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Eat Curry With Turmeric to Fight Dementia

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This Potent Spice Taken as Little as Once a Week Can Fight Dementia

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New research shows that eating curry once or twice a week could help prevent the onset of Alzheimer’s disease and dementia. The key reason is curcumin, a component of the spice turmeric.

Curcumin prevents the spread of amyloid protein plaques, which are thought to cause dementia. Amyloid plaques, along with tangles of nerve fibers, contribute to the degradation of the wiring in brain cells.

There is evidence that people who eat a curry meal two or three times a week have a lower risk of dementia. Researchers are currently testing the impact of higher doses, such as the equivalent of going on a curry spree for a week, to see if they can maximize the effect.

You may click to see:->Turmeric May Work for Alzheimer’s

Resources:
BBC News June 3, 2009
Royal College of Psychiatrists’ Annual Meeting, Liverpool, UK, June 2-5, 2009

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Alzheimer’s Disease Drug

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Introduction:-
This public information leaflet provides information about drugs used to treat Alzheimer’s disease. It discusses how the drugs work, why they are prescribed, their side effects and alternative treatments. Alzheimer’s disease is only one of many possible causes for memory problems in people. The other causes are described in detail in our Help is at Hand leaflet, ‘Memory and Dementia’.

Cholinesterase Inhibitors
What are Cholinesterase inhibitors?
These are the main drugs used for Alzheimer’s disease in the United Kingdom. Three drugs are currently licensed:

Drug name….Donepezil.       Other name ….Aricept

Drug Name….Galantamine   Other Name.… Reminyl

Drug Name.…Rivastigmine  Other Name.... Exelon

There are no major differences between these drugs. They are all designed to alleviate certain symptoms of Alzheimer’s disease – for example, memory loss, apathy and anxiety. They are not a cure, though there is some evidence that they may slow the course of the illness.

What effect can these drugs have?
They can improve memory, particularly remembering new information and recall of old information. They can also have general benefits including improving alertness and motivation. It may take some months of treatment for there to be a noticeable improvement or slowing down of memory loss. Some people report improved mood and will be able to perform tasks which they had forgotten how to do such as going shopping.

What side effects are there?
The most common side effects of these drugs are nausea, loss of appetite, tiredness, diarrhoea, muscle cramps and sometimes poor sleep. These may be reduced or avoided by increasing the dose slowly, or taking the medicine after food. The side effects usually fade after a few weeks and will go away if the medicine is stopped. More information about side effects can be obtained from the doctor prescribing the treatment or by reading the leaflet that comes with the prescription.

How do they work?
Acetylcholine is a chemical that is involved in the transmission of information between certain brain cells involved in memory. In Alzheimer’s disease, these brain cells start to die and the amount of acetylcholine available to pass messages between cells is very much reduced. Memory starts to suffer. Cholinesterase Inhibitors reduce the destruction of acetylcholine and increases its levels in the brain. The increase in the amount and effectiveness of acetylcholine reduces some of the effects of Alzheimer’s disease.

How well do they work?
Research has shown that about 50-60% of people who have taken these drugs show a slight improvement or a stabilisation of their condition over a period of six months. However, in the longer term, it is not known whether the effect of these drugs will be temporary or whether they will slow the rate of decline over a longer period of time. Unfortunately not everyone benefits from these medicines, and if no improvement or stabilisation is seen in the first few months, it is recommended that they are stopped. In Britain the National Institute for Health and Clinical Excellence (NICE) has decided that these drugs are not cost effective in the early stages of Alzheimer’s Dementia and should only be given to people in moderate stages of the illness. Many people are unhappy about this decision.

How should these drugs be taken?
It is usual to start on a low dose which is gradually increased. Don’t be put off by any side effects early on in the treatment as these usually wear off after a few weeks. It is important to take the drugs every day for them to be effective.

How long should these drugs be taken?
These drugs are usually prescribed for a trial period of three to four months. If the doctor decides they are not working, he or she will recommend stopping them. If these drugs do work, there is currently no clear consensus as to how long they should continue to be prescribed. People with Alzheimer’s disease are often given a memory test called the ‘Mini Mental State Examination‘ (MMSE). Current guidelines suggest that these drugs should only be used for moderate dementia which equates to an MMSE score of between 10 and 20 out of 30. However, there is some evidence that these drugs work in earlier and later stages of the illness.

