Tag: Methicillin-resistant Staphylococcus aureus

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How to Combat the Latest Supergerms

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As more and more bugs, including some truly nasty bacteria, become impervious to the effects of drugs it’s necessary to come up with effective alternatives.
Fortunately, while some germs may be outpacing our ability to kill them, we’re not completely defenseless. In fact, there are plenty of things we can do to slow their spread.

Here are some of Health.com’s better suggestions:

•Fight the flu with vitamin D. 1,500 to 2,000 I.U. of vitamin D not only bolsters the immune system but also may help prevent infection. (PLEASE NOTE: this is NOT my recommendation, but abstracted from the article on Health.com. I believe most adults need 5,000-8,000 units of vitamin D per day)

•Wash your hands. The flu virus can live for up to 72 hours on surfaces. That makes hand-washing the most effective daily defense. Wash briskly with soap and water for 30 seconds.

•Cover up. Bandage all cuts, even paper cuts and blisters.

•Stay clean at the hospital. If you’re visiting a hospital, wash yourself and your clothes right after. Don’t use bar soap in any hospital bathroom or set your purse on the floor. And researchers recently found that one in three stethoscopes used by emergency-medical-service providers was contaminated with MRSA — ask your doctor to swab his scope with alcohol.

•De-germ the gym. Use a disinfectant wipe to swab the handlebars of equipment, and drape a clean towel over shared yoga mats and sauna and locker room benches.

•Don’t share. You’re at increased risk of MRSA if you share razors, soap, towels, or other personal items.

•Be proactive. If you have to take an antibiotic, take a probiotic at the same time to build up the healthy bacteria in your gut.

Source: Health.com July 15, 2009

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News on Health & Science

‘Bleach Bath’ Benefit for Eczema

Adding bleach to the bath may be an effective treatment for chronic eczema, US researchers say.
……………
In a study of 31 children, there was significant improvement in eczema in those who had diluted bleach baths compared with normal baths.

The Pediatrics study also showed improvements were only on parts of the body submerged in the bath.

The Pediatrics study also showed improvements were only on parts of the body submerged in the bath.

UK experts stressed the treatment could be extremely dangerous and should only be done under the care of a specialist.

Children with bad eczema suffer from chronic skin infections, most commonly caused by Staphylococcus aureus, which worsen the eczema that can be difficult to treat.

Some children get resistant MRSA infections.

“Bleach used incorrectly could cause enormous harm to a child with atopic eczema while in the hands of an expert it can, as this trial indicates lead to benefit” SAYS  Professor Mike Cork, Sheffield Children’s Hospital

Studies have shown a direct correlation between the number of bacteria on the skin and the severity of the eczema.

It has been shown that bacteria cause inflammation and further weaken the skin barrier.

In the study, researchers randomly assigned patients who had infection with Staphylococcus aureus to baths with half a cup of sodium hypochlorite per full tub or normal water baths for five to 10 minutes twice a week for three months.

They also prescribed a topical antibiotic ointment or dummy ointment for them to put into their nose – a key site for growth of the bacteria.

Eczema severity in patients reduced five times as much as those on placebo.

But there was no improvement in eczema on the head and neck – areas not submerged in the bath.

Rapid improvement :-

“We’ve long struggled with staphylococcal infections in patients with eczema,” said study leader Dr Amy Paller, from Northwestern University in Chicago.

She added they saw such rapid improvement in the children having bleach baths that they stopped the study early.

“The eczema kept getting better and better with the bleach baths and these baths prevented it from flaring again, which is an ongoing problem for these kids.

“We presume the bleach has antibacterial properties and decreased the number of bacteria on the skin, which is one of the drivers of flares.”

Professor Mike Cork, head of dermatology research and a consultant at Sheffield Children’s Hospital, said antiseptic baths had been used as a treatment for eczema for quite a while but the trial was important because it highlights the benefits from reducing bacteria.

“But people should not start putting bleach in their children’s bath.

“Bleach used incorrectly could cause enormous harm to a child with atopic eczema while, in the hands of an expert, it can as this trial indicates lead to benefit.”

He added the trial highlighted the need for children with uncontrolled eczema to be referred to a specialist for treatment.

