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Healthy Tips

6 Ways to Reduce Inflammation — Without a Statin Drug

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Experts predict that as a result of the so-called JUPITER study, which seemed to show that the statin drug Crestor lowers the risk of heart attacks and strokes in those with high levels of inflammation, will lead to millions of people being put on statin drugs.

But the benefits were actually tiny — about 0.72 percent of the statin takers in the trial had a heart attack or stroke, compared with 1.5 percent of those taking placebos.

Instead of a statin drug that comes with dangerous side effects, try these six measures instead:

    1. Stop smoking. Smoking hardens the arteries and increase inflammation. But research shows you can reverse all the damaging effects to your arteries within 10 years of quitting.
    2. Exercise  daily :  Exercise  keep you fit,  mobile  & improve  immune system.
    3. Think olive oil, fish, and nuts. People who stick with a Mediterranean-style diet based on fruits, vegetables, nuts, and olive oil can lower their levels of inflammation. It works by increasing the amount of foods you eat that are rich in omega-3 fats, which fight inflammation.
    4. Get active. Exercise a great way to lower inflammation without any of the side effects associated with medications.
    5. Shrink your waist size. If you’re a woman with a waist measurement of over 35 inches or a man with a waist of over 40 inches, you probably have high inflammation. Whittling a few inches off the waist by reducing your portions and increasing activity can go a long way toward solving that problem.
    6. Get enough sleep. A new study shows that elderly people with high blood pressure who sleep less than 7.5 hours a night have dramatically elevated chances of having a stroke or heart attack. Other research has shown that both too little and too much sleep increases inflammation. The American Academy of Sleep Medicine says most adults need between seven and eight hours of sleep each night.
    7. Reduce stress. High levels of stress hormones can lead to the release of excess inflammatory chemicals.
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Ayurvedic Biotherapy

How Green is This Medicine?

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Ayurveda, the oldest health system in the world, is going in for a makeover, but is it all for the good? Till now, the biggest innovation had been coloured ayurvedic pills and capsules. But the government’s recent amendment of the 63-year-old Drugs and Cosmetics Act appears to allow a more fundamental change — ayurvedic medicine can now contain anti-oxidants, flavouring agents, preservatives and sweeteners. So is ayurveda about to lose its unique organic wholesomeness?

click & see the pictures…....(1)..…..(2)……………..

Ayurveda practitioners and drug-makers don’t think so. They say the additives, natural or synthetic, must be in permissible quantities in order that the medicine retains its natural properties. “The purpose of allowing the use of anti-oxidants or sweeteners is to increase the shelf life of the ayurvedic medicines,” says Dr S K Sharma, advisor to the Department of Ayurveda, Yoga & Naturopathy, Unani, Siddha and Homoeopathy (AYUSH). The reasoning is that once they last longer, it would be easier to market ayurvedic medicines nationally and internationally.

But Sharma cautions that the changed law is not “purely for commercial reasons. There is a strong need for scientific innovation. It’s time that we tried to improve ayurvedic medicines.” So, the anti-oxidants that are being allowed to use will prevent the medicine from decomposing. The additives, says Sharma, will only help in making ayurvedic medicines more stable than ever before.

Some ayurvedic practitioners admit that there are legitimate concerns about additives. Dr V V Doiphode, dean of Pune University‘s Department of Ayurveda, stresses the importance of testing any product before it is added to an ayurvedic drug. “The onus is on the drug-makers to ensure these (additives) aren’t detrimental to health,” he says. For that they will have to conduct extensive research and lab testing.

There are other ways of ensuring compliance, not least guidelines issued by the Indian Pharmacopoeia Commission (IPC), an autonomous institution under the Ministry of Health & Family Welfare. The IPC sets strict standards for drugs and other pharmaceutical products. Add to this, the wording of the amended Drugs and Cosmetics Act, which allows “only natural colouring agents as permitted under rule 26 of Prevention of Food Adulteration Rules 1955 for ayurveda, siddha and unani drugs.”

