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Healthy Secret of Red Wine Uncorked

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Resveratrol in red wine is known for controlling inflammation and promoting health. However, how the ingredient works was not known to  scientists – up till now.

In the FASEB Journal, scientists from Scotland and Singapore have unravelled how resveratrol works as an effective therapy for life-threatening inflammation.

The study, not only explains resveratrol’s one-two punch on inflammation, but also shows how it-or a derivative-can be used to treat potentially deadly inflammatory disease, such as appendicitis, peritonitis, and systemic sepsis.

“Strong acute inflammatory diseases such as sepsis are very difficult to treat and many die every day due to lack of treatment,” said Alirio Melendez, senior lecturer on the faculty of medicine at Glasgow Biomedical Research Centre in Scotland and one of the researchers involved in the work.

“Moreover, many survivors of sepsis develop a very low quality of life due to the damage that inflammation causes to several internal organs. The ultimate goal of our study was to identify a potential novel therapy to help in the treatment of strong acute inflammatory diseases,” the expert added.

To reach the conclusion, researchers administered an inflammatory agent to two groups of mice. One group was pretreated with resveratrol and the other group was not. The mice that were not pre-treated with resveratrol experienced a strong inflammatory response, simulating disease in humans, while the group pretreated with resveratrol was protected from the inflammation.

The scientists then examined the tissues of the mice to determine exactly how resveratrol was able to protect the mice from inflammation. They found that resveratrol used a one-two punch to stop inflammation in the mice by preventing the body from creating two different molecules known to trigger inflammation, sphingosine kinase and phospholipase D.

This finding suggests that resveratrol may be harnessed as a treatment for inflammatory diseases and may also lead to entirely new resveratrol-based drugs that are even more effective.

“The therapeutic potential of red wine has been bottled up for thousands of years,” said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, “and now that scientists have uncorked its secrets, they find that studies of how resveratrol works can lead to new treatments for life-threatening inflammation.”

Source: The Times Of India

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Wine, Veg & Meat: Key to Long Life

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Want to know the perfect recipe for a long and healthy life? Drinking a goblet of red wine as well as eating adequate fruit, vegetablesand a small portion of red meat  everyday all add up to it, says a new study.
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Previous research has found that sticking to the diet can protect the brain against developing Alzheimer’s and other memory problems, cut the chances of developing heart disease and even reduce the risk of being diagnosed with cancer.

The latest study, which followed 23,000 people, found that those who adhered most closely to a typical Mediterranean diet were 14 per cent more likely to still be alive at tView Posthe end of eight years, ‘The Daily Telegraph‘ reported.

“The analysis suggests that the dominant components of the Mediterranean diet are moderate consumption of alcohol, mostly in the form of wine during meals, low consumption of meat and meat products, and high consumption of vegetables, fruits and nuts, olive oil and legume,” said lead researcher Dimitrios Trichopoulos of Harvard School of Public Health.

Drinking wine had the most benefit on life span the findings suggest, followed by reducing meat consumption and then eating high numbers of fruit, vegetables and nuts.

Source: The Times Of India

 
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Apples, avocados and a glass of red wine ‘can ease arthritis’

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Suffering from arthritis? Make sure you eat apples, avocados, oily fish and drink a goblet of red wine everyday, for a new study has  revealed that these could ease the painful joint condition.
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Researchers have carried out the study and found a definite link between the food people eat and the severity of the symptoms — in fact, apples, avocados and red wine contain anti-oxidants which reduce the rate at which cartilage breaks down, helping to slow the process of osteoarthritis.

Likewise, oily fish like salmon are a rich source of omega-3 fatty acids that oil the joints and thereby damp down inflammation. Omega-3 could also reduce the long-term need for painkillers in those with joint problems.

The study has also suggested that drinking plenty of fluids, two to three litres a day, to maintain good hydration and a steady flow of nutrients to your joints, leading British newspaper the ‘Daily Mail‘ reported.

And, the foods most commonly found to worsen arthritis are wheat, corn, rye, sugar, caffeine, yeast, dairy products, oranges, grapefruit, lemons and tomatoes. Meats most likely to provoke symptoms are bacon, pork, beef and lamb.

