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Herbs & Plants

Datura

Botanical Name:Datura metel L. (Solanaceae)

Syn : Datura alba Nees, D. fastuosa L. var alba C.B. Clarke

English name: Hindu datura.

Sanskrit name: Dhustura.

Vernacular names :Ben: Dhutra, Dhatura; Hin : Sadahdhatura; Tam: Vellum mattai. Trade name: Dhutra.
Datura is a genus of 12-15 species of vespertine flowering plants belonging to the family Solanaceae. Their exact natural distribution is uncertain, due to extensive cultivation and naturalization throughout the temperate and tropical regions of the globe, but is most likely restricted to the Americas, from the United States south through Mexico (where the highest species diversity occurs) to the mid-latitudes of South America. Some species are reported by some authorities to be native to China, but this is not accepted by the Flora of China, where the three species present are treated as introductions from the Americas. (It also grows naturally throughout most of Australia).

Common names include jimson weed, Hell’s Bells, Devil’s weed, Devil’s cucumber, thorn-apple (from the spiny fruit), pricklyburr (similarly), and somewhat paradoxically, both angel’s trumpet and devil’s trumpet (from their large trumpet-shaped flowers), or as Nathaniel Hawthorne refers to it in the the Scarlet Letter apple-peru. The word Datura comes from Hindi dhatÅ«rā (thorn apple); record of this name dates back only to 1662 (OED).

Scientific Name
Datura Stramonium L. – Named by Carl Linnaeus as published in Species Plantarum (1753). The genus was derived from ancient hindu word for plant, dhatura. The species name is from New Latin, stramonium, meaning thornapple. Stramonium is originally from from Greek, strychnos (nightshade) and manikos (mad).

They are large, vigorous annual plants or short-lived perennial plants, growing to 1-3 m tall. The leaves are alternate, 10-20 cm long and 5-18 cm broad, with a lobed or toothed margin. The flowers are erect or spreading (not pendulous), trumpet-shaped, 5-20 cm long and 4-12 cm broad at the mouth; color varies from white to yellow, pink, and pale purple. The fruit is a spiny capsule 4-10 cm long and 2-6 cm broad, splitting open when ripe to release the numerous seeds.

Jimsonweed is a cosmopolitan weed of worldwide distribution. It is found in most of the continental US from New England to Texas, Florida to the far western states. Jimsonweed is found in most southern Canadian Provinces as well. It gows in cultivated fields being a major weed in soybeans worldwide. Jimsonweed is common on overgrazed pastures, barnyards, and waste land preferring rich soils.

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Datura species are used as food plants by the larvae of some Lepidoptera species including .
Datura contains the alkaloids scopolamine and atropine and has long been used as a poison and hallucinogen. The dose-response curve for the combination of alkaloids is very steep, so people who consume datura can easily take a potentially fatal overdose. In the 1990s and 2000s, the United States media contained stories of adolescents and young adults dying or becoming seriously ill from intentionally ingesting datura.

Datura stramonium is also called jimsonweed. This name comes from the town of Jamestown, Virginia. Various versions of the story exist, but in the most common version, British soldiers sent to quell Bacon’s Rebellion of 1676 were accidentally served this unfamiliar plant as food, causing many to be incapacitated for 11 days. Datura wrightii, also called sacred datura or western jimsonweed, has similar effects.

Medicinal Action and Uses:
Dried leaves and seeds of Datura is used in the British and US Pharmacopoeia as antispasmodic under critical conditions of Asthma and whooping cough. Antispasmodic, anodyne and narcotic. Its properties are virtually those of hyoscyamine. It acts similarly to belladonna, though without constipating, and is used for purposes similar to those for which belladonna is employed, dilating the pupil of the eyes in like manner. It is considered slightly more sedative to the central nervous system than is belladonna.

Stramonium is, in fact, so similar to belladonna in the symptoms produced by it in small or large doses, in its toxicity and its general physiological and therapeutic action, that the two drugs are practically identical, and since they are about the same strength in activity, the preparations may be used in similar doses.

