every part of your colon and rectum without actually going inside your body. Before the scan, your large intestine is cleared of any stool, but researchers are looking into whether the scan can be done successfully without the usual bowel preparation. Although virtual colonoscopy potentially is a tremendous step forward, it may not be as accurate as regular colonoscopy, it is highly dependent on the skill of the doctor reading the test, and it doesn’t allow your doctor to remove polyps or take tissue samples during the procedure.
Another new test checks a stool sample for DNA from abnormal cells. In preliminary studies, the test proved highly accurate, but results in the first large trial of the test were disappointing. In that trial, the DNA test found more colon and rectal cancers than did the fecal occult blood test, but fewer than did colonoscopy.
Treatments and drugs:
Although some types of colon polyps are far more likely to become malignant than are others, a pathologist usually must examine a polyp under a microscope to determine whether it’s potentially cancerous. For that reason, your doctor is likely to remove all polyps discovered during a bowel examination.
The great majority of polyps can be removed during colonoscopy or sigmoidoscopy by snaring them with a wire loop that simultaneously cuts the stalk of the polyp and cauterizes it to prevent bleeding. Some small polyps may be cauterized or burned with an electrical current. Risks of polyp removal (polypectomy) include bleeding and perforation of the colon.
Polyps that are too large to snare or that can’t be reached safely are usually surgically removed — often using laparoscopic techniques. This means your surgeon performs the operation through several small incisions in your abdominal wall, using instruments with attached cameras that display your colon on a video monitor. Laparoscopic surgery may result in a faster and less painful recovery than does traditional surgery using a single large incision. Once the section of your colon that contains the polyp is removed, the polyp can’t recur, but you have a moderate chance of developing new polyps in other areas of your colon in the future. For that reason, follow-up care is extremely important.
In cases of rare, inherited syndromes, such as FAP, your surgeon may perform an operation to remove your entire colon and rectum (total proctocolectomy). Then, in a procedure known as ileal pouch-anal anastomosis, a pouch is constructed from the end of your small intestine (ileum) that attaches directly to your anus. This allows you to expel waste normally, although you may have several watery bowel movements a day.
Prevention:
You can greatly reduce your risk of colon polyps and colorectal cancer by having regular screenings and by making certain changes in your diet and lifestyle. The following suggestions may help lower your risk of colon polyps and colon cancer:
*Pay attention to calcium. Calcium can significantly protect against colon polyps and cancers, even if you’ve had them before. For example, studies have shown a 19 percent to 34 percent reduction in recurrence of polyps in those who take daily calcium supplements. Good food sources of calcium include skim or low-fat milk and other dairy products, broccoli, kale and canned salmon with the bones. Vitamin D, which aids in the absorption of calcium, also appears to help reduce the risk of colorectal cancer. You get vitamin D from foods such as vitamin-D fortified milk products, liver, egg yolks and fish. Sunlight also converts a chemical in your skin into a usable form of the vitamin. If you don’t drink milk or you avoid the sun, you may want to consider taking both a vitamin D and a calcium supplement.
*Include plenty of fruits, vegetables and whole grains in your diet. These foods are high in fiber, which can cut your risk of developing colon polyps. Fruits and vegetables also contain antioxidants, which may help prevent cancer. The American Cancer Society recommends eating five or more servings of fruits and vegetables every day. Look for deep green and dark yellow or orange fruits and vegetables such as Swiss chard, bok choy, spinach, cantaloupe, mango, acorn or butternut squash, and sweet potatoes, as well as vegetables from the cabbage family, including broccoli, brussels sprouts and cauliflower. Lycopene, a nutrient found in tomatoes and other red fruits and vegetables, such as strawberries and red bell peppers, may be a particularly powerful anti-cancer chemical.
*Limit fat. People who eat high-fat diets have a higher rate of colorectal cancer than do people who consume less dietary fat. Be especially careful to limit saturated fats from animal sources such as red meat. Other foods that contain saturated fat include whole milk, cheese, ice cream, and coconut and palm oils. Restrict your total fat intake to less than 35 percent of your daily calories, with no more than 8 percent to 10 percent coming from saturated fats.
