Tag: Cancer

Categories
Herbs & Plants

Epilobium parviflorum

[amazon_link asins=’B00WOH5NQS,B00T7FGVO8,B00VRYW1NW,B0016BEJF4,B0032JX7U6,B00WOH5UH0′ template=’ProductCarousel’ store=’finmeacur-20′ marketplace=’US’ link_id=’8fd9ecd7-f391-11e6-a9aa-57ba233cc776′]

Botanical Name:Epilobium parviflorum
Family: Onagraceae
Genus: Epilobium
Species: E. parviflorumi
Kingdom: Plantae
Division: Magnoliophyta
Order: Myrtales

Common Names :Smallflower Hairy Willowherb or Willowherb

Habitat :Epilobium parviflorum grows  in most of Europe, including Britain, from Sweden to Northern Africa and Western Asia up to India, in USA and Canada.

Description:
Epilobium parviflorum  is a herbaceous perennial plant.

The biological form of the plant  is hemicryptophyte scapose, as its overwintering buds are situated just below the soil surface and the floral axis is more or less erect with a few leaves….

Click to see the pictures..>…..(01)..….(1)…...(2).…...(3)
Epilobium parviflorum reaches on average 30–80 centimetres (12–31 in) in height. The stem is erect and densely covered with hairs, especially in the lower part. The leaves are opposite, unstalked but not amplexicaul, lanceolate and toothed, rounded at the base, 4–10 centimetres (1.6–3.9 in) long. The tiny flowers are pale pink or pale purple, 6–7 millimetres (0.24–0.28 in) in diameter, with four petals, eight stamens and a 4-lobed stigma. Flowering occurs from June to August.  The hermaphroditic flowers are either self-fertilized (autogamy) or pollinated by insects (entomogamy). Fruit is a three-to seven-centimeter long capsule containing very small black seeeds (about 1 mm long), with white fibres that allow the dispersal by wind. This species is quite similar to Epilobium hirsutum, but the flowers are very smaller

Medicinal Uses:
Extracts of this plant have been used by traditional medicine in disorders of the prostate gland, bladder and kidney, having an antioxidant and antiinflammatory effect . Extracts of Epilobium have been shown to inhibit proliferation of human prostate cells in-vitro by affecting progression of the cell cycle.

Small-flowered willow herb has been used as remedies in folk medicine, particularly in Central Europe, for the treatment of prostate disorders and abnormal growths. This pleasant herb and flower tea was highly recommended by Austrian herbalist, Maria Treben, for ailing men with prostate abnormalities.  Enlarged prostate, prostatitis, kidney or bladder disorders, gastro-intestinal disorders, mouth mucus membrane lesions, rectal bleeding, menstrual disorders, cystitis, Preliminary (in vitro) studies at the Prostate Center of Vancouver found that very low concentrations of an extract from small-flowered willow herb tea, in the micrograms per ml level, was among the most active ever seen against abnormal cells and growths of the prostate. Several extracts from Epilobium parviflorum, were evaluated in biochemical assays with 5-alpha-reductase and aromatase, two enzymes involved in the etiology of benign prostatic hyperplasia (BPH). Aqueous extracts displayed inhibition of these enzymes and the active compounds identified were macrocyclic ellagitannins, oenothein A1, B1 and B2, which can make up to 14% of crude plant extracts. Out of a total of 92 plant phenolic extracts tested, small-flowered willow herb was also found to have high antioxidant activity.  Small-flowered willow herb tea is also recommended for treating urinary tract infections in women. Take as a tea for oral, vaginal, and intestinal candidias.  An ingredient of Swedish bitters.

