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Can Alcohol Really Protect Your Heart?

A study has suggested that drinking alcohol every day may cut the risk of heart disease in men by more than a third. But the research has come under fire from scientists who say the study is flawed and should not encourage anyone to drink more.
………..drinking alcohol
The controversial study found that men who drank moderate, high and very high levels of alcohol had a lower risk of coronary heart disease.

Heavy drinking can damage organs and lead to early death. According to the World Health Organization, 76 million of the estimated 2 billion people in the world who drink alcohol suffer ill health as a result, and alcohol causes around 1.8 million deaths every year.


Resources:

Reuters November 18, 2009
BBC News November 18, 2009

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New Way to ‘Stop’ Premature Birth

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A drug used to treat cancer can stop contractions and may prevent premature labour, researchers say.
………click & see
The Newcastle University team tested the drug Trichostatin A on tissue taken from 36 women undergoing a caesarean.

The researchers said the therapy worked by increasing the levels of a protein that controls muscle relaxation.

One expert said with rates of premature births rising – there are 50,000 a year in the UK – a new treatment was badly needed.

Preterm labour and birth continue to be the single biggest cause of death in infants in the developed world and around 1,500 babies die in the UK every year.

A number of drugs are used to try to stop early labour, but most have serious side effects.

Trichostatin A (TSA) is known to promote the death of cancer cells.

The researchers got permission to take samples of the muscles of women undergoing caesarean sections at the Royal Victoria Infirmary in Newcastle, the Cellular and Molecular Medicine journal reported.

Contractions
They exposed the muscle to TSA and measured the effects on both spontaneous contractions and those induced by the labour drug, oxytocin.

They found an average 46% reduction in contractions for the spontaneously contracting tissue and an average 54% reduction in the oxytocin induced contractions.

It has been previously shown that a protein kinase A (PKA) is involved in controlling the relaxation of the uterus during pregnancy.

The researchers showed that TSA increased the levels of a protein sub-unit of PKA.

Professor Nick Europe-Finner, who led the research, said: “We will not give this drug to a patient because it can damage as many as 10% of the genes in a cell.

“But it does show us that other more specific agents that act on the same enzymes but only one at a time are worth investigating.”

New treatment
Dr Yolande Harley, deputy director of research at Action Medical Research which funded the study, said: “This project has uncovered some of the molecular pathways that regulate uterine contractions and so could be linked to premature birth.

“It could have a role in preventing premature birth – finding a new treatment for early labour would be a major step forward.”

Professor Jane Norman, a spokeswoman for the Royal College of Obstetrics and Gynaecology (RCOG), said: “At the moment, it’s not possible to treat preterm labour effectively. We only have drugs that delay it by 24 hours or so – not enough to deliver the baby safely.

“One of the interesting things about this research is that they are using a new kind of drug – the drugs we are currently using have been around for a long time.

“And they are targeting pathways we have not known about before.

“When you consider that preterm birth rates are rising in all four countries of the UK a new more effective drug is badly needed.”

Source:BBC News:Oct.22 ’09

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Chocolet is Good for Heart

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Had a heart attack? Eating chocolate twice a week could save your life
Eat up: But only dark chocolate, not high-fat high-sugar milk chocolate, showed tangible benefits
.

