Categories
Featured WHY CORNER

Why Painkillers Relieve Men Faster

[amazon_link asins=’B0000630BT,B00TLARW74,B01924JKD2,B001AZTU28,B0098AYFHW,B01A45HI3M,B00NJMNEG8,B01H459GUI,B009VURTWC’ template=’ProductCarousel’ store=’finmeacur-20′ marketplace=’US’ link_id=’6af47393-6525-11e7-bbfb-67757629163a’]

Does popping a painkiller provide faster relief to you than your wife?
CLICK & SEE

Thank the middle section of your brain.

Scientists at Georgia State Universitys Neuroscience Institute and Center for Behavioral Neuroscience have for the first time identified the most likely reason why analgesic drug treatment is usually less potent in females than males.

“Opioid-based narcotics such as morphine are the most widely prescribed therapeutic agents for the alleviation of persistent pain. However, it is becoming increasingly clear that morphine is significantly less potent in women compared with men. Until now, the mechanism driving the phenomenon was unknown,” said Anne Murphy, who conducted the research with Dayna Loyd.

Scientists through animal studies have shown that the previously reported differences in morphine’s ability to block pain in male versus female rats are most likely due to sex differences in mu-opioid receptor expression in a region of the brain called the periaqueductal gray area (PAG).

Located in the midbrain area, the PAG plays a major role in the modulation of pain by housing a large population of mu-opioid receptor expressing neurons. Morphine and similar drugs bind to these mu-opioid receptors and ultimately tell the brain to stop responding to pain signals to the nerve cells resulting in the reduced sensation of pain.

The findings have been reported in the December issue of `The Journal of Neuroscience‘.

Scientists say the discovery is a major step toward finding more effective treatments for females suffering from persistent pain.

Reacting to the study, Dr Madhuri Bihari, head of department of neurology at AIIMS said: “There is a difference in reaction of analgesic drugs on male and female bodies even though it is slight. Pain reduces slightly more in men than women after popping a painkiller.”

“It was believed that it’s because of the faster metabolic rate among women. This study is, therefore, significant. How much it will help clinically is yet to be understood,” Dr Bihari said.

Using a series of anatomical and behavioural tests, Murphy and Loyd were able to determine that male rats have a significantly higher level of mu-opioid receptors in the PAG region of the brain compared with females.

This higher level of receptors is what makes morphine more potent in males because less drug is required to activate enough receptors to reduce the experience of pain.

Interestingly, when they used a plant-derived toxin to remove the mu-opioid receptor from the PAG, morphine no longer worked, suggesting that this brain region is required for opiate-mediated pain relief.

Additional tests also found females reacted differently to morphine depending on the stage of their estrous cycle.

Analgesic drug market in India has swelled over the years. Painkiller drug Voveran had emerged as the top brand in the domestic pharmaceutical market with the largest sales for the first seven months of 2007

Sources: The Times Of India

Reblog this post [with Zemanta]
Categories
Ailmemts & Remedies

Burns and Scalds

Scalding caused by a radiator explosion. Pictu...Image via Wikipedia

Definition:
Burns are injuries to tissues caused by heat, friction, electricity, radiation, or chemicals. Scalds are a type of burn caused by a hot liquid or steam....CLICK & SEE
Description:
Burns are classified according to how seriously tissue has been damaged. The following system is used:

* A first degree burn causes redness and swelling in the outermost layers of the skin.
* A second degree burn involves redness, swelling, and blistering. The damage may extend to deeper layers of the skin.
* A third degree burn destroys the entire depth of the skin. It can also damage fat, muscle, organs, or bone beneath the skin. Significant scarring is common, and death can occur in the most severe cases.

The severity of a burn is also judged by how much area it covers. Health workers express this factor in a unit known as body surface area (BSA). For example, a person with burns on one arm and hand is said to have about a 10 percent BSA burn. A burn covering one leg and foot is classified as about a 20 percent BSA burn.


Causes :

Burns may be caused in a variety of ways. In every case, the burn results from the death of skin tissue and, in some cases, underlying tissue. Burns caused by hot objects result from the death of cells caused by heat. In many cases, contact with a very hot object can damage tissue extensively. The contact may last for no more than a second or so, but the damage still occurs.