Stramonium has been employed in all the conditions for which belladonna is more commonly used, but acts much more strongly on the respiratory organs, and has acquired special repute as one of the chief remedies for spasmodic asthma, being used far more as the principal ingredient in asthma powders and cigarettes than internally. The practice of smoking D. ferox for asthma was introduced into Great Britain from the East Indies by a certain General, and afterwards the English species was substituted for that employed in Hindustan. Formerly the roots were much used: in Ceylon, the leaves, stem and fruit are all cut up together to make burning powders for asthma, but in this country the dried leaves are almost exclusively employed for this purpose. The beneficial effect is considered due to the presence of atropine, which paralyses the endings of the pulmonary branches, thus relieving the bronchial spasm. It has been proved that the smoke from a Stramonium cigarette, containing 0.25 grams of Stramonium, leaves contains as much as 0.5 milligrams of atropine. The leaves may be made up into cigarettes or smoked in a pipe, either alone, or with a mixture of tobacco, or with cubebs, sage, belladonna and other drugs. More commonly, however, the coarsely-ground leaves are mixed into cones with some aromatic and with equal parts of potassium nitrate, in order to inincrease combustion and are burned in a saucer, the smoke being inhaled into the lungs. Great relief is afforded, the effect being more immediate when the powdered leaves are burnt and the smoke inhaled than when smoked by the patient in the form of cigars or cigarettes, but like most drugs, after constant use, the relief is not so great and the treatment is only palliative, the causation of the attack not being affected. Accidents have also occasionally happened from the injudicious use of the plant in this manner.

Dryness of the throat and mouth are to be regarded as indications that too large a quantity is being taken.

The seeds, besides being employed to relieve asthma in the same manner as the leaves, being smoked with tobacco, are employed as a narcotic and anodyne, generally used in the form of an extract, prepared by boiling the seeds in water, or macerating them in alcohol. A tincture is sometimes preferred. The extract is given in pills to allay cough in spasmodic bronchial asthma, in whooping-cough and spasm of the bladder, and is considered a better cough-remedy than opium, but should only be used with extreme care, as in over-doses it is a strong narcotic poison.

Applied locally, in ointment, plasters or fomentation, Stramonium will palliate the pain of muscular rheumatism, neuralgia, and also pain due to haemorrhoids, fistula, abscesses and similar inflammation.

Dautra or Jimsonweed Toxicity
All parts of Jimsonweed are poisonous. Leaves and seeds are the usual source of poisoning, but are rarely eaten do to its strong odor and unpleasant taste. Poisoning can occur when hungry animals are on sparse pasture with Jimsonweed infestation. Most animal poisoning results from feed contamination. Jimsonweed can be harvested with hay or silage, and subsequently poisoning occurs upon feeding the forage. Seeds can contaminate grains and is the most common poisoning which occurs in chickens.

Poisoning is more common in humans than in animals. Children can be attracted by flowers and consume Jimsonweed accidentally. In small quantities, Jimsonweed can have medicinal or haulucinagenic properties, but poisoning readily occurs because of misuse. Ingestion of Jimsonweed caused the mass poisoning of soldiers in Jamestown, Virginia in 1676.

Dautra or Jimsonweed toxicity is caused by tropane alkaloids. The total alkaloid content in the plant can be as high as 0.7%. The toxic chemicals are atropine, hyoscine (also called scopolamine), and hyoscyamine.

Cautions:
Because of Jimsonweed’s toxic properties, the custom of destroying the plant should be practiced on every farm. Animals should not be allowed to graze on sparse pasture inhabited by Jimsonweed. Hay and silage should not be made from fields until all Jimsonweed has been removed. Soybean and other grain fields infested with Jimsonweed can be controlled by a variety of broadleaf herbicides.
Note that herbicides should be applied as directed by a qualified applicator.

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Disclaimer:
The information presented herein is intended for educational purposes only. Individual results may vary, and before using any supplements, it is always advisable to consult with your own health care provider

Help taken from: en.wikipedia.org and www.botanical.com

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News on Health & Science

Iyengar yoga improves immunity

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A study, conducted by researchers at the Washington State University, has found that the immunity
system of breast cancer survivors improved significantly after practising the Iyengar form of yoga.

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Created by B K S Iyengar, based on the traditional eight limbs of yoga as expounded by Patanjali in his Yoga Sutras, this yoga form emphasises the development of strength, stamina, flexibility and balance, as well as concentration and meditation.