But what if someone wanted to market a flavoured chyawanprash, say chocolate, to attract the international market? Would that be more synthetic than traditional chyawanprash? Not really, so long as it retains its original properties, says Ranjit Puranik, CEO of Shree Dootapapeshwar Ltd, ayurvedic drug-maker and exporter.

The loophole, however, is that a product like chyawanprash, which is made of 54 herbs — of which amla (gooseberry) is the main — can be marketed internationally as a dietary supplement rather than a medicine. If it has to be marketed as a medicine, then all the 54 herbs have to go through a standardisation process that will certify that none of the herbs are harmful to health.

The amended act allows synthetic additives in ayurvedic drugs but insists they “carry a statutory warning stating the name and quantity of the artificial sweetener.” Puranik says it’s up to the individual manufacturer to decide how natural he wants the ayurvedic drug to be. And if he uses a large quantity of synthetic additive “he clearly can’t then sell the product as ayurveda”.

That may affect ayurvedic core market, but the holistic health treatment has a long way to go in persuading India and the wider world of the goodness of its old-style organic approach to healing. Industry experts estimate that the global market for ayurveda is worth $120 billion. But India’s ayurveda exports are a paltry Rs 450 crore or $91 million. China and Sri Lanka lead the world in ayurveda manufacture and export.

India is finally trying to close the gap by adding innovation to the ayurveda mix. “These medicines can be tweaked a bit to suit people’s tastes, but the medicinal properties should be maintained. Say for instance, a popular ayurvedic medicine, kashayam, is now available in the form of capsules and tablets. This has been achieved by spray drying but the original properties are not tinkered with.” says V G Udayakumar, president of the Kerala-based Ayurveda Medical Association of India. He believes the same can be applicable to other medicines too.

But there’s some way to go before the humble hajmola becomes the world’s prescribed cure for indigestion.

Sources:The Times Of India

Categories
Ailmemts & Remedies

Idiopathic Pulmonary Fibrosis (IPF)

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Alternative Name:
Idiopathic diffuse interstitial pulmonary fibrosis; IPF; Pulmonary fibrosis; Cryptogenic fibrosing alveolitis; CFA; Fibrosing alveolitis; Usual interstitial pneumonitis; UIP

Definition:
Idiopathic pulmonary fibrosis is scarring or thickening of the lungs without a known cause. Gradually, the air sacs of the lungs become replaced by fibrotic tissue. When the scar forms, the tissue becomes thicker causing an irreversible loss of the tissue’s ability to transfer oxygen into the bloodstream.It is a progressive interstitial lung disease with an unknown cause.More specifically, IPF is defined as a distinctive type of chronic fibrosing interstitial pneumonia of unknown cause associated with a histological pattern of usual interstitial pneumonia (UIP).

click & see the pictures

Causes:-
No one knows what causes pulmonary fibrosis or why some people get it. It causes the lungs to become scarred and stiffened. This stiffening makes it increasingly difficult to breathe. In some people the disease gets worse quickly (over months to a few years), but other people have little worsening of the disease over time.

Traditional theories have postulated that it might be an autoimmune disorder, or the after effects of an infection, viral in nature. There is a growing body of evidence which points to a genetic predisposition. A mutation in the SP-C protein has been found to exist in families with a history of Pulmonary Fibrosis. The most current thinking is that the fibrotic process is a reaction to microscopic injury to the lung. While the exact cause remains unknown, associations have been made with the following:

*Inhaled environmental and occupational pollutants
*Cigarette smoking
*Diseases such as Scleroderma, Rheumatoid Arthritis, Lupus and Sarcoidosis
*Certain medications
*Therapeutic radiation

The condition is believed to result from an inflammatory response to an unknown substance. “Idiopathic” means no cause can be found. The disease occurs most often in people between 50 – 70 years old.

