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Agents that regulates appetite identified

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Scientists in Japan have identified a molecule responsible for making mammals feel full, a discovery that could lead to new ways to treat obesity in humans.

Scientists believe appetite is controlled in a region of the brain called the hypothalamus, and the group of researchers claims to be the first to pinpoint an agent that triggers an increase or decrease in appetite.

In an article published on Sunday in the online version of the journal Nature, the scientists identified the molecule as nesfatin-1, which is produced naturally in the brain.

After injecting the molecule into the brains of rats, the scientists observed that the rodents began to eat less and lose weight.

The researchers also were able to induce the rats to eat more, by blocking nesfatin-1

After we injected anti-nesfatin-1 antibody, these rats showed increased appetite and finally showed a progressive increase in body weight,” Masatomo Mori of the medicine and molecular science department at Gunma University Graduate School of Medicine told Reuters in a telephone interview.

Mori said the finding could pave the way for treating obesity, which has become a major health problem in the developing world as well as in economically advanced countries.

There are at least a billion overweight adults across the world, 300 million of them considered obese, according to the World Health Organization.

Obesity has been linked to chronic diseases, such as type 2 diabetes, cardiovascular disease, hypertension and stroke, and some forms of cancer.

In a separate study, it has been found that the hormone leptin could help keep the body from producing too much insulin, according to a study in mice with type 2 diabetes.

People with type 2 diabetes often become resistant to the effects of insulin, causing to much of it to build up in the body.

Reporting in the September issue of the journal Peptides, researchers from the University of Florida injected a gene into the brains of diabetic mice, hoping to increase the production of the appetite-controlling hormone leptin in the hypothalamus.

Insulin levels in mice that received gene therapy returned to normal — even when they were fed a high-fat diet, the
researchers found. High-fat diets typically help trigger or worsen type 2 diabetes.

Mice that ate a high-fat diet but did not receive gene therapy, however, continued to overproduce insulin and have high blood-sugar levels.

“This was totally unexpected. Until now, there way no evidence that leptin action in the hypothalamus had control on insulin secretion.

With leptin gene therapy, we can re-impose that control,” senior author Satya Kalra, a University of Florida, Gainesville, professor of neuroscience, said.

(As published in the Times Of India)

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Ailmemts & Remedies

Cold Allergy

Every year, millions of people use over-the-counter (OTC) products to relieve nasal stuffiness and congestion, sneezing, runny noses, sore throat, and cough. The common causes of these symptoms include the cold virus, influnza virus, allergic rhinitis (hay fever), and sinus infections (sinusitis). Viral infections can also cause headache, body- aches, fatigue, and sometimes fever. Hay fever symptoms can also include itchy eyes, nose, and throat, and watery eyes.

The symptoms are : headache,body-aches, flue like fever, nasal congestion,running nose,sneezing and then cough and some times sore throat.

Often the patient is having symptoms such as nasal congestion, drainage, coughing, sneezing, low grade fever (under 101 degrees). These are symptoms of “colds.” But they are also symptoms of allergy. These symptoms can be confusing. It helps to note on the calendar when symptoms begin and end. You may notice a “pattern;” particularly, if the cause is allergy. The “pattern” may be symptoms that occur at the same “pollen” season each year.

For example, many people get “colds” during December, January and February of each year. Others have “cedar fever” during these months, each year. Patients realize they are having “cold” symptoms, including “cedar fever,” all of which are really “allergies” giving rise to these symptoms. “Cedar fever” or “hay fever” are simply descriptive labels describing the low grade fever that accompanies most allergy reactions. It usually is under 100 degrees and often is accompanied by “night sweats.”

The fever of a real-cold is usually much higher – often 103-105 degrees. The symptoms are similar but are usually much more severe and overwhelming with a “cold.” So we often confuse the two.

These are just a few guidelines to help you tell the difference, but basically one rule helps differentiate allergy from almost every other medical disorder: it comes and goes, comes and goes. Almost any other disorder gets worse . . . or better; but, they don’t appear and disappear, come and go week by week, month by month, season by season, year in and year out.

According to Ayurvedic thought, seasonal allergies are connected to the earth. As the earth is more saturated during this time of the year due to the increased rain, the earth is holding on to more water than usual. This then is also occurring in our bodies, and is what we refer to as congestion. In order to figure out what the best remedy for our bodies would be, we need only refer to what is going on with the earth. During spring, the earth produces many different vegetables and berries. These foods are naturally healthy and fat-free and are exactly what our bodies need to rid ourselves of congestion and counteract all of the increased fats we absorbed.

The Journal of Allergy and Clinical Immunology reports that Allergic disorders affect at least 50 million people in the US. Common symptoms range from Asthma, Eczema, Hay Fever, Headaches, swellings, fatigue, chills, sensitivity to light and Loss of Appetite. These symptoms can be worsened by inherited tendencies, or exposure to environmental toxins such as smog, pesticides, even the food we eat and the water we drink! Allergies are often manifestations of the immune system being overloaded by the constant assault of pollution associated with modern life.

Olive Leaf the Allergy Buster:
The botanical Olea Europaea (olive leaf) tea, extracts and capsules are immune system boosters known to help control and eliminate various allergies. The antioxidants of olive leaf act directly to eliminate free radicals from the body, as well as aiding with digestion. The less energy that your immune system uses acting as a “cleanup crew” for the body, the more of it’s resources are available for combating environmental allergens such as Pollen, Dust and Mold. The key to utilizing olive leaf as consistency so that the immune system may permanently shift it’s focus to environmental allergens, and away from internal toxins, leaving you happier, healthier and more able to enjoy life.

Some home remedies for common cold:

For dry and stuffy nose, try normal saline or salt water nasal drops made by adding 1/4 teaspoon of table salt to about 4 ml lukewarm water. Make a fresh solution every few days keeping it in refrigerator. Use a clean dropper to instill 1 to 2 drops in each nostril about 3 to 4 times daily for common cold .

Do not use medicated nasal drops without physician’s consent as excessive use will cause chemical rhinitis with rebound block

Garlic juice made by adding few drops of garlic oil to a teaspoonful of onion juice and diluting it in a cup of water is helpful for common cold

Ginger tea or a teaspoonful of ginger juice taken with equal quantity of honey brings relief from common cold


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According to me, we can get more benefits if we treat Cold Allergy of all kind with HERBAL REMEDIES .We may visit this web site and at the same time try to develop the immune system that is within our body. Regular Yoga exercise and sometimes Urotherapy may be a few of several natural process of developing this.

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