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Spice Up Your Health

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Your favorite marinades may provide a beneficial source of natural antioxidants, according to a new study by researchers at The University of Western Ontario.
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After analyzing seven popular brands of marinade that contained herbs and spices as their primary ingredients, they found “very good quantities” of antioxidants remained, even after cooking and marinating.

Although marinating meat reduced antioxidants levels by 45-70 percent, there was still a benefit over cooking meat plain, with no marinade.

Consumers can help boost their intake of antioxidants by choosing sauces with the highest levels of antioxidants to begin with, according to researchers.

Foods rich in antioxidants play an essential role in preventing cardiovascular diseases, cancers, neurodegenerative diseases like Alzheimer’s and Parkinson’s, inflammation and problems associated with cutaneous aging,” Science Daily reported.

Science Daily March 24, 2010
Journal of Food Composition and Analysis May 2010, Volume 23, Issue 3, Pages 244-252

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A Grapefruit Pill to Fight Obesity

Tart and tangy with an underlying sweetness, grapefruit has a juiciness which rivals that of the ever popular orange and sparkles with many  of the same health promoting benefits.And, now researchers are on track to develop a pill from a chemical compound in grapefruit, which they claim would help obese people shed the flab and diabetics control their blood sugar levels.

Researchers at University of Western Ontario have found that naringenin, the chemical compound that gives grapefruit its bitter taste, has revolutionary effect on the liver making it burn fat instead of storing it after a meal.


According to them, this means that without having to change diets or cut out particular foods, a dose of naringenin could prevent weight gain and even help to lose it as well as help those having diabetes to control blood sugar levels.

Lead researcher Murray Huff said: “The study shows naringenin, through its insulin-like properties, corrects many of the metabolic disturbances linked to insulin resistance and represents a promising approach for metabolic syndrome.”

They have based their findings on an analysis of tests which were carried out on mice — two groups of rodents were both fed the equivalent of a Western diet to speed up their “metabolic syndrome”, the process leading to Type 2 diabetes.

Source:    The Times Of India

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Some Fruit Juices Lower Drug Effect

Grapefruit, orange and apple juices can harm the body’s ability to absorb certain medications and make the drugs less effective, said a study.

The research showed that these juices can decrease the effectiveness of certain drugs used to treat heart disease, cancer, organ-transplant rejection and infection, “potentially wiping out their beneficial effects”, it said.

David Bailey, a professor of clinical pharmacology with the University of Western Ontario and leader of the study, was the first researcher to identify grapefruit juice‘s potential to increase the absorption of certain drugs two decades ago, possibly turning some doses toxic.

The new findings came as part of his continuing research on the subject, and were presented at the 236th annual meeting of the American Chemical Society on Philadelphia, Pennsylvania.

“Recently, we discovered that grapefruit and these other fruit juices substantially decrease the oral absorption of certain drugs undergoing intestinal uptake transport,” said Bailey. “The concern is loss of benefit of medications essential for the treatment of serious medical conditions.”

Healthy volunteers took fexofenadine, an antihistamine used to fight allergies, along with either a glass of grapefruit juice, a glass of water with naringin (which gives the bitter taste to grapefruit juice), or plain water.

Those who drank the grapefruit juice absorbed only half the amount of fexofenadine, compared to those who drank plain water.

Researchers said the water with naringin served to block “a key drug uptake transporter, called OATP1A2, involved in shuttling drugs from the small intestine to the bloodstream”.

Among the drugs affected by consumption of grapefruit, orange and apple juices are: etoposide, an anticancer agent; beta blockers used to treat high blood pressure and prevent heart attacks; and certain antibiotics (ciprofloxacin, levofloxacin, itraconazole).

The drug-lowering interaction also affected cyclosporine, a drug taken to prevent rejection of transplanted organs, and more drugs were expected to be added to the list as the research continued.

Sources: The Times Of India

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