Who can prescribe these drugs?
A specialist, rather than your GP, will prescribe the medicine during the trial period. You will usually see the specialist in a hospital clinic. You may need blood tests and a brain scan to exclude any other causes for the memory loss. In some areas the specialist will continue to prescribe the drug if they conclude that it is working. In other areas the specialist may continue assessing its effectiveness but ask that the family doctor prescribes it.

Memantine
This drug, which is also known as Ebixa, has been used to treat dementia in Germany since 1989. It is thought to work by affecting glutamate, a brain chemical which is involved in learning and memory 3. In Alzheimer’s disease too much glutamate leaks out of damaged brain cells and this interferes with learning and memory. In the studies completed so far just over half the people taking Memantine show some slowing down in the progression of the dementia but this effect has only been demonstrated so far in people with more severe dementia. The main side effects of Memantine, which are usually mild, are nausea, restlessness, stomach-ache and headache.

More studies are being undertaken to see how effective it is and how the drug can best be used. NICE has issued guidance that Memantine should not be routinely prescribed in Britain due to doubts about its cost effectiveness.
Other Treatments:-

Ginkgo biloba
This is a naturally occurring substance extracted from the Maidenhair tree. It has long been thought to enhance memory.

A recent study looked at the effects of Ginkgo in over 3000 people taking it for an average of 6 years. Unfortunately Ginkgo did not stop dementia developing and in a small number of people with heart problems it actually seemed to make their dementia worse.

Vitamin E
This is a natural substance found in oils from soya beans, sunflower seeds, corn and cotton seed, as well as whole-grain foods, fish-liver oils and nuts. Vitamin E has various functions in the body and acts as a natural anti-oxidant. Vitamin E deficiencies are very rare.

Some studies suggest that taking Vitamin E can slow the progression of Alzheimer’s disease. However, further research needs to be done to establish its place in the treatment of Alzheimer’s disease. It can interfere with blood clotting and should be used with caution in people with a clotting disorder and on oral anticoagulants, although it can be used with aspirin.

In 2004 a review of studies involving a total of over 136,000 patients suggested that people taking over 400 units a day may be at a small increased risk of harm. Some experts are therefore suggesting that not more than 200 units a day should be taken.

There is some evidence that a diet rich in natural Vitamin E may reduce the risk of developing Alzheimer’s disease.

Selegeline
This is a drug that is normally used in Parkinson’s disease. It is also thought to work as an anti-oxidant but has more possible side effects than the use of Vitamin E, including lowering of blood pressure, nausea, dizziness or vivid dreams. Some studies suggest it may slow the progression of Alzheimer’s but further research is needed.

Other therapies:-
Other drugs and therapies are being investigated for Alzheimer’s disease. Developments in this field are rapid and encouraging. It is important to be wary of claims for any new drugs or therapies you read about in the media. Advice should always be sought from your family doctor, specialist or a national organisation such the Alzheimer’s Society.

Dementia can be a great burden for carers and loved ones. Their health and well-being is also vital. Further information about ways in which they can help and be supported can be found in our Memory and Dementia leaflet.

Sources: http://www.rcpsych.ac.uk/mentalhealthinfoforall/olderpeople/drugtreatmentofalzheimers.aspx

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News on Health & Science

Soon, a Pill to Help Your Memory

Here’s some good news for students — a memory pill which can help you with revision for exams is being developed by scientists.
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An international team is coming up with the pill which could make memories stick, in a study that will not only help students revising for exams but also patients with dementia or other brain disorders.

In their study, the scientists discovered that fatty foods not only send feelings of fullness to the brain but they also trigger a process that consolidates long term memories. Now, the team, led by California University, hope to develop drugs which mimic the effect of fat and rich foods to boost memory in those suffering from brain disorders or who need to cement the facts in their brain.

In fact, they found that oleic acids from fats are transformed into a compound called oleoylethanolamide (OEA) in the upper region of the small intestine. OEA not only send hunger-curbing messages to the brain but “causes memory consolidation, the process by which superficial, short-term memories are transformed into meaningful, long-term ones”, according to the scientists.