Disclaimer:The information presented herein is intended for educational purposes only. Individual results may vary, and before using any supplements, it is always advisable to consult with your own health care provider

Resources:
http://en.wikipedia.org/wiki/Epilobium_parviflorum
http://www.herbnet.com/Herb%20Uses_UZ.htm
http://en.wikipedia.org/wiki/File:Epilobium_parviflorum_0.7_R.jpg

Related articles
Enhanced by Zemanta
Categories
Herbs & Plants

Sunflower

[amazon_link asins=’B00SC94N4K,B01GJKDP3I,B00LBWWO1Y,B01JIILDD2,B071NQDJQG,B00MBINC86,B005FTFFYW,B01JO8UZNA,B006WB3J5Y’ template=’ProductCarousel’ store=’finmeacur-20′ marketplace=’US’ link_id=’99627b89-70e1-11e7-84b1-797aecfed5ff’]

Botanical Name ; Helianthus annuus
Family: Asteraceae
Subfamily: Helianthoideae
Tribe: Heliantheae
Genus: Helianthus
Species: annuus
Kingdom: Plantae
Division: Angiospermae
Subdivision: Eudicots
Class: Asterids
Order: Asterales

Common Name : Sunflower,Common Sunflower

Habitat :Sunflower is native to the Americas that possesses a large inflorescence (flowering head). It grows in open dry or moderately moist soils on the plains.

Dscription:

Helianthus annuus is a annual flowering plant growing to 3 m (9ft) by 0.3 m (1ft in) at a fast rate.
It is not frost tender. It is in flower from Jul to September, and the seeds ripen from Sep to October. The flowers are hermaphrodite (have both male and female organs) and are pollinated by Bees, flies.The plant is not self-fertile.It is noted for attracting wildlife.
The sunflower got its name from its huge, fiery blooms, whose shape and image is often used to depict the sun. The sunflower has a rough, hairy stem, broad, coarsely toothed, rough leaves and circular heads of flowers. The heads consist of 1,000-2,000 individual flowers joined together by a receptacle base.

click to see the pictures…>....(01)..…...(1).…...(2).…....(3).….(4).…...(5)..

What is usually called the “flower” on a mature sunflower is actually a “flower head” (also known as a “composite flower“) of numerous florets, (small flowers) crowded together. The outer petal-bearing florets are the sterile ray florets and can be yellow, red, orange, or other colors. The florets inside the circular head are called disc florets, which mature into seeds.

The flower petals within the sunflower’s cluster are usually in a a spiral pattern. Generally, each floret is oriented toward the next by approximately the golden angle, 137.5°, producing a pattern of interconnecting spirals, where the number of left spirals and the number of right spirals are successive Fibonacci numbers. Typically, there are 34 spirals in one direction and 55 in the other; on a very large sunflower there could be 89 in one direction and 144 in the other. This pattern produces the most efficient packing of seeds within the flower head.

Cultivation:
To grow best, sunflowers need full sun. They grow best in fertile, moist, well-drained soil with heavy mulch. In commercial planting, seeds are planted 45 cm (1.5 ft) apart and 2.5 cm (1 in) deep. Sunflower “whole seed” (fruit) are sold as a snack food, raw or after roasting in ovens, with or without salt and/or seasonings added. Sunflowers can be processed into a peanut butter alternative, sunflower butter. In Germany, it is mixed with rye flour to make Sonnenblumenkernbrot (literally: sunflower whole seed bread), which is quite popular in German-speaking Europe. It is also sold as food for birds and can be used directly in cooking and salads. American Indians had multiple uses for sunflowers in the past,such as in bread, medical ointments, dyes and body paints

Propagation :
Seed – sow in mid spring in situ. An earlier start can be made by sowing 2 – 3 seeds per pot in a greenhouse in early spring. Use a fairly rich compost. Thin to the strongest seedling, give them an occasional liquid feed to make sure they do not become nutrient deficient and plant them out in late spring or early summer. Seed, harvested at 12% moisture content and stored, will retain its viability for several years
Edible Uses:
Edible Parts: Flowers; Oil; Seed; Stem.
Edible Uses: Coffee; Oil.

