Tag: Obesity

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The Internet Website Can Help You Keep Your Weight Off

As per new research the web page or the internet  may help you to reduce your weight. During the study it is found that more often people log on specially designed Kaiser  Permanente weight  loss webpage, it is more likely that they were to maintain weight loss.

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Those who made the study  believed that the webpage worked as a result of its mixture of accountability and sociability.

The website users were asked log in once a week to enter their weight and the amount of exercise they’d done — and if they didn’t log in regularly, they got an e-mail and then an automated phone call. Users could also chat with other study participants.


Time Magazine reports:
“The study began with 1,600 overweight or obese participants, about 350 of whom lost enough weight … to stay in the trial … Users who had logged on the most regularly — at least once a month for 28 months — had kept off the most weight, an average of 9 lbs. People who used the website the least kept off only 3 lb. on average.”


Resources:
Time Magazine July 29, 2010
Journal of Medical Internet Research July 27, 2010;12(3):e29

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More and More Americans are getting Obese

Americans are continuing to get fatter. Obesity rates reached 30 percent or more in nine states last year, as opposed to only three states in 2007.

The increases mean that 2.4 million more people became obese from 2007 to 2009.  This brings the total to 72.5 million, or 26.7 percent of the population.

According to the New York Times:

“… [T]he rates are probably underestimates because they are based on a phone survey in which 400,000 participants were asked their weight and height instead of having it measured by someone else, and people have a notorious tendency to describe themselves as taller and lighter than they really are …

Researchers blame the usual suspects: too little exercise and too much of the wrong kind of food.”


Source: New York Times August 3, 2010

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Why Some Diets Work Better for Some People than Others

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Ever notice some people seem to eat anything they want and never gain a pound, while others seem to gain weight just by looking at fattening foods? You may be seeing things correctly after all. According to research this may have a biological cause. Using fruit flies, researchers have found that genes interacting with diet, rather than diet alone, are the main cause of variation in metabolic traits, such as body weight. This helps explain why some diets work better for some people than ot…hers, and suggests that future diets should be tailored to an individual’s genes rather than to physical appearance.

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“There is no one-size-fits all solution to the diseases of obesity and type-2 diabetes,” said Laura K. Reed, the lead investigator in the work. “Each person has a unique set of genetic and environmental factors contributing to his or her metabolic health, and as a society, we should stop looking for a panacea and start accepting that this is a complex problem that may have a different solution for each individual.”

To make this discovery, the scientists studied 146 different genetic lines of fruit flies that were fed four different diets (nutritionally balanced, low calorie, high sugar, and high fat). Researchers then measured a variety of metabolic traits, including body weight, in each group. Flies in some of the genetic lines were highly sensitive to their diets, as reflected by changes in body weight, while flies of other lines showed no change in weight across diets. The scientists were able to ascertain what portion of the total variation in the metabolic traits was determined by genetics alone, by diet alone, or by the interaction between genotype and diet. Results showed that diet alone made a small contribution to the total variation, while genotype and genotype interactions with diet made very large contributions. This study strongly suggests that some individuals can achieve benefits from altering their dietary habits, while the same changes for others will have virtually no effect.

“The summer beach season often serves as a ‘gut check’ for many in terms of their weight,” said Mark Johnston, Editor-in-Chief of the journal Genetics. “This research explains why the one-size-fits-all approach offered by many diet programs can have dramatically different effects for people who try them.”


Source : Elements4Health

 

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An Increase in Leptin Could Promote Colorectal Cancer

While researchers have known that obesity increases the risk for the development of colon cancer, the underlying molecular mechanisms have remained unclear.
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Now, for the first time, researchers have found that an increase in leptin, a cytokine that is normally increased in obese or overweight individuals, may promote colorectal neoplasms by activating colorectal cancer stem cells.

Cancer stem cells constitute a small subfraction of tumor cells that are characterized by long lifespan and capacity for self-renewal, and are responsible for tumor development, resistance to treatments and cancer recurrence. In colon cancer, leptin is able to increase the growth, survival, and resistance to certain chemotherapy treatments in this key cell population.

Leptin, a fat tissue-derived pluripotent cytokine regulating appetite and energy balance in the brain, also controls many physiological and pathological processes in peripheral organs, including carcinogenesis.

Colon cancer has increased in developed countries, possibly due to sedentary lifestyles and high caloric diets. Prior research has linked obesity to colorectal cancer risk by .4-1.0 fold in men and up to 2.0 fold in premenopausal women.

“Since targeting cancer stem cells may be a translationally relevant strategy to improve clinical outcomes, interfering with leptin signaling by targeting leptin receptors might become a novel attractive option for colorectal cancer treatment, particularly in obese patients,” says senior author of the study, Eva Surmacz.

“It is important to consider that cancer stem cells have been identified in several human malignancies,” says Monica Bartucci, study co-author. “Understanding how cancer stem cells interact with a tumor environment, including hormones like leptin, is likely to have significant implications for treatment management of different cancer types in human patients. We hope, in collaboration with Dr. Surmacz, not only to test the effects of leptin antagonist compounds on colon cancer stem cells but also to study the results of leptin stimulation on cancer stem cells isolated in other cancer tissues.”

Source: Elements4Health

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Chili Pepper Ingredient Helps With Weight Loss

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Capsaicin, the stuff that gives chili peppers their kick, may cause weight loss and fight fat buildup by triggering certain beneficial protein changes in the body, according to a new study on the topic.
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Jong Won Yun and colleagues point out that obesity is a major public health threat worldwide, linked to diabetes, high blood pressure, heart disease, and other health problems. Laboratory studies have hinted that capsaicin may help fight obesity by decreasing calorie intake, shrinking fat tissue, and lowering fat levels in the blood. Nobody, however, knows exactly how capsaicin might trigger such beneficial effects.

In an effort to find out, the scientists fed high-fat diets with or without capsaicin to lab rats used to study obesity. The capsaicin-treated rats lost 8 percent of their body weight and showed changes in levels of at least 20 key proteins found in fat. The altered proteins work to break down fats. “These changes provide valuable new molecular insights into the mechanism of the anti obesity effects of capsaicin,” the scientists say.

Source: Elements4Health. July 21.2010

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