Considered to be a more active form of yoga, researchers reported on Monday at the American Physiological Society meeting in Washington DC that in breast cancer survivors, the Iyengar method not only promoted psychological well-being but also benefited the patients’ immune system.

According to lead researcher Pamela E Schultz, practising the yoga form resulted in decreased activation of an important immune system protein called NF-kB in patients, which is a marker of stress in the body.
“So it’s possible,” Schultz said, “that decreased activation of NF-kB indicates decreased stress in the body. NF-kB is activated in the body by physical or mental stress.”

Schultz randomly assigned 19 women, average age 61 years, diagnosed with stage I-III breast cancer and receiving antiestrogen or aromatase inhibitor hormonal therapy, to eight weeks of Iyengar yoga. Beginning level Iyengar yoga classes were conducted two times per week for eight weeks and included the following yoga poses: standing poses, chest and shoulder openers and inversions.

Blood sample to determine lymphocyte NF-kB activation were collected prior to and following the intervention.
“Psychosocial tests showed that the demands of illness, which reflects the burden of hardship of being a breast cancer survivor, lowered in the yoga participants. The survivors showed changes in the way their immune cells respond to activation signals. The function of genes in immune cells can be regulated by proteins called transcription factors. Transcription factor nuclear factor-kappa B (NF-kB) is linked to immune cell activation and to the stress response,” Schultz said.

Speaking to TOI, 89-year-old Iyengar said, “Similar studies in Mumbai found that certain asanas improve the quality of blood and results in better blood circulation. It also improved the production of proteins in the immune system called T-cell receptors that actually direct the immune system to attack specific targets. Immune cells that contain the engineered T-cell receptor better display targeted immunity with a few asanas.”

Cancer and its treatments are associated with considerable distress, impaired quality of life and reduced physical function, especially for women with breast cancer who receive multi-modality treatment over an extended period of time. “Yoga greatly helps to relieve and improve quality of life among cancer patients over time,” Iyengar said.

Dr Chidanand Murthy, director of Central Council for Research in Yoga, said, “A similar study conducted in AIIMS on 30 patients in 2006 found that Sudarshan Kriya and Pranayama greatly helped cut down the growth of breast cancer cells within the body. Through release of stress, adverse effects of chemotherapy were also avoided.”

Indian Council of Medical Research data shows that the incidence of breast cancer is high among Indians and is estimated that one in 22 Indian females is likely to develop breast cancer during her lifetime in contrast to one in eight in America.

According to Delhi’s latest cancer registry, breast cancer among women is rising by about 2% every year. It now affects 30 per 100,000 females.

Source:The Times Of India

Categories
Ailmemts & Remedies

Typhoid fever

Typhoid fever is an illness caused by the bacterium Salmonella typhi. Common worldwide, it is transmitted by ingestion of food or water contaminated with feces from an infected person. The bacteria then multiply in the blood stream of the infected person and are absorbed into the digestive tract and eliminated with the waste.

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Typhoid fever is also called enteric fever. It happens due to the involvement of the intestines and may become very serious if treatment is not provided to the patient at the right time. Typhoid fever has a tendency to relapse the patient. It is sometimes accompanied by hoarse cough and constipation or diarrhoea. Typhoid fever is mainly transmitted by ingestion of food or contaminated water from an infected person. Typhoid fever is still common in many developing countries like india, where it affects about 21.5 million persons each year.

Who gets typhoid fever?
Anyone can get typhoid fever if they drink water or eat food contaminated with the S. typhi bacteria. Travelers visiting developing countries are at greatest risk for getting typhoid fever. Typhoid fever is still common in the developing world, where it affects about 12.5 million persons each year. Only about 400 cases occur each year in the United States.

Symptoms:
Typhoid fever is usually recognized by the sudden onset of sustained fever.
During typhoid fever you may also suffer from severe headaches.
Nausea is an another symptom for typhoid fever.
Some times Stomach Pain is also accounted.
Sometimes the person also suffers from severe loss of appetite.
Typhoid fever accompanied by insomnia and feverishness, particularly at night.
In the beginning the temperature of the body is slightly high in morning, then it gradually becomes normal in the afternoon and then again rises in the evening. The temperature of sustained fever may go up to as high as 103° to 104° F (39° to 40° C ).
They may also feel weak, or have gastroenteritis, headache, diarrhea and anorexia (loss of appetite). In some cases, patients have a rash of flat, rose-colored spots.