Seed – raw or cooked. A delicious nut-like flavour, but very fiddly to extract due to the small size of the seed. Commercially there are machines designed to do this. Rich in fats, the seed can be ground into a powder, made into sunflower butter or used to make seed yoghurt. When mixed with cereal flours, it makes a nutritious bread. Cultivars with up to 50% oil have been developed in Russia. The oil contains between 44 – 72% linoleic acid. The germinated seed is said to be best for seed yoghurt, it is blended with water and left to ferment. The sprouted seed can be eaten raw. A nutritional analysis of the seed is available. Young flower buds – steamed and served like globe artichokes. A mild and pleasant enough flavour, but rather fiddly. Average yields range from 900 – 1,575 kg/ha of seed, however yields of over 3,375 kg/ha have been reported. A high quality edible semi-drying oil is obtained from the seed. It is low in cholesterol, and is said to be equal in quality to olive oil. Used in salads, margarines, or in cooking. The roasted seed is a coffee and drinking chocolate substitute. Another report says the roasted hulls are used. The leaf petioles are boiled and mixed in with other foodstuffs……CLICK & SEE THE PICTURES

Composition:
Figures in grams (g) or miligrams (mg) per 100g of food.
Seed (Fresh weight)

* 560 Calories per 100g
* Water : 4.8%
* Protein: 24g; Fat: 47.3g; Carbohydrate: 19.4g; Fibre: 3.8g; Ash: 4g;
* Minerals – Calcium: 120mg; Phosphorus: 837mg; Iron: 7.1mg; Magnesium: 0mg; Sodium: 30mg; Potassium: 920mg; Zinc: 0mg;
*Vitamins – A: 30mg; Thiamine (B1): 1.96mg; Riboflavin (B2): 0.23mg; Niacin: 5.4mg; B6: 0mg; C: 0mg;

Medicinal Uses:    A tea made from the leaves is astringent, diuretic and expectorant, it is used in the treatment of high fevers. The crushed leaves are used as a poultice on sores, swellings, snakebites and spider bites. The leaves are harvested as the plant comes into flower and are dried for later use. A tea made from the flowers is used in the treatment of malaria and lung ailments. The flowering head and seeds are febrifuge, nutritive and stomachic. The seed is also considered to be diuretic and expectorant. It has been used with success in the treatment of many pulmonary complaints. A decoction of the roots has been used as a warm wash on rheumatic aches and pains.

Russian folk healers chop the head of a sunflower, soak the pieces in vodka and soap chips in a sunny place for nine days, and then rub the mixture on the joints of rheumatic patients as a potent liniment.  In medical clinics, Russian doctors prepare decoctions of the seeds for jaundice, malaria, heart conditions, diarrhea, and other ailments.  The seeds, browned in the oven, and made into an infusion, make a widely used remedy for whooping cough.

Other Uses:
Sunflower oil, extracted from the seeds, is used for cooking, as a carrier oil and to produce margarine and biodiesel, as it is cheaper than olive oil. A range of sunflower varieties exist with differing fatty acid compositions; some ‘high oleic’ types contain a higher level of monounsaturated fats in their oil than even olive oil.

The cake remaining after the seeds have been processed for oil is used as a livestock feed. Some recently developed cultivars have drooping heads. These cultivars are less attractive to gardeners growing the flowers as ornamental plants, but appeal to farmers, because they reduce bird damage and losses from some plant diseases. Sunflowers also produce latex, and are the subject of experiments to improve their suitability as an alternative crop for producing hypoallergenic rubber.

Traditionally, several Native American groups planted sunflowers on the north edges of their gardens as a “fourth sister” to the better known three sisters combination of corn, beans, and squash. Annual species are often planted for their allelopathic properties.[citation needed]

However, for commercial farmers growing commodity crops, the sunflower, like any other unwanted plant, is often considered a weed. Especially in the midwestern US, wild (perennial) species are often found in corn and soybean fields and can have a negative impact on yields.

Sunflowers can be used to extract toxic ingredients from soil, such as lead, arsenic and uranium. They were used to remove cesium-137 and strontium-90 from a nearby pond after the Chernobyl disaster, and a similar campaign was mounted in response to the Fukushima Daiichi nuclear disaster.