*Limit alcohol consumption. Consuming moderate to heavy amounts of alcohol — more than one drink a day for women and two for men — may increase your risk of colon polyps and cancer. A drink is considered to be a 4- to 5-ounce glass of wine, a 12-ounce can of beer, or a 1.5-ounce shot of 80-proof liquor. Curbing alcohol consumption can reduce your risk, even if colon cancer runs in your family.
*Stop smoking. Smoking can increase your risk of colon cancer and a wide range of other diseases. Talk to your doctor about ways to quit that might work for you.
*Stay physically active and maintain a healthy body weight. Controlling your weight alone can reduce your risk of colorectal cancer. And staying physically active may significantly cut your colon cancer risk. Exercise stimulates movement through your bowel and reduces the time your colon is exposed to harmful substances that may cause cancer. The American Cancer Society recommends at least 30 minutes of physical activity five or more days a week. Forty-five minutes of moderate or vigorous activity can lower your risk of breast and colon cancer even more. If you’re overweight, lose weight until you are at a healthy level and maintain it.
*Talk to your doctor about aspirin. Studies on the role of aspirin in colorectal polyp and cancer prevention are mixed. Some show a 13 percent to 28 percent reduction in relative risk of these conditions with aspirin use. Others show no risk reduction. Aspirin appears to decrease the risk of these conditions primarily when taken at a high dose, such as 325 milligrams or more a day, and for more than 10 years. But aspirin use can increase your risk of gastrointestinal bleeding, and in high enough doses, stroke. So check with your doctor before starting any aspirin regimen.
*Talk to your doctor about hormone therapy (HT). If you’re a woman past menopause, hormone therapy may reduce your risk of colorectal cancer. Women who use HT have a somewhat lower risk of colorectal cancer than do women who don’t use HT. But not all effects of HT are positive. Taking HT as a combination therapy — estrogen plus progestin — can increase your risk of breast cancer, dementia, heart disease, stroke and blood clots. Discuss your options with your doctor. Together you can decide what’s best for you.
*If you’re at high risk, consider your options. If you’re at risk of FAP because of a family history of the disease, consider having genetic counseling. And if you’ve been diagnosed with FAP, start having regular colonoscopy tests in your early teens and discuss your options with your doctor. To prevent cancer from developing, most experts recommend having surgery to remove your entire colon when you’re in your 20s. The risk for people with hereditary nonpolyposis colorectal cancer isn’t quite as great as it is for those with FAP. Doctors recommend that people at risk of HNPCC begin having regular colonoscopies around age 20, but less often recommend removing the colon.
In the past, researchers believed that folate could help prevent colon polyps, but subsequent research indicates that it has no protective effect and should not be taken for that purpose.
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Disclaimer: This information is not meant to be a substitute for professional medical advise or help. It is always best to consult with a Physician about serious health concerns. This information is in no way intended to diagnose or prescribe remedies.This is purely for educational purpose.
Definition:
Glucosamine (C6H13NO5) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. A type of glucosamine forms chitin, which composes the exoskeletons of crustaceans and other arthropods, cell walls in fungi and many higher organisms. Glucosamine is one of the most abundant monosaccharides. It is produced commercially by the hydrolysis of crustacean exoskeletons or, less commonly and more expensive to the consumer, by fermentation of a grain such as corn or wheat. Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.
Glucosamine is a compound found naturally in the body, made from glucose and the amino acid glutamine. Glucosamine is needed to produce glycosaminoglycan, a molecule used in the formation and repair of cartilage and other body tissues. Production of glucosamine slows with age.
Glucosamine is available as a nutritional supplement in health food stores and many drug stores. Glucosamine supplements are manufactured in a laboratory from chitin, a substance found in the shells of shrimp, crab, lobster, and other sea creatures. In additional to nutritional supplements, glucosamine is also used in sports drinks and in cosmetics.
Glucosamine is often combined with chondroitin sulfate, a molecule naturally present in cartilage. Chondroitin gives cartilage elasticity and is believed to prevent the destruction of cartilage by enzymes. Glucosamine is sometimes combined with methylsulfonylmethane, or MSM, in nutritional supplements.