Classically, untreated typhoid fever course is divided in 4 weeks. In the first week, there is a slowly rising temperature with relative bradycardia, malaise, headache and cough. Epistaxis is seen in a quarter of cases and abdominal pain is also possible. There is leukopenia with eosinopenia and relative lymphocytosis, a positive diazo reaction and blood cultures are positive for Salmonella typhi or paratyphi. The classic Widal test is negative in the first week.

In the second week of the infection, the patient lies prostrated with high fever in plateau around 40ºC and bradycardia (Sphygmo-thermic dissociation), classically with a dicrotic pulse wave. Delirium is frequent, frequently calm, but sometimes agitated and this delirium gave to typhoid the nickname of “nervous fever”. Rose spots appear in lower chest and abdomen in around 1/3 patients. There are rhonchi in lung bases. The abdomen is distended and painful in the right lower quadrant where borborygmi can be felt. Diarrhea can occur in this stage: six to eight stools in a day, green with a characteristic smell, comparable to pea-soup. Howewer, constipation is also frequent. The spleen and liver are enlarged and tender and there is elevation of transaminases . The widal reaction is strongly positive with antiO and antiH antibodies. Blood cultures are sometimes still positive in this stage. In the third week of the typhoid fever a number of complications can occur:

Intestinal haemorrhage due to bleeding in the congested Peyer patches; that can be very serious but generally does not lead to death.
Intestinal perforation in distal ileon: this is a very serious complication that is frequently fatal. It may occur without alarming symptoms until septicaemia or diffuse peritonitis sets in.
Toxic myocarditis with collapse
Encephalitis
Metastatic abscesses, cholecystitis, endocarditis and osteitis
The fever is still very high and oscillates very little around the day. Dehydration ensues and the patient is delirious (typhoid state). By the end of third week defervescence commences that prolongs itself in the fourth week.

The ways typhoid fever spreads:

Typhoid fever appears to have affected thousands of human beings from last so many years, but the cause of the illness is a poisonous and interruptive bacterium called Salmonella typhi . Typhoid fever mainly spreads when people eat food or drink water which is already been infected with Salmonella typhi. This bacteria lives only in humans. Persons with typhoid fever carry the bacteria in their bloodstream and intestinal tract. Therefore, typhoid fever is more common in unhygienic areas of the world where hand washing is less frequent and water is likely to be contaminated with germs. It also spreads through direct contact with a person who is already infected with this disease.

A different pathogen, Salmonella paratyphi , causes paratyphoid fever. Although they’re related, these aren’t the same bacteria responsible for salmonellosis, another serious intestinal infection.

After treatment, some people who recover from typhoid fever, even then continue to harbor the bacteria in their intestinal tract or gallbladder, for some years. These people are called chronic carriers, usually shed the bacteria in their feces and are capable of infecting others, although they no longer have signs or symptoms of the disease themselves.

Diagnosis:
The only way to know for sure if an illness is typhoid fever is to have samples of stool or blood tested for the presence of S. Typhi.

Diagnosis is made by blood, bone marrow or stool cultures and with the Widal test (demonstration of salmonella antibodies against antigens O-somatic and H-flagellar). In epidemics and less wealthy countries, after excluding malaria, dysentery or pneumonia, a therapeutic trial with chloramphenicol is generally undertaken while awaiting the results of Widal test and blood cultures.

Treatment:
Typhoid fever in most cases is not fatal. However, in some cases it is. Antibiotics, such as ampicillin, chloramphenicol, trimethoprim-sulfamethoxazole, and ciprofloxacin, have been commonly used to treat typhoid fever in developed countries. Prompt treatment of the disease with antibiotics reduces the case-fatality rate to approximately 1%.

When untreated, typhoid fever persists for three weeks to a month. Death occurs in between 10% and 30% of untreated cases. Vaccines for typhoid fever are available and are advised for persons traveling in regions where the disease is common (especially Asia, Africa and Latin America). Typhim Vi is an intramuscular killed-bacteria vaccination and Vivotif is an oral live bacteria vaccination, both of which protect against typhoid fever. Neither vaccine is 100% effective against typhoid fever and neither protects against unrelated typhus.
Resistance:
Resistance to ampicillin, chloramphenicol, trimethoprim-sulfamethoxazole and streptomycin is now common, and these agents have not been used as first line treatment now for almost 20 years. Typhoid that is resistant to these agents is known as multidrug-resistant typhoid (MDR typhoid).

