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Insect Brains ‘are Source of Antibiotics’ to Fight MRSA

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Cockroaches, far from being a health hazard, could be a rich source of antibiotics.

A study of locust and cockroach brains has found a number of chemicals which can kill bugs like MRSA.

Scientists hope these could become a powerful new weapon to boost the dwindling arsenal of antibiotics used to treat severe bacterial infections.

The research was announced at a meeting of the Society for General Microbiology.

The researchers discovered nine different chemicals in the brains of locusts and cockroaches, which all had anti microbrial properties strong enough to kill 90% of MRSA (Methicillin-resistant Staphylococcus aureus) while not harming human cells.

Cockroaches have a reputation for tenacity and for thriving in dirty environments.

Simon Lee from Nottingham University is the author of the study. He said that it is this capacity to live in dirty, infectious conditions that mean insect brains contain these kinds of compounds.

“They must have some sort of defense against micro organisms. We think their nervous system needs to be continuously protected because if the nervous system goes down the insect dies. But they can suffer damage to their peripheral structures without dying,” he told BB News.

He hopes the compounds could go on to be used to treat multi drug resistant infections like E. Coli and MRSA which are becoming increasingly difficult to treat using some of the most powerful antibiotics available to medicine.

“A kill rate of 90% is very very high, and I diluted the substance down so there was only a minute amount there. Conventional antbiotics reduce the number of the bacteria and let your immune system cope with the rest. So to get something with such a high kill rate that is so potent at such a low dose is very promising,” he told BBC News.

The compound would need years of testing for safety and efficacy before any drugs developed from them could go on the market.

Source: BBC NEWS

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Frog Skin may Help Beat Antibiotic Resistance

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Frog skin may be an important source of new antibiotics to treat superbugs say researchers.
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The foothill yellow-legged frog is one potential source of antibiotics, say researchers
.So far, more than 100 potential bacteria-killing substances have been identified from more than 6,000 species of frog.

The team at the United Arab Emirates University are now trying to tweak the substances to make them less toxic and suitable for use as human medicines.

The work was presented at the American Chemical Society meeting.

Drug resistant bacteria, such as MRSA, are becoming an increasing problem worldwide.

Yet there is a lack of new treatments in the pipeline.

Among the substances found by the researchers are a compound from a rare American species that shows promise for killing MRSA.

Another fights a drug-resistant infection seen in soldiers returning from Iraq.

The idea of using chemicals from the skin of frogs to kill bacteria, viruses and other disease-causing agents is not a new one.

But it is not a straightforward process to use these chemicals in humans because they are either destroyed in the bloodstream or are toxic to human cells.

Tweaks:-

After identifying the key chemicals, the researchers have altered their molecular structure to make them less dangerous to human cells while retaining their bacteria-killing properties

They hope their work means some of the substances could be in clinical trials within five years.

They are also investigating how to help the chemicals resist breakdown by the body before they have a chance to act.

Experiments have shown the changes they have made so far do make the antibiotics last longer in the bloodstream.

Study leader Dr Michael Conlon said: “Frog skin is an excellent potential source of such antibiotic agents.

“They’ve been around 300 million years, so they’ve had plenty of time to learn how to defend themselves against disease-causing microbes in the environment.

“Their own environment includes polluted waterways where strong defences against pathogens are a must.”

The work underscored the importance of preserving frog diversity, he added.

“Some frog species, including those that may contain potentially valuable medicinal substances, are in jeopardy worldwide due to loss of habitat, water pollution, and other problems.”

Source: BBC NEWS

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Animals Can Harbor MRSA

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Following a Lancet Infectious Diseases report of the spread of a new drug-resistant superbug spreading from south Asia, news agencies have reported “panic” over the germs’ possible consequences. Writing in the Guardian, for example, editor and columnist Sarah Boseley said:

“The era of antibiotics is coming to a close. In just a couple of generations, what once appeared to be miracle medicines have been beaten into ineffectiveness by the bacteria they were designed to knock out.”

The effectiveness of antibiotics depends on how antibiotics are used — how well drug use is managed in clinical practice and outside of it. But some 70 percent of American antibiotics — tens of millions of pounds of drugs each year — is used in animal feed.

The antibiotic-resistant staph strain that kills 19,000 Americans every year.

According to Time Magazine:

“The European Union banned routine use of antibiotics in animal feed years ago because of evidence about its drug-resistance consequences for humans. Now the U.S. Food and Drug Administration is recommending the same for the U.S. as well, for the same reason. But for now the practice continues.”

According to Grist:
“MRSA has a major food angle: Today, as much as 70 percent of antibiotics consumed in the United States go into concentrated-animal feedlot operations, or CAFOs, and these vast, factory-scale animal farms have been shown to harbor a novel MRSA strain.”

Sources:

Grist June 15, 2010

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Oregano, Garlic Oils Can Prevent Bacteria Attack!

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Essential oils from common spices like oregano, allspice and garlic can act as a natural barrier against bacteria like E-Coli, Salmonella and Oregano, garlic oils can prevent bacteria attack! (Getty Images)

CLICK & SEE.>…....oregano  oil.…….allspice oil..……garlic oil...