According to researchers, these foods trigger joint pain in those with arthritis. But when these are avoided about 70 per cent of sufferers have been seen to be reporting less pain and improved mobility.

The researchers have based their findings on an analysis of 82 people with osteoarthritis. The study also found that pain intensity reduced during the six-week period they had weekly Reiki sessions.

Source:The Times Of India

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Black Tea Prevents Heart Disease

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Drinking just one cup of black tea everyday might protect against cardiovascular disease, a new research has found.

According to the study conducted at University of L’Aquila in Italy and supported by the Lipton Institute of Tea, black tea consumption improves blood vessel reactivity and reduces blood pressure and arterial stiffness, indicating a notably better cardiovascular health profile.

Using a group of 19 healthy men (mean age 33), the researchers assigned the participants to one of five prescribed intakes of the tea over five periods lasting one week each.

The caffeine level of each dose was standardised but the dose of tea flavonoids was controlled at the levels of 0 (the control dose), 100, 200, 400 and 800 mg per day.

A standard cup of black tea contains approximately 100-200 mg of flavonoids, depending on the individual preference of tea making.

During the course of the research, participants avoided naturally flavonoid-rich food and drinks like red wine and chocolate to ensure that the results become a true reflection of flavonoid-rich black tea consumption only.

Source: The Times Of India

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Red Wine Beneficial for Health

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A polyphenol present in red wine, called resveratrol, has been found to have a large number of health benefits for drinkers, say researchers.
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Red wine contains a complex mixture of bioactive compounds, including flavonols, monomeric and polymeric flavan-3-ols, highly coloured anthocyanins, as well as phenolic acids and the stilbene polyphenol, resveratrol.

Lindsay Brown, an associate professor in the School of Biomedical Sciences at The University of Queensland and corresponding author for the study, says that some of these compounds, particularly resveratrol, appear to have health benefits.

“The breadth of benefits is remarkable – cancer prevention, protection of the heart and brain from damage, reducing age-related diseases such as inflammation, reversing diabetes and obesity, and many more,” said Brown.

“It has long been a question as to how such a simple compound could have these effects but now the puzzle is becoming clearer with the discovery of the pathways, especially the sirtuins, a family of enzymes that regulate the production of cellular components by the nucleus. ‘Is resveratrol the only compound with these properties?’ This would seem unlikely, with similar effects reported for other components of wine and for other natural products such as curcumin. However, we know much more about resveratrol relative to these other compounds,” he said.

One of the main points of the review included that resveratrol exhibits therapeutic potential for cancer chemoprevention as well as cardioprotection.

“It sounds contradictory that a single compound can benefit the heart by preventing damage to cells, yet prevent cancer by causing cell death. The most likely explanation for this, still to be rigorously proved in many organs, is that low concentrations activate survival mechanisms of cells while high concentrations turn on the in-built death signals in these cells,” said Brown.

The study suggests that resveratrol may aid in the prevention of age-related disorders, such as neurodegenerative diseases, inflammation, diabetes, and cardiovascular disease.

“The simplest explanation is that resveratrol turns on the cell’s own survival pathways, preventing damage to individual cells. Further mechanisms help, including removing very reactive oxidants in the body and improving blood supply to cells,” said Brown.

The researchers also said that low doses of resveratrol could improve cell survival as a mechanism of cardio- and neuro-protection, while high doses increase cell death.

“The key difference is probably the result of activation of the sirtuins in the nucleus. Low activation reverses age-associated changes, while high activation increases the process of apoptosis or programmed cell death to remove cellular debris. Similar changes are seen with low-dose versus high-dose resveratrol: low-dose resveratrol produces cellular protection and reduces damage, while high-dose resveratrol prevents cancers,” said Brown.

She concluded that current scientific research is starting to explain reports from the last 200 years that drinking red wine improves health.

However, the researchers added that low to moderate drinking, especially of red wine, appears to reduce all causes of mortality, while too much drinking causes multiple organ damage.

The findings will be published in the September issue of Alcoholism: Clinical & Experimental Research.

 

Source: The Times Of India

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