Biochemistry:
Glucosamine was first identified in 1876 by Dr. Georg Ledderhose, but the stereochemistry was not fully defined until 1939 by the work of Walter Haworth.[1] D-Glucosamine is made naturally in the form of glucosamine-6-phosphate, and is the biochemical precursor of all nitrogen-containing sugars. Specifically, glucosamine-6-phosphate is synthesized from fructose-6-phosphate and glutamine[3] as the first step of the hexosamine biosynthesis pathway.[4] The end-product of this pathway is UDP-N-acetylglucosamine (UDP-GlcNAc), which is then used for making glycosaminoglycans, proteoglycans, and glycolipids.
As the formation of glucosamine-6-phosphate is the first step for the synthesis of these products, glucosamine may be important in regulating their production. However, the way that the hexosamine biosynthesis pathway is actually regulated, and whether this could be involved in contributing to human disease, remains unclear.
Health effects:
Oral glucosamine is commonly used for the treatment of osteoarthritis. Since glucosamine is a precursor for glycosaminoglycans, and glycosaminoglycans are a major component of joint cartilage, supplemental glucosamine may help to rebuild cartilage and treat arthritis. Its use as a therapy for osteoarthritis appears safe, but there is conflicting evidence as to its effectiveness. A randomized, double-blind, placebo-controlled trial found glucosamine sulfate is no better than placebo in reducing the symptoms or progression of hip osteoarthritis.
There is promising evidence that glucosamine may reduce pain symptoms of knee osteoarthritis and possibly slow the progression of osteoarthritis. For example, a study published in the journal Archives of Internal Medicine examined people with osteoarthritis over three years. Researchers assessed pain and structural improvements seen on x-ray. They gave 202 people with mild to moderate osteoarthritis 1,500 mg of glucosamine sulfate a day or a placebo.
At the end of the study, researchers found that glucosamine slowed the progression of knee osteoarthritis compared to the placebo. People in the glucosamine group had a significant reduction in pain and stiffness. On x-ray, there was no average change or narrowing of joint spaces in the knees (a sign of deterioration) of the glucosamine group. In contrast, joint spaces of participants taking the placebo narrowed over the three years.
One of the largest studies on glucosamine for osteoarthritis was a 6-month study sponsored by the National Institutes of Health. Called GAIT, the study compared the effectiveness of glucosamine hydrochloride (HCL), chondroitin sulfate, a combination of glucosamine and chondroitin sulfate, the drug celecoxib (Celebrex), or a placebo in people with knee osteoarthritis.
Glucosamine or chondroitin alone or in combination didn’t reduce pain in the overall group, although people in the study with moderate-to-severe knee pain were more likely to respond to glucosamine.
One major drawback of the GAIT Trial was that glucosamine hydrochloride was used rather than the more widely used and researched glucosamine sulfate. A recent analysis of previous studies, including the GAIT Trial, concluded that glucosamine hydrochloride was not effective. The analysis also found that studies on glucosamine sulfate were too different from one another and were not as well-designed as they should be, so they could not properly draw a conclusion. More research is needed.
Still, health care providers often suggest a three month trial of glucosamine and discontinuing it if there is no improvement after three months. A typical dose for osteoarthritis is 1,500 mg of glucosamine sulfate each day.
Other Conditions
Other conditions for which glucosamine is used include rheumatoid arthritis, inflammatory bowel disease (Crohn’s disease and ulcerative colitis), chronic venous insufficiency, and skin conditions, although further evidence is needed.
Use:
A typical dosage of glucosamine salt is 1,500 mg per day. Glucosamine contains an amino group that is positively charged at physiological pH. The anion included in the salt may vary. Commonly sold forms of glucosamine are glucosamine sulphate and glucosamine hydrochloride. The amount of glucosamine present in 1500 mg of glucosamine salt will depend on which anion is present and whether additional salts are included in the manufacturer’s calculation. Glucosamine is often sold in combination with other supplements such as chondroitin sulfate and methylsulfonylmethane.
Glucosamine is a popular alternative medicine used by consumers for the treatment of osteoarthritis. Glucosamine is also extensively used in veterinary medicine as an unregulated but widely accepted supplement.