Symptoms:-

*Chest pain (occasionally)
*Chronic dry, hacking cough
*Decreased tolerance for activity
*Shortness of breath during activity that lasts for months or years and over time will also occur at rest
*Fatigue and weakness
*Discomfort in the chest
*Loss of appetite
*Rapid weight loss

 

Prevalence of Pulmonary Fibrosis:-
There are five million people worldwide that are affected by this disease. In the United States there are over 200,000 patients with Pulmonary Fibrosis. As a consequence of misdiagnosis the actual numbers may be significantly higher. Of these more than 40,000 expire annually. This is the same as die from Breast Cancer. Typically, patients are in their forties and fifties when diagnosed. However, diagnoses have ranged from age seven to the eighties. Current research indicates that many infants are afflicted by Pediatric Interstitial Lung Disease. At this time there is limited data on prevalence for this group.

Diagnosis:-
Exams and Tests

The health care provider will perform a physical exam and ask questions about your medical history. Your doctor will ask whether you have been exposed to asbestos.

Patients with idiopathic pulmonary fibrosis have abnormal breath sounds called crackles. Patients with advanced disease may have blue-colored skin (cyanosis) around the mouth or in the fingernails due to low oxygen.

 

Examination of the fingers and toes may show abnormal enlargement of the fingernail bases (clubbing).

The diagnosis of IPF can be made by demonstrating UIP pattern on lung biopsy in a patient without clinical features suggesting an alternate diagnosis (see clinical features, above). Establishing the diagnosis of IPF without a lung biopsy has been shown to be reliable when expert clinicians and radiologists concur that the presenting features are typical of IPF. Based on this evidence, the 2002 ATS/ERS Multidisciplinary Consensus Statement on the Idiopathic Interstitial Pneumonias proposes the following criteria for establishing the diagnosis of IPF without a lung biopsy:

Major criteria (all 4 required):

*Exclusion of other known causes of interstitial lung disease (drugs, exposures, connective tissue diseases)

*Abnormal pulmonary function tests with evidence of restriction (reduced vital capacity) and impaired gas exchange (pO2, p(A-a)O2, DLCO)

*Bibasilar reticular abnormalities with minimal ground glass on high-resolution CT scans

*Transbronchial lung biopsy or bronchoalveolar lavage (BAL) showing no features to support an alternative diagnosis

Minor criteria (3 of 4 required):

*Age > 50

*Insidious onset of otherwise unexplained exertional dyspnea

*Duration of illness > 3 months

*Bibasilar inspiratory crackles

Tests that help diagnose idiopathic pulmonary fibrosis include the following:

*Bronchoscopy with transbronchial lung biopsy
*Chest CT scan
*Chest x-ray
*Measurements of blood oxygen level
*Pulmonary function tests
*Surgical lung biopsy
*Tests for connective tissue diseases such as rheumatoid arthritis, lupus, or scleroderma

Treatment :-

There are currently no effective treatments or a cure for Pulmonary Fibrosis. The pharmacological agents designed to treat lung scarring are still in the experimental phase while the treatments intended to suppress inflammation have only limited success in reducing the fibrotic progress.

No known cure exists for idiopathic pulmonary fibrosis. Medications such as corticosteroids and cytotoxic drugs may be given to reduce swelling (inflammation), but these treatments usually don’t work. Oxygen is given to patients who have low blood oxygen levels.

There is a lack of large, randomized placebo-controlled trials of therapy for IPF. Moreover, many of the earlier studies were based on the hypothesis that IPF is an inflammatory disorder, and hence studied anti-inflammatory agents such as corticosteroids. Another problem has been that studies conducted prior to the more recent classification of idiopathic interstitial pneumonias failed to distinguish IPF/UIP from NSIP in particular. Hence, many patients with arguably more steroid-responsive diseases were included in earlier studies, confounding the interpretation of their results.