In other cases, cells are killed by heat produced by some physical event. For example, a rope burn is caused by friction between the rope and a person’s body. The rope itself is not hot, but the heat produced by friction is sufficient to cause a burn.

Chemicals can also cause burns. The chemicals attack and destroy cells in skin tissue. They produce an effect very similar to that of a heat burn.

.
Symptoms:
The major signs of a burn are redness, swelling, and pain in the affected area. A severe burn will also blister. The skin may also peel, appear white or charred (blackened), or feel numb. A burn may also trigger a headache and fever. The most serious burns may cause shock. The symptoms of shock include faintness, weakness, rapid pulse and breathing, pale and clammy skin, and bluish lips and fingernails.
Burns and Scalds: Words to Know

Burns and Scalds: Words to Know

BSA:
A unit used in the treatment of burns to express the amount of the total body surface area covered by the burn.
Debridement:
The surgical removal of dead skin.
Scald:
A burn caused by a hot liquid or steam.
Shock:
A life-threatening condition that results from low blood volume due to loss of blood or other fluids.
Skin graft:
A surgical procedure in which dead skin is removed and replaced by healthy skin, usually taken from the patient’s own body.
Thermal burns:
Burns caused by hot objects.

Diagnosis:

Most burn cases are easily diagnosed. Patients know that they have touched a hot object, spilled a chemical on themselves, or been hit by steam. Doctors can confirm that a burn has occurred by conducting a physical examination.
Treatment:
The form of treatment used for a burn depends on how serious it is. Minor burns can usually be treated at home or in a doctor’s office. A minor burn is defined as a first or second degree burn that covers less than 15 percent of an adult’s body or 10 percent of a child’s body.

Moderate burns should be treated in a hospital. Moderate burns are first or second degree burns that cover more of a patient’s body or a third degree burn that covers less than 10 percent of BSA.

The most severe burns should be treated in special burn-treatment facilities. These burns are third degree burns that cover more than 10 percent of BSA. Specialized equipment and methods are used to treat these burns.

Thermal Burn Treatment:
Thermal burns are burns caused by heat, hot liquids, steam, fire, or other hot objects. The first objective in treating thermal burns is to cool the burned area. Cool water, but not very cold water or ice, should be used for the cooling process. Minor burns can also be cleaned with soap and water.

A burn victim receiving debridement treatment, or removal of dead skin, for severe burns.

Blisters should not be broken. If the skin is broken, the burned area should be covered with an antibacterial ointment and covered with a bandage to prevent infection. Aspirin, acetaminophen (pronounced uh-see-tuh-MIN-uh-fuhn, trade name Tylenol), or ibuprofen (pronounced i-byoo-PRO-fuhn, trade names Advil, Motrin) can be used to ease pain and relieve inflammation. However, children should not take aspirin due to the risk of contracting Reye’s syndrome (see Reye’s syndrome entry). If signs of infection appear, the patient should see a doctor.

More serious burns may require another approach. A burn may be so severe that it causes life-threatening symptoms. The patient may stop breathing or go into shock. In such cases, the first goal of treatment is to save the patient’s life, not treat the burns. The patient may require mouth-to-mouth resuscitation or artificial respiration.

There are three classifications of burns based on how deeply the skin has been damaged: first degree, second degree, and third degree.

Specialized treatment for severe burn cases may also include:

* Installation of a breathing tube if the patient’s airways or lungs have been damaged
* Administration of fluids through an intravenous tube
* Immunization with tetanus vaccine to prevent infection
* Covering the burned area with antibiotic ointments and bandages
* Debridement, or removal of dead tissue
* Removal of scars as healing occurs in order to improve blood flow
* Physical and occupational therapy to keep burn areas flexible and prevent scarring

Sometimes skin tissue is damaged so badly that it cannot heal properly. In that case, a skin graft may be required. In a skin graft, a doctor removes a section of healthy skin from an area of the patient’s body that has not been burned. The tissue scarred by the burn is also removed. The healthy tissue is then put into place where the damaged tissue was removed. Over a period of time, the healthy tissue begins to grow and replace the damaged tissue.