Sources: BBC News :27th.April.’09

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The New Bone Cement

New Bone Cement to Prevent Dangerous Injury Infections:-

…..
Osteomyelitis (OM) is a dangerous bacterial bone infection that often occurs in patients with open fractures. So it is not surprising that injured American soldiers serving in Afghanistan and Iraq have been getting OM, with an end result sometimes being a limb amputation. Now researchers from the Center for Musculoskeletal Research in Rochester with help from the Department of Orthopedics at Aarhus University Hospital in Denmark, Infectious Disease Service at Brooke Army Medical Center in San Antonio, and Heraeus Medical GmbH, created a new colistin-infused bone cement that is showing itself to be effective against the variety of bacterial pathogens that cause OM. Interestingly, Stryker already has a bone cement that features colistin, a product called Simplex P with Erythromycin & Colistin.

From a press statement by the University of Rochester Medical Center:
Not common in the United States and not potentially fatal, A. baumannii OM had been largely ignored until recently by physicians and the pharmaceutical industry, which focuses on life-threatening infections that affect millions, not hundreds. Then military outbreaks of the infection started among American soldiers returning from Iraq in 2003, with the number of A. baumannii OM infections seen in field hospitals, and in stateside facilities receiving injured soldiers, growing. At the same time, data began to emerge from hospitals treating soldiers suggesting that easily contracted A. baumannii may be arriving first at the fracture site and “priming” it so that it becomes more vulnerable to methicillin-resistant Staphylococcus aureus (MRSA), which recently surpassed HIV as the most deadly pathogen in the United States despite nearly universal use of the best available antibiotics.
“If you apply the findings from two small studies to the entire U.S. military, which is a leap, perhaps 2,000 soldiers come into field hospitals with compound fractures each year that become infected with A. baumannii,” said Edward Schwarz, Ph.D., professor of Orthopaedics within the Center for Musculoskeletal Research at the University of Rochester Medical Center. “About a third of them go on to get a staph infection after they reach the hospital, with about a third of those, perhaps 200 soldiers, suffering infectious complications that could cost them a limb. Studies already underway in our lab seek to clarify how the initial infections could gradually be replaced by catastrophic MRSA, and to prove that we can save limbs by putting an established antibiotic into bone cement for the first time.”

Approaches commonly used to overcome MDR [multi-drug resistant] infections after orthopaedic injuries include applying a large dose of antibiotic locally to the site of infection via bone cement. Bone cements composed of Plexiglas (polymethyl methacrylate or PMMA) have been used for decades for plastic surgery, to anchor in bone prostheses and to fill in holes in bone caused by trauma. Such materials became even more useful when researchers realized decades ago that they could load them with antibiotics to deliver large doses of drug directly to the injury site without subjecting the whole body to toxic levels of antibiotic. While bone cements laced antibiotics against staph and strep infections are common (e.g. vancomycin), no group had ever developed a bone cement treatment using colistin against A. baumannii.

Schwarz and colleagues developed a group of mice infected with drug resistant A. baumannii strains isolated directly from soldiers wounded in Iran and Afghanistan. The mice were then treated with either colistin by injection, local colistin via PMMA bead bone cement or a bone cement control with no drug.

Researchers measured the amount of bacteria in the mice as they responded to treatment with a new test of parC gene activity, a gene known to be present only in A. baumannii. Experiments confirmed that all study mice were infected with the bacteria, and that 75 percent of the strains were resistant to multiple antibiotics. Importantly, the bone cement containing colistin significantly reduced the infection rate such that only 29.2 percent of mice had detectable levels of parC after 19 days (p<0.05 vs. i.m. colistin and placebo). Colistin via injection failed to control the infection and was no better than placebo.

You may click to see:->

Press release: New Bone Cement May Prevent Amputations

Flashback: Rapid-Sequencing the Superbug

Sources:http://www.medgadget.com/archives/2009/01/new_bone_cement_to_prevent_dangerous_battle_injury_infections.html

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Diagnonistic Test

Rapid Detection of Infectious Diseases.

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Only a few minutes and a simple, ready-to-use diagnostic test kit are needed to determine an individual’s infectious disease status.
CLICK & SEE THE ICTURES
In about the middle of the 20th century, mass vaccination programs and the widespread availability of antibiotics significantly reduced the threat of infectious diseases in Canada and many other regions of the world. Indeed, a concerted worldwide effort led to eradication of the smallpox virus, the cause of the most serious infectious disease in the western world during the 17th and 18th centuries , and the incidence of other diseases, such as the common childhood ailments measles, mumps, and pertussis, have been reduced by similar vaccination programs . Despite these advances, however, infectious diseases remain the world’s leading cause of premature death, accounting for about 17 million deaths in 1995.