Daniele Piomelli, who led the team, said the pill works by activating memory-enhancing signals in amygdala — the part of the brain involved in the consolidation of memories of the emotional events. “Remembering the location and context of a fatty meal was probably an important survival mechanism for early humans. It makes sense that mammals have this capability.

“OEA is part of the molecular glue that makes memories stick. By helping mammals remember where and when they have eaten a fatty meal, OEA’s memory-enhancing activity seems to have been an important evolutionary tool for early humans and other mammals,” the Daily Telegraph quoted him as saying.

The study found administering OEA to laboratory rodents improved the memory retention in two tests. When cell receptors activated by OEA were blocked, memory retention effects decreased. Piomelli said drugs that mimic OEA are currently in clinical trials.

Rebecca Wood, chief executive of the Alzheimer’s Research Trust said the research offered “fascinating” insights into the way we remember. “When thinking about what constitutes a healthy diet, usually what’s good for the heart is also good for the head. Better understanding of how memories are formed could lead to new treatments that help the brain when it becomes affected by Alzheimer’s.”

You may click to see:->Memory MHz Benchmark Impact

Sources: The Times Of India

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Ailmemts & Remedies

Aluminium Toxity

Introduction:
While aluminum is not a heavy metal, it has been found to be toxic. Because aluminum permeates our air,water, and soil, small amounts are present in our food. The average person consumes between three and ten milligrams of aluminum a day. Only recently has research revealed that aluminum is absorbed and accumulated in the body. Aluminum is a popular metal used to make cookware, cooking utensils, and foil. Excessive use of antacids is the most common cause of aluminum toxicity. Mylanta, Maalox, Glusil, Amphojel, and many others have a high aluminum hydroxide content. Many over-the-counter drugs used for inflammation and pain contain aluminum, including Arthritis Pain Formula, Ascriptin, Bufferin, and Vanquish. Several douche preparations, including Massengil and Summer’s Eve, contain aluminum. It is also an additive in most baking powders and is sometimes evident in drinking water.

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The highest exposure to aluminum is most frequently due to the chronic consumption of aluminum-containing antacid products. Research shows that aluminum builds up in the body over time; thus, the health hazard to older people is greater.

Concentrations of aluminum that are toxic to many biochemical processes are found in at least ten human neurological conditions.

Recent studies suggest that aluminum contributes to neurological disorders such as Alzheimer’s disease, Parkinson’s disease, senile and presenile dementia, clumsiness of movements, staggering when walking, and inability to pronounce words properly.

Behavioral difficulties among schoolchildren have also been correlated with elevated levels of aluminum and other neurotoxic heavy metals.

Symptoms: Flatulence, headaches, dry skin, weak and aching muscles, senility, spleen pain, stomach pain, liver dysfunction, kidney dysfunction, neuromuscular disorders, osteomalacia, colitis, anemia, Alzheimer’s disease, amyotrophic lateral sclerosis, hemolysis, leukocytosis, porphyria, heartburn, memory loss, numbness, paralysis, Parkinson’s disease, excessive perspiration, leg twitching, cavities, colds, behavioral problems, constipation .

Many symptoms of aluminum toxicity are similar to those of Alzheimer’s disease and osteoporosis. Aluminum toxicity can lead to colic, rickets, gastro-intestinal disturbances, poor calcium metabolism, extreme nervousness, anemia, headache, decreased liver and kidney function, forgetfulness, speech disturbances,and memory loss, softening of the bones, and weak, aching muscles. Research suggests that a chronic calcium deficiency may change the way in which the body uses minerals. Bone loss and increased intestinal absorption of aluminum and silicon combine to form compounds that accumulate in the cerebral cortex of the brain. These compounds prevent impulses from being carried to or from the brain.

An accumulation of aluminum salts in the brain has been implicated in seizures and reduced mental faculties. Autopsies performed on Alzheimer’s victims revealed that four times the normal amount of aluminum had accumulated in the nerve cells in the brain. This suggests that long-term accumulation of aluminum in the brain may contribute to the development of Alzheimer’s disease. In addition, an unidentified protein not found in normal brain tissue has been discovered in the the brain tissue of Alzheimer’s victims.