Chemical Burn Treatment:
The first step in treating a chemical burn is to remove the material causing the burn. If the material is a dry powder, it can be brushed off. If the material is a liquid, it can be flushed away with water. If the chemical that caused the burn is known, it may be neutralized with some other chemical. For example, if the burn is caused by an acid, a weak base can be used to neutralize the acid. The burned area can then be covered with a clean gauze and, if necessary, treated further by a doctor.
Electrical Burn Treatment

As with severe thermal burns, the first step in treating electrical burns usually involves saving the patient’s life. An electrical charge large enough to burn the skin may also produce life-threatening symptoms. The source of electricity must be removed and life support treatment provided to the patient. When the patient’s condition is stable, the burn can be covered with a clean gauze and medical treatment sought.

Alternative Treatment:
Serious burns should always be treated by a modern medical doctor. Less serious burns may benefit from a variety of alternative treatments. Some herbs that can be used to treat burns include aloe, oil of St. John’s wort, calendula (pronounced KUH-len-juh-luh), comfrey, and tea tree oil. Supplementing one’s diet with vitamins C and E and the mineral zinc may help a wound to heal faster.

Prognosis:
The prognosis for burns depends on many factors. These factors include the degree of the burn, the amount of skin affected by the burn, what parts of the body were affected, and any additional complications that might have developed.

In general, minor burns heal in five to ten days with few or no complications or scarring. Moderate burns heal in ten to fourteen days and may leave scarring. Major burns take more than fourteen days to heal and can leave significant scarring or, in the most severe cases, can be fatal.

Prevention:
Most thermal burns are caused by fires in the home. Every family member should be aware of basic safety rules that can reduce the risk of such fires. The single most important safety device is a smoke detector. The installation of smoke detectors throughout a house can greatly reduce the chance that injuries will result if a fire breaks out. Children should also be taught not to play with matches, lighters, fireworks, gasoline, cleaning fluids, or other materials that could burn them.

Burns from scalding water can be prevented by monitoring the temperature in the home hot water heater. That temperature should never be set higher than about 120°F (49°C). Taking care when working in the kitchen can also prevent scalds. For instance, be cautious when removing the tops from pans of hot foods and when uncovering foods heated in a microwave oven.

Sunburns can be prevented by limiting the time spent in the sun each day. The use of sunscreens can also reduce exposure to the ultraviolet radiation that causes sunburns.

Electrical burns can be prevented by covering unused electrical outlets with safety plugs. Electrical cords should also be kept out of the reach of infants who may chew on them. People should seek shelter indoors during thunderstorms in order to avoid being struck by lightning or coming in contact with fallen electrical wires.

Chemical burns may be prevented by wearing protective clothing, including gloves and eyeshields. Individuals should also be familiar with the chemicals they handle and know which ones are likely to pose a risk for burns.

For More Information:

Books
Munster, Andrew M., and Glorya Hale. Severe Burns: A Family Guide to Medical and Emotional Recovery. Baltimore: Johns Hopkins University Press, 1993.
Organizations

American Burn Association. 625 North Michigan Avenue, Suite 1530, Chicago, IL 60611. http://www.ameriburn.org.

Shriners Hospitals for Children. 2900 Rocky Point Drive, Tampa, FL 33607–1435. (813) 281–0300. http://www.shriners.org.
Web sites

“Cool the Burn: A Site for Children Touched by a Burn.” [Online] http://www.cooltheburn.com (accessed on October 11, 1999).

You may also click to learn more about Burns & Scalda:->..(1)……..(2)…...(3)…..(4)…….(5)

Sources: http://www.faqs.org/health/Sick-V1/Burns-and-Scalds.html

Enhanced by Zemanta
Categories
News on Health & Science

Body’s Natural Painkillers Can Block Phobias

Magnetic resonance image showing a median sagittal cross section through a human head.

Image via Wikipedia

Human body’s own pain-relief system has the ability to block phobias, claims a new study which is likely to soon throw light on the neural mechanisms behind anxiety and stress.

A international team, led by researchers at the University Medical Centre of Hamburg-Eppendorf, has found that the way humans are conditioned by fearful stimuli is to some extent damped down by the body’s own pain-relief system.

For their study, the researchers recruited 30 male volunteers who were asked to watch green triangles and blue pentagons on a screen inside an MRI scanner. One symbol was followed half the time by a moderately painful application of heat to the forearm; the other was never followed by pain.