Bioavailability and pharmacokinetics:
Two recent studies confirm that glucosamine is bioavailable both systemically and at the site of action (the joint) after oral administration of crystalline glucosamine sulfate in osteoarthritis patients. Steady state glucosamine concentrations in plasma and synovial fluid were correlated and in line with those effective in selected in vitro studies
Clinical studies:
There have been multiple clinical trials of glucosamine as a medical therapy for osteoarthritis, but results have been conflicting. The evidence both for and against glucosamine’s efficacy has led to debate among physicians about whether to recommend glucosamine treatment to their patients.
Multiple clinical trials in the 1980s and 1990s, all sponsored by the European patent-holder, Rottapharm, demonstrated a benefit for glucosamine. However, these studies were of poor quality due to shortcomings in their methods, including small size, short duration, poor analysis of drop-outs, and unclear procedures for blinding. Rottapharm then sponsored two large (at least 100 patients per group), three-year-long, placebo-controlled clinical trials of the Rottapharm brand of glucosamine sulfate. These studies both demonstrated a clear benefit for glucosamine treatment. There was not only an improvement in symptoms but also an improvement in joint space narrowing on radiographs. This suggested that glucosamine, unlike pain relievers such as NSAIDs, can actually help prevent the destruction of cartilage that is the hallmark of osteoarthritis. On the other hand, several subsequent studies, independent of Rottapharm, but smaller and shorter, did not detect any benefit of glucosamine.
Due to these controversial results, some reviews and meta-analyses have evaluated the efficacy of glucosamine. Richy et al. performed a meta-analysis of randomized clinical trials in 2003 and found efficacy for glucosamine on VAS and WOMAC pain, Lequesne index and VAS mobility and good tolerability.
Recently, a review by Bruyere et al. about glucosamine and chondroitin sulfate for the treatment of knee and hip osteoarthritis concludes that both products act as valuable symptomatic therapies for osteoarthritis disease with some potential structure-modifying effects.
This situation led the National Institutes of Health to fund a large, multicenter clinical trial (the GAIT trial) studying reported pain in osteoarthritis of the knee, comparing groups treated with chondroitin sulfate, glucosamine, and the combination, as well as both placebo and celecoxib. The results of this 6-month trial found that patients taking glucosamine HCl, chondroitin sulfate, or a combination of the two had no statistically significant improvement in their symptoms compared to patients taking a placebo. The group of patients who took celecoxib did have a statistically significant improvement in their symptoms. These results suggest that glucosamine and chondroitin did not effectively relieve pain in the overall group of osteoarthritis patients, but it should be interpreted with caution because most patients presented only mild pain (thus a narrow margin to appraise pain improvement) and because of an unusual response to placebo in the trial (60%). However, exploratory analysis of a subgroup of patients suggested that the supplements taken together (glucosamine and chondroitin sulfate) may be significantly more effective than placebo (79.2% versus 54%; p = 0.002) and a 10% higher than the positive control, in patients with pain classified as moderate to severe (see testing hypotheses suggested by the data).
In an accompanying editorial, Dr. Marc Hochberg also noted that “It is disappointing that the GAIT investigators did not use glucosamine sulfate … since the results would then have provided important information that might have explained in part the heterogeneity in the studies reviewed by Towheed and colleagues” But this concern is not shared by pharmacologists at the PDR who state, “The counter anion of the glucosamine salt (i.e. chloride or sulfate) is unlikely to play any role in the action or pharmacokinetics of glucosamine”. Thus the question of glucosamine’s efficacy will not be resolved without further updates or trials.
In this respect, a 6-month double-blind, multicenter trial has been recently performed to assess the efficacy of glucosamine sulfate 1500 mg once daily compared to placebo and acetaminophen in patients with osteoarthritis of the knee (GUIDE study). The results showed that glucosamine sulfate improved the Lequesne algofunctional index significantly compared to placebo and the positive control. Secondary analyses, including the OARSI responder indices, were also significantly favorable for glucosamine sulfate.