Known Hazards : The growing plant can accumulate nitrates, especially when fed on artificial fertilizers. The pollen or plant extracts may cause allergic reactions

Disclaimer:The information presented herein is intended for educational purposes only. Individual results may vary, and before using any supplements, it is always advisable to consult with your own health care provider

Resources:
http://en.wikipedia.org/wiki/Sunflower
http://www.herbnet.com/Herb%20Uses_RST.htm
http://www.pfaf.org/user/Plant.aspx?LatinName=Helianthus+annuus

Related articles
Categories
Herbs & Plants

Rhododendron aureum

[amazon_link asins=’B01N94CIZI,B004YR3QPG,B01MQVD7T2,B06Y649DPK,B01JYGE6E6,B00T8979T4,B012QJCXUW,B01NBLAZFF’ template=’ProductCarousel’ store=’finmeacur-20′ marketplace=’US’ link_id=’7a957716-315b-11e7-8372-fd5ff3abecac’][amazon_link asins=’7208128219,B01I2O2MKQ,B013GCAVMU,B013D6AB4C,B013GC15XO,B013GC3G5E’ template=’ProductCarousel’ store=’finmeacur-20′ marketplace=’US’ link_id=’fbab13c6-315a-11e7-b5ee-7f7d5677585a’]

 

Botanical Name : Rhododendron aureum
Family: Ericaceae
Subfamily: Ericoideae
Tribe: Rhodoreae
Genus: Rhododendron
Kingdom: Plantae
Order: Ericales

Synonyms : R. chrysanthum. Pall.

Common Mane :Rosebay, Yellow-flowered rhododendron,Snow rose.

Habitat :
Rhododendron aureum is native to E. Asia – China, Japan, Korea. It grows on the thickets in high mountain areas, both alpine and sub-alpine. Grasslands or liverwort-mosses strata in the alpine region at elevations of 1000 – 2500 metres.

Description:
It is a small evergreen  compact or prostrate shrub.This is a small bush, with the stem from 1 to 1 1/2 feet high, spreading, very much branched, often almost hidden among moss, from which the tips only of its shoots are protruded. The leaves are alternate, of the texture of a laurel leaf, ovate, somewhat acute, tapering into the stalk, reticulated and very rough above, and paler and smoother underneath. The flowers are large, showy, nodding, and borne on clustered, terminal, loose peduncles, emerging from among large downy scales. Corolla campanulate, 5-cleft, with rounded segments, of which the three upper are rather the largest, and streaked with livid dots next the tube, the lower unspotted. Stamens 10, unequal, and deflexed; the anthers oblong, incumbent, and without appendages, opening by two terminal pores. Capsule ovate, rather angular, 5-celled, 5-valved, and septicidal; seeds numerous and minute (L.). It is in leaf 12-Jan It is in flower in May, and the seeds ripen from Jul to August. The flowers are hermaphrodite (have both male and female organs) and are pollinated by Insects.

CLICK & SEE THE PICTURES

Cultivation:
Succeeds in a most humus-rich lime-free soils except those of a dry arid nature or those that are heavy or claye. Prefers a peaty or well-drained sandy loam. Succeeds in sun or shade, the warmer the climate the more shade a plant requires. A pH between 4.5 and 5.5 is ideal. Succeeds in a woodland though, because of its surface-rooting habit[200], it does not compete well with surface-rooting trees. Plants need to be kept well weeded, they dislike other plants growing over or into their root system, in particular they grow badly with ground cover plants, herbaceous plants and heathers. Plants form a root ball and are very tolerant of being transplanted, even when quite large, so long as the root ball is kept intact. Closely related to R. caucasicum. This species is very rare and difficult to cultivate. Plants in this genus are notably susceptible to honey fungus.
Propagation:
Seed – best sown in a greenhouse as soon as it is ripe in the autumn and given artificial light. Alternatively sow the seed in a lightly shaded part of the warm greenhouse in late winter or in a cold greenhouse in April. Surface-sow the seed and do not allow the compost to become dry. Pot up the seedlings when they are large enough to handle and grow on in a greenhouse for at least the first winter. Layering in late July. Takes 15 – 24 months. Cuttings of half-ripe wood, August in a frame. Difficult.