Half the volunteers were infused with a drug that blocks the effects of opioids, while the others got saline solution as a control. The brain scans showed that in people whose opioid systems had been blocked, the amygdala showed a fear response that did not diminish with exposure. Every time they saw the symbol associated with pain, their amygdalas reacted strongly.

In the control group, however, the activation decreased over the course of the experiment. As the group receiving the drug was reacting fearfully, the researchers speculate, they were learning the association intensively.

At the beginning of each trial, volunteers had to perform a reaction time task – pressing a button to indicate on which half of the screen the symbol had appeared. Overall, the subjects reacted more quickly to the cue signalling pain than the cue signalling nothing – but the opioid-free subjects reacted significantly faster.

The team speculates that opioid deficiency could be a contributing factor to anxiety disorders and exaggerated fear responses.

Sources:The Times Of India

Categories
Anti Drug Movement

Dangers Of Prescription Drug Abuse

[amazon_link asins=’1507846134,1579511686,1440839786,1886039224,1534997342,1886039887,0737760672,1537060805,1682174557′ template=’ProductCarousel’ store=’finmeacur-20′ marketplace=’US’ link_id=’7eb66f65-018a-11e8-a118-774e19e748fe’]

Although teens are turning away from street drugs, now there’s a new threat and it’s from the family medicine cabinet: The abuse of prescription (Rx) and over-the-counter (OTC) drugs.

CLICK TO SEE

Parents and caregivers are the first line of defense in addressing this troubling trend.

What’s the problem?
Teens are abusing some prescription and over-the-counter drugs to get high. This includes painkillers, such as those drugs prescribed after surgery; depressants, such as sleeping pills or anti-anxiety drugs; and stimulants, such as those drugs prescribed for attention deficit hyperactivity disorder (ADHD). Teens are also abusing over-the-counter drugs, such as cough and cold remedies.

Every day 2,500 youth age 12 to 17 abuse a pain reliever for the very first time. More teens abuse prescription drugs than any illicit drug except marijuana. In 2006, more than 2.1 million teens ages 12 to 17 reported abusing prescription drugs. Among 12- and 13-year-olds, prescription drugs are the drug of choice.

Because these drugs are so readily available, and many teens believe they are a safe way to get high, teens who wouldn’t otherwise touch illicit drugs might abuse prescription drugs. And not many parents are talking to them about it, even though teens report that parental disapproval is a powerful way to keep them away from drugs.

What are the dangers?
There are serious health risks related to abuse of prescription drugs. A single large dose of prescription or over-the-counter painkillers or depressants can cause breathing difficulty that can lead to death. Stimulant abuse can lead to hostility or paranoia, or the potential for heart system failure or fatal seizures. Even in small doses, depressants and painkillers have subtle effects on motor skills, judgment, and ability to learn.

The abuse of OTC cough and cold remedies can cause blurred vision, nausea, vomiting, dizziness, coma, and even death. Many teens report mixing prescription drugs, OTC drugs, and alcohol. Using these drugs in combination can cause respiratory failure and death.

Prescription and OTC drug abuse is addictive. Between 1995 and 2005, treatment admissions for prescription painkillers increased more than 300 percent.

Found out your teen is abusing Rx drugs?

Step-by-step guide
Talk to your teen about the dangers of Rx abuse
Build a support group

Click to learn:->
Why you should care
Why teens are using
Sources of Rx Drugs
Over-the-counter drugs
Could Your Teen Be Abusing?
What Can You Do?
Videos, Ads & More

Sources:http://www.theantidrug.com/drug_info/prescription_dangers.asp#foot

Enhanced by Zemanta
Categories
Ailmemts & Remedies

Bowen’s Disease

Definition:
Bowen’s disease (BD) is a sunlight-induced skin disease, considered either as an early stage or intraepidermal form of squamous cell carcinoma. It was named after Dr John T. Bowen, the doctor who first described it in 1912.

CLICK & SEE

Bowen’s disease is also called squamous cell carcinoma in situ (SCC in situ), is a form of skin cancer. The term “in situ” added on the end tells us that this is a surface form of skin cancer. “Invasive” squamous cell carcinomas are the type that grow inward and may spread. SCC in situ is also known as Bowen’s disease after the doctor who first described it almost 100 years ago.