Small early studies demonstrated that the combination of prednisone with either cyclophosphamide or azathioprine over many months had very modest, if any, beneficial effect in IPF, and were associated with substantial adverse effects (predominantly myelotoxicity). Other treatments studied have included interferon gamma-1b, the antifibrotic agent pirfenidone and bosentan. Pirfenidone and bosentan are currently being studied in patients with IPF while interferon gamma-1b is no longer considered a viable treatment option. Finally, the addition of the antioxidant N-acetylcysteine to prednisone and azathioprine produced a slight benefit in terms of FVC and DLCO over 12 months of follow up. However, the major benefit appeared to be prevention of the myelotoxicity associated with azathioprine

Because the origin and development of the disease is not completely understood, misdiagnosis is common. Varying terminology and lack of standard diagnostic criteria have complicated the gathering of accurate statistics about people with pulmonary fibrosis. Supplemental oxygen improves the quality of life and exercise capacity. Single lung transplant may be considered for some patients. Pulmonary Fibrosis is a very complex disease and the prediction of longevity of patients after diagnosis vary greatly.

Some patients with advanced pulmonary fibrosis may need a lung transplant. Lung rehabilitation will not cure the lung disease, but it can help maintain exercise capacity.

There are a number of new trials testing drugs to treat Pulmonary Fibrosis. For more information contact us at:

Pulmonary Fibrosis Foundation
1332 North Halsted Street Suite 201
Chicago, Illinois 60642-2642
(312) 587-9272 fax (312) 587- 9273

Support Groups
You can ease the stress of illness by joining a support group where members share common experiences and problems.

You may click to see about Herbal remedies of IPF………..(1)……(2)…….(3).…….(4).…….(5)

Click learn about Homeopathic Medication.>..……..(1)…...(2)…….(3)…….(4)……..(5)

See also: Lung disease – support group

Prognosis:-

Some patients may improve when they are treated with corticosteroids or cytotoxic drugs, but in most people the disease can get worse even with treatment. This worsening can happen quickly, or very slowly.

Possible Complications:-
*Chronic hypoxemia (low blood oxygen level)
*Cor pulmonale
*Pneumothorax
*Polycythemia (abnormally high levels of red blood cells)
*Pulmonary hypertension
*Respiratory failure

When to Contact a Medical Professional

Call for an appointment with your health care provider if you develop a regular cough or shortness of breath.

Prevention
Avoiding smoking may help prevent this condition, but how to prevent the cause is not exactly known.

Disclaimer: This information is not meant to be a substitute for professional medical advise or help. It is always best to consult with a Physician about serious health concerns. This information is in no way intended to diagnose or prescribe remedies.This is purely for educational purpose

Resources:
http://www.nlm.nih.gov/MEDLINEPLUS/ency/article/000069.htm
http://www.pulmonaryfibrosis.org/ipf.htm
http://en.wikipedia.org/wiki/Idiopathic_pulmonary_fibrosis

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Health Quaries

Some Health Quaries & Answers

Q: Once there was only one Robitussin cough medicine. Now there are lots. The one with dextromethorphan almost killed me. I had such a hard time breathing, I thought I was going to die.

I reported this to my pharmacist and was told that I might be allergic to the DM in Robitussin. He warned me to read all labels on cough medicines from now on.

People need to be warned, especially parents who might give this to their children.

A: Dextromethorphan, or DM, is the leading ingredient in most over-the-counter cough medicines. Its effectiveness has been controversial, particularly in children. Parents have been warned to avoid cough and cold medicines for kids 4 years and younger.

Although allergic reactions to DM seem uncommon, there are reports in the medical literature of serious breathing difficulties triggered by this cough medicine (Allergy, August 2004). Follow your pharmacist’s advice to read labels.

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Q: My boyfriend was recently released from prison and believes saltpeter was put in the food. How do you remove the effects after numerous years?

A:  Saltpeter: (potassium nitrate) is falsely believed to lower libido. Youngsters in boarding schools and summer camps, as well as men in the military or in prison, have perpetuated the myth that they are being fed saltpeter.

If time and support don’t overcome your boyfriend’s sexual difficulties, counseling may help. Hormonal assessment also may be needed.

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Q:Is there anything to help with pediatric eczema? Topical steroids helped my granddaughter for a while, but I worry about long-term side effects. Probiotics were suggested; I don’t know anything about them.