Because aluminum is excreted by the kidneys, toxic amount of aluminum may impair kidney function. Working in aluminum smelting plants for long periods can lead to dizziness, impaired coordination, and losses of balance and energy. Accumulations of aluminum in the brain was cited as a possible cause for these symptoms as well.

Aluminum is excreted by the kidneys, therefore toxic amounts can impair kidney function. Aluminum can also accumulate in the brain causing seizures and reduced mental alertness. The brain is normally protected by a blood-brain barrier, which filters the blood before it reaches it. Elemental aluminum does not pass easily through this barrier, but certain compounds contained within aluminum, such as aluminum fluoride do. Interestingly, many municipal water supplies are treated with both aluminum sulfate and aluminum fluoride. These two chemicals can also combine easily in the blood. Aluminum fluoride is also poorly excreted in the urine.

When there is a high level of absorption of aluminum and silicon, the combination can result in an accumulation of certain compounds in the cerebral cortex and can prevent nerve impulses being carried to and from the brain properly. Long term calcium deficiency can further aggravate the condition. Workers in aluminum smelting plants on a long term basis, have been know to experience dizziness, poor coordination, balance problems and tiredness. It has been claimed that the accumulation of aluminum in the brain could be a possible cause for these issues.

It is estimated that the normal person takes in between 3 and 10 milligrams of aluminum per day. Aluminum is the most abundant metallic element produced by the earth. It can be absorbed into the body through the digestive tract, the lungs and the skin, and is also absorbed by and accumulates in the bodies tissues. Aluminum is found naturally in our air, water and soil. It is also used in the process of making cooking pots and pans, utensils and foil. Other items such as over the counter pain killers, anti-inflammatory products, and douche preparations can also contain aluminum. Aluminum is also an additive in most baking powders, is used in food processing, and is present in antiperspirants, toothpaste, dental amalgams, bleached flour, grated cheese, table salt, and beer, (especially when the beer is in aluminum cans). The biggest source of aluminum, however, comes from our municipal water supplies.

Excessive use of antacids is also a common cause of aluminum toxicity in this country, especially for those who have kidney problems. Many over the counter type antacids contain amounts of aluminum hydroxide that may be to much for the kidneys to handle properly.

In addition to aluminum cookware, foil, antacids, baking powders, buffered aspirin, and most city water,aluminum is also used in food processing (pickles and relishes, in particular), antiperspirants, deodorants, beer (especially when in aluminum cans), bleached flour, table salt, tobacco smoke, cram of tartar, Parmesan and grated cheeses, aluminum salts, douches, and canned goods.

Those who enjoy fast foods should be aware that processed cheese has a high aluminum content. The food product having perhaps the highest aluminum content is the cheeseburger. This mineral is added to give processed cheese its melting quality for use on hamburgers.

Sources: Aluminum foil, antacids, aspirin, dust, auto exhaust, treated water, vanilla powder, nasal spray, milk products, salt, commercially-raised beef, tobacco smoke, anti-perspirants, bleached flour, cans, animal feed, ceramics, commercial cheese.

Supplument Helpful.

*Calcium(1,500 mg daily) in the chelate form with magnesium.(750mg daily)………This chelating agent binds with aluminum and eliminates it from the body.

*Garlic tablets(kyolic)… 2 capsules 3 times daily…….. Acts as a detoxifier.
*Kelp….. 6 tablets daily………. has a balanced mineral content. Acts as a detoxifier of excess metals.
*Lecithin…. 2 tbsp. 3 times daily with meals….. Aids in healing of the brain (and other cell membranes).

*Multivitamin and mineral complex (high potency, hypoallergenic).. As directed on label… Basic in stabilizing vitamin and mineral imbalance in toxic conditions.
*Vitamin B complex plus vitamin B6(pyroxidine) and B12 lozenges or B12 injections …100 mg 3 times daily and 50 mg 3 times daily. But Injections under doctor’s recommendation and supervision only…..The B vitamins, especially B6, are important in ridding the intestinal tract of excess metals in in removing them from the body.

So, what can we do to prevent aluminum toxicity from happening to ourselves and our families?