To further control communicable diseases, global efforts must overcome ongoing challenges provided by the evolution of infectious agents. Among the more significant evolutionary changes in the past 25 years are the increased prevalence of antibiotic resistance in infectious bacteria (e.g., methicillin resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococci (VRE))  and the emergence of about 30 new infectious agents (e.g., human immunodeficiency virus (HIV), hepatitis C virus (HCV), and the ebola virus) . Moreover, rapid evolutionary changes create new appearances for some infectious agents (e.g., the influenza virus and HIV), allowing them to circumvent the defensive mechanisms of our immune systems.

Another obstacle for the control of communicable diseases arises when the role of an infectious agent in a disease goes unnoticed. The significance of this point was demonstrated in the 1980s when the bacterium Helicobacter pylori was finally recognized as a causative factor of duodenal ulcers and other gastric diseases . As a result of the H. pylori discovery, many gastric diseases are now effectively treated with antibiotics, and it is possible that new therapeutic directions will be stimulated by a recent proposal, which implicates chronic infections as a cause of several well-Known diseases (e.g., atneroscierosis and Alzheimer’s Disease).

For infectious diseases, an unambiguous diagnosis obtained in a timely fashion is extremely important, not only from a personal viewpoint (i.e., the initiation of an appropriate treatment), but also from a public health perspective (i.e., the prevention of disease transmission from one individual to another).

To a large extent, evidence for the presence of an infectious agent, and thus the diagnosis of infectious disease status, is provided by the results of one or more diagnostic tests. In addition to providing an accurate result, an ideal rapid diagnostic test should be easy to perform while yielding a definite result within a reasonable length of time ([less than]30 min to be considered as a rapid test).

For these reasons, most rapid diagnostic tests for infectious diseases are based on the highly selective, noncovalent interactions between an antibody and an antigen. Antibodies are proteins produced by the immune system in response to the entry of a foreign entity, such as an infectious agent. Because antibodies specifically bind to a distinct site (or epitope) in a protein or another macromolecule (i.e., the antigen) associated with the infectious agent, the unique group of antibodies generated during each infection is an excellent diagnostic marker for disease. This immunoassay approach can be limited by the time required for antibody levels to increase to detectable levels after infection (e.g., antibodies for HIV are detectable on average 25 days post infection).

Immunoassays in various forms (e.g., enzyme immunoassays) are increasingly employed in clinical laboratories; however, the rapid test format is the most recent innovation in an industry undergoing substantial growth. In rapid tests, membrane immobilized antigens are used to capture the antibodies generated against the infectious agent. The specificity of a test towards a particular disease relies on the highly specific antigen-antibody interaction, and the appropriate choice of an antigen captures only the disease specific antibodies on the rapid test membrane. The appropriate antigen can be obtained from the infectious agent, produced by recombinant methods, or mimicked by synthetic peptides.

Antibodies captured by the membrane-immobilized antigen are detected using a colour reagent (e.g., protein A-colloidal gold or anti-human IgG antibodies conjugated to coloured particles), and a positive test typically is signified by the appearance of a coloured dot or line on the test membrane. If no disease antibodies are present in the sample, the colour reagent is not trapped on the membrane, and a negative result is obtained. A control dot or line often is included to verify that the colour reagent is functioning properly. While the rapid test format with visual interpretation provides only a qualitative result, a positive/negative result is sufficient in many diagnostic applications, including infectious disease diagnosis.

An immediate result provided by a rapid test is particularly advantageous when knowledge of a communicable disease is needed quickly (e.g., emergency surgery) or when a patient is apprehensive about the disease and might not make a second visit to a medical facility to receive the test result. The latter is a significant problem; about 30% of patients tested for HIV in publicly funded clinics in the United States during 1995 did not return , and a large cost is incurred by tracking them down to deliver the result of a laboratory test and to arrange a confirmatory test when a positive first result is obtained. The simplicity of the rapid test format allows the test to be used wherever an infectious disease has a high prevalence, or in remote clinical settings where patients must travel significant distances to get to the test centre.

The timeline from the initial idea to sales of an approved rapid diagnostic test is about five years. Over this period, research is undertaken to validate the concept; the optimum parameters are established for the immunoassay in the rapid test format, and in-house evaluation is conducted. The safety and effectiveness of the test is then established by independent clinical trials at several different locations before applications are submitted for regulatory approval by Health Canada and agencies in other countries, such as the Food and Drug Administration (FDA) in the United States. In April 1998, Health Canada granted its first approval for a rapid HIV test to MedMira Laboratories Inc.