Listeria, according to a new US government study.

Oregano oil has been found to be the most effective antimicrobial, followed by allspice and garlic.

Researchers at Processed Foods Research and Produce Safety and Microbiology units of Western Regional Research Centre from the U.S. Department of Agriculture (USDA) investigated the effectiveness of the oils by incorporating them in thin, tomato-based antimicrobial coatings known as edible films.

In addition to its flavour properties, tomatoes are reported to possess numerous beneficial nutritional and bioactive components that may benefit human health.

Edible tomato films containing antimicrobials may protect food against contamination by pathogenic microorganisms.

The findings revealed that oregano oil consistently inhibited the growth of all three bacteria.

Although garlic oil was not effective against E. coli or Salmonella, but was effective against Listeria.

Vapour tests of oregano and allspice oils indicated that these two oils diffuse more efficiently through the air than through direct contact with the bacteria.

Listeria was less resistant to EO vapors while E. coli was more resistant.

“The results show that apple-based films with allspice, cinnamon or clove bud oils were effective against the three bacteria. The essential oils have the potential to provide multiple benefits to consumers,” said lead researcher R. J. Avena-Bustillos.

Source: The study appears in Journal of Food Science.

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Health Problems & Solutions

Some Health Tips Woman to Know

PRE-MENSTRUAL SYNDROME

PRE- MENSTRUAL
The irritable moods and water retention that affect many women the week before their period can be helped by taking more magnesium, says Dr Ann Walker.
While it’s not known exactly how the nutrient helps, it’s thought to boost the production of dopamine, a brain chemical which may be linked to mood.

Magnesium may also help prevent the inflammation which causes water retention. Dr Walker, who runs a herbal medicine clinic in Berkshire, says: ‘Many people don’t eat the foods which contain magnesium, such as wholegrains, beans and green leafy vegetables, so supplements may help. You need about 270mg a day, and look for magnesium citrate, which is easier to absorb than magnesium oxide.’

BACK PAIN

Back-Pain
Millions of people in the UK suffer from back pain, but women are more prone to lower back trouble – as a result of a combination of factors including the menstrual cycle, pregnancy and large breasts.
But this pain is often easily curable by performing stomach exercises, says GP Dr Claire Rushton, vice chairman of the Family Doctor Association.
She says: ‘People don’t realise that when the stomach muscles are weak, it can lead to back pain. The stomach muscles actually support the back; if their tone is poor, you tend to sag and your back then takes the strain.’
A simple exercise performed ten times each morning and evening will strengthen your tummy muscles.
Go down on all fours, keeping your back straight, then pull in your belly button as far as you can and hold for a count of ten. ‘After a week you should start to feel better,’ she says.
Dr Rushton also recommends pulling your tummy in if you’re bending forward to pick up something, as this also protects your back.

INFECTED HAIR FOLLICLES
INFECTED HAIR FOLLICLES
If you’ve had any part of your body waxed, wait a couple of days before going swimming or using a Jacuzzi, advises Alison Cope, consultant virologist at Sheffield Teaching Hospitals NHS Foundation Trust.
‘The open hair follicles make women prone to skin infection with bacteria such as Pseudomonas aeruginosa, which thrives in warm, wet areas and which causes “hot tub folliculitis”,’ she says.
This is an itchy, red rash which can lead to infected bumps. In serious cases, antibiotics are needed to clear up the problem.
And while hot tubs are the worst offenders because the temperature of the water makes it an ideal breeding ground, swimming pools also pose a risk.

Cope advises showering before and after using a pool or spa to minimise the chance of spreading bacteria or becoming infected yourself. Showering afterwards helps ensure you get rid of other people’s bacteria; showering before stops you spreading yours.
‘Also, don’t go to a place for waxing where they dip the spatula in a large tub of wax,’ she warns. ‘Chances are lots of other spatulas have been dipped in the same tub and the wax has become contaminated with other peoples’ skin flora (micro organisms that live on the skin).
‘This means organisms such as streptococci and staphylococci (even MRSA) can be transferred and cause infections like cellulitis ( infection of the tissues below the skin).’

THRUSH

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The moment thrush strikes, many women reach for a tub of yoghurt to treat the fierce, burning pain. But this won’t cure the Candida infection that’s causing the flare-up, says Dr Meera Kishen, consultant in sexual and reproductive health and member of the Medical Women’s Federation. ‘Although it feels like it is helping, this is because it’s cooling and soothing – cold water will have the same effect.’
Instead, sufferers should take a vaginal or oral preparation such as Canestan, available over the counter from chemists, and wear loose-fitting clothes and cotton underwear.
Despite common wisdom, thrush isn’t the most common vaginal infection – twice as many women get bacterial vaginosis, an infection caused by overgrowth of bacteria.
‘This can be caused by bath additives, sex or the coil,’ says Gloucestershire GP Dawn Harper. ‘One in three women gets it. The discharge is thinner than thrush and has a characteristic odour.’
Treat vaginosis with gels such as Balance-activ (from chemists).