Medicinal Uses:
It has been much used in folk medicine in Siberia for the treatment of rheumatism, gout, and urinary tract infections.  It has been used in homeopathic medicine in the treatment of urinary calculi and inflammation of the prostate gland. Caution should be exercised when using the flowers because they are toxic. Hemostatic, they are used in the treatment of spreading pus and blood in the thoracic region, especially the lungs.  Much used in Siberia as a remedy for rheumatism. Also useful in gout and syphilis.  The flowers are used in Tibetan medicine, they are said to have a bitter taste and a neutral potency. Caution should be exercised when using the flowers because they are toxic. Hemostatic, they are used in the treatment of spreading pus and blood in the thoracic region, especially the lungs.

Known Hazards:  Although no specific mention of toxicity has been seen for this species, it belongs to a genus where many members have poisonous leaves. The pollen of many if not all species of rhododendrons is also probably toxic, being said to cause intoxication when eaten in large quantities.

Disclaimer:
The information presented herein is intended for educational purposes only. Individual results may vary, and before using any supplements, it is always advisable to consult with your own health care provider.

Resources:
http://www.rosebay.org/chapterweb/specaur.htm
http://commons.wikimedia.org/wiki/File:Rhododendron_aureum_Georgi.jpg
http://www.henriettesherbal.com/eclectic/kings/rhododendron.html
http://commons.wikimedia.org/wiki/Rhododendron_aureum
http://www.herbnet.com/Herb%20Uses_RST.htm?Voucher2=Connect+to+Internet

Related articles
Categories
Herbs & Plants

Coix lacryma-jobi

[amazon_link asins=’B016NGWIEK,B01HKLVN6Q,B00FK1NRZY,B073Z1KQKV,B01A2UKRSM,B004ZRG2V0′ template=’ProductCarousel’ store=’finmeacur-20′ marketplace=’US’ link_id=’2faa5b31-d590-11e7-82b3-b98d9bd24983′]

Botanical name: Coix lacryma-jobi
Family: Gramineae, grass family
Genus :    Coix L. – Job’s tears
Species :Coix lacryma-jobi L. – Job’s tears
Kingdom :Plantae – Plants
Subkingdom :Tracheobionta – Vascular plants
Superdivision: Spermatophyta – Seed plants
Division: Magnoliophyta – Flowering plants
Class : Liliopsida – Monocotyledons
Subclass: Commelinidae
Order : Cyperales

Common name: Coix, Job’s tears
Habitat :
Coix lacryma-jobi is  perhaps native  to southeast Asia, but now rather pantropical as cultigen and weed. Listed as a serious weed in Polynesia, a principle weed in Italy and Korea, a common weed in Hawaii, Iran, Japan, Micronesia, and Puerto Rico, also in Australia, Borneo, Burma, Cambodia, China, Congo, Colombia, Costa Rica, Dominican Republic, Fiji, Ghana, Guatemala, Honduras, Hong Kong, India, Iraq, Melanesia, Nepal, Pakistan, Peru, Philippines, Rhodesia, Senegal, South Africa, Sudan, Thailand, United States, and Venezuela (Holm et al, 1979).

Description
Coix lacryma-jobi is an Annual (in the temperate zone) but perennial plant where frost is absent or mild, freely branching upright or ascending herb 1-2 m tall, the cordate clasping leaf blades 20-50 cm long, 1-5 cm broad. Spikelets terminal, and in the upper axils, unisexual, staminate spikelets two-flowered, in twos or threes on the continuous rachis; pistillate spikelets three together, one fertile, and two sterile; glumes of the fertile spikelet several-nerved, all enclosed finally in a bony beadlike involucre, the grain, white to bluish white, or black, globular orvoid, 6-12 mm long.

Coix lacryma-jobi L.
Coix lacryma-jobi L. (Photo credit: adaduitokla)

You may click to see the picture

Propagation & Cultivation:
Propagation by seeds, sown during monsoon (in India) at rate of 6-10 kg/ha. Seed dibbled 2.5 cm deep, at spacing of 60 x 60 cm. One intercultivation, before the plants tiller, and shade on ground may be necessary. Sufficient rains in early stage of growth and a dry period when grain is setting are necessary for good yields. Plants respond well to liberal applications of organic manure.