1. Eat a diet that is high in fiber and includes apple pectin.
2. Use stainless steel, glass, or iron cookware. Stainless steel is the best choice.
3. Beware of any product containing aluminum or dihydroxyaluminum.
4. A hair analysis can be used to determine levels of aluminum in the body.
5. Research has shown that the longer you cook food in aluminum pots, the more they corrode, and the more aluminum is absorbed into the food and hence into the body. Aluminum is more readily dissolved by acid forming foods, such as coffee, cheese, meat, black and green tea, cabbage, cucumbers, tomatoes, turnips, spinach and radishes.
6. Acid rain leeches aluminum out of the soil and into drinking water.

Recommendations
*Make sure that your diet is high in fiber and contains apple pectin.
*Use glass, iron, or stainless steel cookware. There is still much controversy as to whether aluminum collects in the neurons as a result of a dysfunctions of the neurons or if it actually causes the dysfunction of the neurons. It is best to avoid aluminum as much as possible!
*Beware of products containing aluminum. Read the labels and avoid those that contain aluminum, bentonite, or dihydorxyaluminum.

Considerations
If you use chelation therapy, use oral chelating agents only. Aluminum cannot be chelated out of the body, but it can be displaced or moved.

YOU can reduce excess aluminum in the body with the herbs like Apple pectin, Norwegian kelp, coral calcium and trace minerals, high-potency garlic extract.
Click to see the recent Tesearch Papers on Alzimers due to Aluminium Toxity

Disclaimer: This information is not meant to be a substitute for professional medical advise or help. It is always best to consult with a Physician about serious health concerns. This information is in no way intended to diagnose or prescribe remedies.This is purely for educational purpose

Resources:
http://www.relfe.com/Chelation%20by%20Suppository/aluminum_toxicity.htm
http://www.vitawise.com/Nutritional_Healing/aluminum%20toxicity.htm
http://herbnews.org/aluminumdone.htm
http://www.bellaonline.com/articles/art7739.asp

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Suppliments our body needs

Dimethylaminoethanol (DMAE)

chemical structure of dimethylaminoethanol (DMAE)
Image via Wikipedia

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Definition:
Dimethylaminoethenol (DMAE) is a metabolite, a product produced by the body’s metabolic process of procaine. It is a central nervous system stimulant that has a mild impact. It’s effect is similar to an amphetamine, but it is not such a drug. The term DMAE is actually an abbreviation for dimethylaminoethanol, a naturally occurring chemical produced by the human brain. It is a choline molecule that has one methyl group missing from the nitrogen, and it may be for this reason that it can cross the blood-brain barrier more easily than choline. While choline is known to be the precursor of acetylcholine, a recognized neurotransmitter, DMAE may prove to offer a more direct approach to this function by moving into the brain, being acted on by an enzyme (methylation), and thereby undergoing conversion into choline directly where it is needed.

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Although free-radicals are a natural result of the human body’s activity, the human equilibrium may be upset because of modern diet and environmental conditions that add further stressors to the system. These conditions cause a need for additional antioxidants in order for the body to cope with industrialized life. Antioxidants seem to reinforce one another, and for this reason it seems prudent to combine the use of several rather than to rely on only one type.

Dimethylaminoethanol, also known as DMAE or dimethylethanolamine, is an organic compound. This compound also goes by the names of N,N-dimethyl-2-aminoethanol, beta-dimethylaminoethyl alcohol, beta-hydroxyethyldimethylamine and Deanol. It is a liquid with a color that ranges from clear to pale yellow.

DMAE is known chemically as dimethyl-amino-ethanol. DMAE has been known in Europe by the product name Deanol for more than three decades. DMAE has two methyl groups and is chemically similar to choline. DMAE has been popular for many years in those interested in improving mental alertness and clarity of thinking.

Industrial uses
Dimethylaminoethanol is used as a curing agent for polyurethanes and epoxy resins. It is also used in mass quantities for water treatment, and to some extent in the coatings industry. It is used in the synthesis of dyestuffs, textile auxiliaries, pharmaceuticals, emulsifiers, and corrosion inhibitors. It is also an additive to paint removers, boiler water and amino resins.

Biochemical precursor
Dimethylaminoethanol is related to choline and is a biochemical precursor to the neurotransmitter acetylcholine, and found naturally in fish like sardines and anchovies. It is reported to have nootropic effects, although research on this chemical has found both positive and negative potential results.