Causes
Causes of BD include solar damage, arsenic, immunosuppression (including AIDS), viral infection (human papillomavirus or HPV) and chronic skin injury and dermatoses.

Like other forms of skin cancer, SCC in situ is mainly caused by chronic sun exposure and aging. There are two other less important causes which are unique to SCC in situ. The wart virus that causes cervical cancer (HPV 16) is often found to be infecting SCC in situ. It is thought that infection with this virus is one of the reasons why two people may have the same amount of sun damage, but only one keeps getting skin cancers. The other factor that causes SCC in situ is arsenic, the same poison made famous by the play “Arsenic and Old Lace” and the Russian villain Rasputin. Arsenic contaminated some old water wells, and also many years ago was used in some medical elixirs. People with mild Arsenic poisoning didn’t die, but tend to develop cancers, both of the skin and internally. For a time it was thought that SCC in situ was a sign that cancer was going to develop internally, until it was discovered that was a false impression caused by arsenic poisoning.

Signs and symptoms:
Bowen’s disease typically presents as a gradually enlarging, well demarcated erythematous plaque with an irregular border and surface crusting or scaling. BD may occur at any age in adults but is rare before the age of 30 years – most patients are aged over 60. Any site may be affected, although involvement of palms or soles is uncommon. BD occurs predominantly in women (70-85% of cases); about three-quarters of patients have lesions on the lower leg (60-85%), usually in previously or presently sun-exposed areas of skin. A persistent progressive non-elevated red scaly or crusted plaque which is due to an intradermal carcinoma and is potentially malignant. Atypical squamous (resembling fish scales) cells proliferate through the whole thickness of the epidermis. The lesions may occur anywhere on the skin surface or on mucosal surfaces. The cause most frequently found is trivalent arsenic compounds. Freezing, cauterization or diathermy coagulation is often effective treatment.

SCC in situ is usually a red, scaly patch. It tends to be seen on areas frequently exposed to the sun. Some itch, crust or ooze, but most have no particular feeling. SCC in situ may be mistaken for rashes, eczema, fungus or psoriasis. Sometimes they are brown and look like a keratosis or a melanoma. Because of this, a biopsy must usually be done to confirm the diagnosis.

Treatment:
Photodynamic therapy (PDT), Cryotherapy (freezing) or local chemotherapy (with 5-fluorouracil) are favored by some clinicians over excision. Because the cells of Bowen’s disease have not invaded the dermis, it has a much better prognosis than invasive squamous cell carcinoma.

The simplest and most common treatment for smaller SCC in situ is surgical excision. The standard practice is to remove about a quarter inch beyond the edge of the cancer. Larger ones can also be excised, but Mohs surgery may be needed. It offers the highest cure rate of all treatment methods.

For those not up to surgery, there are some choices. SCC in situ can be burned off by several methods. These are “curettage and electrodessication”, liquid nitrogen cryotherapy and laser destruction. These heal with similar scars.

X-ray or grenz ray radiation can be given to poor surgical candidates or patients with multiple sites. This is very expensive and requires multiple visits to the hospital. Efudex Cream applied for 1 to 3 months will often work, but leaves an uncomfortable raw area during that time. Aldara cream can also be used to treat Bowen’s, with a two to three month treatment period required.

The latest treatment approved by the FDA but not yet in common use, is photodynamic therapy (PDT). PDT is an alternative way to “burn off” SCC in situ using a drug that is absorbed only by cancer cells. A bright light is then applies causing the release of toxins and destruction of the tumor.

If you have had an SCC in situ, you have a higher risk of other skin cancers. For this reason, you will need a regular skin exam by a dermatologist. Untreated, SCC in situ grows larger over time and may spread out to be several inches. 5% of SCC in situ will eventually develop into invasive squamous cell carcinoma if not treated.

The dermatologist based on his experience, expertise and analysis of your personal situation is the one best equipped to decide your personal treatment plan.

Disclaimer: This information is not meant to be a substitute for professional medical advise or help. It is always best to consult with a Physician about serious health concerns. This information is in no way intended to diagnose or prescribe remedies.This is purely for educational purpose

Resources:
http://www.aocd.org/skin/dermatologic_diseases/bowens_disease.html
http://en.wikipedia.org/wiki/Bowen%27s_disease

css.php