Chemical constituents:
Per 100 g, the seed is reported to contain 380 calories, 11.2 g H2O, 15.4 g protein, 6.2 g fat, 65.3 g total carbohydrate, 0.8 g fiber, 1.9 g ash, 25 mg Ca, 435 mg P, 5.0 mg Fe, 0 ug beta-carotene equivalent, 0.28 mg thiamine, 0.19 mg riboflavin, 4.3 mg niacin, and 0 mg ascorbic acid. According to Hager’s Handbook (List and Horhammer, 1969-1979), there is 50-60% starch 18.7% protein (with glutamic-acid, leucine, tyrosine, arginine, histidine, and lysine) and 5-10% fatty oil with glycerides of myristic- and palmitic-acids.

Uses
Weed to some, necklace to others, staff-of-life to others, job’s tear is a very useful and productive grass increasingly viewed as a potential energy source. Before Zea became popular in South Asia, Coix was rather widely cultivated as a cereal in India. Still taken as a minor cereal, it is pounded, threshed and winnowed, as a cereal or breadstuff. The pounded flour is sometimes mixed with water like barley for barley water. The pounded kernel is also made into a sweet dish by frying and coating with sugar. It is also husked and eaten out of hand like a peanut. Beers and wines are made from the fermented grain. Chinese use the grain, like barley, in soups and broths.

Medicinal Uses:
Folk Medicine
According to Hartwell (1967-1971), the fruits are used in folk remedies for abdominal tumors, esophageal, gastrointestinal, and lung cancers, various tumors, as well as excrescences, warts, and whitlows. This folk reputation is all the more interesting when reading that coixenolide has antitumor activity (List and Horhammer, 1969-1979). Job’s tear is also a folk remedy for abscess, anodyne, anthrax, appendicitis, arthritis, beriberi, bronchitis, catarrh, diabetes, dysentery, dysuria, edema, fever, gotter, halitosis, headache, hydrothorax, metroxenia, phthisis, pleurisy, pneumonia, puerperium, rheumatism, small-pox, splenitis, strangury, tenesmus, and worms (Duke and Wain, 1981). Walker (1971) cites other medicinal uses.

In Chinese medicine, the seeds strengthen the spleen and counteract “damp heat”, and are used for edema, diarrhea, rheumatoid arthritis and difficult urination.  Drains dampness, clears heat, eliminates pus, tonifies the spleen. This herb is added to medicinal formulas to regulate fluid retention and counteract inflammation. It is very good for all conditions and diseases associated with edema and inflammation, including pus, diarrhea, phlegm, edema or abscesses of either the lungs or the intestines, and rheumatic and arthritic conditions. A tea from the boiled seeds is drunk as part of a treatment to cure warts. It is also used in the treatment of lung abscess, lobar pneumonia, appendicitis, rheumatoid arthritis, beriberi, diarrhea, oedema and difficult urination.  The roots have been used in the treatment of menstrual disorders. The FDA has approved testing for cancer therapy. Currently going through testing, the Kanglaite Injection is a new effective diphasic anti-cancer medicine prepared by extracting with modern technology the active anti-cancer component from the Coix Seed, to form an advanced dosage form for intravenous and intra- arterial perfusion. It had been proved experimentally and clinically that the Kanglaite Injection had a broad spectrum of anti-tumor and anti-metastasis action, such as hepatic cancer and pulmonary cancer, along with the action of enhancing host immunity. When used in combined treatment with chemotherapy or radiotherapy, the Kanglaite Injection can increase the sensitivity of tumor cells, reduce the toxicity of chemotherapy and radiotherapy, relieve cancerous pain, improve cachexia, and raise the quality of life in advanced cancer victims. As a fat emulsion, the Kanglaite Injection can provide patients with high-energy nutrients with little toxicity.  It inhibits formation of new blood vessels that promote tumor growth, counteracts weight loss due to cancer.

Some of the latest research also shows that Job’s tears is immunostimulating, induces interferon, Bronchodialates; Lowers blood sugar; Reduces muscle spasms and is anti-convulsant; Stimulates respiration in small doses and inhibits it in higher doses; reduces arterial plaque; Anti-inflammatory, possibly through the suppression of macrophage activity

Disclaimer:
The information presented herein is intended for educational purposes only. Individual results may vary, and before using any supplements, it is always advisable to consult with your own health care provider.