It is believed that dimethylaminoethanol is methylated to produce choline in the brain[1]. It is known that dimethylaminoethanol is processed by the liver into choline; however, the choline molecule is charged and cannot pass the blood-brain barrier.

Research
Short term studies have shown an increase in vigilance and alertness, with a positive influence on mood. Long term studies are equivocal. Some showed dimethylaminoethanol to increase the lifespan of animals in which it was tested, while others indicate a possible reduction in the average life span of quail.  With the uncertainty of whether this could be extrapolated to humans, dimethylaminoethanol supplementation is not generally recommended. It is possible that dose is a major determining factor in the overall effects of dimethylaminoethanol – a high dose could produce effects opposite to those sought and contribute to life-shortening.

DMAE Research for Alzheimer’s, memory loss, age related mental decline
Studies with DMAE go back to the 1950s. One double blind, placebo-controlled trial performed in twenty-seven patients with severe Alzheimer’s disease did not show significant benefits (Fisman 1981). Another study on twenty-one patients with memory deficits was also discouraging since no improvement was found in memory (Caffarra 1980). However, DMAE was found helpful in patients with age related mental decline. DMAE was given for four weeks to fourteen older patients (Ferris 1977). Ten patients improved and four were unchanged. The patients on DMAE had reduced depression, less anxiety, and increased motivation, but they had no improvement in memory. The researchers say, “the results thus suggest that although DMAE may not improve memory, it may produce positive behavioral changes in some senile patients.” Dementia is a term that is now substituted for senility and is sometimes used to denote a severe case of age related cognitive decline.

DMAE has been touted as an anti-aging nutrient but there have not been any human studies evaluating the claim that DMAE slows aging.

DMAE Positive effects – Benefit of DMAE – DMAE Enhances Mood and Alertness
Most people notice being more alert and focused within a couple of hours after taking DMAE. The DMAE benefit of alertness and focus can last most of the day. A few report a higher sense of wellbeing. DMAE is recommended to be taken in the early part of the day. I also like the mind boosting effect of Acetyl-l-carnitine, but my favorite is a combination of several nutrients and herbs, including DMAE bitartrate, found in Mind Power Rx.

There are dozens of herbs and nutrients available in health food stores that influence mental function. One that has been popular for many years is DMAE, which stands for dimethyl-amino-ethanol. A recent German study evaluated the brain’s electrical reaction during presentation of videoclips of 7 minute duration in 80 subjects with borderline emotional disturbance. The researchers recorded the different emotional states by having the subjects watch these film excerpts. Half of the subjects were then started on a daily dose of DMAE and the testing was repeated after 6 and 12 weeks. The testing included showing the videoclips, filling out mood questionnaires, and also evaluating the brain’s electrical reaction through EEGs (electrodes placed on the scalp that measure brain activity) . The results showed that those who took the DMAE daily had a decrease in theta and alpha1 brain electrical activity indicating that they were more alert. Furthermore, the questionnaires revealed that those on DMAE had a better mood. The researchers conclude, “DMAE can be interpreted to induce a psychophysiological state of better feeling of wellbeing on both levels of analysis mood and electrical pattern of brain activity in subjects suffering from borderline emotional disturbance.”

Dr Sahelian says: Most people notice being more alert and focused within a couple of hours after taking DMAE. DMAE is available in dosages ranging from 100 to 400 mg. It is best to start with a low dose, such as 50 to 150 mg of actual DMAE since high doses can cause anxiety, restlessness, and muscle tenseness in the neck and shoulders. DMAE taken late in the day may cause insomnia.

Efficacy of dimethylaminoethanol (DMAE) containing vitamin-mineral drug combination on EEG patterns in the presence of different emotional states. Dimpfel W. Forschung und Entwicklung -, Kurt-Schumacher-Str. 9, D-35440 Linden, Germany. Eur J Med Res. 2003 May 30;8(5):183-91.

