Tag Archives: Indian Institute of Science

The Science of Yoga

Scientific evidence proves the benefits of yogic postures, especially surya namaskar.
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The “S.N.” in his name does not stand for “surya namaskar”. But it may not be inappropriate for S.N. Omkar, an aerospace researcher at the Bangalore-based Indian Institute of Science (IISc), to have the term as his second name, considering his contribution to the art of yoga, particularly surya namaskar or sun salutation.

Omkar — who is also the yoga coach of the Indian cricket team — recently demonstrated why surya namaskar is one of the best forms of exercise for the human body. And that’s a claim he supports with his own scientific studies.

According to a study by him that appeared last week in the Journal of Bodywork and Movement Therapies, regularly practising surya namaskar aids in bone formation (osteogenesis) and bone remodelling. The paper is co-authored by Meenakshi Mour and Debarun Das, research students at the National Institute of Technology, Durgapur.

Independent experts agree that performing surya namasakar every day greatly benefits mental and physical well being. But to say that it helps in osteogenesis is slightly far-fetched, they argue.

To prove his point, Omkar developed a mathematical model to tabulate the forces acting on the various joints in the body — such as the wrists, elbows, shoulders, hip, knees and ankles — during the 10 different postures the exercise involves. According to him, no major joint is overstressed during any of the sequences. At the same time, the activity burns calories at rates comparable to those of many rigorous aerobic exercises. For instance, quoting his own earlier work, the IISc scientist says that if a person weighing 70kg does the exercise 120 times at a stretch — and this can be done in around 55 minutes — he or she could burn up to 380 kilo calories, which is almost equal to the energy expenditure in one hour of brisk walking.

A product of the B.K.S. Iyengar School of Yoga in Pune, Omkar was always interested in unravelling the science behind different yoga postures. An opportunity beckoned to him when recently the Indian Space Research Organisation (Isro) approached him for a project. The space agency — which is contemplating an indigenous man mission to space in the near future — wanted Omkar, an aerospace expert, to probe aspects of the balance and stability required by an astronaut to combat space motion sickness, a condition produced by the absence of a gravitational field and subsequent confusion of the human vestibular (balance) system. “The project is in its nascent stage,” says Omkar, refusing to elaborate further.

As a first step, the IISc researcher wanted to derive a mathematical model of the forces and moments acting on the various joints in the body. “The model is based on simple mechanics. It will help detect the forces and moments experienced by major joints during the practice of surya namaskar. Through this one can compare the joint forces and moments during various yoga activities,” Omkar told KnowHow.

The joints are subjected to dynamic strains and moments as the body executes the various postures, explains Omkar. Earlier studies by bone specialists have shown that persistent low-amplitude but high-frequency mechanical strain on the bones can hasten the rate of bone formation, he adds.

Experts such as Venkatesh Balasubramanian — an associate professor of biomechanics at the Indian Institute of Technology (IIT), Madras — have lauded the effort to scientifically validate the ancient practice of yoga. “But the calculations are too simplistic to be accurate,” Balasubramanian told KnowHow from Melbourne in Australia, where he is on a sabbatical.

According to Balasubramanian, Omkar’s study largely ignores the forces exerted by most of the muscles and ligaments involved in the exercise. “Overall, it is a good attempt to scientifically explain surya namaskar. A more rigorous study would be a step forward in this direction,” he says. Balasubramanian is also not very sure of the calorie-burning rate the IISc researchers have cited.

Melany Westwell of the Connecticut Children’s Medical Center in the US, who has studied yoga postures, too thinks there is a flaw in the biomechanical model used in the study. But she agrees that since the postures require the use of large muscle groups — which are core muscles — and a large range of motion, a lot of calories are burnt. “As long as you have muscle contraction, you have to be burning calories,” she says.

Omkar, however, argues that the calorie counting was done using a Polar watch, which is commonly used by sportspersons all over the world. “They are quite dependable,” he asserts.

Whatever be the research methodology, one thing seems clear: understanding the scientific basis of yoga asanas and pranayamas will enable their use in therapy in a more effective manner.

List of asanas

Source: The Telegraph (Kolkata, India)

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Indian Redwood Cure for Cancer

Scientists in Bangalore have discovered that an extract from Indian redwood kills cancer cells. :-

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A substance found in the roots of Indian redwood (commonly known as Rohan), or soymida febrifuga, may help treat severe forms of blood and bone marrow cancers, researchers at the Indian Institute of Science (IISc), Bangalore, have found.

 

IISc biochemists, led by Sathees Raghavan, discovered that the compound — methyl angolensate — found in the roots of the Indian redwood tree (which grows in most parts of the country) was very effective in killing blood and bone marrow cancer cells in a lab experiment.

Cancers like leukaemia and lymphoma, triggered by chromosomal aberrations, are life threatening and very difficult to treat unless diagnosed very early. Moreover, the drugs that are currently in use against these tumours are toxic, and don’t spare normal cells.

The plant extract was found to be very effective and had no side effects, the IISc scientists reported recently, online, in the journal FEBS Letters.

This was first study to explore the anti-cancer properties of the compound. Used in many ayurvedic preparations, the extract is known to be effective against malaria, ulcer and inflammation of different body organs.

According to Raghavan, the study is one of the most sophisticated ones to be conducted, as the researchers have been able to pinpoint the exact mechanisms by which it seeks to kill the tumour cells.

Typically, any drug used for treating cancers does this, either by checking the runaway proliferation of cancer cells, thus helping the body’s immunity effectively counter the problem, or making tumour cells commit suicide, a process called apoptosis.

“We were surprised that methyl angolensate does both,” Raghavan told KnowHow. While they haven’t studied the inhibition of tumour cell proliferation yet, they have worked out in detail the cellular mechanisms that the compound employs to induce the suicide of the cancerous cells.

Raghavan said it was too early to talk about the effectiveness of the compound in humans. They have to conduct a number of tests to confirm the safety and effectiveness. The IISc scientists have proceeded in this direction by launching animal studies using mice.

Sources: The Telegraph (Kolkata, India)

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Turmeric Or Indian Haldi to take the sting out of malaria

They are known to have anti-oxidant, anti-infectious and anti-inflammatory properties.

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Now, curcumin, the active ingredient of turmeric (haldi)  that has proved effective in lowering cholesterol, glucose and combating cancer   will join in India‘s fight against malaria.

Top scientists from the Indian Institute of Science, Bangalore, and National Institute of Malarial Research, Delhi, are embarking on human trials to see the effectiveness of a combination therapy that uses curcumin with artemisinin derivative artesunate, the most potent compound against malaria.

Studies on mice have shown this new combination therapy to be highly effective. The Rs 1 crore human phase II trials, being funded by the Department of Biotechnology, will take place in four centres — IIS, Institute of Life Sciences, Bhubaneswar, NIMR and ISPAT General Hospital, Rourkela.

A team of scientists is meeting in Rourkela on December 23 to finalise the size, duration and protocols of the study. The trial is expected to begin next month.

According to an IIS study, the combination will prove superior from several perspectives. Both are from natural sources and no resistance is known to curcumin.

Artemisinin runs the risk of resistance development when used widely as monotherapy while curcumin can be tolerated at very high doses, as much as 8 g/day. This will decrease the dose of artemisinin and lower the cost of therapy.

Each year, between 300 and 500 million people become infected with malaria in Africa and Asia.

Source:The Times Of India