Resources:
http://www.hort.purdue.edu/newcrop/duke_energy/Coix_lacryma-jobi.html
http://www.jadeinstitute.com/herbal-detail-page.php?show=25&order=common_name
http://www.robsplants.com/plants/CoixLacry
http://www.herbnet.com/Herb%20Uses_IJK.htm

Related articles

 

Categories
Ailmemts & Remedies

Retinoblastoma

Definition:
Retinoblastoma is an eye cancer that begins in the retina — the sensitive lining on the inside of your eye. Retinoblastoma most commonly affects young children, but can rarely occur in adults.
CLICK & SEE THE PICTURES

Our retina is made up of nerve tissue that senses light as it comes through the front of your eye. The retina sends signals through your optic nerve to your brain, where these signals are interpreted as images.

A rare form of eye cancer, retinoblastoma is the most common form of cancer affecting the eye in children. Retinoblastoma may occur in one or both eyes.

In the developed world, Rb has one of the best cure rates of all childhood cancers (95-98%), with more than nine out of every ten sufferers surviving into adulthood.

Retinoblastoma is rare and affects approximately 1 in 15,000 live births. In the UK, around 40 to 50 new cases are diagnosed each year.

Most children are diagnosed before the age of five years old. In the UK, bilateral cases usually present within the first year with the average age at diagnosis being 9 months. Diagnosis of unilateral cases peaks between 24 and 30 months.

Classification:
There are two forms of the disease; a heritable form and non-heritable form (all cancers are considered genetic in that mutations of the genome are required for their development, but this does not imply that they are heritable, or transmitted to offspring). Approximately 55% of children with Rb have the non-heritable form. If there is no history of the disease within the family, the disease is labeled “sporadic”, but this does not necessarily indicate that it is the non-heritable form.

In about two thirds of cases,  only one eye is affected (unilateral retinoblastoma); in the other third, tumours develop in both eyes (bilateral retinoblastoma). The number and size of tumours on each eye may vary. In certain cases, the pineal gland is also affected (trilateral retinoblastoma). The position, size and quantity of tumours are considered when choosing the type of treatment for the disease.

Symptoms:
The most common and obvious sign of retinoblastoma is an abnormal appearance of the pupil, leukocoria. Other less common and less specific signs and symptoms are: deterioration of vision, a red and irritated eye, faltering growth or delayed development. Some children with retinoblastoma can develop a squint, commonly referred to as “cross-eyed” or “wall-eyed” (strabismus). Retinoblastoma presents with advanced disease in developing countries and eye enlargement is a common finding.

Depending on the position of the tumors, they may be visible during a simple eye exam using an ophthalmoscope to look through the pupil. A positive diagnosis is usually made only with an examination under anesthetic (EUA). A white eye reflection is not always a positive indication of retinoblastoma and can be caused by light being reflected badly or by other conditions such as Coats’s Disease.

In a photograph, the photographic fault red eye may be a sign of retinoblastoma, if in the photograph it is in one eye and not in the other eye. A more clear sign is “white eye” or “cat’s eye”.

The child’s vision may also start to deteriorate and the eye may become  inflamed and sometimes painful.

In two-thirds of cases the cancer is unilateral (affecting one eye). In the rest it’s bilateral.

In 95 per cent of children, the tumour develops before the age of five. Occasionally, babies are born with a retinoblastoma. There’s an increased risk of developing other tumours later in life.

Causes:
Cause of retinoblastomaIn children with the heritable genetic form of retinoblastoma there is a mutation on chromosome 13, called the RB1 gene.The genetic codes found in chromosomes control the way in which cells grow and develop within the body.  If a portion of the code is missing or altered (mutation) a cancer may develop.

The defective RB1 gene can be inherited from either parent; in some children, however, the mutation occurs in the early stages of fetal development. It is unknown what causes the gene abnormality; it is most likely to be a random mistake during the copy process which occurs when a cell divides.