The psychophysiological model of provoking different emotional states by watching film excerpts with various emotional contents was used to characterize drug action in 80 subjects (male /f emale = 50%) with threshold emotional disturbance within a randomized, group-parallel, double-blind, placebo-controlled study. Analyzing the brain’s electrical reaction during presentation of 5 videoclips of 7 min duration followed by 3 minutes pause revealed a content specific representation of topographical frequency changes. This procedure was repeated after 6 and 12 weeks of daily intake of a vitamin-mineral drug combination containing dimethylaminoethanol (DMAE) or placebo. Subjects taking DMAE supplement for 3 months developed significant less theta and alpha1 power in sensomotoric areas of the cortex. Since decreases in theta and alpha1 electrical power have been associated with increased vigilance and attention, subjects taking DMAE combination obviously were more active and felt better. Therefore the vitamin-mineral combination containing DMAE can be interpreted to induce a psychophysiological state of better feeling of wellbeing on both levels of analysis mood and electrical pattern of brain activity in subjects suffering from borderline emotional disturbance.

DMAE Side effects
DMAE is available in varying dosages. It is best to start with a low dose, such as 50 to 150 mg of actual DMAE to avoid DMAE side effects. High doses can cause anxiety, restlessness, and muscle tenseness or stiffness in the neck, jaw, and shoulders. DMAE taken late in the day may cause insomnia. Other DMAE side effects on high dosages include irritability, headache, and overstimulation.

DMAE Availability
DMAE is usually sold by the name of DMAE bitartrate. A 350 mg pill of DMAE bitartrate yields 130 mg of actual DMAE. It is also available as DMAE liquid. One product contains 35 mg of DMAE per drop. Most users notice an effect from 50 to 150 mg of actual DMAE or 150 to 350 mg of DMAE bitartrate.

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DMAE Summary
DMAE can be helpful in the elderly who have cognitive decline. This nutrient can also be taken by an adult of any age who needs to be more focused and alert.

DMAE and Skin
A recent study shows DMAE cream is able to increase firmness of skin. Perhaps DMAE cream has anti-wrinkle potential. See below for the abstract.

The role of dimethylaminoethanol in cosmetic dermatology.
Am J Clin Dermatol. 2005;6(1):39-47. Grossman R.
Johnson and Johnson Consumer Products Worldwide, Skillman, NJ 08558
Skincare formulations for the improvement of aging skin are increasingly important consumer products. Here, we review available data on one such agent – 2-dimethylaminoethanol ( DMAE ) or deanol – that has recently been evaluated in a placebo-controlled trial. DMAE is an analog of the B vitamin choline and is a precursor of acetylcholine. Although the role of acetylcholine as a neurotransmitter is well known, growing evidence points to acetylcholine as a ubiquitous cytokine-like molecule that regulates basic cellular processes such as proliferation, differentiation, locomotion, and secretion in a paracrine and autocrine fashion. Indeed, this modulatory role may contribute to the cutaneous activity of DMAE. In a randomized clinical study, 3% DMAE facial gel applied daily for 16 weeks has been shown to be safe and efficacious in the mitigation of forehead lines and periorbital fine wrinkles, and in improving lip shape and fullness and the overall appearance of aging skin. Conclusions: Thus, the benefits of DMAE in dermatology include a potential anti-inflammatory effect and a documented increase in skin firmness with possible improvement in underlying facial muscle tone. Studies are needed to evaluate the relative efficacy of DMAE compared with other skin-care regimens (e.g., topical antioxidant creams, alpha-hydroxy acids).

Split face study on the cutaneous tensile effect of 2-dimethylaminoethanol (dmae) gel.
Skin Res Technol 2002 Aug;8(3):164-7
Beyond subjective assessments, the effect of skin tensors is difficult to assess. The present 2-phase randomized double-blind split face study was designed to compare the effect of a gel containing 3% 2-dimethylaminoethanol (deanol, DMAE) with the same formulation without DMAE. METHODS: In a first pilot study, sensorial assessments and measures of the skin distension under suction were performed in eight volunteers. In a second study conducted in 30 volunteers, shear wave propagation was measured. RESULTS: Large interindividual variations precluded any significant finding in the first study. The DMAE formulation showed, however, a significant effect characterized by increased shear wave velocity in the direction where the mechanical anisotropy of skin showed looseness. The DMAE formulation under investigation increased skin firmness.

Resources:
http://en.wikipedia.org/wiki/Dimethylethanolamine
http://www.raysahelian.com/dmae.html
http://www.dmae.org/

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