MedMira is a publicly traded (CDNX: MIR) Canadian medical biotechnology company at the leading edge of rapid diagnostic test development. The company has expanded considerably since the early 1990s when it was established in Nova Scotia’s Annapolis Valley. At present, MedMira has over 45 employees and a corporate office in Toronto, ON. Separate locations for research and manufacturing are located in the Halifax Regional Municipality. In July 1999, MedMira Laboratories received International Organization of Standards ISO9001 registration designed around Health Canada’s ISO 13485 essentials for the manufacture of medical devices, and a system of product manufacturing compliant with the U.S. FDA current Good Manufacturing Practices (cGMP) was established and implemented at MedMira in April 1999.

In addition to the HIV test, which is able to detect HIV-1, HIV-2, and the rare group O variant of HIV-1, MedMira also has developed rapid tests for other infectious agents, including H. pylori, hepatitis B virus (HBV), HCV, and a HIV/HCV combination. The MedMira rapid tests meet the approval requirements in several countries and the approval process is underway in others. For example, the H. pylori test was granted U.S. FDA 510(k) clearance last year, and the U.S. FDA/PMA committee and the Chinese State Drug Administration (SDA) have accepted the MedMira HIV test for review. The MedMira test kits are marketed worldwide.

While the acute effects of infectious diseases are widely known, a connection between infectious agents and cancer has been established for HBV/HCV (liver cancer) , H. pylori (gastric cancer) , and human papillomaviruses (HPV) (cervical cancer) . Currently, rapid tests for infectious diseases identify certain underlying risk factors for cancer, but in the future, rapid test methodology will be available to detect markers associated with other forms of cancer.

Diagnostic tests are an integral part of modern health care. The availability of rapid diagnostic tests demonstrates that the complex interactions between molecules such as antigens and antibodies (and up-to-date science) can be utilized to provide a reliable diagnostic test in a simple format. Ongoing research is needed to keep rapid test methodology current with the evolution of infectious agents, and to expand the rapid test approach to the diagnosis of other diseases. Because of the simple format and reasonable cost, rapid test methodology holds the promise of bringing more efficient and effective diagnostic testing to both developed and undeveloped countries around the world.

Sources:http://www.allbusiness.com/north-america/canada/791219-1.html

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Diagnonistic Test

Throat Culture

 

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Definition:
A throat infection with streptococcus bacteria (called strep throat) needs to be treated with an antibiotic.Throat swab culture is a laboratory test done to isolate and identify organisms that may cause infection in the throat. It is the traditional test used for identifying streptococcus bacteria on your throat surface. Throat cultures also can identify some other bacteria that can cause sore throat.

….CLICK  & SEE

Throat swab culture is a laboratory test done to isolate and identify organisms that may cause infection in the throat.The test is performed when a throat infection is suspected, particularly strep throat.

How do you prepare for the test?
No preparation is necessary.Only do not use antiseptic mouthwashes before the test.

What happens when the test is performed?
Tilt your head back with your mouth wide open.A sterile cotton swab is rubbed against the back of your throat to gather a sample of mucus from near the tonsils.Resist gagging and closing the mouth while the swab touches the back of the throat near the tonsils. This takes only a second or two and makes some people feel a brief gagging or choking sensation.

.….click & see

In order to improve the chances of detecting bacteria, the swab may be used to scrape the back of the throat several times. The mucus sample is then placed on a culture plate that helps any bacteria present in the mucus grow, so they can be examined and identified.

How the Test Will Feel :
Your throat may be sore at the time the test is taken. You may experience a gagging sensation when the back of your throat is touched with the swab, but the test only lasts a few seconds.

What risks are there from the test?
There are no risks.This test is safe and well-tolerated. In very few patients, the sensation of gagging may lead to an urge to vomit or cough.

Normal Results:
The presence of the usual mouth and throat bacteria is a normal finding.

What Abnormal Results Mean :
An abnormal result means bacteria or other organism is present. This is usually a sign of infection.

Must you do anything special after the test is over?
Nothing.

How long is it before the result of the test is known?
Results from a strep culture are available in two or three days.

Resources:
https://www.health.harvard.edu/diagnostic-tests/throat-culture.htm
http://www.nlm.nih.gov/medlineplus/ency/article/003746.htm

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