Inherited forms of retinoblastomas are more likely to be bilateral; in addition, they may be associated with pinealoblastoma (also known as trilateral retinoblastoma) with a dismal outcome. The genetic codes found in chromosomes control the way in which cells grow and develop within the body.

Several methods have been developed to detect the RB1 gene mutations.  Attempts to correlate gene mutations to the stage at presentation have not shown convincing evidence of a correlation

Complications:
Recurrent retinoblastoma
Children treated for retinoblastoma have a risk of cancer returning in and around the treated eye. For this reason, your child’s doctor will schedule follow-up exams to check for recurrent retinoblastoma. The doctor may design a personalized follow-up exam schedule for your child. In most cases, this will likely involve eye exams every few months for the first few years after retinoblastoma treatment ends.

Additionally, children with the inherited form of retinoblastoma have an increased risk of developing other types of cancers in any part of the body in the years after treatment. For this reason, children with inherited retinoblastoma require long-term follow-up with a cancer doctor (oncologist).

Diagnosis:
Tests and procedures used to diagnose retinoblastoma include:

*Eye exam. A doctor who specializes in diagnosing and treating diseases of the eye (ophthalmologist) will likely conduct an eye exam to determine what’s causing your child’s signs and symptoms. For a more thorough exam, the doctor may recommend using anesthetics to keep your child still.

*Imaging tests. Scans and other imaging tests can help your child’s doctor determine whether retinoblastoma has grown to affect other structures around the eye. Imaging tests may include ultrasound, computerized tomography (CT) and magnetic resonance imaging (MRI), among others.

*Consulting with other doctors. Your child’s doctor may refer you to other specialists, such as a doctor who specializes in treating cancer (oncologist), a genetic counselor or a surgeon.

Treatment:
Treatment of retinoblastoma varies from country to country.  The first priority is to preserve the life of the child, then to preserve the vision and thirdly to minimize any complications or side effects of the treatment. The exact course of treatment will depend on the individual case and will be decided by the ophthalmologist in discussion with the paediatric oncologist.

Many treatment options exist, including chemotherapy (administered locally via a thin catheter threaded through the groin, through the aorta and the neck, into the optic vessels), cryotherapy, radioactive plaques, laser therapy, external beam radiotherapy and surgical removal of the eyeball.  Any combinations of these treatments may be adopted.

In recent years, there has been an effort to find alternatives to enucleation and radiation therapy.

Prognosis;
Treatment for retinoblastoma has one of the highest success rates of all childhood cancers – nine out of ten children can be cured.

Prevention:
In most cases, doctors aren’t sure what causes retinoblastoma, so there’s no proven way to prevent the disease.

Prevention for families with inherited retinoblastoma
In families with the inherited form of retinoblastoma, preventing retinoblastoma may not be possible. However, genetic testing enables families to know which children have an increased risk of retinoblastoma, so eye exams can begin at an early age. That way, retinoblastoma may be diagnosed very early — when the tumor is small and a chance for a cure and preservation of vision is still possible.

If your doctor determines that your child’s retinoblastoma was caused by an inherited genetic mutation, your family may be referred to a genetic counselor.

Genetic testing can be used to determine whether:

*Your child with retinoblastoma is at risk of other related cancers
*Your other children are at risk of retinoblastoma and other related cancers, so they can start eye exams at an early age
*You and your partner have the possibility of passing the genetic mutation on to future children

The genetic counselor can discuss the risks and benefits of genetic testing and help you decide whether you, your partner or your other children will be tested for the genetic mutation.

Disclaimer: This information is not meant to be a substitute for professional medical advise or help. It is always best to consult with a Physician about serious health concerns. This information is in no way intended to diagnose or prescribe remedies.This is purely for educational purpose.

Resources:
http://www.bbc.co.uk/health/physical_health/conditions/in_depth/cancer/retinoblastoma1.shtml
http://en.wikipedia.org/wiki/Retinoblastoma
http://www.mayoclinic.com/health/retinoblastoma/DS00786
http://trialx.com/curebyte/2011/06/02/retinoblastoma-photos-and-a-listing-of-clinical-trials/

Related articles
Enhanced by Zemanta
css.php