A subsequent meta-analysis of randomized controlled trials, including the NIH trial by Clegg, concluded that hydrochloride is not effective and that there was too much heterogeneity among trials of glucosamine sulfate to draw a conclusion.[46] In response to these conclusions, Dr. J-Y Reginster in an accompanying editorial suggests that the authors failed to apply the principles of a sound systematic review to the meta-analysis, but instead put together different efficacy outcomes and trial designs by mixing 4-week studies with 3-year trials, intramuscular/intraarticular administrations with oral ones, and low-quality small studies reported in the early 1980s with high-quality studies reported in 2007.
However, currently OARSI (OsteoArthritis Research Society International) is recommending glucosamine as the second most effective treatment for moderate cases of osteoarthritis. Likewise, recent European League Against Rheumatism practice guidelines for knee osteoarthritis grants to glucosamine sulfate the highest level of evidence, 1A, and strength of the recommendation, A.
Safety:
Clinical studies have consistently reported that glucosamine appears safe. Since glucosamine is usually derived from shellfish, those allergic to shellfish may wish to avoid it. However, since glucosamine is derived from the shells of these animals while the allergen is within the flesh of the animals, it is probably safe even for those with shellfish allergy. Alternative sources using fungal fermentation of corn are available. Another concern has been that the extra glucosamine could contribute to diabetes by interfering with the normal regulation of the hexosamine biosynthesis pathway, but several investigations have found no evidence that this occurs. A review conducted by Anderson et al in 2005 summarizes the effects of glucosamine on glucose metabolism in in vitro studies, the effects of oral administration of large doses of glucosamine in animals and the effects of glucosamine supplementation with normal recommended dosages in humans, concluding that glucosamine does not cause glucose intolerance and has no documented effects on glucose metabolism. Other studies conducted in lean or obese subjects concluded that oral glucosamine at standard doses does not cause or significantly worsen insulin resistance or endothelial dysfunction.
The U.S. National Institutes of Health is currently conducting a study of supplemental glucosamine in obese patients, since this population may be particularly sensitive to any effects of glucosamine on insulin resistance.
In the United States, glucosamine is not approved by the Food and Drug Administration for medical use in humans. Since glucosamine is classified as a dietary supplement in the US, safety and formulation are solely the responsibility of the manufacturer; evidence of safety and efficacy is not required as long as it is not advertised as a treatment for a medical condition.
In Europe, glucosamine is approved as a medical drug and is sold in the form of glucosamine sulfate. In this case, evidence of safety and efficacy is required for the medical use of glucosamine and several guidelines have recommended its use as an effective and safe therapy for osteoarthritis. Actually, the Task Force of the European League Against Rheumatism (EULAR) committee recently granted glucosamine sulfate a level of toxicity of 5 in a 0-100 scale, and recent OARSI (OsteoArthritis Research Society International) guidelines for hip and knee osteoarthritis also confirm its excellent safety profile.
Most studies involving humans have found that short-term use of glucosamine is well-tolerated. Side effects may include drowsiness, headache, insomnia, and mild and temporary digestive complaints such as abdominal pain, poor appetite, nausea, heartburn, constipation, diarrhea, and vomiting. In rare human cases, the combination of glucosamine and chondroitin has been linked with temporarily elevated blood pressure and heart rate and palpitations.
Since glucosamine supplements may be made from shellfish, people with allergies to shellfish should avoid glucosamine unless it has been confirmed that it is from a non-shellfish source. The source of glucosamine is not required to be printed on the label, so it may require a phone call to the manufacturer.
There is some evidence suggesting that glucosamine, in doses used to treat osteoarthritis, may worsen blood sugar, insulin, and/or hemoglobin A1c (a test that measures how well blood sugar has been controlled during the previous three months) levels in people with diabetes or insulin resistance.
Theoretically, glucosamine may increase the risk of bleeding. People with bleeding disorders, those taking anti-clotting or anti-platelet medication, such as warfarin, clopidogrel, and Ticlid, or people taking supplements that may increase the risk of bleeding, such as garlic, ginkgo, vitamin E, or red clover, should not take glucosamine unless under the supervision of a healthcare provider.
The safety of glucosamine in pregnant or nursing women isn’t known.
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