………………EATING BLACK CHOCOLATE
Heart attack survivors who snack on chocolate at least twice a week could slash their risk of dying from heart disease.
New research shows chocolate-loving victims are nearly 70 per cent less likely to die from cardiac problems than those who rarely eat the confectionery.
Even a weekly chocolate treat can help, almost halving the risk of death from heart problems, researchers found.
The latest findings, published in the Journal of Internal Medicine, are the latest in a long line of studies highlighting the health benefits of chocolate, especially dark chocolate.
Previous investigations have found dark chocolate, which is rich in disease-busting antioxidants called flavonoids, can lower the risk of blood clots, protect against bowel cancer and even help prevent premature births.
Antioxidants are compounds that protect against so-called free radicals, molecules which accumulate in the body and damage cells.
Every year, around 270,000 people in Britain suffer a heart attack, and coronary disease remains Britain’s biggest killer.
About a third die before reaching hospital, often because they have delayed seeking help.
If someone is lucky enough to survive a heart attack, they can still be left with severe damage that drastically increases their risk of dying from cardiac problems in the future.
But the latest research, by experts at the Karolinska Institute in Stockholm, Sweden,  indicates snacking on chocolate could be the perfect remedy.
They tracked 1,169 patients aged between 45 and 70 who had been admitted to hospital with a heart attack between 1992 and 1994.
Each one was quizzed on dietary habits, including how much chocolate they ate.
All the patients were then followed up for the best part of a decade.
The results showed those eating a few chunks of chocolate twice a week or more were 66 per cent less likely to die from cardiac disease than non-eaters.
Chocolate once a week reduced the risk by almost half and even an occasional treat – once a month or less – had a small benefit, cutting the risk by 27 per cent.
But other sweets were no help at all.
In a report on their findings, the researchers said: ‘The health effects of chocolate have been of great interest in recent years. But we know of no other studies assessing the possible effects of chocolate on post-heart attack prognosis.
‘We found it had a strong inverse association with subsequent cardiac mortality.’

owever, it’s unlikely that indulging in high-fat milk chocolate – the most popular type in the UK – will have the same advantages.
Ellen Mason, senior cardiac nurse at the British Heart Foundation, said: ‘We need to interpret this study with caution as it’s based on decade old events, and our diagnosis and treatment of heart attacks have moved on considerably since that time.
‘Being high in sugar and saturated fat, chocolate is unlikely to prove a miracle solution for heart disease.

‘Dark chocolate does contain anti-oxidants, but we can all get the beneficial effects of anti-oxidants by eating plenty of fruit and vegetables and should keep chocolate as an occasional treat in a healthy, balanced diet.’

Source: Mail OnLine. 14th. Aug.2009

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Anger Alert for Heart

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Episodes of anger may lead to potentially lethal abnormal heart rhythms in patients with heart disease and those who are survivors of heart attacks, a medical study has suggested.

…….CLICK & SEE

The study by researchers at the Yale University School of Medicine in the US is the first to show how emotion triggers a distinct pattern of electrical activity that contributes to arrhythmias — abnormal heart rhythms.

The researchers who monitored a group of 62 patients found that those with high levels of anger-induced electrical cardiac activity called T-wave alternans were more likely to experience arrhythmias than patients with low levels of this electrical activity.

Anger appeared to increase the risk of arrythmias by up to 10 times. The findings will appear shortly in the Journal of the American College of Cardiology.

“Our study identified individuals vulnerable to increased electrical instability due to emotion,” said Rachel Lampert, associate professor of medicine at Yale who has been exploring how mental stress can disturb heart rhythms.

The researchers studied patients with heart problems who had implantable cardioverter-defibrillators — small, battery-powered devices in the chest from where they constantly monitor the heart rate and rhythm.

When the device detects abnormal heart rhythms, it delivers an electrical shock to the heart muscle to stop the arrhythmia and return the heart to its normal rhythm.

The study examined incidence of arrhythmias over three years and found that patients with arrhythmias had higher T-wave alternans induced by anger than patients who had not experienced arrhythmias.

Arrhythmias of concern are rare in healthy people. “The implications of our findings are for the increasing number of people who have survived a heart attack or are living with heart failure,” Lampert told The Telegraph.

Cardiologists believe it is important to identify patients who are at risk of developing life-threatening arrhythmias. The results suggest that therapy to help patients deal with anger and other negative emotions may reduce arrhythmias, said Lampert.

Sources:
The Telegraph (Kolkata, India)

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Potassium to Sodium Ratio Affects the Heart

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Consuming twice as much potassium as sodium might halve your risk of dying from cardiovascular disease.

CLICK & SEE
Ate too many nachos? Consider a banana chaser — your heart might thank you for it.

A new study suggests that consuming twice as much potassium as sodium can halve your risk of dying from cardiovascular disease. The study is the first to show that the ratio of these nutrients in your diet matters more than exactly how much you get of either one.

The best strategy for good health, experts are quick to stress, is to eat less sodium and more potassium. But the new research suggests that simply upping your intake of potassium can at least soften the blow of a high-sodium diet.