Ciprofloxacin resistance is an increasing problem, especially in the Indian subcontinent and Southeast Asia. Many centres are therefore moving away from using ciprofloxacin as first line for treating suspected typhoid originating in India, Pakistan, Bangladesh, Thailand or Vietnam. For these patients, the recommended first line treatment is ceftriaxone.

There is a separate problem with laboratory testing for reduced susceptibility to ciprofloxacin: current recommendations are that isolates should be tested simultaneously against ciprofloxacin (CIP) and against nalidixic acid (NAL), and that isolates that are sensitive to both CIP and NAL should be reported as “sensitive to ciprofloxacin”, but that isolates testing sensitive to CIP but not to NAL should be reported as “reduced sensitivity to ciprofloxacin”. However, an analysis of 271 isolates showed that around 18% of isolates with a reduced susceptibility to ciprofloxacin (MIC 0.125–1.0 mg/l) would not be picked up by this method. It not certain how this problem can be solved, because most laboratories around the world (including the West) are dependent disc testing and cannot test for MICs.

Ayurvedic Treatment for Typhoid fever
Given below course you may follow for general treatment of typhoid fever, it depends on subjective or objective symptoms of the patient.

In first week: You may take 125 mg each of Muktashukti Bhasma and Mrigshringa Bhasma, at least three times daily which should be mixed with honey. A decoction of 12 gm of Khub Kalan and 10 gm of dried grapes with one litre of water, boiled down to about one-third, can be given along with the above medicines.

In second week: You may take a dose of Muktashukti Bhasma (10-12mg) & a dose of Kasturibhairava Rasa (120-125mg) with honey thrice daily. You may also take a mixture of Saubhagya Vati (240 mg) and Jwararyabhra (120 mg) three times in a day with juice of fresh ginger.

In third week: Mix 120 mg of Pravala Bhasma and 120 mg of Vasantmalati Ras with atleast 120 mg Amritsattva, to be taken with honey at least two times in a day. After at least three hours of serving the above medication give a dose of 240 mg of Powder of Pippali & also 240 mg of sarvajwaralauha with honey atleast two times in a day.

That is first, second & third, second should be taken alternatively.

In fourth week:You may take a mixture of Navayasa Choorna (Powder) – 2.5 mg & Vasantmalati Ras 125 mg & Sitopladi Choorna – 1.5 gm (Two Doses) to be taken with honey at least two times in a day. After meals, take a liquid compound prepared from- 10ml of Amritarishta & 5ml of Vishmushtayasava with 10ml of Lauhasava (one dose to be taken for each with equal quantity of water after lunch & dinner meals).

If whole body is massaged with oil, preferably Mahalakhshadi Tail daily, it will provide much desired relief to the patient and also help in quicker recovery. Some people suggest massage with olive oil or Johnson’s Body oil but, then, it is simply a matter of individual response and suitability, availability and choice.

Preventions:
Now vaccines for typhoid fever are also available, but these vaccines are not effective so much and are just partially effective and are usually reserved for people who may be exposed to the disease or are traveling to areas where typhoid fever is endemic. No vaccine has been discovered till date for paratyphoid fever.

It is always adviced to follow the Tips (Specially in Typhoid prune area)

Avoid foods and drinks that you may think may be contaminated. Also avoid eating things that have been kept in the open for long time.

Most important thing – Get vaccinated against typhoid fever.

Use careful selection of food and drink while you are in a developing country. This will also help protect you from other illnesses such as cholera, dysentery and hepatitis A.
Only use clean water. Buy it bottled or make sure it has been brought to a rolling boil for at least one minute before you drink it. Bottled carbonated water is safer than uncarbonated water.
Ask for drinks without ice unless the ice is made from bottled or boiled water.
Only eat foods that have been thoroughly cooked.
Avoid raw vegetables and fruits that cannot be peeled.
When you eat raw fruits or vegetables that can be peeled, wash your hands with soap, then peel them yourself. Do not eat the peelings.
Avoid foods and beverages from street vendors. Many travelers get sick from food bought from street vendors.
Remember:
Even if your symptoms go away without treatment, you may still be carrying the S. typhi bacteria, and your illness could return and be passed to other people.
If you work at a job where you handle food or care for small children, you should not go back to work until a doctor has determined that you no longer carry any S.typhi bacteria.
Even if you are vaccinated, you should carefully select your food and drink, especially when visiting areas where typhoid fever is common.