A:Research suggests that good bacteria (probiotics) may prevent or reduce eczema severity in children (Journal of Allergy and Clinical Immunology online, Sept. 2). American health professionals are less familiar than those in Europe with using probiotics to treat eczema, food allergies, irritable bowel syndrome and diarrhea.

Q:I have several little skin tags in my armpits. I do not want to pay a doctor to cut them off.

A:Dermatologists can easily remove skin tags (small, benign fleshy skin growths), but it will cost you. Readers have offered suggestions: “Band-Aid makes a product called Clear Spots — 50 tiny square pads with adhesive around all four sides. I cover the skin tag tightly with a Clear Spot, and after a week to 10 days, it shrivels up and falls off.”

“I have skin tags on my neck and chest. The smallest shriveled and fell off after a couple of days of applying New-Skin [liquid bandage] twice a day.”

“I am a nurse, and for years I have tied a piece of thread around the tag at the base, pulled it tight, made a tight knot and cut off the long ends. (It stings at first.) After three or four days, the tag turns black and falls off. It works every time. It helps to have someone do it for you.”

Reach Joe Graedon, a pharmacologist, and Teresa Graedon, an expert in medical anthropology and nutrition, at www.peoplespharmacy.com or in care of this newspaper.

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Q:I appreciate you writing about home remedies for children when they come down with colds, but I am alarmed that you suggested lemon and honey for coughs. I feel this needs an urgent disclaimer.

A.Honey can be dangerous for a child under age 2. A friend’s 6-month-old baby nearly died of infant botulism. Honey can cause this in infants. Even honey jars have a warning that it is not for small children.

Children 1 year old and younger should never be given honey. You are correct that this warning is designed to reduce the risk of infant botulism. Honey is occasionally contaminated with spores of the bacteria that cause botulism. Honey poses little risk for adults or children older than 1, but babies may not be able to fend off the bacteria.

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Q. Someone asked about natural migraine remedies and you mentioned spicy hot and sour soup, among other things. I’ve had migraines since before I was in kindergarten (I’m 58 now), and the best thing I’ve found is ginger.

A.Jamaican-style ginger beer is good, though rather sweet. The pickled ginger sold with sushi is a godsend. It also helps with the nausea.

Ginger has been documented as a migraine treatment for decades (Journal of Ethnopharmacology, July 1990). A small study testing a combination product (GelStat Migraine) containing ginger and the herb feverfew found that it could help alleviate migraines (Medical Science Monitor, September 2005).

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Q.My life is so much better since I read your column about rinsing my hair with vinegar. I am 56 years old, and for the previous 30 years my scalp has itched intensely whenever I sweat. No anti-itching shampoo or skin specialist could cure me, but rinsing with vinegar did.

A.Itching and flaking can be caused by dandruff or seborrheic dermatitis. Dermatologists believe that these conditions are caused by the yeast malassezia that grows on the scalp. A vinegar rinse apparently makes conditions unfavorable for this fungus. One woman has used a solution of 4 parts warm water to 1 part apple cider vinegar for more than 50 years. Others prefer a 1-to-1 water/vinegar mixture.

In India, we offer fennel seeds after meals. This helps avoid flatulence. Fennel is also good for sore throat and sinus problems.

I use the following recipe for my sinus trouble: Combine 1 tablespoon fennel seeds, 1/4 teaspoon powdered ginger, 1 clove, a 1/2 -inch piece of stick cinnamon and 1 teaspoon brown sugar in 2 cups of water. Boil it until there are 1 1/2 cups of liquid left, strain it and drink it hot with a little milk. You can substitute honey for the brown sugar.

I also rinse my nasal passages with a homemade saline solution and find it helpful.

Your recipe sounds delicious. Traditional uses for fennel include preventing flatulence and treating upper respiratory infections. Whether that extends to sinus congestion, we don’t know.

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Q.I am having trouble leveling out my Coumadin. Cranberries are a puzzle: The nurse says eat them; the doctor says don’t.