“Potassium and sodium are like peas in a pod, except they’re in opposite pods,” says epidemiologist Paul Whelton, president and chief executive of the Loyola University Health System in Chicago and one of the authors of the study. “This is the first study to show that the two together give you a benefit over and above what you can get with either one.”

Between processed foods and restaurant meals, most Americans eat far too much sodium — significantly above the 2,300 milligrams the Dietary Guidelines for Americans recommend as a maximum daily intake for adults. Excess sodium, according to plenty of large, well-designed studies, causes the body to retain fluids, which raises blood pressure and ups the risk of dying from heart disease.

Just as strong — albeit less commonly known — is the link between heart health and potassium. In 1997, a study published in the Journal of the American Medical Assn. compiled the results of 33 clinical trials and found that people who took potassium supplements lowered their blood pressure by 3/2 mm Hg. (Blood pressure is measured as two numbers that indicate how hard it is for the heart to pump blood through the blood vessels. Ideally, it should be 120/80 or less.) High blood pressure is a major risk factor for heart attacks and strokes.

That study was pivotal in influencing current dietary guidelines, which recommend that Americans get at least 4,700 mg of potassium daily — about double the recommended maximum for sodium. Yet, according to nationwide nutritional surveys, the average American gets just 2,600 mg of potassium a day and 4,000 mg or more of sodium — far more sodium than potassium, even though guidelines suggest we do the opposite.

Scientists have long suspected that the ratio of the two nutrients in our diets is important, but there hasn’t been strong enough evidence to say for sure. In the new study, Nancy Cook, a statistician at Brigham and Women’s Hospital and associate professor at Harvard Medical School in Boston, and colleagues were able to test the idea with data from two large trials originally designed to see how blood pressure responds to a variety of factors, such as diet and weight loss.

The studies involved thousands of people and took place in the late 1980s and early ’90s. For either 18 months or three years, some participants were assigned to cut sodium intake by up to 35%. Others went along eating like they always did. A handful of times over the course of the study, participants provided all their urine over a 24-hour period. Then, by analyzing the urine, scientists could accurately determine what nutrients each person was eating. (Prior studies relied on people reporting everything they ate — a method that is notoriously inaccurate.)

One earlier report from this project, published in the British Medical Journal in 2007, found that participants who had been instructed to reduce sodium intake, even for just a few years, were 25% less likely to die from cardiovascular disease 10 to 15 years later than were those who kept eating larger amounts of sodium.

In the current study, the researchers looked at the other group — those who had continued to eat as they normally would. They found that people who ate more potassium tended to have a slightly lower long-term risk of death from heart disease.

But they also found that people who had consumed the highest levels of potassium and the lowest levels of sodium (about twice as much potassium as sodium) were 50% less likely to die of cardiovascular disease than those who ate the most sodium and the least potassium (about four times as much sodium as potassium).

The ratio of the two nutrients mattered more than the amount of either one when it came to predicting cardiovascular disease, the study found.

Scientists aren’t sure how potassium dampens the heart-damaging effects of salt. One possibility, Cook says, is that potassium may prevent the body from absorbing as much sodium. But regardless of the mechanism, trying to boost your ratio is pretty much guaranteed to improve your health because you’ll eat more fruits and vegetables, says Edgar Miller III, an epidemiologist at Johns Hopkins Medical University in Baltimore.

A banana has more than 400 mg of potassium, for example. There are more than 900 mg in a potato, nearly 950 mg in a cup of spinach, 600 mg in half a cup of raisins and 500 mg in an 8-ounce cup of orange juice.

A diet rich in fruits and vegetables delivers other health-enhancing properties, Miller says, including fiber and antioxidants. And filling up on fresh, whole foods may reduce the reliance on sodium-packed processed meals.

In that way, the new study supports the results of the landmark DASH trials, which in the 1990s found that even when people ate plenty of sodium they were able to lower their blood pressure by eating lots of fruits, vegetables, whole grains and low-fat dairy foods, and not a lot of red meat, sweets or saturated fats. “This provides further proof,” says Eva Obarzanek, a registered dietitian and research nutritionist at the National Heart, Lung and Blood Institute, and one of the authors of the new study, “that sodium is bad and potassium is good.”

Sources: Los Angeles Times

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