Disclaimer: This information is not meant to be a substitute for professional medical advise or help. It is always best to consult with a Physician about serious health concerns. This information is in no way intended to diagnose or prescribe remedies.

Help taken from :Ayurvedic-medicines.com , en.wikipedia.org and http://health.utah.gov/epi/fact_sheets/typhoid.html

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News on Health & Science

Leukemia stem cells to map how disease begins

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In a major breakthrough that could help devise better treatment for blood cancer and aid the development of drugs that would stop the process before it advances, Canadian scientists have for the first time converted normal human blood cells to leukemia stem cells in the lab.

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The team then transplanted the converted cells into lab mice and watched it replicate the entire disease process, from the very moment it begins. Till now, most human leukemia research involved studying a patient’s diseased cells. But because cancer takes months to develop, “just studying the cells at the end of the process does not tell us the series of changes that caused the cells to become leukemic and when they happened. We have now duplicated the natural process of cell death, as it happens. This will help us understand how cancer begins,” Dr John Dick at Ontario Cancer Institute said.

According to Dick, this peek into leukemia’s development will allow scientists to ask questions that include: Is the childhood disease different from that in adults? In which cell type does leukemia arise? And which genes are involved and in which order do they have to operate?

Reacting to the study, former head of Rajiv Gandhi Cancer Institute Dr Y P Bhatia told TOI, “Once the basic cellular structure is known, better treatment solutions can be devised. This is a major breakthrough. Scientists can now see the first cells that will give birth to leukemia and then watch as the disease as it slowly progresses.”

The groundbreaking research involved infecting cells from umbilical cord blood with a virus engineered to carry one of the genes known to cause certain types of leukemia. Dr Dick’s team introduced a specific leukemia gene into normal stem cells and injected the genetically altered cells into mice that lacked immune systems. This resulted in the mices developing leukemia, displaying the same characteristics and patterns of human disease.

He said, “We are studying how leukemia arises in the first place. We found that with the leukemia gene we were using, the disease only arose from immature stem and progenitor cells. The leukemic stem cells that were created seemed to change as the human leukemia was grown for longer times in a series of transplanted mice.”

Source:The Times Of India

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News on Health & Science

High School Can Be a Tough World for your chield

Helping your teen grow into a healthy and responsible adult is a rewarding part of being a parent, but it’s not always an easy job. Kids can be brutal to each other. Helping your child cope and manage feelings he or she encounters during the high school years are difficult and fragile tasks, but they are important. Peer-related stress for your teen can result from being the target of vicious gossip, getting teased or bullied, or knowing that her friends are involved in dangerous things like alcohol, drugs, and other risky behaviors. Stress can also result from not joining the crowd, and fear of rejection. Most teens will encounter some of these scenarios, so it’s vital to give your child the tools she needs to handle her complex peer environment.

Here are some things you can do to help your teen deal with her life:

1. Emotionally connect with your child. Give your child extra attention and consideration. Keeping the lines of communication open and encouraging discussion is key. Be there to listen and share your own experiences from high school.

2.Be alert to signs of stress. These signs may present as anxiety, aggressive behavior, stomachaches/headaches or a desire to stay home from school and other activities.

3.Consult with teachers and staff. If you know your teen is going through a hard time at school or has come into conflict with peers, make sure teachers and other school staff are in the loop.

Feelings don’t need to be “fixed.” Instead, focus on helping your child understand and deal with his/her experiences. If signs of stress don’t seem to be subsiding after a few weeks, consider consulting a mental health professional who has special experience working with youth.

In addition, speak with your teen about not being on the other side of the coin the person doing the teasing or gossiping. Being popular may be a very important goal for your teen, but gaining popularity should not be at the expense of a peer’s feelings or your child’s personal well-being.

Source:ParentingTips@TheAntiDrug.com

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