SKIN CANCER

SKIN CANCER
News stories about the huge rise in skin cancer have made many women afraid to go out in the sun or, if they do, they smother themselves head-to-toe in sun block.
But they could be doing themselves more harm than good, warns dermatologist Dr Cecelia Tregear, of the Wimpole Skin Care Centre in London.
The body needs the sun to manufacture vitamin D and a deficiency can lead to serious problems such as rickets and osteoporosis. ‘A deficiency is also linked to cancers, bone disease and heart disease.’
Dr Tregear says women should try to strike a balance between avoiding skin cancer and protecting their bones, by going outside when it’s sunny for 20 minutes without wearing sun cream.

LOW LIBIDO

LOW LIBIDO
The onset of menopause often brings with it a loss of libido, but tibolone, a drug commonly prescribed to treat associated symptoms such as hot flushes and osteoporosis, can help.
Because the drug contains testosterone, one of its added benefits is that it helps perk up many women’s love lives as well as combating the symptoms of menopause.
‘Studies show that taking it for four to six months can improve your sex life,’ says GP Dr Zara Aziz, a GP in Bristol. ‘It’s thought to work by increasing blood flow to the genitals as well as replacing female hormones.’
DIARRHOEA
We all think of milk as soothing for our stomachs, but it’s the worst thing you can drink if you’ve just had a bout of diarrhoea, warns Winchester GP Anna Wilson.
Diarrhoea is a common symptom of irritable bowel syndrome, which affects an estimated four million women in Britain.
Dr Wilson recommends avoiding milk for at least 48 hours after a tummy upset.
‘Diarrhoea tends to knock out the lining cells of the gut which produce a lot of milk-digesting enzymes. It takes time for them to recover and, while they do, you have transient milk intolerance,’ she says.

‘But people very often make the mistake of drinking milk when they are getting better. Instead you should drink water or soya milk for a day or two to let the gut lining recover.
FATIGUE

fatigue-woman
Being tired all the time is often put down to anaemia and women think they should take more iron, but that could do more harm than good.
You may actually have haemochromatosis – a condition where the body absorbs too much iron and which can be toxic, leading to a build up of iron in organs, liver or heart failure and even death.
‘If you see your GP because you’re tired all the time and have aches and pains, you’ll usually be tested for anaemia,’ says Dr Pixie McKenna, a presenter on Channel 4’s Embarrassing Illnesses.
‘Your doctor may then tell you all is well – in fact you have a really good supply of iron – that’s why haemochromatosis is often missed. It’s an inherited condition and is very common in people of Celtic origin – one in 83 are carriers. Yet it’s easily detected by having a blood test, and is treatable.’

PREMATURE AGING

aging
Eating the wrong foods can make you age ahead of your time, says London cosmetic surgeon Dr Lucy Glancey. ‘One of the theories of ageing is that we have too many free radicals in our skin which accelerates the ageing process,’ she explains.
Free radicals are molecules that destroy body cells. A major source is thought to be sugar.
As Dr Glancey says, food such as doughnuts give you a sudden ‘massive rush of sugar’ – the body can’t eliminate this sugar effectively, and in the long run that sugar creates free radicals.
She recommends sticking to foods with a low glycemic index, such as most fruits and vegetables, fish, eggs and meat, which don’t raise the body’s blood sugar levels so high.
HYSTERECTOMIES

hysterectomy
During her 40s, a woman’s menstrual cycle can shorten to every three weeks, premenstrual syndrome symptoms become more severe and periods longer and heavier. To improve their quality of life, many women opt for a hysterectomy.
But according to sexual health consultant Dr Tina Peers, who is based in East Surrey, many women could be spared this operation if they simply changed their contraception.
‘Mirena, the progestogen coil, is the Rolls-Royce of contraception for women this age. It stops periods in 85 per cent of women.
‘Another choice that’s possible for those concerned about taking the combined pill until they’re 50 is NuvaRing, a disposable vaginal ring that’s as effective as the Pill but delivers a lower rate of hormones.’
BLOATED TUMMY

bloatedtummy
Ovarian cancer is known as the ‘silent killer’ and claims more than 4,300 lives a year in the UK because it has few symptoms, so is hard to detect.
One of the signs that’s most commonly missed or misdiagnosed is a bloated tummy, which women often put down to irritable bowel syndrome, says Dr Rupal Shah, a GP in Battersea, London.
‘If you feel constantly bloated for more than a couple of weeks and that feeling doesn’t disappear after you’ve been to the loo, then book an appointment to see your GP.
‘If it was IBS, you would expect to get some relief when you go to the loo and your bowel settles down. It’s not right to feel bloated day after day.’

DEPRESSION

depression-
Depression isn’t always in the mind – it can often be the warning sign of another illness or condition, warns London GP Ellie Cannon.
‘Depression and anxiety can be early symptoms of physical conditions such as anaemia, thyroid problems or the menopause,’ she says.

‘Before taking antidepressants, talk to your doctor about whether you need a blood test to rule out the possibility of these conditions.’

Source: Mail Online

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