A.Maintaining a steady anticoagulant effect from Coumadin (warfarin) can be like walking a tightrope. Too much can lead to bleeding, while too little may permit blood clots to form.

British health authorities warned against combining cranberries or cranberry juice with Coumadin after some people on a stable dose of Coumadin had serious bleeding after drinking cranberry juice or eating cranberries. Australian scientists have reported that cranberry significantly increases warfarin’s anticoagulant effect. We suggest you avoid cranberries and cranberry juice while on Coumadin.

::

Q.I have a 17-year-old son. For years, I have suspected that he has a mild form of ADD. He’s willing to try medicine but I’d like to try a more natural approach.

A.Diagnosing attention-deficit disorder (ADD) is not simple. There’s no definitive blood test or questionnaire.

Medications that can help focus attention don’t work for everyone and they have some side effects. Ritalin, for example, can cause nausea, insomnia, weight loss, anxiety, heart palpitations, headaches and increases in blood pressure.

Dr. Edward Hallowell, one of the world’s leading experts on ADD, suggests dietary supplements such as fish oil, grape seed extract and pine bark extract (Pycnogenol), as well as exercise, adequate sleep and a structured environment.

Sources: Los Angles Time

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News on Health & Science

New Drug May Put Jet Lag to Rest

The experimental medication, called tasimelteon, works like melatonin and restores normal sleep patterns, researchers say.
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An experimental drug that mimics the effects of the hormone melatonin can reset the body’s circadian rhythms, bringing relief to jet-lagged travelers and night-shift workers, researchers reported Monday.

In a study of 450 people who were subjected to simulated jet lag in a sleep laboratory, a team from Brigham and Women’s Hospital in Boston found that the drug restored near normal sleep the first night it was used.

There were no aftereffects from the drug, minimal side effects, and people who took it performed normally the next day, said Dr. Elizabeth B. Klerman, one of the co-authors of the study published online in the journal Lancet.

And unlike conventional sleeping aids such as Ambien or Lunesta, she added, the new drug, called tasimelteon, has no potential for addiction or abuse.

The main limitations of the study were the relatively small size and the researchers’ inability to measure performance and mood after the drug was used, experts said.

The study was designed and funded by Vanda Pharmaceuticals Inc. of Rockville, Md., which developed tasimelteon, and all of the researchers reported receiving funds from Vanda or other pharmaceutical companies.

“This is a very promising first step,” said Dr. Jay Udani, who runs the integrative medicine program at Northridge Hospital Medical Center and who was not involved in the study. But the research “does not prove that it works for jet lag or shift workers,” he added. “That needs controlled studies in the field.”

The body’s sleep-wake cycle is controlled by melatonin, which is produced by the pineal gland in response to patterns of light and darkness. Higher concentrations of melatonin in the blood are associated with greater sleepiness.

Some research has shown that administering melatonin can adjust sleep cycles in travelers and workers, but the results have been mixed.

Because melatonin can’t be patented, drug companies have been interested in developing melatonin mimics, such as tasimelteon, which can be patented.

In the first part of the study, 39 patients’ normal sleep habits were monitored for three nights in the laboratory before they were sent to bed five hours early.

They were then given one of four different doses of tasimelteon or a placebo 30 minutes before bedtime.

Researchers monitored their sleep efficiency — the percentage of time in bed they actually slept — and the amount of time required for them to fall asleep.

Although all the subjects benefited from the drug, those receiving the highest dose had a sleep efficiency of 89% the first night, virtually the same as the 90% efficiency before the trail started. Those receiving a placebo had an efficiency of 71%.

Patients taking the highest doses slept for an average of about 428 minutes, compared with 430 minutes before the trial and 324 minutes for those taking a placebo. It took an average of seven minutes for them to go to sleep, compared with 11 minutes before the trial and 22 minutes for those receiving a placebo.

Blood analysis showed that the melatonin cycle of those receiving the drug was altered to match the new conditions.

“They would be expected to sleep better because their internal clock is on the right time,” Klerman said.

Sources Los Angles Times

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